Metabolomic profile of human myocardial ischemia by nuclear magnetic resonance spectroscopy of peripheral blood serum: A translational study based on transient coronary occlusion models

Journal of the American College of Cardiology

Volumn 59, Issue 18, 2012, Pages 1629-1641

  Bodi, Vicente ^a   Sanchis, Juan ^a   Morales, Jose M ^a   Marrachelli, Vannina G ^a   Nunez, Julio ^a   Forteza, Maria J ^a   Chaustre, Fabian ^a   Gomez, Cristina ^a   Mainar, Luis ^a   Minana, Gema ^a   Rumiz, Eva ^a   Husser, Oliver ^a   Noguera, Inmaculada ^a   Diaz, Ana ^a   Moratal, David ^b   Carratala, Arturo ^c   Bosch, Xavier ^d   Llacer, Angel ^a   Chorro, Francisco J ^a   Via, Juan R ^c,e   Monleon, Daniel ^c   more..

^a UNIVERSITY OF VALENCIA   (Spain)

^b UNIVERSITAT POLITÈCNICA DE VALÈNCIA   (Spain)

^c Instituto Universitario IVI INCLIVA   (Spain)

^d UNIVERSITY OF BARCELONA   (Spain)

^e UNIVERSITY OF VALENCIA   (Spain)

Author keywords

metabolomics; myocardial ischemia; nuclear magnetic resonance

Indexed keywords

CREATININE; FATTY ACID; GLUCOSE; GLUTAMINE; GLYCEROL; GLYCINE; LACTIC ACID; PHENYLALANINE; PHOSPHOETHANOLAMINE; TRIACYLGLYCEROL; TYROSINE;

ACUTE DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BALLOON; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HEART INFARCTION; HEART MUSCLE ISCHEMIA; HUMAN; METABOLOMICS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PERCUTANEOUS CORONARY INTERVENTION; PRIORITY JOURNAL; SERUM; STABLE ANGINA PECTORIS; SWINE; THORAX PAIN; TRANSLUMINAL CORONARY ANGIOPLASTY; VALIDATION PROCESS;

ADULT; AGED; ANIMALS; BIOLOGICAL MARKERS; CORONARY OCCLUSION; DIAGNOSIS, DIFFERENTIAL; DISEASE MODELS, ANIMAL; ENERGY METABOLISM; FEMALE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; METABOLOMICS; MIDDLE AGED; MYOCARDIAL ISCHEMIA; MYOCARDIUM; REPRODUCIBILITY OF RESULTS; SWINE;

EID: 84860283097     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2011.09.083     Document Type: Article

References (25)

1. J. Sanchis, V. Bodi, J. Nunez New risk score for patients with acute chest pain, non-ST-segment deviation, and normal troponin concentrations: a comparison with the TIMI risk score J Am Coll Cardiol 46 2005 443 449 (Pubitemid 41040284)
2. D.A. Morrow, J.A. de Lemos, M.S. Sabatine, E.M. Antman The search for a biomarker of cardiac ischemia Clin Chem 49 2003 537 539 (Pubitemid 36379516)
3. P.A. Kavsak, X. Wang, M. Henderson, D.T. Ko, A.R. Macrae, A.S. Jaffe PAPP-A as a marker of increased long-term risk in patients with chest pain Clin Biochem 42 2009 1012 1018
4. V. Bodi, J. Sanchis, A. Llacer Multimarker risk strategy for predicting 1-month and 1-year major events in non-ST-elevation acute coronary syndromes Am Heart J 149 2005 268 274 (Pubitemid 40348533)
5. G.D. Lewis, A. Asnani, R.E. Gerszten Application of metabolomics to cardiovascular biomarker and pathway discovery J Am Coll Cardiol 52 2008 117 123 (Pubitemid 351885452)
6. J.T. Brindle, H. Antti, E. Holmes Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics Nat Med 8 2002 1439 1444 (Pubitemid 36019430)
7. M.S. Sabatine, E. Liu, D.A. Morrow Metabolomic identification of novel biomarkers of myocardial ischemia Circulation 112 2005 3868 3875 (Pubitemid 43739484)
8. I. Barba, E. Jaimez-Auguets, A. Rodriguez-Sinovas, D. Garcia-Dorado 1H NMR-based metabolomic identification of at-risk areas after myocardial infarction in swine MAGMA 20 2007 265 271
9. G.R. Heyndrickx, R.W. Millard, R.J. McRitchie, P.R. Maroko, S.F. Vatner Regional myocardial functional and electrophysiological alterations after brief coronary artery occlusion in conscious dogs J Clin Invest 56 1975 978 985
10. V. Bodi, J. Sanchis, L. Mainar Right ventricular involvement in anterior myocardial infarction: a translational approach Cardiovasc Res 87 2010 601 608
11. G. Lewis, R. Wei, E. Liu Metabolite profiling of blood from individuals undergoing planned myocardial infarction reveals early markers of myocardial injury J Clin Invest 118 2008 3503 3512
12. A.T. Turer, R.D. Stevens, J.R. Bain, Muehlbauer Metabolomic profiling reveals distinct patterns of myocardial substrate use in humans with coronary artery disease or left ventricular dysfunction during surgical ischemia/reperfusion Circulation 119 2009 1736 1746
13. D.J. Grainger Metabolic profiling in heart disease Heart Metab 32 2006 22 25 (Pubitemid 44690928)
14. W.C. Stanley, F.A. Recchia, G.D. Lopaschuk Myocardial substrate metabolism in the normal and failing heart Physiol Rev 85 2005 1093 1129 (Pubitemid 40894649)
15. J.M. Huss, D.P. Kelly Nuclear receptor signaling and cardiac energetics Circ Res 95 2004 568 578 (Pubitemid 39274371)
16. A.J. Liedtke Effects of coronary perfusion during myocardial hypoxia Comparison of metabolic and hemodynamic events with global ischemia and hypoxemia J Thorac Cardiovasc Surg 71 1976 726 735
17. M. Sebastiani, C. Giordano, C. Nediani Induction of mitochondrial biogenesis is a maladaptive mechanism in mitochondrial cardiomyopathies J Am Coll Cardiol 50 2007 1362 1369 (Pubitemid 47454690)
18. D.H. Williamson Regulation of ketone body metabolism and the effects of injury Acta Chir Scand Suppl 507 1981 22 29 (Pubitemid 12205417)
19. M.C. Sugden, A.J. Ball, V. Ilic, D.H. Williamson Stimulation of [1-14C]oleate oxidation to 14CO2 in isolated rat hepatocytes by vasopressin: effects of Ca2+ FEBS Lett 116 1980 37 40 (Pubitemid 11227325)
20. M.F. Oliver Control of free fatty acids during acute myocardial ischaemia Heart 96 2010 1883 1884
21. C. Metzsch, Q. Liao, S. Steen, L. Algotsson Myocardial glycerol release, arrhythmias and hemodynamic instability during regional ischemia-reperfusion in an open chest pig model Acta Anaesthesiol Scand 50 2006 99 107 (Pubitemid 43339038)
22. H. Lin, J. Zhang, P. Gao Silent myocardial ischemia is associated with altered plasma phospholipids J Clin Lab Anal 23 2009 45 50
23. P.C. Choy, M. Chan, G. Hatch, R.Y. Man Phosphatidylcholine metabolism in ischemic and hypoxic hearts Mol Cell Biochem 116 1992 53 58
24. K. Emoto, N. Toyama-Sorimachi, H. Karasuyama Exposure of phosphatidylethanolamine on the surface of apoptotic cells Exp Cell Res 232 1997 430 434 (Pubitemid 27194059)
25. V. Zemgulis, G. Ronquist, T. Bjerner Energy-related metabolites during and after induced myocardial infarction with special emphasis on the reperfusion injury after extracorporeal circulation Acta Physiol Scand 171 2001 129 143 (Pubitemid 33757147)