Dipyrone attenuates acute sickness response to lipopolysaccharide in mice

Neuroscience Letters

Volumn 516, Issue 1, 2012, Pages 114-118

  Soncini, Roseli ^a   de Souza, Denise F ^a   Neves, Andrea P ^a   Braga, Daniela S ^a   Andrade, Carina A F ^a   Giusti Paiva, Alexandre ^a  

^a FEDERAL UNIVERSITY OF ALFENAS   (Brazil)

Author keywords

Dipyrone; Endotoxin; Sepsis; Sickness behavior; Stress

Indexed keywords

DIPYRONE; LIPOPOLYSACCHARIDE; PROSTAGLANDIN SYNTHASE; SUCROSE;

ANHEDONIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANOREXIA; ARTICLE; CONTROLLED STUDY; DARK LIGHT BOX TEST; DARKNESS; EXPERIMENTAL TEST; FOOD INTAKE; FORCED SWIMMING TEST; ILLNESS BEHAVIOR; IMMOBILIZATION; LIGHT; MALE; MOUSE; NONHUMAN; OPEN FIELD TEST; PRIORITY JOURNAL; TAIL SUSPENSION TEST;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BEHAVIOR, ANIMAL; DIPYRONE; DOSE-RESPONSE RELATIONSHIP, DRUG; ILLNESS BEHAVIOR; LIPOPOLYSACCHARIDES; MALE; MICE;

EID: 84860248531     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2012.03.070     Document Type: Article

References (31)

1. Asarian L., Langhans W. A new look on brain mechanisms of acute illness anorexia. Physiology and Behavior 2010, 100:464-471.
2. Banks W.A., Kastin A.J. Passage of peptides across the blood-brain barrier: pathophysiological perspectives. Life Sciences 1996, 59:1923-1943.
3. Bourin M., Hascoët M. The mouse light/dark box test. European Journal of Pharmacology 2003, 463:55-65.
4. Chandrasekharan N.V., Dai H., Roos K.L., Evanson N.K., Tomsik J., Elton T.S., Simmons D.L. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proceedings of the National Academy of Sciences of the United States of America 2002, 99:13926-13931.
5. Cross-Mellor S.K., Roberts S., Kavaliers M., Ossenkopp K.P. Activation of the immune system in rats with lipopolysaccharide reduces voluntary sucrose intake but not intraoral intake. Pharmacology, Biochemistry, and Behavior 2003, 76:153-159.
6. Dallaporta M., Pecchi E., Jacques C., Berenbaum F., Jean A., Thirion S., Troadec J.D. c-Fos immunoreactivity induced by intraperitoneal LPS administration is reduced in the brain of mice lacking the microsomal prostaglandin E synthase-1 (mPGES-1). Brain, Behavior, and Immunity 2007, 21:1109-1121.
7. Dantzer R. Cytokine sickness behavior, and depression. Immunology and Allergy Clinics of North America 2009, 29:247-264.
8. De La Garza R. Endotoxin- or pro-inflammatory cytokine-induced sickness behavior as an animal model of depression: focus on anhedonia. Neuroscience and Biobehavioral Reviews 2005, 29:761-770.
9. de Paiva V.N., Lima S.N., Fernandes M.M., Soncini R., Andrade C.A., Giusti-Paiva A. Prostaglandins mediate depressive-like behaviour induced by endotoxin in mice. Behavioural Brain Research 2010, 215:146-151.
10. Dunn A.J., Swiergiel A.H. Effects of interleukin-1 and endotoxin in the forced swim and tail suspension tests in mice. Pharmacology, Biochemistry, and Behavior 2005, 81:688-693.
11. Elander L., Engström L., Hallbeck M., Blomqvist A. IL-1beta LPS induce anorexia by distinct mechanisms differentially dependent on microsomal prostaglandin E synthase-1. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 2007, 292:R258-R267.
12. Elmquist J.K., Scammell T.E., Saper C.B. Mechanisms of CNS response to systemic immune challenge: the febrile response. Trends in Neurosciences 1997, 20:565-570.
13. Grosser T., Yu Y., Fitzgerald G.A. Emotion recollected in tranquility: lessons learned from the COX-2 saga. Annual Review of Medicine 2010, 61:17-33.
14. Guo J.Y., Li C.Y., Ruan Y.P., Sun M., Qi X.L., Zhao B.S., Luo F. Chronic treatment with celecoxib reverses chronic unpredictable stress-induced depressive-like behavior via reducing cyclooxygenase-2 expression in rat brain. European Journal of Pharmacology 2009, 612:54-60.
15. Hinz B., Cheremina O., Bachmakov J., Renner B., Zolk O., Fromm M.F., Brune K. Dipyrone elicits substantial inhibition of peripheral cyclooxygenases in humans: new insights into the pharmacology of an old analgesic. FASEB Journal 2007, 21:2343-2351.
16. Ibáñez L., Vidal X., Ballarín E., Laporte J.R. Agranulocytosis associated with dipyrone (metamizol). European Journal of Clinical Pharmacology 2005, 60:821-829.
17. Kelley K.W., Bluthe R.M., Dantzer R., Zhou J.H., Shen W.H., Johnson R.W., Broussard S.R. Cytokine induced sickness behavior. Brain, Behavior, and Immunity 2003, 17:112-118.
18. Kentner A.C., McLeod S.A., Field E.F., Pittman Q.J. Sex-dependent effects of neonatal inflammation on adult inflammatory markers and behavior. Endocrinology 2010, 151:2689-2699.
19. Langhans W., Balkowski G., Savoldelli D. Differential feeding responses to bacterial lipopolysaccharide and muramyl dipeptide. American Journal of Physiology 1991, 261:R659-R664.
20. Langhans W. Signals generating anorexia during acute illness. Proceedings of the Nutrition Society 2007, 66:321-330.
21. Madrigal J.L., García-Bueno B., Moro M.A., Lizasoain I., Lorenzo P., Leza J.C. Relationship between cyclooxygenase-2 and nitric oxide synthase-2 in rat cortex after stress. European Journal of Neuroscience 2003, 18:1701-1705.
22. Malvar D.C., Soares D.M., Fabrício A.S., Kanashiro A., Machado R.R., Figueiredo M.J., Era G.A., De Souza G.E. The antipyretic effect of dipyrone is unrelated to inhibition of PGE(2) synthesis in the hypothalamus. British Journal of Pharmacology 2010, 162:1401-1409.
23. Miller D.W. Immunobiology of the blood-brain barrier. Journal of Neurovirology 1999, 5:570-578.
24. Pecchi E., Dallaporta M., Jean A., Thirion S., Troadec J.D. Prostaglandins and sickness behavior: old story new insights. Physiology and Behavior 2009, 97:279-292.
25. Pierre S.C., Schmidt R., Brenneis C., Michaelis M., Geisslinger G., Scholich K. Inhibition of cyclooxygenases by dipyrone. British Journal of Pharmacology 2007, 151:494-503.
26. Pitychoutis P.M., Nakamura K., Tsonis P.A., Papadopoulou-Daifoti Z. Neurochemical and behavioral alterations in an inflammatory model of depression: sex differences exposed. Neuroscience 2009, 159:1216-1232.
27. Rezende R.M., França D.S., Menezes G.B., dos Reis W.G., Bakhle Y.S., Francischi J.N. Different mechanisms underlie the analgesic actions of paracetamol and dipyrone in a rat model of inflammatory pain. British Journal of Pharmacology 2007, 153:760-768.
28. Silva-Moreno A., López-Muñoz F.J., Cruz S.L. d-Propoxyphene and dipyroneco-administration produces greater antinociception and fewer adverse effects than single treatments in rats. European Journal of Pharmacology 2009, 607:84-90.
29. Tatsuo M.A., Carvalho W.M., Silva C.V., Miranda A.E., Ferreira S.H., Francisch J.N. Analgesic and antiinflammatory effects of dipyrone in rat adjuvant arthritis model. Inflammation 1994, 18:399-405.
30. Teeling J.L., Cunningham C., Newman T.A., Perry V.H. The effect of non-steroidal anti-inflammatory agents on behavioural changes and cytokine production following systemic inflammation: implications for a role of COX-1. Brain, Behavior, and Immunity 2010, 24:409-419.
31. Vane J.R., Bakhle Y.S., Botting R.M. Cyclooxygenases 1 and 2. Annual Review of Pharmacology and Toxicology 1998, 38:97-120.