Yin Yang-1 inhibits tumor cell growth and inhibits p21 WAF1/Cip1complex formation with cdk4 and cyclin D1

International Journal of Oncology

Volumn 40, Issue 5, 2012, Pages 1575-1580

  Ishii, Hideto ^a   Hulett, Mark D ^b   Li, Jian Mei ^a   Santiago, Fernando S ^a   Parish, Christopher R ^c   Khachigian, Levon M ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b LA TROBE UNIVERSITY   (Australia)

^c Australian National University   (Australia)

Author keywords

Cancer cells; Proliferation; Tumor growth

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE 4; PROTEIN P21; TRANSCRIPTION FACTOR YY1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CARCINOMA; CANCER INHIBITION; CARCINOMA CELL; CONTROLLED STUDY; FEMALE; GLIOBLASTOMA; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; TUMOR GROWTH;

ADENOCARCINOMA; ANIMALS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN D1; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE INHIBITOR P21; FEMALE; GREEN FLUORESCENT PROTEINS; HUMANS; MICROVESSELS; PHOSPHORYLATION; PROLIFERATING CELL NUCLEAR ANTIGEN; RATS; RATS, INBRED F344; RETINOBLASTOMA PROTEIN; SIGNAL TRANSDUCTION; TRANSFECTION; TUMOR BURDEN; YY1 TRANSCRIPTION FACTOR;

EID: 84860289963     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2012.1362     Document Type: Article

References (27)

1. Shi Y, Seto E, Chang LS and Shenk T: Transcriptional repression by YY1, a human GLI-Kruppel-related protein, and relief of repression by adenovirus E1A protein. Cell 67: 377-388, 1991. (Pubitemid 121001453)
2. Park K and Atchison ML: Isolation of a candidate repressor/activator, NF-E1 (YY1), that binds to the immunoglobulin kappa3′ enhancer and the immunoglobulin heavy chain microE1 site. Proc Natl Acad Sci USA 88: 9804-9808, 1991. (Pubitemid 21915722)
3. Yao Y-L, DuPont BR, Ghosh S, Fang Y, Leach RJ and Seto E: Cloning, chromosomal localization and promoter analysis of the human transcription factor YY1. Nucleic Acids Res 26: 3776-3783, 1998. (Pubitemid 28367985)
4. Shi Y, Lee JS and Galvin KM: Everything you have ever wanted to know about Yin Yang 1. Biochim Biophys Acta 1332: F49-F66, 1997. (Pubitemid 27211616)
5. Santiago FS, Lowe HC, Bobryshev YV and Khachigian LM: Induction of the transcriptional repressor Yin Yang-1 by vascular cell injury: autocrine/paracrine role of endogenous fibroblast growth factor-2. J Biol Chem 276: 41143-41149, 2001.
6. Santiago FS, Ishii H, Shafi S, Khurana R, Kanellakis P, Bhindi R, Ramirez M, Bobik A, Martin J, Chesterman CN, Zachary I and Khachigian L: Yin Yang-1 inhibits intimal thickening by repressing p21WAF1/Cip1 transcription and p21WAF1/Cip1-Cdk4-Cyclin D1 assembly. Circ Res 101: 146-155, 2007.
7. Khachigian LM, Owensby DA and Chesterman CN: A tyrosinated peptide representing the alternatively spliced exon of the PDGF A-chain binds specifically to cultured cells and interferes with binding of several growth factors. J Biol Chem 267: 1660-1666, 1992.
8. Coombe DR, Parish CR, Ramshaw IA and Snowden JM: Analysis of the inhibition of tumour metastasis by sulphated polysaccharides. Int J Cancer 39: 82-88, 1987. (Pubitemid 17233832)
9. Chellappan SP, Hiebert S, Mudryj M, Horowitz JM and Nevins JR: The E2F transcription factor is a cellular target for the RB protein. Cell 65: 1053-1061, 1991. (Pubitemid 121001693)
10. Petkova V, Romanowski MJ, Sulijandikusumo I, Rohne D, Kang P, Shenk T and Usheva A: Interaction between YY1 and the retinoblastoma protein. J Biol Chem 276: 7932-7936, 2001.
11. Gordon S, Akopyan G, Garban H and Bonavida B: Transcription factor YY1: structure, function, and therapeutic implications in cancer biology. Oncogene 25: 1125-1142, 2006.
12. Wang CC, Chen JJ and Yang PC: Multifunctional transcription factor YY1: a therapeutic target in human cancer? Expert Opin Ther Targets 10: 253-266, 2006.
13. Sui G, Affar el B, Shi Y, Brignone C, Wall NR, Yin P, Donohoe M, Luke MP, Calvo D and Grossman SR: Yin Yang 1 is a negative regulator of p53. Cell 117: 859-872, 2004.
14. Garban HJ and Bonavida B: Nitric oxide inhibits the transcription repressor Yin-Yang 1 binding activity at the silencer region of the Fas promoter: a pivotal role for nitric oxide in the up-regulation of Fas gene expression in human tumor cells. J Immunol 167: 75-81, 2001. (Pubitemid 32567763)
15. Baritaki S, Huerta-Yepez S, Sakai T, Spandidos DA and Bonavida B: Chemotherapeutic drugs sensitize cancer cells to TRAIL-mediated apoptosis: up-regulation of DR5 and inhibition of Yin Yang 1. Mol Cancer Ther 6: 1387-1399, 2007. (Pubitemid 46712002)
16. Baritaki S, Sifakis S, Huerta-Yepez S, Neonakis IK, Soufla G, Bonavida B and Spandidos DA: Overexpression of VEGF and TGF-beta1 mRNA in Pap smears correlates with progression of cervical intraepithelial neoplasia to cancer: Implication of YY1 in cervical tumorigenesis and HPV infection. Int J Oncol 31: 69-79, 2007.
17. Lee MH, Lahusen T, Wang RH, Xiao C, Xu X, Hwang YS, He WW, Shi Y and Deng CX: Yin Yang 1 positively regulates BRCA1 and inhibits mammary cancer formation. Oncogene 2011.
18. Zaravinos A and Spandidos DA: Yin yang 1 expression in human tumors. Cell Cycle 9: 512-522, 2010.
19. Seligson D, Horvath S, Huerta-Yepez S, Hanna S, Garban H, Roberts A, Shi T, Liu X, Chia D, Goodglick L and Bonavida B: Expression of transcription factor Yin Yang 1 in prostate cancer. Int J Oncol 27: 131-141, 2005.
20. Sawtell RM, Rew DA, Stradling RN and Wilson GD: Pan cycle expression of proliferating cell nuclear antigen in human colorectal cancer and its proliferative correlations. Cytometry 22: 190-199, 1995.
21. Mamay CL, Schauer IE, Rice PL, McDoniels-Silvers A, Dwyer-Nield LD, You M, Sclafani RA and Malkinson AM: Cyclin D1 as a proliferative marker regulating retinoblastoma phosphorylation in mouse lung epithelial cells. Cancer Lett 168: 165-172, 2001. (Pubitemid 32524278)
22. Leonardi E, Girlando S, Serio G, Mauri FA, Perrone G, Scampini S, Dalla Palma P and Barbareschi M: PCNA and Ki67 expression in breast carcinoma: correlations with clinical and biological variables. J Clin Pathol 45: 416-419, 1992.
23. Bowman GD, O'Donnell M and Kuriyan J: Structural analysis of a eukaryotic sliding DNA clamp-clamp loader complex. Nature 429: 724-730, 2004. (Pubitemid 38833117)
24. Sherr CJ and Roberts JM: CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 13: 1501-1512, 1999. (Pubitemid 29297917)
25. Fang Y and Sheffield LG: Regulation of epidermal growth factor expression in mammary epithelial cells by a Yin-Yang-1-like element. J Mol Endocrinol 20: 337-344, 1998. (Pubitemid 28277522)
26. Khazaie K, Schirrmacher V, Lichtner RB: EGF receptor in neoplasia and metastasis. Cancer Metastasis Rev 12: 255-274, 1993. (Pubitemid 23293284)
27. Wang CC, Tsai MF, Dai TH, Hong TM, Chan WK, Chen JJ and Yang PC: Synergistic activation of the tumor suppressor, HLJ1, by the transcription factors YY1 and activator protein 1. Cancer Res 67: 4816-4826, 2007. (Pubitemid 46910190)