Social-economic factors and irrational antibiotic use as reasons for antibiotic resistance of bacteria causing common childhood infections in primary healthcare

European Journal of Pediatrics

Volumn 171, Issue 5, 2012, Pages 767-777

  Ilić, Katarina ^a   Jakovljević, Emil ^a   Škodrić Trifunović, Vesna ^b  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b CLINICAL CENTER OF SERBIA   (Serbia)

Author keywords

Antibacterial resistance; Antibiotic use; Bacterial infections; Children

Indexed keywords

AMPICILLIN; CEPHALOSPORIN; CHLORAMPHENICOL; CIPROFLOXACIN; COTRIMOXAZOLE; ERYTHROMYCIN; LEVOFLOXACIN; MACROLIDE; NALIDIXIC ACID; PENICILLIN G; TETRACYCLINE;

ANTIBIOTIC PROPHYLAXIS; ANTIBIOTIC RESISTANCE; BACTEREMIA; BACTERIAL INFECTION; BELGIUM; BLOOD CULTURE; BRONCHITIS; CATTLE FARMING; CHILDHOOD DISEASE; COMMUNITY ACQUIRED PNEUMONIA; DIARRHEA; ENTERITIS; ESCHERICHIA COLI; GASTROENTERITIS; GASTROINTESTINAL INFECTION; GERMANY; HAEMOPHILUS INFLUENZAE; HUMAN; HUNGARY; MENINGITIS; PARATYPHOID FEVER; PHARYNGITIS; PNEUMONIA; PRIMARY HEALTH CARE; PRIORITY JOURNAL; RESPIRATORY TRACT INFECTION; REVIEW; RHINITIS; RUSSIAN FEDERATION; SEPTICEMIA; SHIGELLA; SHIGELLA BOYDII; SHIGELLA DYSENTERIAE; SHIGELLA FLEXNERI; SHIGELLOSIS; STREPTOCOCCUS PNEUMONIAE; SWITZERLAND; TONSILLITIS; TYPHOID FEVER; URINALYSIS; UROGENITAL TRACT INFECTION;

ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIAL INFECTIONS; CATTLE; CHILD; DRUG RESISTANCE, BACTERIAL; HEALTH SERVICES MISUSE; HUMANS; INFANT; PRIMARY HEALTH CARE; RESPIRATORY TRACT INFECTIONS; SOCIOECONOMIC FACTORS; URINARY TRACT INFECTIONS;

EID: 84860311365     PISSN: 03406199     EISSN: 14321076     Source Type: Journal    
DOI: 10.1007/s00431-011-1592-5     Document Type: Review

References (90)

1. Accinelli C, Koskinen WC, Becker JM, Sadowsky MJ (2007) Environmental fate of two sulfonamide antimicrobial agents in soil. J Agric Food Chem 55(7):2677-2682 (Pubitemid 46623765)
2. Akhtar N, Alzahrani AJ (2006) Antibiotic resistance of diarrheagenic Escherichia coli (DEC) isolated from children under the age of 3 years in a teaching hospital in Saudi Arabia. Ann Pak Inst Med Sci 2(4):218-221
3. Al-Tawfiq JA (2006) Antibiotic resistance of pediatric isolates of Streptococcus pneumoniae in a Saudi Arabian hospital from 1999 to 2004. Med Sci Monit 12(11):CR471-CR475
4. Appelbaum PC (2002) Resistance among Streptococcus pneumoniae: implications for drug selection. Clin Infect Dis 34(12):1613-1620 (Pubitemid 34615447)
5. Arri SJ, Fluegge K, Mueller U, Berner R (2006) Antibiotic resistance patterns among respiratory pathogens at a German university children's hospital over a period of 10 years. Eur J Pediatr 165(1):9-13 (Pubitemid 41830881)
6. Ashkenazi S, Levy I, Kazaronovski V, Samra Z (2003) Growing antimicrobial resistance of Shigella isolates. J Antimicrob Chemother 51(2):427-429 (Pubitemid 36231170)
7. Ashworth M, Latinovic R, Charlton J, Cox K, Rowlands G, Gulliford M (2004) Why has antibiotic prescribing for respiratory illness declined in primary care? A longitudinal study using the General Practice Research Database. J Public Health (Oxf) 26 (3):268-274 (Pubitemid 39312930)
8. Bartoloni A, Pallecchi L, Benedetti M, Fernandez C, Vallejos Y, Guzman E, Villagran AL, Mantella A, Lucchetti C, Bartalesi F, Strohmeyer M, Bechini A, Gamboa H, Rodríguez H, Falkenberg T, Kronvall G, Gotuzzo E, Paradisi F, Rossolini GM (2006) Multidrug-resistant commensal Escherichia coli in children, Peru and Bolivia. Emerg Infect Dis 12(6):907-913 (Pubitemid 43848411)
9. Barza M, Gorbach SL, editors (2002) The need to improve antimicrobial use in agriculture: ecological and human health consequences: a report of the facts about antibiotics in animals and the impact on resistance (FAAIR) project - The Alliance for the Prudent Use of Antibiotics. Clin Infect Dis 34(Suppl 3):71-144
10. Belongia EA, Sullivan BJ, Chyou PH, Madagame E, Reed KD, Schwartz B (2001) A community intervention trial to promote judicious antibiotic use and reduce penicillin-resistant Streptococcus pneumoniae carriage in children. Pediatrics 108(3):575-583 (Pubitemid 32786583)
11. Biswas R, Lyon DJ, Nelson EA, Lau D, Lewindon PJ (1996) Aetiology of acute diarrhoea in hospitalized children in Hong Kong. Trop Med Int Health 1(5):679-683 (Pubitemid 26356707)
12. Brinsley KJ, Sinkowitz-Cochran RL, Cardo DM, CDC Campaign to Prevent Antimicrobial Resistance Team (2005) Assessing motivation for physicians to prevent antimicrobial resistance in hospitalized children using the Health Belief Model as a framework. Am J Infect Control 33(3):175-181 (Pubitemid 40417934)
13. Cappelletty DM (2008) Lower respiratory tract infections. In: Cappelletty DM. Pharmacotherapy Principles & Practice. Editors Di Piro JT et al. The McGraw-Hill Companies, pp 1049-1060
14. Cars O, Mölstad S, Melander A (2001) Variation in antibiotic use in the European Union. Lancet 357(9271):1851-1853 (Pubitemid 32539121)
15. Cars O, So A, Högberg L, Manz C (2007) Innovating for bacterial resistance. ESCMID News 2:22-24
16. Chiang WC, Teoh OH, Chong CY, Goh A, Tang JP, Chay OM (2007) Epidemiology, clinical characteristics and antimicrobial resistance patterns of community-acquired pneumonia in 1702 hospitalized children in Singapore. Respirology 12(2):254-261 (Pubitemid 46239400)
17. Cizman M, Beovic B, Krcmery V, Barsic B, Tamm E, Ludwig E, Pelemis M, Karovski K, Grzesiowski P, Gardovska D, Volokha A, Keuleyan E, Stratchounski L, Dumitru C, Titov LP, Usonis V, Dvorák P (2004) Antibiotic policies in Central Eastern Europe. Int J Antimicrob Agents 24(3):199-204
18. Conway PH, Cnaan A, Zaoutis T, Henry BV, Grundmeier RW, Keren R (2007) Recurrent urinary tract infections in children: risk factors and association with prophylactic antimicrobials. JAMA 298(2):179-186 (Pubitemid 47057764)
19. Demachy MC, Vernet-Garnier V, Cottin J, Cattier B, Chardon H, Chomarat M, Dupont P, Fauchere JL, Fosse T, Laaberki MF, Laurans G, Lemozy J, Maugein J, Murbach V, Pechinot A, Romaszko JP, Roussel-Delvallez M, Thoreux PH, Vaucel J, Vergnaud M, Weber M, Ploy MC (2005) Antimicrobial resistance data on 16,756 Streptococcus pneumoniae isolates in 1999: a pan-regional multicenter surveillance study in France. Microb Drug Resist 11(4):323-329 (Pubitemid 43099769)
20. Doern GV, Heilmann KP, Huynh HK, Rhomberg PR, Coffman SL, Brueggemann AB (2001) Antimicrobial resistance among clinical isolates of Streptococcus pneumoniae in the United States during 1999-2000, including a comparison of resistance rates since 1994-1995. Antimicrob Agents Chemother 45(6):1721-1729 (Pubitemid 32466340)
21. Ergönül O, Imre A, Celikbaş A, Dokuzoǧuz B (2004) Drug resistance of Shigella species: changes over 20 years in Turkey. Int J Antimicrob Agents 23(5):527-528 (Pubitemid 38569608)
22. Finnell SM, Carroll AE, Downs SM, the Subcommittee on Urinary Tract Infection (2011) Technical report - diagnosis and management of an initial UTI in febrile infants and young children. Pediatrics 1;128(3):e749-e770
23. Fritzsche M, Ammann RA, Droz S, Bianchetti MG, Aebi C (2005) Changes in antimicrobial resistance of Escherichia coli causing urinary tract infections in hospitalized children. Eur J Clin Microbiol Infect Dis 24(3):233-235 (Pubitemid 40576674)
24. Fullá N, Prado V, Durán C, Lagos R, Levine MM (2005) Surveillance for antimicrobial resistance profiles among Shigella species isolated from a semirural community in the northern administrative area of Santiago, Chile. AmJTrop Med Hyg 72 (6):851-854 (Pubitemid 41278811)
25. Giannella RA (1996) Salmonella. In: Baron S (ed) Medical Microbiology, 4th edn. University of Texas Medical Branch at Galveston, Chapter 21, Galveston
26. Green M, Martin JM, Barbadora KA, Beall B, Wald ER (2004) Reemergence of macrolide resistance in pharyngeal isolates of group A streptococci in southwestern Pennsylvania. Antimicrob Agents Chemother 48(2):473-476 (Pubitemid 38141704)
27. Halstead DC, Yao JDC (2001) Antimicrobial resistance in common bacterial pathogens causing community-acquired pneumonia. Jacksonville Medicine 52:177-180
28. Hand K (2007) Antibiotic pharmacists in the ascendancy. J Antimicrob Chemother 60(Suppl 1):i73-i76
29. Harbarth S, Albrich W, Brun-Buisson C (2002) Outpatient antibiotic use and prevalence of antibiotic-resistant pneumococci in France and Germany: a sociocultural perspective. Emerg Infect Dis 8(12):1460-1467 (Pubitemid 36008785)
30. Herwana E, Surjawidjaja JE, Salim OCh, Indriani N, Bukitwetan P, Lesmana M (2010) Shigella-associated diarrhea in children in South Jakarta, Indonesia. Southeast Asian J Trop Med Public Health 41(2):418-425
31. Hirose K, Tamura K, Sagara H, Watanabe H (2001) Antibiotic susceptibilities of Salmonella enterica serovar Typhi and S. enterica serovar Paratyphi A isolated from patients in Japan. Antimicrob Agents Chemother 45(3):956-958 (Pubitemid 32182055)
32. Hoban DJ, Doern GV, Fluit AC, Roussel-Delvallez M, Jones RN (2001) Worldwide prevalence of antimicrobial resistance in Streptococcus pneumoniae, H. influenzae, and Moraxella catarrhalis in the Sentry Antimicrobial Surveillance Program, 1997-1999. Clin Infect Dis 32(Suppl 2):S81-S93 (Pubitemid 32424263)
33. Houdouin V, Doit C, Mariani P, Brahimi N, Loirat C, Bourrillon A, Bingen E (2004) A pediatric cluster of Shigella dysenteriae serotype 1 diarrhea with hemolytic uremic syndrome in 2 families from France. Clin Infect Dis 1;38(9):e96-e99
34. Hsueh PR, Teng LJ, Lee LN, Yang PC, Ho SW, Luh KT (1999) Extremely high incidence of macrolide and trimethoprim- sulfamethoxazole resistance among clinical isolates of Streptococcus pneumoniae in Taiwan. J Clin Microbiol 37(4):897-901
35. Huang SS, Labus BJ, Samuel MC, Wan DT, Reingold AL (2002) Antibiotic resistance patterns of bacterial isolates from blood in San Francisco County, California, 1996-1999. Emerg Infect Dis 8 (2):195-201 (Pubitemid 34207664)
36. Jaecklin T, Rohner P, Jacomo V, Schmidheiny K, Gervaix A (2006) Trends in antibiotic resistance of respiratory tract pathogens in children in Geneva, Switzerland. Eur J Pediatr 165(1):3-8 (Pubitemid 41830880)
37. Jakovljevic E, Ilic K, Konstantinidis G (2011) One year prospective study on antibiotic resistance of E. coli urine isolates obtained from patients hospitalized at the Department of Nephrology of a University Pediatric Hospital in Novi Sad, Serbia. Clin Pharmacol Ther 89(Suppl 1):S64
38. Jakovljevic E, Ilic K, Kostantinidis G (2010) Antibiotic resistance of E. coli urinary tract isolates in pediatric patients hospitalized in a University Pediatric Hospital in Novi Sad, Serbia. Basic Clinical Pharmacol Toxicol 107(Suppl 1):135
39. Kaplan SL, Mason EO Jr, Wald ER, Schutze GE, Bradley JS, Tan TQ, Hoffman JA, Givner LB, Yogev R, Barson WJ (2004) Decrease of invasive pneumococcal infections in children among 8 children's hospitals in the United States after the introduction of the 7-valent pneumococcal conjugate vaccine. Pediatrics 113 (3 Pt 1):443-449 (Pubitemid 38280781)
40. Khan AI, Huq S, Malek MA, Hossain MI, Talukder KA, Faruque AS, Salam MA, Sack DA (2004) Shigella serotypes among hospitalized patients in urban Bangladesh and their antimicrobial resistance. Epidemiol Infect 132(4):773-777 (Pubitemid 39140112)
41. Krivoy N, El-Ahal WA, Bar-Lavie Y, Haddad S (2007) Antibiotic prescription and cost patterns in a general intensive care unit. Pharm Pract 5(2):67-73 (Pubitemid 47299740)
42. Larsson M, Kronvall G, Chuc NT, Karlsson I, Lager F, Hanh HD, Tomson G, Falkenberg T (2000) Antibiotic medication and bacterial resistance to antibiotics: a survey of children in a Vietnamese community. Trop Med Int Health 5(10):711-721
43. Lauderdale TL, Wagener MM, Lin HM, Huang IF, Lee WY, Hseih KS, Lai JF, Chiou CC (2006) Serotype and antimicrobial resistance patterns of Streptococcus pneumoniae isolated from Taiwanese children: comparison of nasopharyngeal and clinical isolates. Diagn Microbiol Infect Dis 56(4):421-426 (Pubitemid 44854350)
44. Lee JE, Reed J, Shields MS, Spiegel KM, Farrell LD, Sheridan PP (2007) Phylogenetic analysis of Shiga toxin 1 and Shiga toxin 2 genes associated with disease outbreaks. BMC Microbiol 4;7:109
45. Leibovitz E, Dragomir C, Sfartz S, Porat N, Yagupsky P, Jica S, Florescu L, Dagan R (1999) Nasopharyngeal carriage of multidrug-resistant Streptococcus pneumoniae in institutionalized HIV-infected and HIV-negative children in northeastern Romania. Int J Infect Dis 3(4):211-215
46. Levy SB (1998) Multidrug resistance - a sign of the times. N Engl J Med 338(19):1376-1378
47. Levy SB (2001) Antibiotic resistance: consequences of inaction. Clin Infect Dis 33(Suppl 3):S124-S129 (Pubitemid 32835780)
48. Levy SB (2005) Antibiotic resistance - the problem intensifies. Adv Drug Deliv Rev 57(10):1446-1450 (Pubitemid 40984600)
49. Levy SB, Marshall B (2004) Antibacterial resistance worldwide: causes, challenges and responses. Nat Med 10(12 Suppl):S122-S129 (Pubitemid 40018235)
50. Lin WJ, LoWT, Chou CY, Chen YY, Tsai SY, Chu ML,Wang CC (2006) Antimicrobial resistance patterns and serotype distribution of invasive Streptococcus pneumoniae isolates from children in Taiwan from 1999 to 2004. Diagn Microbiol Infect Dis 56(2):189-196
51. Linder JA, Bates DW, Lee GM, Finkelstein JA (2005) Antibiotic treatment of children with sore throat. JAMA 294(18):2315-2322 (Pubitemid 41607407)
52. Liu Y, Wang H, Chen M, Sun Z, Zhao R, Zhang L, Wang H, Zhang H, Wang L, Chu Y, Liu Y, Ni Y (2008) Serotype distribution and antimicrobial resistance patterns of Streptococcus pneumoniae isolated from children in China younger than 5 years. Diagn Microbiol Infect Dis 61(3):256-263 (Pubitemid 351847796)
53. Lutter SA, Currie ML, Mitz LB, Greenbaum LA (2005) Antibiotic resistance patterns in children hospitalized for urinary tract infections. Arch Pediatr Adolesc Med 159(10):924-928 (Pubitemid 41423330)
54. Martin J, Green M, Barbadora K, Wald E (2002) Erythromycinresistant group A Streptococci in schoolchildren in Pittsburgh. N Engl J Med 346(16):1200-1206 (Pubitemid 34984581)
55. Maskey AP, Day JN, Phung QT, Thwaites GE, Campbell JI, Zimmerman M, Farrar JJ, Basnyat B (2006) Salmonella enterica serovar Paratyphi A and S. enterica serovar Typhi cause indistinguishable clinical syndromes in Kathmandu, Nepal. Clin Infect Dis 42(9):1247-1253
56. McCaig LF, Besser RE, Hughes JM (2002) Trends in antimicrobial prescribing rates for children and adolescents. JAMA 287 (23):3096-3102 (Pubitemid 34633984)
57. Meneghetti A (2009) Upper respiratory tract infection. Available via http://emedicine.medscape.com/article/302460-overview Accessed 28 Mar 2011
58. Mölstad S, Erntell M, Hanberger H, Melander E, Norman C, Skoog G, Lundborg CS, Söderström A, Torell E, Cars O (2008) Sustained reduction of antibiotic use and low bacterial resistance: 10-year follow-up of the Swedish Strama programme. Lancet Infect Dis 8(2):125-132
59. Mölstad S, Lundborg CS, Karlsson AK, Cars O (2002) Antibiotic prescription rates vary markedly between 13 European countries. Scand J Infect Dis 34(5):366-371 (Pubitemid 34746258)
60. Murdoch DA, Banatvaia N, Bone A, Shoismatulloev BI, Ward LR, Threlfall EJ (1998) Epidemic ciprofloxacin-resistant Salmonella typhi in Tajikistan. Lancet 351(9099):339 (Pubitemid 28052704)
61. Naheed A, Kalluri P, Talukder KA, Faruque AS, Khatun F, Nair GB, Mintz ED, Breiman RF (2004) Fluoroquinolone-resistant Shigella dysenteriae type 1 in northeastern Bangladesh. Lancet Infect Dis 4(10):607-608 (Pubitemid 39296833)
62. Nasrin D, Collignon PJ, Roberts L, Wilson EJ, Pilotto LS, Douglas RM (2002) Effect of beta lactam antibiotic use in children on pneumococcal resistance to penicillin: prospective cohort study. BMJ 324(7328):28-30 (Pubitemid 34048851)
63. Nguyen TV, Le PV, Le CH, Weintraub A (2005) Antibiotic resistance in diarrheagenic Escherichia coli and Shigella strains isolated from children in Hanoi, Vietnam. Antimicrob Agents Chemother 49(2):816-819 (Pubitemid 40175706)
64. Nyquist AC, Gonzales R, Steiner JF, Sande MA (1998) Antibiotic prescribing for children with colds, upper respiratory tract infections, and bronchitis. JAMA 279(11):875-877 (Pubitemid 28185554)
65. Parry CM (2003) Antimicrobial drug resistance in Salmonella enterica. Curr Opin Infect Dis 16(5):467-472 (Pubitemid 37267266)
66. Quinonez JM (2004) The continuing saga of antimicrobial resistence. Highlights of 2004 National Conference and Exhibition (American Academy of Pediatrics). Medscape. Available via http:// www.medscape.org/viewarticle/495300 Accessed 04 Apr 2011
67. Rang HP, Dale MM, Ritter JM, Flower RJ (2011) Antibacterial drugs. In: Rang HP, Dale MM, Ritter JM, Flower RJ. Rang and Dale's Pharmacology. Churchill Livingstone, Seventh edition, pp 635-54
68. Rovers MM, Schilder AG, Zielhuis GA, Rosenfeld RM (2004) Otitis media. Lancet 363(9407):465-473 (Pubitemid 38210066)
69. Saraswathi K, De A, Jog A, Gogate A (2002) Shigella septicemia. Indian Pediatr 39(8):777-779
70. Savadkoohi RB, Kacho AM (2007) Prevalence of Shigella species and their antimicrobial resistance patterns at Amirkola Children's Hospital, North of Iran. Iran J Ped 17(2):118-122
71. Sener B, Günalp A (1998) Trends in antimicrobial resistance of Streptococcus pneumoniae in children in a Turkish hospital. J Antimicrob Chemother 42(3):381-384 (Pubitemid 28442452)
72. Seppälä H, Klaukka T, Vuopio-Varkila J, Muotiala A, Helenius H, Lager K, Huovinen P (1997) The effect of changes in the consumption of macrolide antibiotics on erythromycin resistance in group A streptococci in Finland. Finnish Study Group for Antimicrobial Resistance. N Engl J Med 337(7):441-446 (Pubitemid 27333044)
73. Sharma AK (2007) Antimicrobial resistance pattern of Salmonella in Kanti Children's Hospital: which drug to choose? J Nepal Paediatr Soc 26(1):31-34
74. Shibl AM (2008) Distribution of serotypes and antibiotic resistance of invasive pneumococcal disease isolates among children aged 5 years and under in Saudi Arabia (2000-2004). Clin Microbiol Infect 14(9):876-879
75. Shulman S, Gerber M (2004) So what's wrong with penicillin for strep throat? Pediatrics 113(6):1816-1819 (Pubitemid 38698000)
76. Sivapalasingam S, Nelson JM, Joyce K, Hoekstra M, Angulo FJ, Mintz ED (2006) High prevalence of antimicrobial resistance among Shigella isolates in the United States tested by the National Antimicrobial Resistance Monitoring System from 1999 to 2002. Antimicrob Agents Chemother 50(1):49-54 (Pubitemid 43042901)
77. Škodric-Trifunovic V, Pilipović N, Stefanović B (2006) Treatment of community-acquired pneumonia using the modern therapeutical guides (in Serbian). Vojnosanit Pregl 63(11):967-970
78. Soh SW, Poh CL, Lin RV (2000) Serotype distribution and antimicrobial resistance of Streptococcus pneumoniae isolates from pediatric patients in Singapore. Antimicrob Agents Chemother 44 (8):2193-2196 (Pubitemid 30484452)
79. Stefan-Mikić S, Jovanović J, Jovanović N, Aleksić-Dordević M, Cvjetković D, Krajcir I (2008) Phamacoeconomic analysis of antibiotics use in the Clinical Center of Vojvodina (In Serbian). Med Pregl 61(Suppl 1):50-58
80. Subcommittee on Urinary Tract Infection, Steering Committee on Quality Improvement and Management (2011) Urinary tract infection: clinical practice guideline for the diagnosis and management of the initial UTI in febrile infants and children 2 to 24 months. Pediatrics 1;128(3):595-610
81. Sunakawa K, Farrell DJ (2007) Mechanisms, molecular and seroepidemiology of antimicrobial resistance in bacterial respiratory pathogens isolated from Japanese children. Ann Clin Microbiol Antimicrob 6:7
82. Syrogiannopoulos GA, Grivea IN, Katopodis GD, Geslin P, Jacobs MR, Beratis NG (2000) Carriage of antibiotic-resistant Streptococcus pneumoniae in Greek infants and toddlers. Eur J Clin Microbiol Infect Dis 19(4):288-293 (Pubitemid 30255611)
83. Trepka MJ, Belongia EA, Chyou PH, Davis JP, Schwartz B (2001) The effect of a community intervention trial on parental knowledge and awareness of antibiotic resistance and appropriate antibiotic use in children. Pediatrics 107(1):E6
84. Vila J, Vargas M, Casals C, Urassa H, Mshinda H, Schellemberg D, Gascon J (1999) Antimicrobial resistance of diarrheagenic Escherichia coli isolated from children under the age of 5 years from Ifakara, Tanzania. Antimicrob Agents Chemother 43 (12):3022-3024
85. Vrints M, Mairiaux E, Van Meervenne E, Collard JM, Bertrand S (2009) Surveillance of antibiotic susceptibility patterns among Shigella sonnei strains isolated in Belgium during the 18-year period 1990 to 2007. J Clin Microbiol 47(5):1379-1385
86. Whitney CG, Farley MM, Hadler J, Harrison LH, Lexau C, Reingold A, Lefkowitz L, Cieslak PR, Cetron M, Zell ER, Jorgensen JH, Schuchat A, Active Bacterial Core Surveillance Program of the Emerging Infections Program Network (2000) Increasing prevalence of multidrug-resistant Streptococcus pneumoniae in the United States. N Engl J Med 343(26):1917-1924 (Pubitemid 32064785)
87. World Health Organization (2007) WHO model list of essential medicines: 15th list, March 2007
88. Yao K, Shen X, Yul S, Lu Q, Deng L, Ye Q, Zhang H, Deng Q, Hu Y, Yang Y (2007) Antimicrobial resistance and serotypes of nasopharyngeal strains of Streptococcus pneumoniae in Chinese children with acute respiratory infections. J Int Med Res 35 (2):253-267 (Pubitemid 46838468)
89. Yu S, Yao K, Shen X, Zhang W, Liu X, Yang Y (2008) Serogroup distribution and antimicrobial resistance of nasopharyngeal isolates of Streptococcus pneumoniae among Beijing children with upper respiratory infections (2000-2005). Eur J Clin Microbiol Infect Dis 27(8):649-655
90. Zbinden R (2006) Trends in antibiotic resistance among respiratory tract pathogens in children in two regions near France, a high level resistance country. Eur J Pediatr 165(1):1-2 (Pubitemid 41830879)