NR2F1 disrupts synergistic activation of the MTTP gene transcription by HNF-4α and HNF-1α

Journal of Lipid Research

Volumn 53, Issue 5, 2012, Pages 901-908

  Dai, Kezhi ^a,b   Hussain, M Mahmood ^a  

^a SUNY DOWNSTATE MEDICAL CENTER   (United States)

^b WEILL CORNELL MEDICAL CENTER   (United States)

Author keywords

Apolipoprotein; Caco 2; Intestine; Microsomal triglyceride transfer protein; Repression

Indexed keywords

CELL NUCLEUS RECEPTOR; CELL PROTEIN; DIRECT REPEAT 1 PROTEIN; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN; NUCLEAR RECEPTOR COREPRESSOR; NUCLEUS RECEPTOR NR2F1; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GENE INTERACTION; HUMAN; HUMAN CELL; MARKER GENE; MTTP GENE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

BASE SEQUENCE; CACO-2 CELLS; CARRIER PROTEINS; COUP TRANSCRIPTION FACTOR I; HEK293 CELLS; HEPATOCYTE NUCLEAR FACTOR 1-ALPHA; HEPATOCYTE NUCLEAR FACTOR 4; HUMANS; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS, GENETIC; TANDEM REPEAT SEQUENCES; TRANSCRIPTIONAL ACTIVATION;

EID: 84860274532     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M025130     Document Type: Article

References (24)

1. Hussain, M. M., J. Shi, and P. Dreizen. 2003. Microsomal triglyceride transfer protein and its role in apolipoprotein B-lipoprotein assembly. J. Lipid Res. 44: 22-32. (Pubitemid 36114766)
2. Wetterau, J. R., M. C. Lin, and H. Jamil. 1997. Microsomal triglyceride transfer protein. Biochim. Biophys. Acta. 1345: 136-150. (Pubitemid 27138415)
3. Davidson, N. O., and G. S. Shelness. 2000. Apolipoprotein B: mRNA editing, lipoprotein assembly, and presecretory degradation. Annu. Rev. Nutr. 20: 169-193.
4. Hussain, M. M., N. Nijstad, and L. Franceschini. 2011. Regulation of microsomal triglyceride transfer protein. Clin. Lipidol. 6: 293-303.
5. Hussain, M. M., P. Rava, M. Walsh, M. Rana, and J. Iqbal. Multiple functions of microsomal triglyceride transfer protein. Nutr. Metab. (Lond). 9: 14.
6. Dai, K., I. Khatun, and M. M. Hussain. 2010. NR2F1and IRE1β suppress MTP expression and lipoprotein assembly in undifferentiated intestinal epithelial cells. Arterioscler. Thromb. Vasc. Biol. 30: 568-574.
7. Roeder, R. G. 2005. Transcriptional regulation and the role of diverse coactivators in animal cells. FEBS Lett. 579: 909-915. (Pubitemid 40361864)
8. Hagan, D. L., B. Kienzle, H. Jamil, and N. Hariharan. 1994. Transcriptional regulation of human and hamster microsomal triglyceride transfer protein genes. Cell type-specific expression and response to metabolic regulators. J. Biol. Chem. 269: 28737-28744.
9. Hussain, M. M., P. Rava, X. Pan, K. Dai, S. K. Dougan, J. Iqbal, F. Lazare, and I. Khatun. 2008. Microsomal triglyceride transfer protein in plasma and cellular lipid metabolism. Curr. Opin. Lipidol. 19: 277-284. (Pubitemid 351653566)
10. Hayhurst, G. P., Y. H. Lee, G. Lambert, J. M. Ward, and F. J. Gonzalez. 2001. Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. Mol. Cell. Biol. 21: 1393-1403. (Pubitemid 32114986)
11. Mendel, D. B., and G. R. Crabtree. 1991. HNF-1, a member of a novel class of dimerizing homeodomain proteins. J. Biol. Chem. 266: 677-680. (Pubitemid 21907165)
12. Sheena, V., R. Hertz, J. Nousbeck, I. Berman, J. Magenheim, and J. Bar-Tana. 2005. Transcriptional regulation of human microsomal triglyceride transfer protein by hepatocyte nuclear factor-4alpha. J. Lipid Res. 46: 328-341. (Pubitemid 40271097)
13. Lee, Y. H., B. Sauer, and F. J. Gonzalez. 1998. Laron dwarfism and non-insulin-dependent diabetes mellitus in the Hnf-1alpha knockout mouse. Mol. Cell. Biol. 18: 3059-3068. (Pubitemid 28183474)
14. Ringeisen, F., J. Rey-Campos, and M. Yaniv. 1993. The transactivation potential of variant hepatocyte nuclear factor 1 is modified by alternative splicing. J. Biol. Chem. 268: 25706-25711. (Pubitemid 23358183)
15. Kang, S., N. J. Spann, T. Y. Hui, and R. A. Davis. 2003. ARP-1/COUP-TF II determines hepatoma phenotype by acting as both a transcriptional repressor of microsomal triglyceride transfer protein and an inducer of CYP7A1. J. Biol. Chem. 278: 30478-30486. (Pubitemid 36994551)
16. Mathur, S. N., E. Born, S. Murthy, and F. J. Field. 1997. Microsomal triglyceride transfer protein in CaCo-2 cells: characterization and regulation. J. Lipid Res. 38: 61-67. (Pubitemid 27097074)
17. Shibata, H., Z. Nawaz, S. Y. Tsai, B. W. O'Malley, and M. J. Tsai. 1997. Gene silencing by chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI) is mediated by transcriptional corepressors, nuclear receptor-corepressor (N-CoR) and silencing mediator for retinoic acid receptor and thyroid hormone receptor (SMRT). Mol. Endocrinol. 11: 714-724. (Pubitemid 27225299)
18. Park, J. I., S. Y. Tsai, and M. J. Tsai. 2003. Molecular mechanism of chicken ovalbumin upstream promoter-transcription factor (COUP-TF) actions. Keio J. Med. 52: 174-181.
19. Tsai, S. Y., and M. J. Tsai. 1997. Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): coming of age. Endocr. Rev. 18: 229-240. (Pubitemid 27171521)
20. Rosenfeld, M. G., V. V. Lunyak, and C. K. Glass. 2006. Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response. Genes Dev. 20: 1405-1428. (Pubitemid 43830648)
21. Battaglia, S., O. Maguire, and M. J. Campbell. 2010. Transcription factor co-repressors in cancer biology: roles and targeting. Int. J. Cancer. 126: 2511-2519.
22. Doyon, G., S. St-Jean, M. Darsigny, C. Asselin, and F. Boudreau. 2009. Nuclear receptor co-repressor is required to maintain proliferation of normal intestinal epithelial cells in culture and down-modulates the expression of pigment epithelium-derived factor. J. Biol. Chem. 284: 25220-25229.
23. Rowley, C. W., L. J. Staloch, J. K. Divine, S. P. McCaul, and T. C. Simon. 2006. Mechanisms of mutual functional interactions between HNF-4alpha and HNF-1alpha revealed by mutations that cause maturity onset diabetes of the young. Am. J. Physiol. Gastrointest. Liver Physiol. 290: G466-G475.
24. Hu, C., and D. H. Perlmutter. 1999. Regulation of alpha1-antitrypsin gene expression in human intestinal epithelial cell line caco-2 by HNF-1alpha and HNF-4. Am. J. Physiol. 276: G1181-G1194. (Pubitemid 29251917)