The C5b-9 Membrane Attack Complex of Complement Activation Localizes to Villous Trophoblast Injury in vivo and Modulates Human Trophoblast Function in vitro

Placenta

Volumn 29, Issue 10, 2008, Pages 855-861

  Rampersad, R ^a   Barton, A ^a   Sadovsky, Y ^a   Nelson, D M ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Complement; Hypoxia; Membrane attack complex; Trophoblast differentiation

Indexed keywords

CHORIONIC GONADOTROPIN; COMPLEMENT MEMBRANE ATTACK COMPLEX; CYTOKERATIN 18; FIBRIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PLACENTA PROTEIN; PROTEIN SYNCYTIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL DAMAGE; CELL DEATH; CELL DIFFERENTIATION; CELL FUNCTION; CELL HYPOXIA; COMPLEMENT ACTIVATION; COMPLEMENT DEPOSITION; CONTROLLED STUDY; CYTOTROPHOBLAST; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; INTRAUTERINE GROWTH RETARDATION; PHENOTYPE; PLACENTA VILLUS; PREECLAMPSIA; PREGNANCY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TROPHOBLAST;

APOPTOSIS; CHORIONIC VILLI; COMPLEMENT MEMBRANE ATTACK COMPLEX; FEMALE; FETAL GROWTH RETARDATION; FIBRIN; HUMANS; PLACENTA DISEASES; PRE-ECLAMPSIA; PREGNANCY; TROPHOBLASTS;

EID: 51249107095     PISSN: 01434004     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.placenta.2008.07.008     Document Type: Article

References (34)

1. Soleymanlou N., Jurisica I., Nevo O., Ietta F., Zhang X., Zamudio S., et al. Molecular evidence of placental hypoxia in preeclampsia. J Clin Endocrinol Metab 90 (2005) 4299-4308
2. Tjoa M.L., Cindrova-Davies T., Spasic-Boskovic O., Bianchi D.W., and Burton G.J. Trophoblastic oxidative stress and the release of cell-free feto-placental DNA. Am J Pathol 169 (2006) 400-404
3. Hung T.H., Charnock-Jones D.S., Skepper J.N., and Burton G.J. Secretion of tumor necrosis factor-alpha from human placental tissues induced by hypoxia-reoxygenation causes endothelial cell activation in vitro: a potential mediator of the inflammatory response in preeclampsia. Am J Pathol 164 (2004) 1049-1061
4. Nelson D.M., Crouch E.C., Curran E.M., and Farmer D.R. Trophoblast interaction with fibrin matrix. Epithelialization of perivillous fibrin deposits as a mechanism for villous repair in the human placenta. Am J Pathol 136 (1990) 855-865
5. Frank H.G., Malekzadeh F., Kertschanska S., Crescimanno C., Castellucci M., Lang I., Desoye G., and Kaufmann P. Immunohistochemistry of two different types of placental fibrinoid. Acta Anat (Basel) 150 (1994) 55-68
6. Mayhew T.M., and Barker B.L. Villous trophoblast: morphometric perspectives on growth, differentiation, turnover and deposition of fibrin-type fibrinoid during gestation. Placenta 22 (2001) 628-638
7. Nelson D.M. Apoptotic changes occur in syncytiotrophoblast of human placental villi where fibrin type fibrinoid is deposited at discontinuities in the villous trophoblast. Placenta 17 (1996) 387-391
8. Smith S.C., Baker P.N., and Symonds E.M. Placental apoptosis in normal human pregnancy. Am J Obstet Gynecol 177 (1997) 57-65
9. Mayhew T.M., Ohadike C., Baker P.N., Crocker I.P., Mitchell C., and Ong S.S. Stereological investigation of placental morphology in pregnancies complicated by pre-eclampsia with and without intrauterine growth restriction. Placenta 24 (2003) 219-226
10. Bohana-Kashtan O., Ziporen L., Donin N., Kraus S., and Fishelson Z. Cell signals transduced by complement. Mol Immunol 41 (2004) 583-597
11. Kim D.D., and Song W.C. Membrane complement regulatory proteins. Clin Immunol 118 (2006) 127-136
12. Walport M.J. Complement. Second of two parts. N Engl J Med 344 (2001) 1140-1144
13. Holers V.M., Girardi G., Mo L., Guthridge J.M., Molina H., Pierangeli S.S., et al. Complement C3 activation is required for antiphospholipid antibody-induced fetal loss. J Exp Med 195 (2002) 211-220
14. Joyama S., Yoshida T., Koshikawa M., Sawai K., Yokoi H., Tanaka A., et al. C4d and C4bp deposition along the glomerular capillary walls in a patient with preeclampsia. Am J Kidney Dis 37 (2001) E6
15. Xu C., Mao D., Holers V.M., Palanca B., Cheng A.M., and Molina H. A critical role for murine complement regulator crry in fetomaternal tolerance. Science 287 (2000) 498-501
16. Girardi G., Berman J., Redecha P., Spruce L., Thurman J.M., Kraus D., et al. Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome. J Clin Invest 112 (2003) 1644-1654
17. ACOG Practice Bulletin. Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002. Obstet Gynecol 99 (2002) 159-167
18. Levy R., Smith S.D., Chandler K., Sadovsky Y., and Nelson D.M. Apoptosis in human cultured trophoblasts is enhanced by hypoxia and diminished by epidermal growth factor. Am J Physiol Cell Physiol 278 (2000) C982-C988
19. Mayhew T.M. Stereology and the placenta: where's the point? - a review. Placenta 27 Suppl. A (2006) S17-S25
20. Nelson D.M., Johnson R.D., Smith S.D., Anteby E.Y., and Sadovsky Y. Hypoxia limits differentiation and up-regulates expression and activity of prostaglandin H synthase 2 in cultured trophoblast from term human placenta. Am J Obstet Gynecol 180 (1999) 896-902
21. Hu C., Smith S.D., Pang L., Sadovsky Y., and Nelson D.M. Enhanced basal apoptosis in cultured term human cytotrophoblasts is associated with a higher expression and physical interaction of p53 and bak. Placenta 27 (2006) 978-983
22. Morgan B.P., and Holmes C.H. Immunology of reproduction: protecting the placenta. Curr Biol 10 (2000) R381-R383
23. Richani K., Romero R., Soto E., Espinoza J., Nien J.K., Chaiworapongsa T., et al. Unexplained intrauterine fetal death is accompanied by activation of complement. J Perinat Med 33 (2005) 296-305
24. Haeger M., Unander M., Norder-Hansson B., Tylman M., and Bengtsson A. Complement, neutrophil, and macrophage activation in women with severe preeclampsia and the syndrome of hemolysis, elevated liver enzymes, and low platelet count. Obstet Gynecol 79 (1992) 19-26
25. Tedesco F., Nurnberger W., and Perissutti S. Inherited deficiencies of the terminal complement components. Int Rev Immunol 10 (1993) 51-64
26. Sinha D., Wells M., and Faulk W.P. Immunological studies of human placentae: complement components in pre-eclamptic chorionic villi. Clin Exp Immunol 56 (1984) 175-184
27. Tedesco F., Radillo O., Candussi G., Nazzaro A., Mollnes T.E., and Pecorari D. Immunohistochemical detection of terminal complement complex and S protein in normal and pre-eclamptic placentae. Clin Exp Immunol 80 (1990) 236-240
28. van de Geijn F.E., Roos A., de Man Y.A., Laman J.D., de Groot C.J., Daha M.R., et al. Mannose-binding lectin levels during pregnancy: a longitudinal study. Hum Reprod 22 (2007) 362-371
29. Wang C.C., Yim K.W., Poon T.C., Choy K.W., Chu C.Y., Lui W.T., et al. Innate immune response by ficolin binding in apoptotic placenta is associated with the clinical syndrome of preeclampsia. Clin Chem 53 (2007) 42-52
30. Shamonki J.M., Salmon J.E., Hyjek E., and Baergen R.N. Excessive complement activation is associated with placental injury in patients with antiphospholipid antibodies. Am J Obstet Gynecol 196 167 (2007) e161-e165
31. Zwaka T.P., Manolov D., Ozdemir C., Marx N., Kaya Z., Kochs M., et al. Complement and dilated cardiomyopathy: a role of sublytic terminal complement complex-induced tumor necrosis factor-alpha synthesis in cardiac myocytes. Am J Pathol 161 (2002) 449-457
32. Rus H., Cudrici C., David S., and Niculescu F. The complement system in central nervous system diseases. Autoimmunity 39 (2006) 395-402
33. Cybulsky A.V., Takano T., Papillon J., Khadir A., Liu J., and Peng H. Complement C5b-9 membrane attack complex increases expression of endoplasmic reticulum stress proteins in glomerular epithelial cells. J Biol Chem 277 (2002) 41342-41351
34. Miller R.K., Genbacev O., Turner M.A., Aplin J.D., Caniggia I., and Huppertz B. Human placental explants in culture: approaches and assessments. Placenta 26 (2005) 439-448