Effect of beta vulgaris l. on cholesterol rich diet-induced hypercholesterolemia in rats

Farmacia

Volumn 59, Issue 5, 2011, Pages 669-678

  Al Dosari, Mohammed ^a   Alqasoumi, Saleh ^a   Ahmad, Majid ^b   Al Yahya, Mohammed ^a   Nazam Ansari, M ^b   Rafatullah, Syed ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b PRINCE SATTAM BIN ABDULAZIZ UNIVERSITY   (Saudi Arabia)

Author keywords

Antioxidant; Beet root; Beta vulgaris; Hypercholesterolemia; Lipid profile

Indexed keywords

ALKALOID; ANTHRAQUINONE DERIVATIVE; BEET EXTRACT; CARDIAC GLYCOSIDE; COUMARIN DERIVATIVE; CYANOGENIC GLYCOSIDE; ESSENTIAL OIL; FLAVONOID; FREE RADICAL; GLYCOSIDE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; MALONALDEHYDE; PLANT EXTRACT; SAPONIN DERIVATIVE; STEROL DERIVATIVE; TANNIN DERIVATIVE; THIOL DERIVATIVE; TRITERPENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERCHOLESTEROLEMIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BEET; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CONTROLLED STUDY; DRUG ISOLATION; DRUG MECHANISM; EXPERIMENTAL MODEL; FEMALE; GLUCOSE BLOOD LEVEL; HEART; HYPERCHOLESTEROLEMIA; LIPID PEROXIDATION; LIVER HOMOGENATE; LIVER LEVEL; MALE; NONHUMAN; PHYTOCHEMISTRY; RAT; TOXICITY TESTING; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 80054117321     PISSN: 00148237     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Ashraf ZA, Hussain ME, Fahim M. Antiatherosclerotic effects of dietary supplementation of garlic and turmeric: restoration of endothelial function in rats. Life Sci. 2005, 77, 837-857.
2. Braunwald E. Shattuck lecture - Cardiovascular medicine at the turn of the millennium: triumphs, concerns, and opportunities. N. Engl. J. Med. 1997, 337, 1360-1369.
3. Cheeke PR. Nutritional and physiological implications of saponins. Can. J. Animal Sci. 1971, 51, 621-632.
4. Chen M, Masaki T, Sawamura T. Lox-1, the receptor for oxidized lowdensity lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis. Pharmacol. Ther. 2000, 95, 89-100.
5. Chevallier A. The Encyclopedia of Medicinal Plants. New York: DK Publishing Inc.; 1996,176.
6. Chopra RN, Nayar SL, Chopra IC. Glossary of Indian Medicinal Plants. Council of Scientific & Industrial Research. New Delhi, 1956, 110.
7. Das NP, Ramanathan L. Studies on flavonoids and related compounds as anti-oxidants in food. In: Ong, A.S.H., Packer, L. (Eds.), Lipid-Soluble Anti-Oxidants: Biochemistry and Clinical Applications. Birkhauser, Basel, 1992, 295-306.
8. Dhalla NS, Temshah RM, Netticadan T. Role of oxidative stress in cardiovascular diseases. J. Hypertens. 2000, 18, 655-673.
9. Fransworth, N.R.: Biological and phytochemical screening of plants. J. Pharm. Sci. 1966, 55, 225-272.
10. Gokkusu C, Mostafazadeh T. Changes of oxidative stress in various tissues by long-term administration of vitamin E in hypercholesterolemic rats. Clin. Chim. Acta 2003, 328, 155-161.
11. Gokkusu C, Mostafazadeh T. Changes of oxidative stress in various tissues by long-term administration of vitamin E in hypercholesterolemic rats. Clin. Chim. Acta 2003, 328, 155-161.
12. Grundy SM, Denke MA. Dietry influences on serum lipids and lipoproteins. J. lipid Res. 1991, 31,1149-1172.
13. Gupta R, Gupta HP, Kumar N, Joshi AK, Gupta VP. Lipoprotein lipids and prevelence of hyperlipidaemia in rural India. J Cardiovasc Risk 1994, 1, 179-183.
14. Gupta R, Kaul V, Prakash H. Profiles of cholesterol and other lipids in Indian men. Indian Heart J 1995, 47, 636.
15. Hostettman K, Marston A. Saponins. Cambridge University Press, Cambridge, 1995, 232-286.
16. Kapadia GJ, Tokuda H, Konoshima T, Nishino H. Chemoprevention of lung and skin cancer by Beta vulgaris (beet) root extract. Cancer lett. 1996, 100(1-2), 211-214.
17. Khoo KL, Tan H, Liew YM, Deslypere JP, Janus E. Lipids and coronary heart disease in Asia. Atherosclerosis 2003, 169, 1-10.
18. Kim BJ, Kim YK, Park WH, Ko JH, Lee YC, Kim CHA. water-extract of the Korean traditional formulation Geiji-Bokryung-Hwan reduces atherosclerosis and hypercholesteremia in cholesterol-fed rabbits. Int immunopharmacol. 2003. 3, 723734.
19. Lum H, Roebuck KA. Oxidant stress and endothelial cell dysfunction. Am. J. Physiol. 2001, 280, 719-714.
20. Oakenfull D. Saponins in food. Food Chem. 1981, 6, 19-40.
21. Ou HC, Chou FP, Lin TM, Yang CH, Sheu, WH. Protective effects of honokiol against oxidized LDL-induced cytotoxicity and adhesion molecule expression in endothelial cells. Chemico-Biological Interactions 2006, 161, 1-13.
22. Parthasarathy S, Santanam N, Ramachandran S, Meilhac O. Potential role of oxidized lipids and lipoproteins in antioxidant defense. Free Radic Res 2000;33:197-215.
23. Prajapati ND, Purohit SS, Sharma AK, Kumar TA. A handbook of medicinal plants. A complete source book: Agorbios 2003. p. 88.
24. Prasad K, Kalra J. Oxygen free radicals and hypercholesterolemic atherosclerosis. Am. Heart Journal 1993, 125, 958-971.
25. Ramakrishnan S. Biochemistry Students' Manual, India: 1994.
26. Rosenson RS. Statins in atherosclerosis: lipid-lowering agents with antioxidant capabilities. Atherosclerosis 2004, 173, 1-12.
27. Ross R. The pathogenesis of atherosclerosis -an update. N. Engl. J. Med. 1986. 314, 488-500.
28. Saini HK, Arneja AS, Dhalla NS. Role of cholesterol in cardiovascular dysfunction. Can J Cardiol. 2004;20:333-346.
29. Sedlak J, Lindasy RH. Estimation of total protein bound and nonprotein sulfhydryl group in tissue with Ellman's reagents. Anal. Biochem. 1968, 25, 192-205.
30. The Organization of Economic Co-operation Development (OECD). The OECD Guideline for Testing of Chemical: 420 Acute Oral Toxicity. OECD, 2001, Paris, 1-14.
31. Utley HG, Bernheim F, Hochstein P. Effect of sulfhydryl reagents on peroxidation in microsomes. Arch. Biochem. Biophys. 1967, 118, 29-32.
32. Wettasinghe M, Bolling B, Plhak LC, Xiao H, Parkin KL. Phase II enzyme-inducing and antioxidant activities of extracts of beetroot (Beta vulgaris L.). J. Agric. Food Chem. 2002, 50, 6704-6709.
33. Wilson PW. High density lipoprotein, low density lipoprotein and coronary heart disease. Am J Cardiol 1990, 66, 7A-10A.
34. Wollenweber E. Occurrence of flavonoid aglycones in medicinal plants. In: Cody, V, Middelton, E. Jr., Harborne, J.B., Beretz, A. (Eds.), Plant Flavonoids in Biology and Medicine II: Biochemical, Cellular and Medicinal Properties. Progress in Clinical and Biological Research, 1988, vol. 280, Alan R. Liss, New York, pp. 45-55.
35. Wu R, Lamontagne D, de Champlain J. Anti-oxidative properties of acetylsalicylic acid on vascular tissues from normotensive and spontaneously hypertensive rats. Circulation 2002, 105, 387-392.