A study on nosocomial pathogens in ICU with special reference to multiresistant Acinetobacter baumannii harbouring multiple plasmids

Indian Journal of Medical Research

Volumn 128, Issue 2, 2008, Pages 178-187

  Patwardhan, R B ^a   Dhakephalkar, P K ^b   Niphadkar, K B ^c   Chopade, B A ^a  

^a UNIVERSITY OF PUNE   (India)

^b AGHARKAR RESEARCH INSTITUTE   (India)

^c KEM HOSPITAL   (India)

Author keywords

Acinetobacter baumannii; Antibiotic resistance; ICU; Nosocomial infections; Plasmid curing

Indexed keywords

ACRIDINE ORANGE; AMIKACIN; AMOXICILLIN; AMPICILLIN; CEFOTAXIME; CEFTAZIDIME; CEFTRIAXONE; CEFUROXIME; CHLORAMPHENICOL; CIPROFLOXACIN; CLINDAMYCIN; DOXYCYCLINE; ERYTHROMYCIN; ETHIDIUM BROMIDE; GENTAMICIN; LOMEFLOXACIN; NALIDIXIC ACID; NORFLOXACIN; OFLOXACIN; PENICILLIN G; PIPERACILLIN; PLASMID DNA; POLYMYXIN B; RIFAMPICIN; SPARFLOXACIN; STREPTOMYCIN; TETRACYCLINE; TOBRAMYCIN; UNINDEXED DRUG; VANCOMYCIN;

ACINETOBACTER BAUMANNII; AGAR DILUTION; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTEREMIA; BACTERIUM ISOLATE; BACTERIUM TRANSFORMATION; BRONCHITIS; CONTROLLED STUDY; ESCHERICHIA COLI; HOSPITAL INFECTION; INTENSIVE CARE UNIT; KLEBSIELLA PNEUMONIAE; MENINGITIS; MINIMUM INHIBITORY CONCENTRATION; MULTIDRUG RESISTANCE; NONHUMAN; PLASMID; PNEUMONIA; PSEUDOMONAS AERUGINOSA; RESPIRATORY TRACT INFECTION; SEPTICEMIA; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PYOGENES; URINARY TRACT INFECTION; WOUND INFECTION;

ACINETOBACTER BAUMANNII; CROSS INFECTION; DRUG RESISTANCE, MULTIPLE, BACTERIAL; HUMANS; INDIA; INTENSIVE CARE UNITS; MICROBIAL SENSITIVITY TESTS; PLASMIDS; TRANSFORMATION, BACTERIAL;

EID: 55849116342     PISSN: 09715916     EISSN: 09715916     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. Hosein IK, Hill DW, Jenkins LE, Magee JT. Clinical significance of emergence of bacterial resistance in the hospital environment. Sym Ser Soc J Appl Microbiol, 2002; 31: 90S-7S.
2. Courvalin P. Evasion of antibiotic action by bacteria. J Antimicrob Chemother 1996; 37: 855-69.
3. Chopra I. Research and development of antibacterial agents. Curr Opin Microbiol 1998; 1: 495-501.
4. Bergogne-Berezin E, Towner KJ. Acinetobacter spp. as nosocomial pathogens: microbiological, clinical and epidemiological features. Clin Microbiol Rev 1996; 9: 148-65.
5. Koprnova J, Svetlansky I, Babel AR, Bilikova E, Hanzen J, Zuscakova IJ. Prospective study of antibacterial susceptibility, risk factors and outcome of 157 episodes of Acinetobacter baumannii bacteremia in 1999 in Slovakia. Scand J Infect Dis 2001; 33: 891-5.
6. Wisplinghoff H, Edmond MB, Pfaller MA, Jones RN, Wenzel RP, Selfert H. Nosocomial blood stream infections caused by Acinetobacter species in United States hospitals: Clinical features, molecular epidemiology and antimicrobial susceptibility. Clin Infect Dis 2000; 31: 690-7.
7. Catalano M, Quelle LS, Jeric PE, Martino AD, Maimone SM. Survival of Acinetobacter baumannii on bed rails during and outbreak and during sporadic cases. J Hosp Infect 1999; 42: 27-35.
8. Larson E. A decade of nosocomial Acinetobacter. Am J Infect Control 1984; 12: 14-8.
9. Jawad A, Seifert H, Snelling AM, Heritage J, Hawkey PM. Survival of Acinetobacter baumannii on dry surfaces: comparison of outbreak and sporadic isolates. J Clin Microbiol 1998; 36: 1938-41.
10. Seifert H, Baginski R, Schulze A, Pulverer G. Antimicrobial susceptibility of Acinetobacter species. J Antimicrob Chemother 1993; 37: 750-3.
11. Gulati S, Kapil A, Dass B, Dwivedi SN, Mahapatra AK. Nosocomial infections due to Acinetobacter baumannii in a neurosurgery ICU. Neurol India 2001; 49: 134-7.
12. Matthew EF, Patra KK, Ioannis AB. The diversity of definitions of multidrug resistant (MDR) and pandrug resistant (PDR) Acinetobacter baumannii and Pseudomonas aeruginosa. J Med Microbiol 2006; 55: 1619-29.
13. Smolyakov R, Borer A, Riesenberg K, Schlaeffer F, Alkan M, Porath A, et al. Nosocomial multidrug resistant Acinetobacter baumannii bloodstream infection: risk factors and outcome with ampicillin-sulbactam treatment. J Hosp Infect 2004; 56: 165-6.
14. Towner KJ. Clinical importance and antibiotic resistance of Acinetobacter spp. Proceedings of a symposium held on 4-5 November 1996 at Eilat. Israel J Med Microbiol. 1997; 46: 721-46.
15. Joshi SG. Assignment of antibiotic resistance to naturally occurring plasmids from clinical isolates of Acinetobacter species. PhD Thesis. University of Pune, Pune, India; 1998.
16. Joshi SG, Litake GM, Ghole VS, Niphadkar KB. Plasmid borne extended spectrum β lactamase in a clinical isolate of Acinetobacter baumannii. J Med Microbiol 2003; 52: 1125-27.
17. Gerner-Smidt P. Ferquency of plasmids in strains of Acinetobacter calcoaceticus. J Hosp Infect 1989; 14: 23-8.
18. Chopade BA, Wise PJ, Towner KJ. Plasmid transfer and behaviour in Acinetobacter calcoaceticus EBF65/65. J Gen Microbiol 1985; 131: 2805-11.
19. Bergogne-Berezin E. The increasing role of Acinetobacter species as a nosocomial pathogen. Curr Infect Dis Rep 2001; 3: 440-4.
20. Kloos WE, Schleifer KH. Genus IV Staphylococcus Rosenbach. 1884, 18AL. In: Sneath PHA, Mair NS, Sharpe ME, Holt JG, editors. Bergey's Manual of systematic bacteriology. Baltimore: Williams and Wilkins; 1986. p. 1013-35.
21. Bouvet PJM, Grimont PAD. Taxonomy of the Genus Acinetobacter with the recognition of Acinetobacter baumannnii sp. nov., Acinetobacter haemolyticus sp. nov., Acinetobacter johnsonnii sp. nov., and Acinetobacter junii sp. nov., and emended descriptions of Acinetobacter calcoacticus and Acinetobacter lwoffii. Int J Syst Bacteriol 1986; 36: 228-40.
22. Bouvet PJM, Grimont PAD. Identification and biotyping of clinical isolates of Acinetobacter. Ann Inst Pasteur Microbiol 1987; 138: 569-78.
23. Juni E. Interspecies transformation of Acinetobacter: genetic evidence for a ubiquitous genus. J Bacteriol 1972; 112: 917-31.
24. Towner KJ, Chopade BA. Biotyping of Acinetobacter calcoaceticus using the API 2ONE system. J Hosp Infect 1987; 10: 145-51.
25. Bauer AW, Kirby WMM, Sherris JC, Turck M. Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol 1996; 45: 493-6.
26. National Committee for Clinical Laboratory Standards (now Clinical and Laboratory Standards Institute, CLSI). Performance standards for antimicrobial susceptibility testing; 12th information supplement (M100-S1). Villanova, PA; NCCLS: 2002.
27. Jacques FA, Goldstein FW. Disc susceptibility test, In: Lorian V, editor. Antibiotics in laboratory medicine, 2nd ed. Williams & Wilkins, Baltimore, MD, USA; 1986. p. 27-63.
28. Dhakephalkar PK, Chopade BA. High levels of multiple metal resistance and its correlation to antibiotic resistance in environmental isolates of Acinetobacter. BioMetals 1994; 7: 67-74.
29. National Committee for Clinical Laboratory Standards (now Clinical and Laboratory Standards Institute, CLSI). Methods for dilution antimicrobial susceptibility testing for bacteria that grows aerobically. Approved Standards M7-A4. Villanova, PA: NCCLS, 1997.
30. Kado CI, Liu ST, Rapid procedure for detection and isolation of large and small plasmids. J Bacteriol 1981; 145: 1365-73.
31. Sambrook J, Fritsch EF, Maniatis T. Plasmid vectors. In: Molecular cloning: A laboratory manual, 2nd ed. Cold Spring Harbour: CSH Press. 1989; P.1.1-1.109.
32. Deshpande NM, Dhakephalkar PK, Kanekar PP. Plasmid mediated dimethoate degradation in Pseudomonas aeruginosa MCMB-427. Lett Appl Microbiol 2001; 33: 275-9.
33. Pimentel JD, Low J, Styles K, Harris OC, Hughes A, Athan E. Control of an outbreak of multidrug resistant Acinetobacter baumannii in an ICUand a surgical ward. J Hosp Infect 2005; 59: 249-53.
34. Jeong SH, Bae IK, Kwon SB, Lee K, Yong D, Woo GJ, et al. Investigation of a nosocomial outbreak of Acinetobacter baumannii producing PER-1 extended spectrum β-lactamase in an ICU. J Hosp Infect 2005; 59: 242-8.
35. Jeon BC, Jeong SH, Bae IK, Kwon SB, Lee K, Yong D, et al. Investigation of a nosocomial outbreak of imipenem resistant Acinetobacter baumannii producing the OXA-23 β-lactamase in Korea. J Clin Microbiol 2005; 43: 2241-5.
36. Navon VS, Ben AR, Carmeli Y. Update on Pseudomonas aeruginosa and Acinetobacter baumannii infections in the healthcare setting. Curr Opi Infect Dis 2005; 18: 306-13.
37. Singh AK, Sen MR, Anupurba S, Bhattacharya P. Antibiotic sensitivity pattern of bacteria isolated from nosocomial infections in ICU. J Commun Dis 2002; 34: 257-63.
38. Hsueh PR, Teng LJ, Chen CY, Chen WH, Yu CJ, Ho SW, et al. Pan drug-Resistant Acinetobacter baumannii causing nosocomial infections in a university hospital, Taiwan. Emerg Infect Dis 2002; 8: 827-32.
39. Chopade BA, Patwardhan RB. Acinetobacter: A potential pathogen of urinary tract infection: A review. Mutropnishad 2002; 1: 165-81.
40. Richards DA, Toop LJ, Chambers ST, Sutherland MG, Harris BH, Ikram RB, et al. Antibiotic resistance in uncomplicated urinary tract infection: problems with interpreting cumulative resistance rates from local community laboratories. N Z Med J 2002; 25115: 12-4.
41. Dy ME, Nord JA, LaBombardi VJ, Kislak JW. The emergence of resistant strains of Acinetobacter baumannii: clinical and infection control implications. Infect Control Hosp Epidemiol 1999; 20: 565-7.
42. Patil JR, Jog NR, Chopade BA. Isolation and characterization of Acinetobacter from upper respiratory tract of healthy humans and demonstration of lectin activity. Indian J Med Microbiol 2001; 19: 30-5.
43. Kapil A. Antibiotics in gram negative sepsis. Trop Gastroenterol 2000; 21: 95-102.
44. Wroblewska MM, Dijkshoorn L, Marchel H, Van Den Barselaar M, Swoboda-Kopec E, Van Den Broek PJ, et al. Outbreak of nosocomial meningitis caused by Acinetobacter baumannii in neurosurgical patients. J Hosp Infect 2004; 57: 300-7.
45. Prashanth K, Badrinath S. In vitro susceptibility pattern of Acinetobacter species to commonly used cephalosporins, quinolones and aminoglycosides, Indian J Med Microbiol 2004; 22: 97-103.
46. Prashanth K, Badrinath S. Nosocomial infections due to Acinetobacter species: Clinical findings, Risk and Prognostic Factors. Indian J Med Microbiol. 2006; 24: 39-44.
47. Jain R, Danziger LH. Multidrug resistant Acinetobacter infections: An emerging challenge to clinicians. Ann Pharmacother 2004; 38: 1449-59.
48. Chopade BA, Patwardhan RB, Dhakephalkar PK. Acinetobacter infections in India: Genetic and molecular biological studies and some approaches to the problem. In: Sushil Kumar AK, Sen GPD, Sharma RN, editors. Tropical diseases: Molecular biology and control strategies. New Delhi: CSIR Publications & Information Directorate, 1994. p. 704-17.
49. Deshpande LM, Kapadnis BP, Chopade BA. Metal resistance in Acinetobacter and its relation to β-lactamase production. BioMetals 1993; 6: 55-9.
50. Pardesi KR, Yavankar SP, Chopade BA. Plasmid distribution and antimicrobial susceptibility patterns of Acinetobacter genospecies from healthy skin of a tribal population in western India. Indian J Med Res 2007; 125: 79-88.
51. Kapil A. The challenge of antibiotic resistance: Need to contemplate. Indian J Med Res 2005; 121: 83-91.
52. Heritier C, Dubouix A, Poirel L, Marty N, Nordmann P. A nosocomial outbreak of Acinetobacter baumannii isolates expressing the carbapenem hydrolyzing oxacillinase OXA-58. J Antimicrob Chemother 2005; 55: 115-8.