'Okra' Hibiscus esculentus L.: A study of its hepatoprotective activity

Saudi Pharmaceutical Journal

Volumn 20, Issue 2, 2012, Pages 135-141

  Alqasoumi, S I ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Antioxidant; Carbon tetrachloride; Hepatoprotection; Hibiscus esculentus; Lipid peroxidation; Okra

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; ALKALINE PHOSPHATASE; ANTIOXIDANT; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CARBON TETRACHLORIDE; CHOLESTEROL; GAMMA GLUTAMYLTRANSFERASE; HIBISCUS ESCULENTUS EXTRACT; LIVER PROTECTIVE AGENT; MALONALDEHYDE; PENTOBARBITAL; PLANT EXTRACT; SILYMARIN; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DRUG SCREENING; FEMALE; HISTOLOGY; LIVER PROTECTION; LIVER TOXICITY; MALE; NONHUMAN; OKRA; RAT; SLEEP TIME; TOXIC HEPATITIS;

EID: 84860329117     PISSN: 13190164     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsps.2011.10.002     Document Type: Article

References (33)

1. Al-Dosari M., Alqasoumi S., Ahmed M., Al-Yahya M., Ansari M.N., Rafatullah S. Effect of Beta vulgaris L. on cholesterol rich diet-induced hypercholesterolemia in rats. FARMAC 2011, 59(5):669-678.
2. Al-Howiriny T.A., Al-Sohaibani M., El-Tahir K., Rafatullah S. Preliminary evaluation of the anti-inflammatory and antihepatotoxic activity of " Parsley" Petroselinumcrispum in rats. J. Nat. Med. 2003, 3:54-62.
3. Al-Rehaily A.J., Al-Said M.S., Al-Yahya M.A., Mossa J.S., Rafatullah S. Ethnopharmacological studies on Allspice (Pimentadioica) in laboratory animals. Pharm. Biol. 2002, 40:200-205.
4. Aman M. Medicinal Secrets of Your Food 1969, Indo-American Hospital, Mysore, India, pp. 430-432. second ed.
5. Ansari N.M., Houlihan L., Hussain B., Pieroni A. Antioxidant activity of five vegetables traditionally consumed by South-Asian migrants in Bradford, Yorkshire, UK. Phytother. Res. 2005, 19(10):907-911.
6. Arapitsas P. Identification and quantification of polyphenols compounds fromokra seeds and skins. Food Chem. 2008, 110:1041-1045.
7. Chopra R.N., Nayar S.L., Chopra I.C. Glossary of Indian Medicinal Plants 1956, Council of Scientific & Industrial Research, New Delhi, p. 133.
8. Cook J.A., Vanderjagt D.J., Pastuszyn A., Mounkaila G., Glew R.S., Millson M. Nutrient and chemical composition of 13 wild plant foods of Niger. J. Food Comp. Anal. 2000, 13:82-92.
9. Culling C.F. Handbook of histopathological and histochemical techniques 1974, Butterworth and Co., London, p. 37. third ed.
10. Dandiya P.C., Collumbine H. Studies on acoruscalamus: pharmacological actions of essential oil. J. Pharmacol. Exp. Ther. 1959, 125:353-359.
11. Demacher P.N.M., Hijamaus A.G.M. A study of the use of polyethylene glycol in estimating cholesterol. Clin. Chem. 1980, 26:1775-1778.
12. Fernandes N.P.C., Lagishetty C.V., Panda V.S., Naik S.R. An experimental evaluation of the antidiabetic and antilipidemic properties of a standardized Momordica charantia fruit extract. BMC Complement. Altern. Med. 2007, 7(29):1-8.
13. Foster L.B., Dunn R.T. Stable reagents for the determination of serum triglycerides by a colorimetric Hantzch condensation method. J. Clin. Chem. 1973, 19:338-340.
14. Fransworth N.R. Biological and phytochemical screening of plants. J. Pharm. Sci. 1966, 55:225-272.
15. Gurbuz I., Ustun O., Yesilada E., Sezik E., Kutsal O. Anti-ulcerogenic activity of some plants used as folk remedy in Turkey. J. Ethnopharmacol. 2003, 88:93-97.
16. Heber D. Vegetables, fruits and phytoestogens in the prevention of diseases. J. Postgrad. Med. 2004, 50:145-149.
17. Hertog M.G., Feskens E.J., Hollman P.C., Katan M.B., Kromhout D. Dietaryantioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet 1993, 342:1007-1011.
18. Hirose K., Kosuge Y., Otomatsu T., Endo K., Hasegawa K. Preparation of a growth-promoting substance, lepidimoic acid, from Okra; ectic polysaccharide. Tetrahed. Lett. 2003, 44:2171-2173.
19. Huang R., Okuno H., Takasu M., Shiozaki Y. Protective effect of rifampicin against acute liver injury induced by carbon tetrachloride in mice. Jpn. J. Pharmacol. 1995, 69:325-334.
20. Janbaz K.H., Saeed S.A., Gilani A.H. Studies on the protective effects of caffeic acid and quercetin on chemical-induced hepatotoxicity in rodents. Phytomedicine 2004, 11:424-430.
21. 4 poisoning?. Free Radic. Biol. Med. 2000, 28:838-845.
22. Kamal, H., 1975. Encyclopaedia of Islamic medicine. General Egyptian Book Organization, p. 328.
23. Pradeep K., Mohan C.V.R., Gobianand K., Karthikeyan S. Effect of Cassia fistula Linn, leaf extract on diethylnitrosamine induced hepatic injury in rats. Chem. Biol. Interact. 2007, 167:12-18.
24. Rafatullah S., Mossa J.S., Ageel A.M., Al-Yahya M.A., Tariq M. Hepatoprotective and safety evaluation studies on sarsaparilla. Int. J. Pharmacog. 1991, 29:296-300.
25. Rafatullah S., Al-Sheikh A., Alqasoumi S., Al-Yahya M., ElTahir K., Galal A. Protective effect of fresh radish juice (Raphanus sativus L.) against carbon tetrachloride-induced hepatotoxicity. Int. J. Pharmacol. 2008, 4:130-134.
26. Recknagel R.O., Glende E.A., Dolak J.A., Waller R.L. Mechanisms of carbon tetrachloride toxicity. Pharmacol. Ther. 1989, 43:139-154.
27. Sedlak J., Lindasy R.H. Estimation of total protein bound and nonprotein sulfhydryl group in tissue with Ellman's reagents. Anal. Biochem. 1968, 25:192-205.
28. Shui G., Peng L.L. An improved method for the analysis of major antioxidants of Hibiscus esculentus Linn. J. Chromatogr. A 2004, 1048:17-24.
29. Souza M.F., Rao V.Sn., Silveira E.R. Inhibition of lipid peroxidation by ternatin, a tetramethoxyflavone from Egletes viscose L. Phytomedicine 1997, 4:25-29.
30. Sunilson J.A.J., Jayaraj P., Mohan M.S., Kumari A.A.G., Varatharajan R. Antioxidant and hepatoprotective effect of the roots of Hibiscus esculentus Linn. Int. J. Green Pharm. 2008, 2(4):200-203.
31. Utley H.G., Bernheim F., Hochstein P. Effect of sulfhydryl reagents on peroxidation in microsomes. Arch. Biochem. Biophys. 1967, 118:29-32.
32. Yang V.S., Ahn T.H., Lee J.C., Moon C.J., Kim S.H.O., Jun W. Protective effects of Pycngenol® on carbon tetrachloride-induced hepatotoxicity in Sprague-Dawley rats. Food Chem. Toxicol. 2008, 46:380-387.
33. Yazdanparast R., Bahramikia S., Ardestani A. Nasturium officinale reduces oxidative stress and enhances antioxidant capacity in hypercholesterolaemic rats. Chem. Biol. Interact. 2008, 172:176-184.