Prepregnancy obesity and complement system activation in early pregnancy and the subsequent development of preeclampsia

American Journal of Obstetrics and Gynecology

Volumn 206, Issue 5, 2012, Pages 428.e1-428.e8

  Lynch, Anne M ^a   Eckel, Robert H ^a   Murphy, James R ^c   Gibbs, Ronald S ^a   West, Nancy A ^b   Giclas, Patricia C ^c   Salmon, Jane E ^d   Holers, V Michael ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b Global Health and Health Disparities   (United States)

^c DEPARTMENT OF MEDICINE   (United States)

^d HOSPITAL FOR SPECIAL SURGERY   (United States)

Author keywords

complement system; obesity; preeclampsia

Indexed keywords

ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; COMPLEMENT COMPONENT C3A; EDETIC ACID;

ADULT; BLOOD SAMPLING; COMPLEMENT ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FIRST TRIMESTER PREGNANCY; GESTATIONAL AGE; HIGH RISK PATIENT; HUMAN; MAJOR CLINICAL STUDY; OBESITY; PREECLAMPSIA; PREPREGNANCY CARE; PRIORITY JOURNAL; PROSPECTIVE STUDY; REVIEW;

EID: 84860279819     PISSN: 00029378     EISSN: 10976868     Source Type: Journal    
DOI: 10.1016/j.ajog.2012.02.035     Document Type: Article

References (50)

1. P.M. Catalano, S. Hauguel-De Mouzon Is it time to revisit the Pedersen hypothesis in the face of the obesity epidemic? Am J Obstet Gynecol 204 2011 479 487
2. Y. Yogev, P.M. Catalano Pregnancy and obesity Obstet Gynecol Clin North Am 36 2009 285 300 viii
3. C.D. Williams Weight in relation to pregnancy toxaemia Br Med J 2 1957 1338 1340
4. D.B. Armstrong, L.I. Dublin, G.M. Wheatley, H.H. Marks Obesity and its relation to health and disease JAMA 147 1951 1007 1014
5. L. Poston, L. Harthoorn, E.M. van der Beek Obesity in pregnancy: implications for the mother and lifelong health of the child A consensus statement Pediatr Res 69 2011 175 180
6. A. Vahratian Prevalence of overweight and obesity among women of childbearing age: results from the 2002 National Survey of Family Growth Matern Child Health J 13 2009 268 273
7. A.H. Berg, P.E. Scherer Adipose tissue, inflammation, and cardiovascular disease Circ Res 96 2005 939 949
8. R. Cancello, K. Clement Is obesity an inflammatory illness? Role of low-grade inflammation and macrophage infiltration in human white adipose tissue BJOG 113 2006 1141 1147
9. L.N. Choy, B.S. Rosen, B.M. Spiegelman Adipsin and an endogenous pathway of complement from adipose cells J Biol Chem 267 1992 12736 12741
10. K.S. Cook, H.Y. Min, D. Johnson Adipsin: a circulating serine protease homolog secreted by adipose tissue and sciatic nerve Science 237 1987 402 405
11. B.S. Rosen, K.S. Cook, J. Yaglom Adipsin and complement factor D activity: an immune-related defect in obesity Science 244 1989 1483 1487
12. R.T. White, D. Damm, N. Hancock Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue J Biol Chem 267 1992 9210 9213
13. M. Pattrick, J. Luckett, L. Yue, C. Stover Dual role of complement in adipose tissue Mol Immunol 46 2009 755 760
14. K. Sodowski, K. Zwirska-Korczala, D. Kuka Acylation stimulating protein is associated with pregnancy weight gain J Physiol Pharmacol 59 Suppl 4 2008 33 43
15. V.M. Holers The spectrum of complement alternative pathway-mediated diseases Immunol Rev 223 2008 300 316
16. A.M. Lynch, J.E. Salmon Dysregulated complement activation as a common pathway of injury in preeclampsia and other pregnancy complications Placenta 31 2010 561 567
17. A.M. Lynch, J.R. Murphy, R.S. Gibbs The interrelationship of complement-activation fragments and angiogenesis-related factors in early pregnancy and their association with pre-eclampsia BJOG 117 2010 456 462
18. A.M. Lynch, J.R. Murphy, T. Byers Alternative complement pathway activation fragment Bb in early pregnancy as a predictor of preeclampsia Am J Obstet Gynecol 198 2008 385.e1 385.e9
19. A.M. Lynch, R.S. Gibbs, J.R. Murphy, P.C. Giclas, J.E. Salmon, V.M. Holers Early elevations of the complement activation fragment C3a and adverse pregnancy outcomes Obstet Gynecol 117 2011 75 83
20. L. Duley The global impact of pre-eclampsia and eclampsia Semin Perinatol 33 2009 130 137
21. C.J. Fang, A. Richards, M.K. Liszewski, D. Kavanagh, J.P. Atkinson Advances in understanding of pathogenesis of aHUS and HELLP Br J Haematol 143 2008 336 348
22. M. Haeger, M. Unander, B. Norder-Hansson, M. Tylman, A. Bengtsson Complement, neutrophil, and macrophage activation in women with severe preeclampsia and the syndrome of hemolysis, elevated liver enzymes, and low platelet count Obstet Gynecol 79 1992 19 26
23. Z. Derzsy, Z. Prohaszka, J. Rigo Jr, G. Fust, A. Molvarec Activation of the complement system in normal pregnancy and preeclampsia Mol Immunol 47 2010 1500 1506
24. E. Soto, R. Romero, K. Richani Preeclampsia and pregnancies with small-for-gestational age neonates have different profiles of complement split products J Matern Fetal Neonatal Med 23 2010 646 657
25. A. Elimian, R. Figueroa, J. Canterino, U. Verma, M. Aguero-Rosenfeld, N. Tejani Amniotic fluid complement C3 as a marker of intra-amniotic infection Obstet Gynecol 92 1998 72 76
26. E. Soto, R. Romero, K. Richani Anaphylatoxins in preterm and term labor J Perinat Med 33 2005 306 313
27. A.M. Lynch, R.S. Gibbs, J.R. Murphy Complement activation fragment Bb in early pregnancy and spontaneous preterm birth Am J Obstet Gynecol 199 2008 354 e1-8
28. B. Sibai, G. Dekker, M. Kupferminc Pre-eclampsia Lancet 365 2005 785 799
29. P.M. Catalano Management of obesity in pregnancy Obstet Gynecol 109 2 Pt 1 2007 419 433
30. C.W. Redman, I.L. Sargent Pre-eclampsia, the placenta and the maternal systemic inflammatory response - a review Placenta 24 Suppl A 2003 S21 S27
31. F. Fakhouri, M. Jablonski, J. Lepercq Factor H, membrane cofactor protein, and factor I mutations in patients with hemolysis, elevated liver enzymes, and low platelet count syndrome Blood 112 2008 4542 4545
32. C.J. Fang, V. Fremeaux-Bacchi, M.K. Liszewski Membrane cofactor protein mutations in atypical hemolytic uremic syndrome (aHUS), fatal Stx-HUS, C3 glomerulonephritis, and the HELLP syndrome Blood 111 2008 624 632
33. R. Rampersad, A. Barton, Y. Sadovsky, D.M. Nelson The C5b-9 membrane attack complex of complement activation localizes to villous trophoblast injury in vivo and modulates human trophoblast function in vitro Placenta 29 2008 855 861
34. J.C. Challier, S. Basu, T. Bintein Obesity in pregnancy stimulates macrophage accumulation and inflammation in the placenta Placenta 29 2008 274 281
35. B.G. Gabrielsson, J.M. Johansson, M. Lonn High expression of complement components in omental adipose tissue in obese men Obes Res 11 2003 699 708
36. A. Hernandez-Mijares, M.M. Jarabo-Bueno, A. Lopez-Ruiz, E. Sola-Izquierdo, C. Morillas-Arino, M.L. Martinez-Triguero Levels of C3 in patients with severe, morbid and extreme obesity: its relationship to insulin resistance and different cardiovascular risk factors Int J Obes (Lond) 31 2007 927 932
37. K. Cianflone, Z. Xia, L.Y. Chen Critical review of acylation-stimulating protein physiology in humans and rodents Biochim Biophys Acta 1609 2003 127 143
38. M. Maslowska, H. Vu, S. Phelis Plasma acylation stimulating protein, adipsin and lipids in non-obese and obese populations Eur J Clin Invest 29 1999 679 686
39. A.D. Sniderman, K.M. Cianflone, R.H. Eckel Levels of acylation stimulating protein in obese women before and after moderate weight loss Int J Obes 15 1991 333 336
40. J.M. Moreno-Navarrete, R. Martinez-Barricarte, V. Catalan Complement factor H is expressed in adipose tissue in association with insulin resistance Diabetes 59 2010 200 209
41. J. Zhang, W. Wright, D.A. Bernlohr, S.W. Cushman, X. Chen Alterations of the classic pathway of complement in adipose tissue of obesity and insulin resistance Am J Physiol Endocrinol Metab 292 2007 E1433 E1440
42. R.A. Irani, Y. Zhang, C.C. Zhou Autoantibody-mediated angiotensin receptor activation contributes to preeclampsia through tumor necrosis factor-alpha signaling Hypertension 55 2010 1246 1253
43. N.G. Than, R. Romero, O. Erez A role for mannose-binding lectin, a component of the innate immune system in pre-eclampsia Am J Reprod Immunol 60 2008 333 345
44. Centers for Disease Control and Prevention Vital signs: state-specific obesity prevalence among adults - United States, 2009 MMWR Morb Mortal Wkly Rep 59 2010 951 955
45. L.M. Bodnar, A.M. Siega-Riz, H.N. Simhan, J.C. Diesel, B. Abrams The impact of exposure misclassification on associations between prepregnancy BMI and adverse pregnancy outcomes Obesity (Silver Spring) 18 2010 2184 2190
46. P.M. Catalano, L. Presley, J. Minium, S. Hauguel-de Mouzon Fetuses of obese mothers develop insulin resistance in utero Diabetes Care 32 2009 1076 1080
47. R.H. Eckel, S.M. Grundy, P.Z. Zimmet The metabolic syndrome Lancet 365 2005 1415 1428
48. V.M. Holers Complement R.R. Rich, T.A. Fleisher, W.T. Shearer, B.L. Kotzin, H.W. Schroeder Jr Clinical immunology Principles and practice 2001 Mosby St Louis, MO Chapter 21.1-21.8
49. V.M. Holers, J.M. Thurman The alternative pathway of complement in disease: opportunities for therapeutic targeting Mol Immunol 41 2004 147 152
50. C. Janeway Immunobiology: the immune system in health and disease, 6th ed C.A. Janeway Jr 2005 Garland Science New York