Endogenous polyamines regulate cortical neuronal excitability by blocking voltage-gated Na+ channels

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 48, 2008, Pages 18994-18999

  Fleidervish, Ilya A ^a   Libman, Lior ^a   Katz, Efrat ^a   Gutnick, Michael J ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Layer 5 pyramidal neuron; Neocortex; Persistent sodium current; Sodium channel; Spermine

Indexed keywords

POLYAMINE; POLYCATION; SPERMIDINE; SPERMINE; VOLTAGE GATED SODIUM CHANNEL;

ARTICLE; BRAIN CORTEX; BRAIN NERVE CELL; DEPLETION; DRUG METABOLISM; ELECTRIC POTENTIAL; EXCITABILITY; HUMAN; METABOLISM; NEOCORTEX; NEUROMODULATION; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; WHOLE CELL;

ACTION POTENTIALS; ANIMALS; CEREBRAL CORTEX; ION CHANNEL GATING; MICE; NEURONS; PATCH-CLAMP TECHNIQUES; POLYAMINES; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; SPERMIDINE; SPERMINE; TETRODOTOXIN;

EID: 57749116314     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0803464105     Document Type: Article

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