Investigation of unmedicated early onset restless legs syndrome by voxel-based morphometry, T2 relaxometry, and functional MR imaging during the night-time hours

American Journal of Neuroradiology

Volumn 33, Issue 4, 2012, Pages 667-672

  Margariti, P N ^a   Astrakas, L G ^a   Tsouli, S G ^a   Hadjigeorgiou, G M ^b   Konitsiotis, S ^a   Argyropoulou, Maria I ^a  

^a UNIVERSITY OF IOANNINA   (Greece)

^b UNIVERSITY OF THESSALY   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

IRON;

ADULT; AGED; ANTERIOR CINGULATE; ARTICLE; BRAIN SIZE; CEREBELLUM; CLINICAL ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DIFFUSION WEIGHTED IMAGING; EARLY ONSET RESTLESS LEGS SYNDROME; ELECTROENCEPHALOGRAM; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GLOBUS PALLIDUS; HUMAN; INFERIOR PARIETAL LOBULE; LEFT HEMISPHERE; MALE; MESENCEPHALON; NIGHT; PARS OPERCULARIS; PERIODIC LIMB MOVEMENT DISORDER; PONS; PREFRONTAL CORTEX; PRIMARY MOTOR CORTEX; RELAXOMETRY; RESTLESS LEGS SYNDROME; RIGHT HEMISPHERE; SENSORY LEG DISCOMFORT; SOMATOSENSORY CORTEX; SUPERIOR PARIETAL LOBULE; THALAMUS; VOXEL BASED MORPHOMETRY;

ADULT; AGED; BRAIN; DIFFUSION MAGNETIC RESONANCE IMAGING; EARLY DIAGNOSIS; FEMALE; HUMANS; IRON; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; ORGAN SIZE; REPRODUCIBILITY OF RESULTS; RESTLESS LEGS SYNDROME; SENSITIVITY AND SPECIFICITY; TISSUE DISTRIBUTION;

EID: 84860254587     PISSN: 01956108     EISSN: 1936959X     Source Type: Journal    
DOI: 10.3174/ajnr.A2829     Document Type: Article

References (47)

1. Garcia-Borreguero D. Time to REST: epidemiology and burden. Eur J Neurol 2006;13:15-20
2. Paulus W, Dowling P, Rijman R, et al. Update of the pathophysiology of the restless-legs-syndrome. Mov Disord 2007;22:S431-39
3. Jellen LC, Beard JL, Jones BC. Systems genetics analysis of iron regulation in the brain. Biochimie 2009;91:1255-59
4. Connor JR, Boyer PJ, Menzies SL, et al. Neuropathological examination suggests impaired brain iron acquisition in restless legs syndrome. Neurology 2003;61:304-09 (Pubitemid 36975956)
5. Earley CJ, B Barker P, Horská A, et al. MRI-determined regional brain iron concentrations in early- and late-onset restless legs syndrome. Sleep Med 2006; 7:458-61. Epub 2006 Jun 5
6. Astrakas LG, Konitsiotis S, Margariti P, et al. T2 relaxometry and fMRI of the brain in late-onset restless legs syndrome. Neurology 2008;71:911-16
7. Unrath A, Juengling FD, Schork M, et al. Cortical grey matter alterations in idiopathic restless legs syndrome: an optimized voxel-based morphometry study. Mov Disord 2007;22:1751-56 (Pubitemid 47597598)
8. Etgen T, Draganski B, Ilg C, et al. Bilateral thalamic gray matter changes in patients with restless legs syndrome. Neuroimage 2005;24:1242-47 (Pubitemid 40164526)
9. Hornyak M, Ahrendts JC, Spiegelhalder K, et al. Voxel-based morphometry in unmedicated patients with restless legs syndrome. Sleep Med 2007;9 22-26 (Pubitemid 350187591)
10. Bucher SF, Seelos KC, Oertel WH, et al. Cerebral generators involved in the pathogenesis of the restless legs syndrome. Ann Neurol 1997;41:639-45 (Pubitemid 27212658)
11. Tzarouchi LC, Astrakas LG, Konitsiotis S, et al. Voxel-based morphometry and voxel-based relaxometry in parkinsonian variant of multiple system atrophy. J Neuroimaging 2010;20:260-66
12. Astrakas LG, Argyropoulou MI. Shifting from region of interest (ROI) to voxel-based analysis in human brain mapping. Pediatr Radiol 2010;40:1857-67. Epub 2010 May 13
13. Norris DG. Principles of magnetic resonance assessment of brain function. J Magn Reson Imaging 2006;23:794-807 (Pubitemid 43825435)
14. Walters AS, LeBrocq C, Dhar A, et al. Validation of the International Restless Legs Syndrome Study Group rating scale for restless legs syndrome. Sleep Med 2003;4:121-32 (Pubitemid 36527232)
15. Benes H, Walters AS, Allen RP, et al. Definition of restless legs syndrome, how to diagnose it, and how to differentiate it from RLS mimics. Mov Disord 2007;22:401-08
16. Ashburner J, Friston KJ. Unified segmentation. Neuroimage 2005;26:839-51 (Pubitemid 40825026)
17. Kosta P, Argyropoulou MI, Markoula S, et al. MRI evaluation of the basal ganglia size and iron content in patients with Parkinson's disease. J Neurol 2006;253:26-32 (Pubitemid 43157384)
18. Metafratzi Z, Argyropoulou M, Kiortsis DN, et al. T(2) relaxation rate of basal ganglia and cortex in patients with beta-thalassaemia major. Br J Radiol 2001;74:407-10 (Pubitemid 32586545)
19. Maldjian JA, Laurienti PJ, Kraft RA, et al. An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Neuroimage 2003;19:1233-39 (Pubitemid 36918259)
20. Celle S, Roche F, Peyron R, et al. Lack of specific gray matter alterations in restless legs syndrome in elderly subjects. J Neurol 2010;257:344-48
21. Comley RA, Cervenka S, Palhagen SE, et al. Comparison of gray matter density in restless legs syndrome patients and matched controls using voxel-based morphometry. J Neuroimaging 2012;22:28-32
22. Chakos MH, Lieberman JA, Alvir J, et al. Caudate nuclei volumes in schizophrenic patients treated with typical antipsychotics or clozapine. Lancet 1995;18:456-57
23. Scheepers FE, Gespen de Wied CC, Kahn RS. The effect of olanzapine treatment on m-chlorophenylpiperazine-induced hormone release in schizophrenia. J Clin Psychopharmacol 2001;21:575-82 (Pubitemid 33116656)
24. Tyvaert L, Houdayer E, Devanne H, et al. Cortical involvement in the sensory and motor symptoms of primary restless legs syndrome. Sleep Med 2009 10:1090-96
25. Clemens S, Rye D, Hochman S. Restless legs syndrome: revisiting the dopamine hypothesis from the spinal cord perspective. Neurology 2006;67:125-30 (Pubitemid 44305475)
26. Connor JR, Ponnuru P, Wang XS, et al. Profile of altered brain iron acquisition in restless legs syndrome. Brain 2011;134:959-68. Epub 2011 Mar 11
27. Connor JR, Wang XS, Patton SM, et al. Decreased transferrin receptor expression by neuromelanin cells in restless legs syndrome. Neurology 2004;62: 1563-67 (Pubitemid 38608196)
28. Rodrigue KM, Haacke EM, Raz N. Differential effects of age and history of hypertension on regional brain volumes and iron. Neuroimage 2011;54: 750-59
29. Argyropoulou MI, Astrakas L.MRIevaluation of tissue iron burden in patients with beta-thalassaemia major. Pediatr Radiol 2007;37:1191-200 (Pubitemid 350160029)
30. Du F, Qian ZM, Zhu L, et al. L-DOPA neurotoxicity is mediated by up-regulation of DMT1-IRE expression. PLoS One 2009;4:e4593
31. Sun ER, Chen CA, Ho G, et al. Iron and the restless legs syndrome. Sleep 1998;21:371-77 (Pubitemid 128470320)
32. Argyropoulou MI, Kiortsis D, Astrakas L, et al. Liver, bone marrow, pancreas and pituitary gland iron overload in young and adult thalassemic patients: a T2 relaxometry study. Eur Radiol 2007;17:3025-30 (Pubitemid 350142326)
33. Ciccarelli O, Toosy AT, Marsden JF, et al. Identifying brain regions for integrative sensorimotor processing with ankle movements. Exp Brain Res 2005 166: 31-42 (Pubitemid 41451034)
34. Alexander GE, Crutcher MD. Functional architecture of basal ganglia circuits: neural substrates of parallel processing. Trends Neurosci 1990;13:266-71 (Pubitemid 20193456)
35. Khaldy H, León J, Escames G, et al. Circadian rhythms of dopamine and dihydroxyphenyl acetic acid in the mouse striatum: effects of pinealectomy and of melatonin treatment. Neuroendocrinology 2002;75:201-08 (Pubitemid 34253076)
36. Zywicke HA, van Gelderen P, Connor JR, et al. Microscopic R2*mapping of reduced brain iron in the Belgrade rat. Ann Neurol 2002;52:102-05 (Pubitemid 34693751)
37. Petrides M, Pandya DN. Dorsolateral prefrontal cortex: comparative cytoarchitectonic analysis in the human and the macaque brain and corticocortical connection patterns. Eur J Neurosci 1999;11:1011-36 (Pubitemid 29106062)
38. Okun MS, Fernandez HH, Foote KD. Deep brain stimulation of the GPi treats restless legs syndrome associated with dystonia. Mov Disord 2005;20:500-01 (Pubitemid 40779029)
39. Kedia S, Moro E, Tagliati M, et al. Emergence of restless legs syndrome during subthalamic stimulation for Parkinson disease. Neurology 2004;63:2410-12 (Pubitemid 40024365)
40. Driver-Dunckley E, Evidente VG, Adler CH, et al. Restless legs syndrome in Parkinson's disease patientsmayimprove with subthalamic stimulation.Mov Disord 2006;21:1287-89 (Pubitemid 44336636)
41. Benabid AL, Chabardes S, Mitrofanis J, et al. Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson's disease. Lancet Neurol 2009;8:67-81
42. Gómez-Esteban JC, Tijero B, Ciordia R, et al. Factors influencing the symmetry of Parkinson's disease symptoms. Clin Neurol Neurosurg 2010;112:302-05
43. Lu CS, Ikeda A, Terada K, et al. Electrophysiological studies of early stage corticobasal degeneration. Mov Disord 1998;13:140-46 (Pubitemid 28029865)
44. Yarnitsky D, Barron SA, Bental E. Disappearance of phantom pain after focal brain infarction. Pain 1998;32:285-87
45. Saalmann YB, Kastner S. Gain control in the visual thalamus during perception and cognition. Curr Opin Neurobiol 2009;19:408-14
46. San Pedro EC, Mountz JM, Mountz JD, et al. Familial painful restless legs syndrome correlates with pain dependent variation of blood flow to the caudate, thalamus, and anterior cingulate gyrus. J Rheumatol 1998;25:2270-75 (Pubitemid 28505880)
47. Hagelberg N, Jääskeläinen SK, Martikainen IK, et al. Striatal dopamine D2 receptors in modulation of pain in humans: a review. Eur J Pharmacol 2004; 500:187-92 (Pubitemid 39304007)