Acinetobacter infections in a tertiary level intensive care unit in northern India: Epidemiology, clinical profiles and outcomes

Journal of Infection and Public Health

Volumn 5, Issue 2, 2012, Pages 145-152

  Mathai, Ashu Sara ^a   Oberoi, Aroma ^a   Madhavan, Sheeba ^a   Kaur, Parmdeep ^a  

^a CHRISTIAN MEDICAL COLLEGE   (India)

Author keywords

Acinetobacter; Infection; Intensive care unit

Indexed keywords

AMIKACIN; CARBAPENEM DERIVATIVE; CEFALEXIN; CEFOPERAZONE; CEFOTAXIME; CEFTAZIDIME; MEROPENEM; PEFLOXACIN; PIPERACILLIN; POLYMYXIN; POLYMYXIN B; QUINOLONE DERIVATIVE; TAZOBACTAM;

ACINETOBACTER INFECTION; ADULT; AGED; ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; ARTICLE; CATHETER INFECTION; DEMOGRAPHY; FEMALE; HUMAN; INDIA; INTENSIVE CARE UNIT; INTUBATION; LUNG INFECTION; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTIDRUG RESISTANCE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RESPIRATORY TRACT INFECTION; TERTIARY HEALTH CARE; VENTILATOR ASSOCIATED PNEUMONIA; WOUND INFECTION;

ACINETOBACTER INFECTIONS; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; CROSS INFECTION; FEMALE; HUMANS; INDIA; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; SURVIVAL ANALYSIS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84860250432     PISSN: 18760341     EISSN: 1876035X     Source Type: Journal    
DOI: 10.1016/j.jiph.2011.12.002     Document Type: Article

References (26)

1. Fournier P.E., Richet H. The epidemiology and control of Acinetobacter baumannii in health care facilities. Clin Infect Dis 2006, 42:692-699.
2. Dima S., Kritsotakis E.I., Roumbelaki M., Metalidis S., Karabinis A., Maguina N., et al. Device-associated nosocomial infection rates in intensive care units in Greece. Infect Control Hosp Epidemiol 2007, 28:602-605.
3. Schreckenberger P.C., Daneshvar M.I., Weyant R.S., Hollis D.G. Acinetobacter, Achromobacter, Chryseobacterium, Moraxella and other nonfermentative gramnegative rods. Manual of clinical microbiology 2007, 770-802. ASM Press, Washington, DC. 9th ed. P.R. Murray, E.J. Baron, J.H. Jorgensen, M.L. Landry, M.A. Pfaller (Eds.).
4. Hosein I.K., Hill D.W., Jenkins L.E., Magee J.T. Clinical significance of emergence of bacterial resistance in the hospital environment. Symp Ser Soc J Appl Microbiol 2002, 31:90-97.
5. Agarwal R., Gupta D., Ray P., Aggarwal A.N., Jindal S.K. Epidemiology, risk factors and outcome of nosocomial infections in a Respiratory Intensive Care Unit in North India. J Infect 2006, 53:98-105.
6. Prashanth K., Bhadrinath S. Nosocomial infections due to Acinetobacter species: clinical findings, risks and prognostic factors. Indian J Med Microbiol 2006, 24:39-44.
7. Corbella X., Pujol M., Ayats J., Sendra M., Ardanuy C., Dominguez M.A., et al. Relevance of digestive tract colonization in the epidemiology of nosocomial infections due to multiresistant Acinetobacter baumannii. Clin Infect Dis 1996, 23:329-334.
8. Rosenthal V.D., Maki D.G., Salomao R., lvarez-Moreno C.A., Mehta Y., Higuera F., et al. Device-associated nosocomial infections in 55 intensive care units of 8 developing countries. Ann Intern Med 2006, 145:582-591.
9. Mulin B., Talon D., Viel J.F., Vincent C., Leprat R., Thouverez M., et al. Risk factor for nosocomial colonization with multiresistant Acinetobacter baumannii. Eur J Clin Microbiol Infect Dis 1995, 14:569-576.
10. Scerpella E.G., Wanger A.R., Armitige L., Anderlini P., Ericsson C.D. Nosocomial outbreak caused by a multiresistant clone of Acinetobacter baumannii: results of the case-control and molecular epidemiologic investigations. Infect Control Hosp Epidemiol 1995, 16:92-97.
11. Munoz-Price L.S., Weinstein R.A. Acinetobacter infection. N Engl J Med 2008, 358:1271-1281.
12. Chen M.Z., Hsueh P.R., Lee L.N., Yu C.J., Yang P.C., Luh K.T. Severe community acquired pneumonia due to Acinetobacter baumannii. Chest 2001, 120:1072-1077.
13. Leung W.S., Chu C.M., Tsang K.Y., Lo F.H., Lo K.F., Ho P.L. Fulminant community acquired Acinetobacter baumannii pneumonia as a distinct clinical syndrome. Chest 2006, 129:102-109.
14. Joseph N.M., Sistla S., Dutta T.K., Badhe A.S., Rasitha D., Parija S.C. Ventilator-associated pneumonia in a tertiary care hospital in India: role of multi-drug resistant pathogens. J Infect Dev Countries 2010, 4:218-225.
15. Gladstone P., Rajendran P., Brahmadathan K.N. Incidence of carbapenem resistant nonfermenting Gram negative bacilli from patients with respiratory infections in the intensive care units. Indian J Med Microbiol 2005, 23:189-191.
16. Dey A., Bairy I. Incidence of multidrug-resistant organisms causing ventilator-associated pneumonia in a tertiary care hospital: a nine months' prospective study. Ann Thorac Med 2007, 2:52-57.
17. Cisneros J.M., Rodríguez-Baño J. Nosocomial bacteremia due to Acinetobacter baumannii: epidemiology, clinical features and treatment. Clin Microbiol Infect 2002, 8:687-693.
18. Bergogne-Berezin E., Towner K.J. Acinetobacter spp. as nosocomial pathogens: microbiological, clinical, and epidemiological features. Clin Microbiol Rev 1996, 9:148-165.
19. Lee N.Y., Lee H.C., Ko N.Y., Chang C.M., Shih H.I., Wu C.J., et al. Clinical and economic impact of multidrug resistance in nosocomial Acinetobacter baumannii bacteremia. Infect Control Hosp Epidemiol 2007, 28:713-719.
20. Patwardhan R.B., Dhakephalkar P.K., Niphadkar K.B., Chopade B.A. A study on nosocomial pathogens in ICU with special reference to multiresistant Acinetobacter baumannii harbouring multiple plasmids. Indian J Med Res 2008, 128:178-187.
21. Lolans K., Rice T.W., Munoz-Price L.S., Quinn J.P. Multicity outbreak of carbapenem-resistant Acinetobacter baumannii isolates producing the carbapenemase OXA-40. Antimicrob Agents Chemother 2006, 50:2941-2945.
22. Talbot G.H., Bradley J., Edwards J.E., Gilbert D., Scheld M., Bartlett J.G. Bad bugs need drugs: an update on the development pipeline from the Antimicrobial Availability Task Force of the Infectious Diseases Society of America. Clin Infect Dis 2006, 42:657-668.
23. Carey RB, Banerjee SN, Srinivasan A. Multidrug-resistant Acinetobacter infections, 1995-2004. Presented at the 46th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, September 27-30, 2006.
24. Sunenshine R.A., Wright M.O., Maragakis L.L., Harris A.D., Song X., Hebden J., et al. Multidrug-resistant Acinetobacter infection mortality rate and length of hospitalization. Emerg Infect Dis 2007, 13:97-103.
25. Jang T.N., Lee S.H., Huang C.H., Lee C.L., Chen W.Y. Risk factors and impact of nosocomial Acinetobacter baumannii bloodstream infections in the adult intensive care unit: a case-control study. J Hosp Infect 2009, 73:143-150.
26. Kwon K.T., Oh W.S., Song J.H., Chang H.H., Jung S.I., Kim S.W., et al. Impact of imipenem resistance on mortality in patients with Acinetobacter bacteraemia. J Antimicrob Chemother 2007, 59:525-530.