Sexing the baby: Part 1 - What do we really know about sex differentiation in the first three years of life?

Social Science and Medicine

Volumn 74, Issue 11, 2012, Pages 1684-1692

  Fausto Sterling, Anne ^a   Coll, Cynthia Garcia ^a   Lamarre, Meghan ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

Disease; Dynamic systems; Gender; Infant development; Nature nurture debate; Sex related behavioral difference; Sex related differences

Indexed keywords

FOLLITROPIN; TESTOSTERONE;

DISEASE; GENDER IDENTITY; GENDER RELATIONS; HEALTH STATUS; SEX-RELATED DIFFERENCE;

ANATOMICAL VARIATION; ARTICLE; BIOLOGICAL ACTIVITY; BIOLOGICAL DIFFERENCE; BIRTH WEIGHT; BODY WEIGHT; BRAIN SIZE; CHILD; CHILD BEHAVIOR; CHILD DEVELOPMENT; HORMONE DETERMINATION; HORMONE SYNTHESIS; HUMAN; MOTOR ACTIVITY; NONHUMAN; PARENTAL ATTITUDE; PERINATAL PERIOD; PHYSICAL ACTIVITY; PLAY; PRENATAL PERIOD; PRESCHOOL CHILD; SENSORY SYSTEM; SENSORY SYSTEM BEHAVIOR; SEX DETERMINATION; SEX DIFFERENTIATION; STRENGTH; TODDLER; TOY PREFERENCE; VOCALIZATION;

CHILD BEHAVIOR; CHILD DEVELOPMENT; CHILD, PRESCHOOL; FEMALE; GENDER IDENTITY; HORMONES; HUMANS; INFANT; INFANT BEHAVIOR; MALE; SEX FACTORS; UNITED STATES;

EID: 84860254581     PISSN: 02779536     EISSN: 18735347     Source Type: Journal    
DOI: 10.1016/j.socscimed.2011.05.051     Document Type: Article

References (120)

1. Achiron R., Achiron A. Development of the human fetal corpus callosum: a high-resolution, cross-sectional sonographic study. Ultrasound in Obstetrics and Gynecology 2001, 18(4):343-347.
2. Achiron R., Lipitz S., Achiron A. Sex-related differences in the development of the human fetal corpus callosum: in utero ultrasonographic study. Prenatal Diagnosis 2001, 21(2):116-120.
3. Arnold A.P., van Nas A., Lusis A.J. Systems biology asks new questions about sex differences. Trends in Endocrinology & Metabolism 2009, 20(10):471-476.
4. Australia's mothers and babies 2000, Australian Inst. of Health and Welfare, N. P. S. U, Australian Institute of Helath and Welfare, Canberra.
5. Auyeung B., Baron-Cohen S., Ashwin E., Knickmeyer R., Taylor K., Hackett G., et al. Fetal testosterone predicts sexually differentiated childhood behavior in girls and in boys. Psychological Science: A Journal of the American Psychological Society/APS 2009, 20(2):144-148.
6. Balogh R.D., Porter R.H. Olfactory preferences resulting from mere exposure in human neonates. Infant Behavior and Development 1986, 9(4):395-401.
7. Baron-Cohen S., Hammer J. Is autism an extreme form of the " male brain" ?. Advances in Infancy Research 1997, 11:193-217.
8. Baron-Cohen S., Knickmeyer R.C., Belmonte M.K. Sex differences in the brain: implications for explaining autism. Science 2005, 310(5749):819-823.
9. Bell R.Q., Costello N. Three tests for sex differences in tactile sensitivity in the newborn. Biologia Neonatorum 1964, 7:335-347.
10. Berenbaum S.A., Bryk K.L.K. Biological contributors to gendered occupational outcome: prenatal androgem effects on predictors of outcome. Gender and occupational outcomes: Longitudinal assessments of individual, social and cultural influences 2008, American Psychological Association, Washington, DC. H.M.G. Watt, J.S. Eccles (Eds.).
11. Berenbaum S.A., Martin C.L., Hanish L.D., Briggs P.T., Fabes R.A. Sex differences in children's play. Sex differences in the brain: From genes to behaviour 2008, 275-290. Oxford University Press, Oxford. J.B. Becker, K.J. Berkley, N. Geary, E. Hampson, J.P. Herman, Y. Elizabeth (Eds.).
12. Bierman A.S. Sex matters: gender disparities in quality and outcomes of care. Canadian Medical Association Journal 2007, 177(12):1520-1521.
13. Bird C.E., Rieker P.P. Gender matters: an integrated model for understanding men's and women's health. Social Science & Medicine 1999, 48:745-755.
14. Blakemore J.E., LaRue A.A., Olejnik A.B. Sex-appropriate toy preference and the ability to conceptualize toys as sex-role related. Developmental Psychology 1979, 15(3):339-340.
15. Brundin K., Roedholm M., Larsson K. Vocal communication between parents and infants. Early Human Development 1988, 16(1):35-53.
16. Buitelaar J.K., Huizink A.C., Mulder E.J., de Medina P.G., Visser G.H. Prenatal stress and cognitive development and temperament in infants. Neurobiology Aging 2003, 24(Suppl. 1):S53-S60. discussion S67-58.
17. Campbell D.W., Eaton W.O. Sex differences in the activity level of infants. Infant and Child Development 1999, 8(1):1-17.
18. Campbell A., Shirley L., Heywood C., Crook C. Infants' visual preference for sex-congruent babies, children, toys and activities: a longitudinal study. British Journal of Developmental Psychology 2000, 18(4):479-498.
19. Caron R.F., Caron A.J. Degree of stimulus complexity and habituation of visual fixation in infants. Psychonomic Science 1969.
20. 2000, Center for Disease Control, 2000 CDC Growth Charts, United states.
21. Chiel H.J., Beer R.D. The brain has a body: adaptive behavior emerges from interactions of nervous system, body and environment. Trends in Neuroscience 1997, 20(12):553-557.
22. Crawford M., Doyle W., Meadows N. Gender differences at birth and differences in fetal growth. Human Reproduction 1987, 2(6):517-520.
23. Creighton D.E. Sex differences in the visual habituation of 4-, 6- and 8-month-old infants. Infant Behavior and Development 1984, 7(2):237-249.
24. Davis R., Cutter G., Goldenberg R., Hoffman H., Cliver S., Brumfield C. Fetal biparietal diameter, head circumference, abdominal circumference and femur length. A comparison by race and sex. Journal of Reproductive Medicine 1993, 38(3):201-206.
25. Devilly G.J. The effect size generator for Windows: Version 2.0 2004, The Centre for Neuropsychology, Swinburne University, Australia.
26. Dmitrieva L.P., Gottlieb G. Influence of auditory experience on the development of brain stem auditory-evoked potentials in Mallard Duck embryos and Hatchlings. Behavioral and Neural Biology 1994, 61:19-28.
27. Eaton W.O., Enns L.R. Sex differences in human motor activity level. Psychological Bulletin 1986, 100(1):19-28.
28. Edelman G.M. Neural Darwinism 1987, Basic Books, New York.
29. Eisenberg N., Wolchik S.A., Hernandez R., Pasternack J.F. Parental socialization of young children's play: a short-term longitudinal study. Child Development 1985, 56(6):1506-1513.
30. Eliot L. Pink brain, blue brain 2009, Houghton, Mifflin, Harcourt, Boston.
31. Engel R., Benson R.C. Estimate of conceptual age by evoked response activity. Biologia Neonatorum 1968, 12:201-213.
32. Evardone M., Alexander G.M., Morey L.C. Hormones and borderline personality features. Personality and Individual Differences 2008, 44(1):278-287.
33. Fagot B.I. The influence of sex of child on parental reactions to toddler children. Child Development 1978, 49(2):459-465.
34. Fausto-Sterling, A., & García Coll, C. (2006). Developmental systems and gender differentiation: is a new paradigm helpful?. In: Second gender development research Conference. San Francisco, CA.
35. Fausto-Sterling, A., García Coll, C., & Lamarre, M. (2011). Sexing the baby: Part 2. Applying dynamic systems theory to the emergences of sex-related differences in infants and toddlers. Social Science & Medicine, . http://10.1016/j.socscimed.2011.06.027.
36. Fausto-Sterling A. Myths of gender: Biological theories about women and men 1992, Basic Books, New York.
37. Fausto-Sterling A. Sexing the body: Gender politics and the construction of sexuality 2000, Basic Books, New York.
38. Fausto-Sterling A. The problem with sex/gender and nature/nurture. Debating biology 2003, 123-132. Routledge, London. S.J. Williams, L. Birke, G.A. Bendelow (Eds.).
39. Fausto-Sterling A. The bare bones of sex. Part I: sex and gender. Signs 2005, 30(2):1491-1527.
40. Fausto-Sterling A. The bare bones of race. Social Studies of Sciences 2008, 38(5):657-694.
41. Finegan J.A., Bartleman B., Wong P.Y. A window for the study of prenatal sex hormone influences on postnatal development. Journal of Genetic Psychology 1989, 150(1):101-112.
42. Forest M.G., Cathiard A.M., Bertrand J.A. Evidence of testicular activity in early infancy. Journal of Clinical Endocrinology & Metabolism 1973, 37:148-151.
43. Friedman S., Bruno L.A., Vietze P. Newborn habituation to visual stimuli: a sex difference in novelty detection. Journal of Experimental Child Psychology 1974, 18(2):242-251.
44. Galaburda A.M., LoTurco J., Ramus F., Fitch R.H., Rosen G.D. From genes to behavior in developmental dyslexia. Nature Neuroscience 2006, 9(10):1213-1217.
45. Galaburda A.M. Dyslexia - A molecular disorder of neuronal migration: the 2004 Norman Geschwind Memorial Lecture. Annals of Dyslexia 2005, 55(2):151-165.
46. Geschwind N., Galaburda A.M. Cerebral lateralization: biological mechanisms, associations, and pathology: I. A hypothesis and a program for research. Archives of Neurology 1985, 42(5):428-459.
47. Geschwind D.H., Miller B.L., DeCarli C., Carmelli D. Heritability of lobar brain volumes in twins supports genetic models of cerebral laterality and handedness. Proceedings of the National Academy of Sciences of the United States of America 2002, 99(5):3176-3181.
48. Giedd J.N., Castellanos F.X., Rajapakse J.C., Vaituzis A.C., Rapoport J.L. Sexual dimorphism of the developing human brain. Prog Neuropsychopharmacol Biol Psychiatry 1997, 21(8):1185-1201.
49. Gogtay N., Giedd J.N., Lusk L., Hayashi K.M., Greenstein D., et al. Dynamic mapping of human cortical development during childhood through early adulthood. Proceedings of the National Academy of Sciences U S A 2004, 101(21):8174-8179.
50. Gogtay N., Nugent T.F., Herman D.H., Ordonez A., Greenstein D., Hayashi K.M., et al. Dynamic mapping of normal human hippocampal development. Hippocampus 2006, 16(8):664-672.
51. Golinkoff R.M., Ames G.J. A comparison of fathers' and mothers' speech with their young children. Child Development 1979, 50(1):28-32.
52. Gottlieb G. Synthesizing nature-nurture: Prenatal roots of instinctive behavior 1997, Lawrence Erlbaum, Mahwah.
53. Gunnar M.R., Donahue M. Sex differences in social responsiveness between six months and twelve months. Child Development 1980, 51(1):262-265.
54. Gwiazda J., Bauer J., Held R. Binocular function in human infants: correlation of stereotopic and fusion-rivalry discriminations. The Journal of Pediatric Ophthalmology & Strabismus 1989, 26(3):128-132.
55. Hering-Hanit R., Achiron R., Lipitz S., Achiron A. Asymmetry of fetal cerebral hemispheres: in utero ultrasound study. Archives of Disease in Childhood. Fetal and Neonatal Edition 2001, 85(3):F194-F196.
56. Hines M., Collaer M.L. Gonadal hormones and sexual differentiation of human behavior: developments from research on endocrine syndromes and studies of brain structure. Annual Review of Sex Research 1993, 4:1-48.
57. Hsu H.-C., Fogel A. Infant Vocal development in a dynamic mother-infant communication system. Infancy 2001, 2(1):87-109.
58. Hsu H.-C., Fogel A. Stability and transitions in mother-infant face-to-face communication during the first 6 months: a microhistorical approach. Developmental Psychology 2003, 39(6):1061-1082.
59. Hsu H.-C., Fogel A. Social regulatory effects of infant nondistress vocalization on maternal behavior. Developmental Psychology 2003, 39(6):976-991.
60. Huizink A.C., Robles de Medina P.G., Mulder E.J., Visser G.H., Buitelaar J.K. Stress during pregnancy is associated with developmental outcome in infancy. Journal of Child Psychology and Psychiatry 2003, 44(6):810-818.
61. Hyde J.S., Linn M.C. Gender differences in verbal ability: a meta-analysis. Psychological Bulletin 1988, 104(1):53-69.
62. Exploring the biological contributions to human Health: Does sex matter? 2001, Institute of Medicine, National Academy of Science.
63. Jimenez-Robbins C., Ngnoumen C., Ahl R., Schmidt B., Boghossian E., Toth A., et al. A study of vocalization and mother-infant interactions on the emergence of sex-related differences during infancy 2009, Society for Research on Child Development, Denver, Colorado.
64. Jordan-Young R.M. Brainstorm: The flaws in the science of sex differences 2010, Harvard University Press, Cambridge, MA.
65. Karraker K., Vogel D.A., Lake M.A. Parents' gender-stereotyped perceptions of newborns: the eye of the beholder revisited. Sex Roles 1995, 33(9/10):687-701.
66. Knickmeyer R.C., Wheelwright S., Taylor K., Raggatt P., Hackett G., Baron-Cohen S. Gender-typed play and amniotic testosterone. Developmental Psychology 2005, 41(3):517-528.
67. Korner A.F. Sex differences in newborns with special reference to differences in the organization of oral behavior. Journal of Child Psychology and Psychiatry and Allied Disciplines 1973, 14(1):19-29.
68. Krieger N. If " race" is the answer, what is the question?-on " race" , racism, and health: A social epidemiologist's perspective 2005, Social Science Research Foundation Web Forum.
69. A life course approach to women's health 2002, Oxford University Press, Oxford. D. Kuh, R. Hardy (Eds.).
70. Kuh D., Power C., Bartley M. Social Pathways between childhood and adult health. A life course approach to chronic disease epidemiology 1997, Oxford University Press, Oxford. D. Kuh, Y. Ben-Shlomo (Eds.).
71. Lavelli M., Fogel A. Developmental changes in mother-infant face-to-face communication: birth to 3 months. Developmental Psychology 2002, 38(2):288-305.
72. Lavelli M., Fogel A. Developmental changes in the relationship between the infant's attention and emotion during early face-to-face communication: the 2-month transition. Developmental Psychology 2005, 41(1):265-280.
73. Leader L.R., Baillie P., Martin B., Vermeulen E. The assessment and significance of habituation to a repeated stimulus by the human fetus. Early Human Development 1982, 7(3):211-219.
74. Leaper C., Anderson K.J., Sanders P. Moderators of gender effects on parents' talk to their children: a meta-analysis. Developmental Psychology 1998, 34(1):3-27.
75. Leeb R.T., Rejskind F.G. Here's looking at you, kid! A longitudinal study of perceived gender differences in mutual gaze behavior in young infants. Sex Roles 2004, 50(1-2):1-14.
76. Lenroot R.K., Giedd J.N. The changing impact of genes and environment on brain development during childhood and adolescence: initial findings from a neuroimaging study of pediatric twins. Developmental Psychopathology 2008, 20(4):1161-1175.
77. Lenroot R.K., Gogtay N., Greenstein D.K., Wells E.M., Wallace G.L., Clasen L.S., et al. Sexual dimorphism of brain developmental trajectories during childhood and adolescence. Neuroimage 2007, 36(4):1065-1073.
78. Lewis M. Infants' responses to facial stimuli during the first year of life. Developmental Psychology 1969.
79. Lippa R.A. Gender, nature, and nurture 2002, Lawrence Erlbaum, Mahwah, NJ.
80. Lipsitt L.P., Levy N. Electroactual threshold in the human neonate. Child Development 1959, 30:547-554.
81. Lowe M. Trends in the development of representational play in infants from one to three years: an observational study. Journal of Child Psychology and Psychiatry and Allied Disciplines 1975, 16(1):33-47.
82. Lytton H., Romney D.M. Parents' differential socialization of boys and girls: a meta-analysis. Psychological Bulletin 1991, 109(2):267-296.
83. Maccoby E.E., Jacklin C.N. The psychology of sex differences 1974, Stanford University Press, Palo Alto.
84. Maccoby E.E. The two sexes: Growing up apart-coming together 1998, Harvard University Press, Cambridge, MA.
85. Makin J.W., Porter R.H. Attractiveness of lactating females' breast odors to neonates. Child Development 1989, 60(4):803-810.
86. Martin C.L., Ruble D.N., Szkrybalo J. Cognitive theories of early gender development. Psychological Bulletin 2002, 128(6):903-933.
87. McFadden D. A masculinizing effect on the auditory systems of human females having male co-twins. Proceedings of the National Academy of Science 1993, 90(24):11900-11904.
88. Mondschein E.R., Adolf K.E., Tamis-LeMonda C.S. Gender Bias in mother's expectations about infant crawling. Journal of Experimental Child Psychology 2000, 77:304-316.
89. Muir D.W., Clifton R.K., Clarkson M.G. The development of a human auditory localization response: a U-shaped function. Canadian Journal of Psychology 1989, 43(2):199-216.
90. Nisbett R.E., Gurwitz S.B. Weight, sex and the eating behavior of human newborns. Journal of Comparative Physiological Psychology 1970, 73:245-253.
91. O'Brien M., Huston A.C. Activity level and sex-stereotyped toy choice in toddler boys and girls. Journal of Genetic Psychology 1985, 146(4):527-533.
92. O'Brien M., Huston A.C., Risley T.R. Sex-typed play of toddlers in a day care center. Journal of Applied Developmental Psychology 1983, 4(1):1-9.
93. Pinker S. The sexual paradox: Men, women and the real gender gap 2008, Scribner, New York.
94. Putzar L., Goerendt I., Lange K., Rosler F., Roder B. Early visual deprivation impairs multisensory interactions in humans. Nature Neuroscience 2007, 10(10):1243-1245.
95. Reid G.M. Maternal sex-stereotyping of newborns. Psychological Reports 1994, 75:1443-1450.
96. Rheingold H.L., Cook K.V. The contents of boys' and girls' rooms as an index of parents' behavior. Child Development 1975, 46(2):459-463.
97. Rothenberg S.J., Chicz-DeMet A., Schnaas L., Karchmer S., Salinas V., Guzman L.A. Umbilical cord beta-endorphin and early childhood motor development. Early Human Development 1996, 46(1-2):83-95.
98. Rubin J.Z., Provenzano F.J., Luria Z. The eye of the beholder: parents' views on sex of newborns. American Journal of Orthopsychiatry 1974, 44(4):512-519.
99. Ruble D.N., Martin C.L. Gender development. Handbook of child psychology: Social, emotional, and personality development 1998, 933-1016. Wiley, New York. W. Damon, N. Eisenberg (Eds.).
100. Gender development 2006, John Wiley and Sons, Hoboken. D.N. Ruble, C.L. Martin, S.A. Berenbaum (Eds.).
101. Saxon T.F. A longitudinal study of early mother-infant interaction and later language competence. First Language 1997, 17:271-281.
102. Seifer R., Sameroff A.J., Barrett L.C., Krafchuk E. Infant temperament measured by multiple observations and mother report. Child Development 1994, 65(5):1478-1490.
103. Silvén M. Attention in very young infants predicts learning of first words. Infant Behavior and Development 2001, 24:229-237.
104. Sininger Y.S., Cone-Wesson B., Abdala C. Gender distinctions and lateral asymmetry in the low-level auditory brainstem response of the human neonate. Hearing Research 1998, 126(1-2):58-66.
105. Snow M.E., Jacklin C.N., Maccoby E.E. Sex-of-child differences in father-child interaction at one year of age. Child Development 1983, 54(1):227-232.
106. Society for Women's Health Research. (Last accessed 13.07.11). http://www.womenshealthresearch.org/site/PageServer.
107. Spencer J.P., Clearfield M., Corbetta D., Ulrich B., Buchanan P., Schoner G. Moving toward a grand theory of development: in memory of Esther Thelen. Child Development 2006, 77(6):1521-1538.
108. Stiles J. The fundamentals of brain development: Integrating nature and nurture 2008, Harvard University Press, Cambridge.
109. Stuart A., Yang E.Y. Gender effects in auditory brainstem responses to air- and bone-conducted clicks in neonates. Journal of Communication Disorders 2001, 34(3):229-239.
110. Stukenborg J.K., Colón E., Söder O. Ontogenesis of testis development and function in humans. Sexual Development 2010, 4:199-213.
111. Sung, J., Fausto-Sterling, A., Garcia Coll, C., Elfoson, J., Perry, E., Yu, C., et al. (2010). Dynamics of age and sex in the development of mother-infant Vocal communication between 4 to 12 Months. In: International Conference on Infant Studies. Baltimore Maryland.
112. Sweeney J., Bradbard M.R. Mothers' and fathers' changing perceptions of their male and female infants over the course of pregnancy. Journal of Genetic Psychology 1988, 149(3):393-404.
113. Thelen E., Smith L.B. A dynamic systems approach to the development of cognition and action 1994, MIT Press, Cambridge.
114. Thordstein M., Lofgren N., Flisberg A., Lindecrantz K., Kjellmer I. Sex differences in electrocortical activity in human neonates. Neuroreport 2006, 17(11):1165-1168.
115. van de Beek C., van Goozen S.H., Buitelaar J.K., Cohen-Kettenis P.T. Prenatal sex hormones (maternal and amniotic fluid) and gender-related play behavior in 13-month-old infants. Archives of Sexual Behavior 2009, 38(1):6-15.
116. Vento B.A., Durrant J.D., Sabo D.L., Boston J.R. Development of f2/f1 ratio functions in humans. Journal of the Acoustical Society of America 2004, 115(5 Pt 1):2138-2147.
117. de Weerth C., van Hees Y., Buitelaar J.K. Prenatal maternal cortisol levels and infant behavior during the first 5 months. Early Human Development 2003, 74(2):139-151.
118. Weller G.M., Bell R.Q. Basal skin conductance and neonatal state. Child Development 1965, 36(3):647-657.
119. Will J.A., Self P.A., Datan N. Maternal behavior and perceived sex of infant. American Journal of Orthopsychiatry 1976, 46(1):135-139.
120. Zosuls K.M., Ruble D.N., Tamis-Lemonda C.S., Shrout P.E., Bornstein M.H., Greulich F.K. The acquisition of gender labels in infancy: implications for gender-typed play. Developmental Psychology 2009, 45(3):688-701.