Protective effect of fresh radish juice (Raphanus sativus L.) against carbon tetrachloride-induced hepatotoxicity

International Journal of Pharmacology

Volumn 4, Issue 2, 2008, Pages 130-134

  Rafatullah, Syed ^a   Al Sheikh, Abdulmalik ^a   Alqsoumi, Saleh ^a,b   Al Yahya, Mohammed ^b   El Tahir, Kamal ^b   Galal, Ahmed ^c  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

^c UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

Brassicaceae; Carbon tetrachloride; Fresh juice; Liver protection; Radish; Raphanus sativus

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ANTIOXIDANT; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CARBON TETRACHLORIDE; LIVER ENZYME; NONPROTEIN SULFHYDRYL GROUP; RADISH EXTRACT; SILYMARIN; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BEVERAGE; BILIRUBIN BLOOD LEVEL; CONTROLLED STUDY; ENZYME BLOOD LEVEL; HISTOCHEMISTRY; LIVER; LIVER PROTECTION; LIVER TOXICITY; MALE; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN CONTENT; RADISH; RAT; SLEEP TIME; TREATMENT RESPONSE; WISTAR RAT;

EID: 60249102853     PISSN: 18117775     EISSN: 18125700     Source Type: Journal    
DOI: 10.3923/ijp.2008.130.134     Document Type: Article

References (22)

1. Aggarwal, B.B. and H. Ichikawa, 2005. Molecular targets and anticancer potential of indole-3-carbinol and its derivatives. Cell Cycle, 4: 1201-1215.
2. Aman, M., 1969. Medicinal Secrets of Your Food. 2nd Edn. Indo-American Hospital, Mysore, India, pp: 461-463.
3. Burk, R., 1983. Glutathione-dependent protection by rat liver microsomal protein against lipid peroxidation. Biochem. Biophys. Acta, 757: 21-28.
4. Culling, C.F., 1974. A Handbook of Histopathological and Histochemical Techniques. 3rd Edn. Butterworth and Co., London, pp: 73, 126, 159.
5. Dandiya, P.C. and H. Collumbine, 1959. Studies on Acorus calamus: Pharmacological actions of essential oil. J. Pharmacol. Exp. Ther., 125: 353-359.
6. El Sayed, F., F. Mansur M. C. Marguery, P. Bayle and J. Bazex, 1995. Urticarial manifestations due to Raphanus niger. Contact Dermatitis, 32: 241.
7. Fujimoto, J.M., K.B. Pearce and G.L. Pala, 1966. Barbituarate metabolism as affected by certain agents acting on liver. J. Pharmacol. Exp. Ther., 129: 139-143.
8. Jung, K.Y., Y.K. Choo, H.M. Kim and B.K. Choi, 2000. Radish extract stimulates motility of the intestine via the muscarinic receptors. J. Pharm. Pharmacol., 52: 1031-1036.
9. Kus, I.N. Colakoglu, H. Pekmez, D. Seckin, M. Ogeturk and M. Sarsilmaz, 2004. Protective effect of caffeic acid phenethyl ester (CAPE) on carbon tetrachloride-induced hepatotoxicity in rats. Acta Histochem., 106: 289-297.
10. Lin, C.C., D.E. Shieh and M.N. Yen, 1997. Hepatoprotective effect of fractions Ban-zhi-lian of experimental liver injuries in rats. J. Ethnopharmacol., 56: 193-200.
11. Mayer, C., 1981. Vegetarian Medicines. Mayerbooks, Glenwood Illinois, pp: 20.
12. Plaa, G. and W. Hewitt, 1982. Quantitative Evaluation of Indices of, Hepatotoxicity. In: Toxicology of Liver, Zakin D. and T.D. Bayer (Eds). Raven Press, New York, pp: 103-120.
13. Poterton, D., 1983. Culpeper's Color Herbal. Copyright W. Foulsham and Co. Ltd. Publ. by Sterling Publishing Cp., Inc., Two Part Avenue, New York, 10016, pp: 152.
14. Prahoveanu, E. and V. Esanu, 1990. The effects of aqueous extracts of Raphanus niger on an experimental influenza infection in mice and on the enzyme polymorphism in lung tissue extracts. Revue Roumaine de Virologie, 41: 113-117.
15. Rafatullah, S., J.S. Mossa, A.M. Ageel, M.A. Al-Yahya and M. Tariq, 1991. Hepatoprotective and safety evaluation studies on Sarsaparilla. Int. J. Pharmacol., 29: 296-300.
16. Rafatullah, S., M. Al-Yahya, J.S. Mossa, A. Galal and K. El-Tahir, 2006. Preliminary Phytochemical and Hepatoprotective Studies on Turnip Brassica rapa L. Int. J. Pharmacol., 2: 670-673.
17. Recknogel, R.O., E.A. Glende, J.A. Dholak and R.L. Walter, 1989. Mechanism of carbon tetrachloride toxicity. Pharmacol. Ther., 43: 135.
18. Rej, R., 1978. Aspartate aminotransferase activity and isoenzyme proportions in human liver tissue. Am. J. Clin. Pathol., 28: 56-63.
19. Sedlak, J. and R.H. Lindsay, 1968. Estimation of total, protein bound and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal. Biochem., 25: 192.
20. Sen, T., A. Basu, R.N. Ray and A.K. Nag Chaudhuri, 1993. Hepatoprotective effects of Plucheoa indica (Lees) extract in experimental acute liver damage in rodents. Phytother. Res., 7: 352.
21. Teocharis, S.E., A.P. Margeli, C.A. Skaltsas, Spiliopoulou and A.S. Koutelinis, 2001. Induction of metallothionein in the liver of carbon tetrachloride intoxicated rats: An immunohistochemical study. Toxicology, 161: 129-138.
22. Vargas, B.R., G.R.M. Perez, G.S. Perez, S.M.A. Zavala and G.C. Perez, 1999. Antiurolithiatic activity of Raphanus sativus aqueous extract on rats. J. Ethnopharmacol., 68: 335-338.