Systems genetics analysis of iron regulation in the brain

Biochimie

Volumn 91, Issue 10, 2009, Pages 1255-1259

  Jellen, Leslie C ^a   Beard, John L ^a   Jones, Byron C ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Brain; Genetics; Iron; Mouse; RLS

Indexed keywords

DOPAMINE RECEPTOR; DOPAMINE TRANSPORTER; FERRITIN; HFE PROTEIN; REACTIVE OXYGEN METABOLITE; TRANSFERRIN; TRANSFERRIN RECEPTOR;

ALZHEIMER DISEASE; BLOOD BRAIN BARRIER; CHROMOSOME 17; FERRITIN BLOOD LEVEL; GENE EXPRESSION; GENE REGULATORY NETWORK; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; IRON BALANCE; IRON DEFICIENCY; IRON METABOLISM; IRON TRANSPORT; MESENCEPHALON; NEUROLOGIC DISEASE; NONHUMAN; NUCLEUS ACCUMBENS; PARKINSON DISEASE; PHENOTYPE; PREFRONTAL CORTEX; PUTAMEN; QUANTITATIVE TRAIT LOCUS; RESTLESS LEGS SYNDROME; SHORT SURVEY;

ANIMALS; BRAIN; HUMANS; IRON; MESENCEPHALON; MICE; QUANTITATIVE TRAIT LOCI;

ANIMALIA; RODENTIA;

EID: 69749126668     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2009.04.009     Document Type: Short Survey

References (49)

1. Connor J.R., and Menzies S.L. Relationship of iron to oligodendrocytes and myelination. Glia 17 (1996) 83-93
2. Wu L.L., Zhang L., Shao J., Qin Y.F., Yang R.W., and Zhao Z.Y. Effect of perinatal iron deficiency on myelination and associated behaviors in rat pups. Behav. Brain Res. 188 (2008) 263-270
3. Berg D., Youdim M., and Riederer P. Redox imbalance. Cell Tissue Res. 318 (2004) 201-213
4. Chinta S.J., and Andersen J.K. Redox imbalance in Parkinson's disease. Biochim. Biophys. Acta 1780 (2008) 1362-1367
5. Rhodes S.L., and Ritz B. Genetics of iron regulation and the possible role of iron in Parkinson's disease. Neurobiol. Dis. 32 (2008) 183-195
6. Shcherbatykh I., and Carpenter D.O. The role of metals in the etiology of Alzheimer's disease. J. Alzheimers Dis. 11 (2007) 191-205
7. Connor J.R. Pathophysiology of restless legs syndrome: evidence for iron involvement. Curr. Neurol. Neurosci. Rep. 8 (2008) 162-166
8. Ghanizad A. Regarding the effects of iron supplementation on attention deficit hyperactivity disorder in children. Pediatr. Neurol. 38 (2008) 20-26
9. Beard J.L., Hendricks M.K., and Perez E.M. Maternal iron deficiency anemia affects postpartum emotion and cognition. J. Nutr. 135 (2005) 267-272
10. Lozoff B. Iron deficiency and child development. Food Nutr. Bull. 38 (2007) S560-S571
11. Fix O.K., and Kowdley K.V. Hereditary hemochromatosis. Minerva Med. 99 (2008) 605-617
12. M.L. Island, A.M. Jouanolle, A. Mosser, et al., A new mutation in the hepcidin promoter impairs its BMP response and contributes to a severe phenotype in HFE related hemochromatosis, Haematologica, in press.
13. Burdo J.R., Antonetti D.A., Wolpert E.B., and Connor J.R. Mechanisms and regulation of transferrin and iron transport in a model blood-brain barrier system. Neuroscience 121 (2003) 883-890
14. Hallgren B., and Sourander P. The effect of age on the non-haemin iron in the human brain. J. Neurochem. 3 (1958) 41-51
15. Hock A., Demmel U., Schicha H., Kasperek K., and Feinendegen L.E. Trace element concentration in human brain. Activation analysis of cobalt, iron, rubidium, selenium, zinc, chromium, silver, cesium, antimony, and scandium. Brain 98 (1975) 49-64
16. Aoki S., Okada Y., Nishimura K., Barkovich A.J., Kjos B.O., Brasch R.C., and Norman D. Normal deposition of brain iron in childhood and adolescence: MR imaging at 1.5 T. Radiology 172 (1989) 381-385
17. Roskams A.J., and Connor J.R. Iron transferrin, and ferritin in the rat brain during development and aging. J. Neurochem. 63 (1994) 709-716
18. Churchill G.A. Recombinant inbred strain panels: a tool for systems genetics. Physiol. Genomics 31 (2007) 174-175
19. Williams R.W., Gu J., Qi S., and Lu L. The genetic structure of recombinant inbred mice: high-resolution consensus maps for complex trait analysis. Genome Biol. 2 (2001) 46.1-46.18
20. Wang J., Williams R.W., and Manly K.F. WebQTL: web-based complex trait analysis. Neuroinformatics 1 (2003) 299-308
21. Palmer A.A., Verbitsky M., Suresh R., et al. Gene expression differences in mice divergently selected for methamphetamine sensitivity. Mamm. Genome 16 (2005) 291-305
22. Bryant C.D., Graham M.E., Distler M.G., et al. A role for casein kinase 1 epsilon in the locomotor stimulant response to methamphetamine. Psychopharmacology 203 (2009) 703-711
23. Veenstra-VanerWeele J., Qaadir A., Palmer A., Cook Jr. E.H., and de Wit H. Association between the casein kinase 1 epsilon gene region and subjective response to D-amphetamine. Neuropsychopharmacology 31 (2006) 1056-1063
24. Jones B.C., Reed C.L., Hitzemann R., et al. Quantitative genetic analysis of ventral midbrain and liver iron in BXD recombinant inbred mice. Nutr. Neurosci. 6 (2003) 369-377
25. Phillips T.J., Huson M.G., and McKinnon C.S. Localization of genes mediating acute and sensitized locomotor responses to cocaine in BXD/Ty recombinant inbred mice. J. Neurosci. 18 (1998) 3023-3034
26. Jones L.C., McCarthy K.A., Beard J.L., Keen C.L., and Jones B.C. Quantitative genetic analysis of brain copper and zinc in BXD recombinant inbred mice. Nutr. Neurosci. 9 (2006) 81-92
27. Jones L.C., Beard J.L., and Jones B.C. Genetic analysis reveals polygenic influences on iron, copper, and zinc in mouse hippocampus with neurobiological implications. Hippocampus 18 (2008) 398-410
28. Jones B.C., Beard J.L., Gibson J.N., et al. Systems genetic analysis of peripheral iron parameters in the mouse. Am. J. Physiol. Regul. Integr. Comp. Physiol. 293 (2007) R116-R124
29. Earley C.J., Barker P.B., Horska A., and Allen R.P. MRI-determined regional brain iron concentrations in early- and late-onset restless legs syndrome. Sleep Med. 7 (2006) 458-461
30. Connor J.R., Boyer P.J., Menzies S.L., et al. Neuropathological examination suggests impaired brain iron acquisition in restless legs syndrome. Neurology 61 (2003) 304-309
31. Ortega R., Cloetens P., Deves G., Carmona A., and Bohic S. Iron storage within dopamine neurovesicles revealed by chemical nano-imaging. PLoS ONE 2 (2007) e925
32. A.M. Snyder, J.R. Connor, Iron, the substantia nigra and related neurological disorders, Biochim. Biophys. Acta, in press.
33. Erikson K.M., Jones B.C., and Beard J.L. Iron deficiency alters dopamine transporter functioning in rat striatum. J. Nutr. 130 (2000) 2831-2837
34. Erikson K.M., Jones B.C., Hess E.J., Zhang Q., and Beard J.L. Iron deficiency decreases dopamine D1 and D2 receptors in rat brain. Pharmacol. Biochem. Behav. 69 (2001) 409-418
35. Bianco L.E., Wiesinger J., Earley C.J., Jones B.C., and Beard J.L. Iron deficiency alters dopamine uptake and response to L-DOPA injection in Sprague-Dawley rats. J. Neurochem. 106 (2008) 205-215
36. Beard J.L., Erikson K.M., and Jones B.C. Neurobehavioral analysis of developmental iron deficiency in rats. Behav. Brain Res. 134 (2002) 517-524
37. Beard J.L. Iron deficiency alters brain development and functioning. J. Nutr. 133 (2003) 1468S-1472S
38. Felt B.T., Beard J.L., Schallert T., et al. Persistent neurochemical and behavioral abnormalities in adulthood despite iron supplementation for perinatal iron deficiency anemia in rats. Behav. Brain Res. 171 (2006) 261-270
39. Barriere G., Cazalets J.R., Bioulac B., Tison F., and Ghorayeb I. The restless legs syndrome. Prog. Neurobiol. 77 (2005) 139-165
40. Winkelman J.W., Allen R.P., Tenzer P., and Hening W. Restless legs syndrome: nonpharmacologic and pharmacologic treatments. Geriatrics 62 (2007) 13-16
41. Kavangh D., Siddiqui S., and Geddes C.C. Restless legs syndrome in patients on dialysis. Am. J. Kidney Dis. 43 (2004) 763-771
42. Manconi M., Govoni V., De Vito A., et al. Pregnancy as a risk factor for restless legs syndrome. Sleep Med. 5 (2004) 305-308
43. Earley C.J., Heckler D., and Allen R.P. The treatment of restless legs syndrome with intravenous iron dextran. Sleep Med. 5 (2004) 231-235
44. Earley C.J., Heckler D., and Allen R.P. Repeated IV doses of iron provides effective supplemental treatment of restless legs syndrome. Sleep Med. 6 (2005) 301-305
45. Schormair B., Kemlink D., Roeske D., et al. PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome. Nat. Genet. 40 (2008) 946-948
46. Stefansson H., Rye D.B., Hicks A., et al. A genetic risk factor for periodic limb movements in sleep. N. Engl. J. Med. 357 (2007) 639-647
47. Winkelmann J., Schormair B., Lichtner P., et al. Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. Nat. Genet. 39 (2007) 1000-1006
48. Xiong L., Catoire H., Dion P., et al. MEIS1 intronic risk haplotype associated with restless legs syndrome affects its mRNA and protein expression. Hum. Mol. Genet. 18 (2009) 1065
49. D. Kemlink, O. Polo, B. Frauscher, Replication of restless legs syndrome loci in three European populations, J. Med. Genet., in press.