Effect of theophylline on exercise capacity in COPD patients treated with combination long-acting bronchodilator therapy: A pilot study

International Journal of COPD

Volumn 7, Issue , 2012, Pages 245-252

  Voduc, Nha ^a   Alvarez, Gonzalo G ^a   Amjadi, Kayvan ^a   Tessier, Caroline ^b   Sabri, Elham ^c   Aaron, Shawn D ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

^c OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

Author keywords

Chronic obstructive pulmonary disease; Exercise capacity; Theophylline

Indexed keywords

BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BRONCHODILATING AGENT; CHOLINERGIC RECEPTOR BLOCKING AGENT; CORTICOSTEROID; FORMOTEROL; LONG ACTING DRUG; PLACEBO; SALMETEROL; THEOPHYLLINE; TIOTROPIUM BROMIDE;

ABDOMINAL CRAMP; AGED; ARTICLE; CARDIOPULMONARY EXERCISE TEST; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG INDUCED HEADACHE; DRUG MECHANISM; DRUG WITHDRAWAL; DYSPNEA; EXERCISE TOLERANCE; FEMALE; HUMAN; INSOMNIA; LUNG FUNCTION; LUNG GAS EXCHANGE; LUNG VENTILATION; MALE; NAUSEA; OUTCOME ASSESSMENT; PILOT STUDY; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; REST; SHORT COURSE THERAPY; SUSTAINED RELEASE FORMULATION; TREATMENT DURATION; UNSPECIFIED SIDE EFFECT;

ADMINISTRATION, INHALATION; ADRENERGIC BETA-AGONISTS; AGED; BRONCHODILATOR AGENTS; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; EXERCISE TOLERANCE; FEMALE; HUMANS; MALE; PHYSICAL EXERTION; PILOT PROJECTS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RESPIRATORY FUNCTION TESTS; THEOPHYLLINE; TIME; TREATMENT OUTCOME;

EID: 84860279670     PISSN: 11769106     EISSN: 11782005     Source Type: Journal    
DOI: 10.2147/COPD.S29990     Document Type: Article

References (18)

1. Rennard SI, Anderson W, ZuWallck R, et al. Use of a long-acting inhaled β2-adrenergic agonist, salmeterol xinafoate, in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2001;163:1087-1092.
2. Casaburi R, Mahler DA, Jones P, et al. A long-term evaluation of oncedaily inhaled tiotropium in chronic obstructive pulmonary disease. Eur Respir J. 2002;19:217-224.
3. Vincken W, van Noord JA, Greefhorst APM, Bantje Th A, Kesten S, Korducki L. Improved health outcomes in patients with COPD during 1 yr's treatment with tiotropium. Eur Respir J. 2002;19:209-216.
4. Rabe KF, Hurd S, Anzueto A, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD Executive Summary. Am J Respir Crit Care Med. 2007;176: 532-555.
5. O'Donnell DE, Aaron S, Bourbeau J, et al. Canadian Thoracic Society recommendations for management of chronic obstructive pulmonary disease - 2007 update. Can Respir J. 2007;14(Suppl B):5B-32B.
6. Fink G, Kaye C, Sulkes J, et al. Effects of theophylline on exercise performance in patients with severe chronic obstructive pulmonary disease. Thorax. 1994;49:332-334.
7. Shannon M. Predictors of major toxicity after theophylline overdose. Ann Intern Med. 1993;119:1161-1167.
8. Zuwallack RL, Mahler DA, Reilly D, Church N, Emmett A, Richard K. Salmeterol plus theophylline combination therapy in the treatment of COPD. Chest. 2001;119(6):1628-1630.
9. Cazzola M, Matera MG. The additive effect of theophylline on a combination of formoterol and tiotropium in stable COPD: A pilot study. Respir Med. 2007;101:957-962.
10. McKay SE, Howie CA, Thomson AH, Whiting B, Addis GJ. Value of theophylline treatment in patients handicapped by chronic obstructive lung disease. Thorax. 1993;48:227-232.
11. Tsukino M, Nishimura K, Ikeda A, Hajiro T, Koyama H, Izumi T. Effects of theophylline and ipratropium bromide on exercise performance in patients with stable chronic obstructive pulmonary disease. Thorax. 1998;53:269-273
12. Liesker J, Wijkstra P, Ten Hacken N, Koeter G, Postma D, Kerstjens H. A systemic review of the effects of bronchodilators on exercise capacity in patients with COPD. Chest. 2002;121:597-608.
13. American Thoracic Society; American College of Chest Physicians. ATS/ACCP Statement on cardio-pulmonary exercise testing. Am J Respir Crit Care Med. 2003;167 (2):211-277. Erratum in: Am J Respir Crit Care Med. 2003:1451-1452.
14. O'Donnell DE, Voduc N, Fitzpatrick M, Webb K. Effect of salmeterol on the ventilatory response to exercise in chronic obstructive pulmonary disease. Eur Respir J. 2004;24:86-94.
15. O'Donnell DE, Fluge T, Gerken F, et al. Effects of tiotropium on lung hypertension, dyspnea, and exercise tolerance. Eur Respir J. 2004;23:832-840.
16. Berton DC, Reis M, Sigueira AC, et al. Effects of tiotropium on dynamic hypertension and exercise endurance in COPD. Respir Med. 2010;104:1288-1296.
17. Puente-Maestu L, Villar F, de Miguel J, et al. Clinical relevance of constant power exercise duration changes in COPD. Eur Respir J. 2009;34(2):340-345.
18. Ford PA, Durham AL, Russell RE, Gordon F, Adcock IM, Barnes PJ. Treatment of low-dose theophylline combined with an inhaled corticosteroid in COPD. Chest. 2010;137(6):1338-1344.