Technical report - Diagnosis and management of an initial UTI in febrile infants and young children

Pediatrics

Volumn 128, Issue 3, 2011, Pages

  Finnell, S Maria E ^a   Carroll, Aaron E ^a   Roberts, Kenneth B ^a   Hellerstein, Stanley ^a   Shortliffe, Linda D ^a   Wald, Ellen R ^a   Zerin, J Michael ^a  

^a NONE

Author keywords

Antibiotic prophylaxis; Antimicrobial; Children; Infants; Prophylaxis; Pyelonephritis; Urinary tract infection; Vesicoureteral reflux; Voiding cystourethrography

Indexed keywords

AMOXICILLIN PLUS CLAVULANIC ACID; ANTIBIOTIC AGENT; CEFADROXIL; CEFIXIME; CEFOTAXIME; COTRIMOXAZOLE; NITROFURANTOIN; PLACEBO;

ACUTE PYELONEPHRITIS; ADVERSE OUTCOME; AGE DISTRIBUTION; ANTIBIOTIC PROPHYLAXIS; ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; CHILD; COST EFFECTIVENESS ANALYSIS; DIAGNOSTIC ACCURACY; DISEASE CLASSIFICATION; DISEASE SEVERITY; DISEASE SURVEILLANCE; DOSAGE SCHEDULE COMPARISON; DRUG ADMINISTRATION ROUTE; DRUG EFFICACY; ECHOGRAPHY; ENDOSCOPIC THERAPY; ESCHERICHIA COLI INFECTION; EVIDENCE BASED MEDICINE; FEBRILE URINARY TRACT INFECTION; FETUS ECHOGRAPHY; FEVER; HIGH RISK PATIENT; HUMAN; INFANT; INFECTION PREVENTION; INFECTION RISK; INTERMETHOD COMPARISON; KIDNEY FAILURE; KIDNEY INJURY; KIDNEY SURGERY; LONG TERM CARE; META ANALYSIS (TOPIC); MICTURITION CYSTOURETHROGRAPHY; NON INVASIVE MEASUREMENT; NONHUMAN; PRACTICE GUIDELINE; PREVALENCE; PRIORITY JOURNAL; PYELONEPHRITIS; RECURRENT INFECTION; REVIEW; SHORT COURSE THERAPY; TREATMENT DURATION; URINALYSIS; URINARY TRACT INFECTION; URINE CULTURE; VESICOURETERAL REFLUX;

ANTIBIOTIC PROPHYLAXIS; CEFIXIME; FEVER; HUMANS; INFANT; PREVALENCE; PYELONEPHRITIS; RECURRENCE; ULTRASONOGRAPHY, PRENATAL; URINARY BLADDER; URINARY TRACT INFECTIONS; VESICO-URETERAL REFLUX;

EID: 80052376961     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2011-1332     Document Type: Review

References (116)

1. American Academy of Pediatrics, Committee on Quality Improvement, Subcommittee on Urinary Tract Infection. Practice parameter: The diagnosis, treatment, and evaluation of the initial urinary tract infection in febrile infants and young children. Pediatrics. 1999;103(4):843-852
2. Downs S.M. Technical report: Urinary tract infections in febrile infants and young children. Pediatrics. 1999;103(4). Available at: www.pediatrics.org/ cgi/content/full/103/4/e54
3. American Academy of Pediatrics, Committee on Quality Improvement, Subcommittee on Urinary Tract Infection. Urinary tract infection: Clinical practice guideline for the diagnosis and management of initial urinary tract infections in febrile infants and children 2 to 24 months of age. Pediatrics. 2011;128(3):595-610
4. Eddy D.M. Clinical decision making: From theory to practice: Guidelines for policy statements: The explicit approach. JAMA. 1990;263(16):2239-2242
5. Haynes R.B., McKibbon K.A., Wilczynski N.L., Walter S.D., Werre S.R.; Hedge Team. Optimal search strategies for retrieving scientifically strong studies of treatment from Medline: Analytical survey. BMJ. 2005;330(7501):1179
6. Downs S., Black N. The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. J Epidemiol Community Health. 1998;52(6):377-384 (Pubitemid 28438523)
7. Hoberman A., Wald E.R., Reynolds E.A., Penchansky L., Charron M. Is urine culture necessary to rule out urinary tract infection in young febrile children? Pediatr Infect Dis J. 1996;15(4):304-309 (Pubitemid 26119269)
8. Haddon R.A., Barnett P.L., Grimwood K., Hogg G.G. Bacteraemia in febrile children presenting to a paediatric emergency department. Med J Aust. 1999;170(10):475-478 (Pubitemid 29224966)
9. Shaw K.N., Gorelick M., McGowan K.L., Yakscoe N.M., Schwartz J.S. Prevalence of urinary tract infection in febrile young children in the emergency department. Pediatrics. 1998;102(2). Available at: www.pediatrics.org/cgi/ content/full/102/2/e16
10. Shaikh N., Morone N.E., Bost J.E., Farrell M.H. Prevalence of urinary tract infection in childhood: A meta-analysis. Pediatr Infect Dis J. 2008;27(4):302-308 (Pubitemid 351483063)
11. To T., Agha M., Dick P.T., Feldman W. Cohort study on circumcision of newborn boys and subsequent risk of urinary-tract infection. Lancet. 1998;352(9143):1813-1816 (Pubitemid 28550070)
12. Shaikh N., Morone N.E., Lopez J., et al. Does this child have a urinary tract infection? JAMA. 2007;298(24):2895-2904
13. Pantell R.H., Newman T.B., Bernzweig J., et al. Management and outcomes of care of fever in early infancy. JAMA. 2004;291(10):1203-1212 (Pubitemid 38541663)
14. Byington C.L., Enriquez F.R., Hoff C., et al. Serious bacterial infections in febrile infants 1 to 90 days old with and without viral infections. Pediatrics. 2004;113(6):1662-1666 (Pubitemid 38697973)
15. Levine D.A., Platt S.L., Dayan P.S., et al. Risk of serious bacterial infection in young febrile infants with respiratory syncytial virus infections. Pediatrics. 2004;113(6):1728-1734 (Pubitemid 38697983)
16. Gorelick M.H., Hoberman A., Kearney D., Wald E., Shaw K.N. Validation of a decision rule identifying febrile young girls at high risk for urinary tract infection. Pediatr Emerg Care. 2003;19(3):162-164 (Pubitemid 36736043)
17. Gorelick M.H., Shaw K.N. Clinical decision rule to identify febrile young girls at risk for urinary tract infection. Arch Pediatr Adolesc Med. 2000;154(4):386-390 (Pubitemid 30198488)
18. Roberts K.B., Charney E., Sweren R.J., et al. Urinary tract infection in infants with unexplained fever: A collaborative study. J Pediatr. 1983;103(6):864-867 (Pubitemid 14204175)
19. Lockhart G.R., Lewander W.J., Cimini D.M., Josephson S.L., Linakis J.G. Use of urinary Gram stain for detection of urinary tract infection in infants. Ann Emerg Med. 1995;25(1):31-35
20. Shaw K.N., McGowan K.L., Gorelick M.H., Schwartz J.S. Screening for urinary tract infection in infants in the emergency department: Which test is best? Pediatrics. 1998;101(6). Available at: www.pediatrics.org/cgi/content/ full/101/6/e1
21. Lin D.S., Huang F.Y., Chiu N.C., et al. Comparison of hemocytometer leukocyte counts and standard urinalyses for predicting urinary tract infections in febrile infants. Pediatr Infect Dis J. 2000;19(3):223-227
22. Leong Y.Y., Tan K.W. Bladder aspiration for diagnosis of urinary tract infection in infants and young children. J Singapore Paediatr Soc. 1976;18(1):43-47
23. Pryles C.V., Atkin M.D., Morse T.S., Welch K.J. Comparative bacteriologic study of urine obtained from children by percutaneous suprapubic aspiration of the bladder and by catheter. Pediatrics. 1959;24(6):983-991
24. Djojohadipringgo S., Abdul Hamid R.H., Thahir S., Karim A., Darsono I. Bladder puncture in newborns: A bacteriological study. Paediatr Indones. 1976;16(11-12):527-534
25. Gochman R.F., Karasic R.B., Heller M.B. Use of portable ultrasound to assist urine collection by suprapubic aspiration. Ann Emerg Med. 1991;20(6):631-635
26. Buys H., Pead L., Hallett R., Maskell R. Suprapubic aspiration under ultrasound guidance in children with fever of undiagnosed cause. BMJ. 1994;308(6930):690-692 (Pubitemid 24979787)
27. Kozer E., Rosenbloom E., Goldman D., Lavy G., Rosenfeld N., Goldman M. Pain in infants who are younger than 2 months during suprapubic aspiration and transurethral bladder catheterization: A randomized, controlled study. Pediatrics. 2006;118(1). Available at: www.pediatrics.org/cgi/content/full/118/ 1/e51
28. El-Naggar W., Yiu A., Mohamed A., et al. Comparison of pain during two methods of urine collection in preterm infants. Pediatrics. 2010;125(6):1224- 1229
29. Al-Orifi F., McGillivray D., Tange S., Kramer M.S. Urine culture from bag specimens in young children: Are the risks too high? J Pediatr. 2000;137(2):221-226 (Pubitemid 30659230)
30. Etoubleau C., Reveret M., Brouet D., et al. Moving from bag to catheter for urine collection in non-toilet-trained children suspected of having urinary tract infection: A paired comparison of urine cultures. J Pediatr. 2009;154(6):803-806
31. Alam M., Coulter J., Pacheco J., et al. Comparison of urine contamination rates using three different methods of collection: Clean-catch, cotton wool pad and urine bag. Ann Trop Paediatr. 2005;25(1):29-34 (Pubitemid 40372448)
32. Li P.S., Ma L.C., Wong S.N. Is bag urine culture useful in monitoring urinary tract infection in infants? J Paediatr Child Health. 2002;38(4):377-381 (Pubitemid 35024979)
33. Karacan C., Erkek N., Senel S., Akin Gunduz S., Catli G., Tavil B. Evaluation of urine collection methods for the diagnosis of urinary tract infection in children. Med Princ Pract. 2010;19(3):188-191
34. Perlhagen M., Forsberg T., Perlhagen J., Nivesjö M. Evaluating the specificity of a new type of urine collection bag for infants. J Pediatr Urol. 2007;3(5):378-381 (Pubitemid 47382634)
35. Ginsburg C.M., McCracken G.H. Jr. Urinary tract infections in young infants. Pediatrics. 1982;69(4):409-412 (Pubitemid 12135937)
36. Hoberman A., Wald E.R., Hickey R.W., et al. Oral versus initial intravenous therapy for urinary tract infections in young febrile children. Pediatrics. 1999;104(1):79-86 (Pubitemid 29315851)
37. Hodson E.M., Willis N.S., Craig J.C. Antibiotics for acute pyelonephritis in children. Cochrane Database Syst Rev. 2007;(4):CD003772
38. Zhanel G.G., Hisanaga T.L., Laing N.M., et al. Antibiotic resistance in outpatient urinary isolates: Final results from the North American Urinary Tract Infection Collaborative Alliance (NAUTICA). Int J Antimicrob Agents. 2005;26(5):380-388 (Pubitemid 41483468)
39. Gaspari R.J., Dickson E., Karlowsky J., Doern G. Antibiotic resistance trends in paediatric uropathogens. Int J Antimicrob Agents. 2005;26(4):267-271 (Pubitemid 41341395)
40. Michael M., Hodson E.M., Craig J.C., Martin S., Moyer V.A. Short versus standard duration oral antibiotic therapy for acute urinary tract infection in children. Cochrane Database Syst Rev. 2003;(1):CD003966
41. Camacho V., Estorch M., Fraga G., et al. DMSA study performed during febrile urinary tract infection: A predictor of patient outcome? Eur J Nucl Med Mol Imaging. 2004;31(6):862-866 (Pubitemid 38758358)
42. Hewitt I.K., Zucchetta P., Rigon L., et al. Early treatment of acute pyelonephritis in children fails to reduce renal scarring: Data from the Italian Renal Infection Study Trials. Pediatrics. 2008;122(3):486-490
43. Doganis D., Siafas K., Mavrikou M., et al. Does early treatment of urinary tract infection prevent renal damage? Pediatrics. 2007; 120(4). Available at: www.pediatrics.org/cgi/content/full/120/4/e922
44. Fernández-Menéndez J.M., Málaga S., Matesanz J.L., SolíS G, Alonso S., Pérez-Méndez C. Risk factors in the development of early technetium-99m dimercaptosuccinic acid renal scintigraphy lesions during first urinary tract infection in children. Acta Paediatr. 2003;92(1):21-26 (Pubitemid 36255926)
45. Keren R., Chan E. A meta-analysis of randomized, controlled trials comparing short-and long-course antibiotic therapy for urinary tract infections in children. Pediatrics. 2002;109(5). Available at: www.pediatrics.org/cgi/ content/full/109/5/e70
46. Tran D., Muchant D.G., Aronoff S.C. Short-course versus conventional length antimicrobial therapy for uncomplicated lower urinary tract infections in children: A meta-analysis of 1279 patients. J Pediatr. 2001;139(1):93-99 (Pubitemid 32613993)
47. Oreskovic N.M., Sembrano E.U. Repeat urine cultures in children who are admitted with urinary tract infections. Pediatrics. 2007; 119(2). Available at: www.pediatrics.org/cgi/content/full/119/2/e325
48. Currie M.L., Mitz L., Raasch C.S., Greenbaum L.A. Follow-up urine cultures and fever in children with urinary tract infection. Arch Pediatr Adolesc Med. 2003;157(12):1237-1240 (Pubitemid 37509333)
49. Lebowitz R.L., Olbing H., Parkkulainen K.V., Smellie J.M., Tamminen-Mobius T.E. International system of radiographic grading of vesicoureteric reflux. Pediatr Radiol. 1985;15(2):105-109 (Pubitemid 15198933)
50. Sargent M.A., Stringer D.A. Voiding cystourethrography in children with urinary tract infection: The frequency of vesicoureteric reflux is independent of the specialty of the physician requesting the study. AJR. 1995;164(5):1237-1241
51. Craig J.C., Knight J.F., Sureshkumar P., Lam A., Onikul E., Roy L.P. Vesicoureteric reflux and timing of micturating cystourethrography after urinary tract infection. Arch Dis Child. 1997;76(3):275-277 (Pubitemid 27128139)
52. McDonald A., Scranton M., Gillespie R., Mahajan V., Edwards G.A. Voiding cystourethrograms and urinary tract infections: How long to wait? Pediatrics. 2000;105(4). Available at: www.pediatrics.org/cgi/content/full/105/4/e50
53. Oostenbrink R., Van der Heijden A.J., Moons K.G., Moll H.A. Prediction of vesico-ureteric reflux in childhood urinary tract infection: A multivariate approach. Acta Paediatr. 2000;89(7):806-810 (Pubitemid 30622580)
54. Mahant S., To T., Friedman J. Timing of voiding cystourethrogram in the investigation of urinary tract infections in children. J Pediatr. 2001;139(4):568-571 (Pubitemid 32977273)
55. Mahant S., Friedman J., MacArthur C. Renal ultrasound findings and vesicoureteral reflux in children hospitalised with urinary tract infection. Arch Dis Child. 2002;86(6):419-420
56. Chand D.H., Rhoades T., Poe S.A., Kraus S., Strife C.F. Incidence and severity of vesicoureteral reflux in children related to age, gender, race and diagnosis. J Urol. 2003;170(4):1548-1550 (Pubitemid 37102405)
57. Hansson S., Dhamey M., Sigström O., et al. Dimercapto-succinic acid scintigraphy instead of voiding cystourethrography for infants with urinary tract infection. J Urol. 2004;172(3):1071-1073 (Pubitemid 39096466)
58. Pinto K. Vesicoureteral reflux in the Hispanic child with urinary tract infection. J Urol. 2004;171(3):1266-1267 (Pubitemid 38327588)
59. Zamir G., Sakran W., Horowitz Y., Koren A., Miron D. Urinary tract infection: Is there a need for routine renal ultrasonography? Arch Dis Child. 2004;89(5):466-468
60. Hannula A., Venhola M., Renko M., Pokka T., Huttunen N.P., Uhari M. Vesicoureteral reflux in children with suspected and proven urinary tract infection. Pediatr Nephrol. 2010;25(8):1463-1469
61. Venhola M., Hannula A., Huttunen N.P., Renko M., Pokka T., Uhari M. Occurrence of vesicoureteral reflux in children. Acta Paediatr. 2010;99(12):1875-1878
62. Alon U.S., Ganapathy S. Should renal ultrasonography be done routinely in children with first urinary tract infection? Clin Pediatr (Phila). 1999;38(1):21-25 (Pubitemid 29042646)
63. Greenfield S.P., Ng M., Wan J. Experience with vesicoureteral reflux in children: Clinical characteristics. J Urol. 1997;158(2):574-577
64. Roussey-Kesler G., Gadjos V., Idres N., et al. Antibiotic prophylaxis for the prevention of recurrent urinary tract infection in children with low grade vesicoureteral reflux: Results from a prospective randomized study. J Urol. 2008;179(2):674-679
65. Lee S.J., Shim Y.H., Cho S.J., Lee J.W. Probiotics prophylaxis in children with persistent primary vesicoureteral reflux. Pediatr Nephrol. 2007;22(9):1315-1320 (Pubitemid 47054922)
66. Montini G., Rigon L., Zucchetta P., et al. Prophylaxis after first febrile urinary tract infection in children? A multicenter, randomized, controlled, noninferiority trial. Pediatrics. 2008;122(5):1064-1071
67. Garin E.H., Olavarria F., Garcia Nieto V., Valenciano B., Campos A., Young L. Clinical significance of primary vesicoureteral reflux and urinary antibiotic prophylaxis after acute pyelonephritis: A multicenter, randomized, controlled study. Pediatrics. 2006;117(3):626-632 (Pubitemid 46063202)
68. Pennesi M., Travan L., Peratoner L., et al. Is antibiotic prophylaxis in children with vesicoureteral reflux effective in preventing pyelonephritis and renal scars? A randomized, controlled trial. Pediatrics. 2008; 121(6). Available at: www.pediatrics.org/cgi/content/full/121/6/e1489
69. Craig J., Simpson J., Williams G. Antibiotic prophylaxis and recurrent urinary tract infection in children. N Engl J Med. 2009;361(18):1748-1759
70. Brandström P., Esbjorner E., Herthelius M., Swerkersson S., Jodal U., Hansson S. The Swedish Reflux Trial in Children, part III: Urinary tract infection pattern. J Urol. 2010;184(1):286-291
71. Moorthy I., Wheat D., Gordon I. Ultrasonography in the evaluation of renal scarring using DMSA scan as the gold standard. Pediatr Nephrol. 2004;19(2):153-156 (Pubitemid 38181006)
72. Biggi A., Dardanelli L., Pomero G., et al. Acute renal cortical scintigraphy in children with a first urinary tract infection. Pediatr Nephrol. 2001;16(9):733-738 (Pubitemid 32816166)
73. Smellie J.M., Rigden S.P., Prescod N.P. Urinary tract infection: A comparison of four methods of investigation. Arch Dis Child. 1995;72(3):247-260
74. Hoberman A., Charron M., Hickey R.W., Baskin M., Kearney D.H., Wald E.R. Imaging studies after a first febrile urinary tract infection in young children. N Engl J Med. 2003;348(3):195-202 (Pubitemid 36077914)
75. Roberts J. Experimental pyelonephritis in the monkey, part III: Pathophysiology of ureteral malfunction induced by bacteria. Invest Urol. 1975;13(2):117-120
76. Wippermann C.F., Schofer O., Beetz R., et al. Renal abscess in childhood: Diagnostic and therapeutic progress. Pediatr Infect Dis J. 1991;10(6):446-450
77. Barry B.P., Hall N., Cornford E., Broderick N.J., Somers J.M., Rose D.H. Improved ultrasound detection of renal scarring in children following urinary tract infection. Clin Radiol. 1998;53(10):747-751 (Pubitemid 28482359)
78. Sinha M.D., Gibson P., Kane T., Lewis M.A. Accuracy of ultrasonic detection of renal scarring in different centres using DMSA as the gold standard. Nephrol Dial Transplant. 2007;22(8):2213-2216 (Pubitemid 47244698)
79. Montini G., Zucchetta P., Tomasi L., et al. Value of imaging studies after a first febrile urinary tract infection in young children: Data from Italian Renal Infection Study 1. Pediatrics. 2009;123(2). Available at: www.pediatrics.org/cgi/content/full/123/2/e239
80. Giorgi L.J. Jr, Bratslavsky G., Kogan B.A. Febrile urinary tract infections in infants: Renal ultrasound remains necessary. J Urol. 2005;173(2):568-570
81. Gelfand M.J., Barr L.L., Abunku O. The initial renal ultrasound examination in children with urinary tract infection: The prevalence of dilated uropathy has decreased. Pediatr Radiol. 2000;30(10):665-670
82. Jothilakshmi K., Vijayaraghavan B., Paul S., Matthai J. Radiological evaluation of the urinary tract in children with urinary infection. Indian J Pediatr. 2001;68(12):1131-1133
83. Jahnukainen T., Honkinen O., Ruuskanen O., Mertsola J. Ultrasonography after the first febrile urinary tract infection in children. Eur J Pediatr. 2006;165(8):556-559 (Pubitemid 43989414)
84. Huang H.P., Lai Y.C., Tsai I.J., Chen S.Y., Tsau Y.K. Renal ultrasonography should be done routinely in children with first urinary tract infections. Urology. 2008;71(3):439-443
85. Economou G., Egginton J., Brookfield D. The importance of late pregnancy scans for renal tract abnormalities. Prenat Diagn. 1994;14(3):177-180 (Pubitemid 24101554)
86. Rosendahl H. Ultrasound screening for fetal urinary tract malformations: A prospective study in general population. Eur J Obstet Gynecol Reprod Biol. 1990;36(1-2):27-33 (Pubitemid 20162056)
87. Paduano L., Giglio L., Bembi B., Peratoner L., Benussi, G. Clinical outcome of fetal uropathy, part II: Sensitivity of echography for prenatal detection of obstructive pathology. J Urol. 1991;146(4):1097-1098
88. Miron D., Daas A., Sakran W., Lumelsky D., Koren A., Horovitz Y. Is omitting post urinary-tract-infection renal ultrasound safe after normal antenatal ultrasound? An observational study. Arch Dis Child. 2007;92(6):502-504 (Pubitemid 46867268)
89. Lakhoo K., Thomas D.F., Fuenfer M., D'Cruz A.J. Failure of pre-natal ultrasonography to prevent urinary infection associated with underlying urological abnormalities. Br J Urol. 1996;77(6):905-908 (Pubitemid 27407605)
90. Scholtmeijer R.J. Treatment of vesicoureteric reflux: Results of a prospective study. Br J Urol. 1993;71(3):346-349 (Pubitemid 23102263)
91. Smellie J.M., Barratt T.M., Chantler C., et al. Medical versus surgical treatment in children with severe bilateral vesicoureteric reflux and bilateral nephropathy: A randomised trial. Lancet. 2001;357(9265):1329-1333 (Pubitemid 32441532)
92. Jodal U., Smellie J.M., Lax H., Hoyer P.F. Tenyear results of randomized treatment of children with severe vesicoureteral reflux: Final report of the International Reflux Study in Children. Pediatr Nephrol. 2006;21(6):785-792 (Pubitemid 43740945)
93. Capozza N., Caione P. Dextranomer/hyaluronic acid copolymer implantation for vesico-ureteral reflux: A randomized comparison with antibiotic prophylaxis. J Pediatr. 2002;140(2):230-234 (Pubitemid 34183664)
94. Wingen A.M., Koskimies O., Olbing H., Seppanen J., Tamminen-Mobius T. Growth and weight gain in children with vesicoureteral reflux receiving medical versus surgical treatment: 10-year results of a prospective, randomized study. Acta Paediatr. 1999;88(1):56-61 (Pubitemid 29100201)
95. Smellie J.M., Tamminen-Möbius T., Olbing H., et al. Radiologic findings in the kidney of children with severe reflux: Five-year comparative study of conservative and surgical treatment [in German]. Urologe A. 1993;32(1):22-29 (Pubitemid 23048456)
96. Olbing H., Smellie J.M., Jodal U., Lax H. New renal scars in children with severe VUR: A 10-year study of randomized treatment. Pediatr Nephrol. 2003;18(11):1128-1131 (Pubitemid 37406859)
97. Olbing H., Hirche H., Koskimies O., et al. Renal growth in children with severe vesicoureteral reflux: 10-year prospective study of medical and surgical treatment. Radiology. 2000;216(3):731-737
98. Al-Sayyad A.J., Pike J.G., Leonard M.P. Can prophylactic antibiotics safely be discontinued in children with vesicoureteral reflux? J Urol. 2005;174(4):1587-1589 (Pubitemid 41318631)
99. Kaneko K., Ohtomo Y., Shimizu T., Yamashiro Y., Yamataka A., Miyano T. Antibiotic prophylaxis by low-dose cefaclor in children with vesicoureteral reflux. Pediatr Nephrol. 2003;18(5):468-470 (Pubitemid 36798494)
100. Lohr J.A., Nunley D.H., Howards S.S., Ford R.F. Prevention of recurrent urinary tract infections in girls. Pediatrics. 1977;59(4):562-565 (Pubitemid 8092809)
101. Smellie J.M., Katz G., Grüneberg R.N. Controlled trial of prophylactic treatment in childhood urinary-tract infection. Lancet. 1978;2(8082):175-178 (Pubitemid 8385015)
102. Savage D.C., Howie G., Adler K., Wilson M.I. Controlled trial of therapy in covert bacteriuria of childhood. Lancet. 1975;1(7903):358-361
103. Stansfeld J.M. Duration of treatment for urinary tract infections in children. Br Med J. 1975;3(5975):65-66
104. Reddy P.P., Evans M.T., Hughes P.A., et al. Antimicrobial prophylaxis in children with vesicoureteral reflux: A randomized prospective study of continuous therapy vs intermittent therapy vs surveillance. Pediatrics. 1997;100(3 suppl):555-556
105. Craig J., Roy L., Sureshkumar P., Burke J., Powell H. Long-term antibiotics to prevent urinary tract infection in children with isolated vesicoureteric reflux: A placebo-controlled randomized trial. J Am Soc Nephrol. 2002;13(3):3A
106. Bitsori M., Maraki S., Kalmanti M., Galanakis E. Resistance against broad-spectrum β-lactams among uropathogens in children. Pediatr Nephrol. 2009;24(12):2381-2386
107. Conway P.H., Cnaan A., Zaoutis T., Henry B.V., Grundmeier R.W., Keren R. Recurrent urinary tract infections in children: Risk factors and association with prophylactic antimicrobials. JAMA. 2007;298(2):179-186 (Pubitemid 47057764)
108. Hodson E.M., Wheeler D.M., Vimalchandra D., Smith G.H., Craig J.C. Interventions for primary vesicoureteric reflux. Cochrane Database Syst Rev. 2007;(3):CD001532
109. xWilliams DI, Kenawi MM. The prognosis of pelviureteric obstruction in childhood: a review of 190 cases. Eur Urol. 1976;2(2):57-63
110. Mihindukulasuriya J.C., Maskell R., Polak A. A study of fifty-eight patients with renal scarring associated with urinary tract infection. Q J Med. 1980;49(194):165-178 (Pubitemid 11177256)
111. McKerrow W., Davidson-Lamb N., Jones P.F. Urinary tract infection in children. Br Med J (Clin Res Ed). 1984;289(6440):299-303 (Pubitemid 14009096)
112. Jacobson S.H., Eklof O., Lins L.E., Wikstad I., Winberg J. Long-term prognosis of postinfectious renal scarring in relation to radiological findings in childhood: A 27-year follow-up. Pediatr Nephrol. 1992;6(1):19-24
113. Craig J.C., Irwig L.M., Knight J.F., Roy L.P. Does treatment of vesicoureteric reflux in childhood prevent end-stage renal disease attributable to reflux nephropathy? Pediatrics. 2000;105(6):1236-1241 (Pubitemid 30346892)
114. Phillips D., Watson A.R., Collier J. Distress and radiological investigations of the urinary tract in children. Eur J Pediatr. 1996;155(8):684-687 (Pubitemid 26232583)
115. Phillips D.A., Watson A.R., MacKinlay D. Distress and the micturating cystourethrogram: Does preparation help? Acta Paediatr. 1998;87(2):175-179 (Pubitemid 28099611)
116. Robinson M., Savage J., Stewart M., Sweeney L. The diagnostic value, parental and patient acceptability of micturating cystourethrography in children. Ir Med J. 1999;92(5):366-368