Sensitivity of cloned muscle, heart and neuronal voltage-gated sodium channels to block by polyamines: A possible basis for modulation of excitability in vivo

Channels

Volumn 6, Issue 1, 2012, Pages 41-49

  Fu, Li Ying ^a   Cummins, Theodore R ^b   Moczydlowski, Edward G ^c  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c SANDIA NATIONAL LABORATORIES   (United States)

Author keywords

Inward rectification; Lidocaine; Local anesthetics; Polyamines; Sodium channels; Spermidine; Spermine; Use dependence

Indexed keywords

POLYAMINE; SODIUM CHANNEL NAV1.2; SODIUM CHANNEL NAV1.4; SODIUM CHANNEL NAV1.5; SODIUM CHANNEL NAV1.7; SODIUM ION; SPERMIDINE; SPERMINE; VOLTAGE GATED SODIUM CHANNEL; LIDOCAINE; SODIUM CHANNEL;

ACTION POTENTIAL; ARTICLE; CELL MEMBRANE TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOPLASM; IN VIVO STUDY; MODULATION; MOLECULAR CLONING; PHARMACOLOGICAL BLOCKING; POLYAMINE METABOLISM; SODIUM CURRENT; TIME; ANIMAL; CELL STRAIN HEK293; CHO CELL; CRICETULUS; HAMSTER; HEART; HUMAN; INWARD RECTIFICATION; LOCAL ANESTHETICS; NERVE CELL; PHYSIOLOGY; PROTEIN SUBUNIT; RAT; SKELETAL MUSCLE; USE-DEPENDENCE; VOLTAGE-GATED NA+ CHANNELS;

MAMMALIA; RATTUS;

INWARD RECTIFICATION; LIDOCAINE; LOCAL ANESTHETICS; POLYAMINES; SODIUM CHANNELS; SPERMIDINE; SPERMINE; USE-DEPENDENCE; VOLTAGE-GATED NA+ CHANNELS;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; HEART; HEK293 CELLS; HUMANS; MUSCLE, SKELETAL; NEURONS; PROTEIN SUBUNITS; RATS; SPERMIDINE; SPERMINE; VOLTAGE-GATED SODIUM CHANNELS;

EID: 84860329345     PISSN: 19336950     EISSN: 19336969     Source Type: Journal    
DOI: 10.4161/chan.19001     Document Type: Article

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