메뉴 건너뛰기




Volumn 205, Issue 1-2, 2012, Pages 34-41

Clinical characteristics and outcomes of BRCA-associated ovarian cancer: Genotype and survival

Author keywords

BRCA1; BRCA2; Cancer; Genetics; Ovarian carcinoma

Indexed keywords

ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER GRADING; CANCER SURVIVAL; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE ASSOCIATION; EPITHELIUM TUMOR; EVENT FREE SURVIVAL; FEMALE; FOLLOW UP; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MUTATIONAL ANALYSIS; OUTCOME ASSESSMENT; OVARY CANCER; OVERALL SURVIVAL; PRIORITY JOURNAL; RETROSPECTIVE STUDY; TUMOR SUPPRESSOR GENE;

EID: 84860230447     PISSN: 22107762     EISSN: 22107770     Source Type: Journal    
DOI: 10.1016/j.cancergen.2012.01.008     Document Type: Article
Times cited : (40)

References (41)
  • 1
    • 0035098503 scopus 로고    scopus 로고
    • Prevalence and Penetrance of Germline BRCA1 and BRCA2 Mutations in a Population Series of 649 Women with Ovarian Cancer
    • Risch H.A., McLaughlin J.R., Cole D.E.C., et al. Prevalence and Penetrance of Germline BRCA1 and BRCA2 Mutations in a Population Series of 649 Women with Ovarian Cancer. Am J Hum Genet 2001, 68:700-710.
    • (2001) Am J Hum Genet , vol.68 , pp. 700-710
    • Risch, H.A.1    McLaughlin, J.R.2    Cole, D.E.C.3
  • 2
    • 0033927850 scopus 로고    scopus 로고
    • BRCA1 and BRCA2 mutation analysis of 208 Ashkenazi Jewish women with ovarian cancer
    • Moslehi R., Chu W., Karlan B., et al. BRCA1 and BRCA2 mutation analysis of 208 Ashkenazi Jewish women with ovarian cancer. Am J Hum Genet 2000, 66:1259-1272.
    • (2000) Am J Hum Genet , vol.66 , pp. 1259-1272
    • Moslehi, R.1    Chu, W.2    Karlan, B.3
  • 3
    • 8544231421 scopus 로고    scopus 로고
    • Hereditary ovarian cancer in Ashkenazi Jews
    • Robles-Diaz L., Goldfrank D.J., Kauff N.D., et al. Hereditary ovarian cancer in Ashkenazi Jews. Fam Cancer 2004, 3:259-264.
    • (2004) Fam Cancer , vol.3 , pp. 259-264
    • Robles-Diaz, L.1    Goldfrank, D.J.2    Kauff, N.D.3
  • 4
    • 0038744296 scopus 로고    scopus 로고
    • Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: a combined analysis of 22 studies
    • Antoniou A., Pharoah P.D., Narod S., et al. Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: a combined analysis of 22 studies. Am J Hum Genet 2003, 72:1117-1130.
    • (2003) Am J Hum Genet , vol.72 , pp. 1117-1130
    • Antoniou, A.1    Pharoah, P.D.2    Narod, S.3
  • 5
    • 0033558282 scopus 로고    scopus 로고
    • Survival in familial, BRCA1-associated, and BRCA2-associated epithelial ovarian cancer
    • Pharoah P.D.P., Easton D.F., Stockton D.L., et al. Survival in familial, BRCA1-associated, and BRCA2-associated epithelial ovarian cancer. Cancer Res 1999, 59:868-871.
    • (1999) Cancer Res , vol.59 , pp. 868-871
    • Pharoah, P.D.P.1    Easton, D.F.2    Stockton, D.L.3
  • 6
    • 17444448154 scopus 로고    scopus 로고
    • Survival of BRCA1 Breast and Ovarian Cancer Patients: A Population-Based Study from Southern Sweden
    • Johannsson O.T., Ranstam J., Borg A., et al. Survival of BRCA1 Breast and Ovarian Cancer Patients: A Population-Based Study from Southern Sweden. J Clin Oncol 1998, 16:397-404.
    • (1998) J Clin Oncol , vol.16 , pp. 397-404
    • Johannsson, O.T.1    Ranstam, J.2    Borg, A.3
  • 7
    • 10544220023 scopus 로고    scopus 로고
    • Clinical and Pathological Features of Ovarian Cancer in Women with Germ-Line Mutations of BRCA1
    • Rubin S.C., Ivor B., Kian B., et al. Clinical and Pathological Features of Ovarian Cancer in Women with Germ-Line Mutations of BRCA1. N Engl J Med 1996, 335:1413-1416.
    • (1996) N Engl J Med , vol.335 , pp. 1413-1416
    • Rubin, S.C.1    Ivor, B.2    Kian, B.3
  • 8
    • 0031881833 scopus 로고    scopus 로고
    • Clinical features of ovarian cancer in Japanese women with germ-line mutations of BRCA1
    • Aida H., Takakuwa K., Nagata H., et al. Clinical features of ovarian cancer in Japanese women with germ-line mutations of BRCA1. Clin Cancer Res 1998, 4:235-240.
    • (1998) Clin Cancer Res , vol.4 , pp. 235-240
    • Aida, H.1    Takakuwa, K.2    Nagata, H.3
  • 9
    • 0034600109 scopus 로고    scopus 로고
    • Clinicopathologic features of BRCA-linked and sporadic ovarian cancer
    • Boyd J., Sonoda Y., Federici M.G., et al. Clinicopathologic features of BRCA-linked and sporadic ovarian cancer. JAMA 2000, 283:2260-2265.
    • (2000) JAMA , vol.283 , pp. 2260-2265
    • Boyd, J.1    Sonoda, Y.2    Federici, M.G.3
  • 10
    • 0037080115 scopus 로고    scopus 로고
    • Effect of BRCA mutations on the length of survival in epithelial ovarian tumors
    • Ben David Y., Chetrit A., Hirsh-Yechezkel G., et al. Effect of BRCA mutations on the length of survival in epithelial ovarian tumors. J Clin Oncol 2002, 20:463-466.
    • (2002) J Clin Oncol , vol.20 , pp. 463-466
    • Ben David, Y.1    Chetrit, A.2    Hirsh-Yechezkel, G.3
  • 11
    • 0037403380 scopus 로고    scopus 로고
    • Improved survival in women with BRCA-associated ovarian carcinoma
    • Cass I., Baldwin R.L., Varkey T., et al. Improved survival in women with BRCA-associated ovarian carcinoma. Cancer 2003, 97:2187-2195.
    • (2003) Cancer , vol.97 , pp. 2187-2195
    • Cass, I.1    Baldwin, R.L.2    Varkey, T.3
  • 12
    • 23844507839 scopus 로고    scopus 로고
    • Prognostic impact of BRCA1 pathogenic and BRCA1/BRCA2 unclassified variant mutations in patients with ovarian carcinoma
    • Majdak E.J., Debniak J., Milczek T., et al. Prognostic impact of BRCA1 pathogenic and BRCA1/BRCA2 unclassified variant mutations in patients with ovarian carcinoma. Cancer 2005, 104:1004-1012.
    • (2005) Cancer , vol.104 , pp. 1004-1012
    • Majdak, E.J.1    Debniak, J.2    Milczek, T.3
  • 13
    • 37849030476 scopus 로고    scopus 로고
    • Effect of BRCA1/2 Mutations on Long-Term Survival of Patients With Invasive Ovarian Cancer: The National Israeli Study of Ovarian Cancer
    • Chetrit A., Hirsh-Yechezkel G., Ben-David Y., et al. Effect of BRCA1/2 Mutations on Long-Term Survival of Patients With Invasive Ovarian Cancer: The National Israeli Study of Ovarian Cancer. J Clin Oncol 2008, 26:20-25.
    • (2008) J Clin Oncol , vol.26 , pp. 20-25
    • Chetrit, A.1    Hirsh-Yechezkel, G.2    Ben-David, Y.3
  • 14
    • 57149093237 scopus 로고    scopus 로고
    • "BRCAness" Syndrome in Ovarian Cancer: A Case-Control Study Describing the Clinical Features and Outcome of Patients With Epithelial Ovarian Cancer Associated With BRCA1 and BRCA2 Mutations
    • Tan D.S.P., Rothermundt C., Thomas K., et al. "BRCAness" Syndrome in Ovarian Cancer: A Case-Control Study Describing the Clinical Features and Outcome of Patients With Epithelial Ovarian Cancer Associated With BRCA1 and BRCA2 Mutations. J Clin Oncol 2008, 26:5530-5536.
    • (2008) J Clin Oncol , vol.26 , pp. 5530-5536
    • Tan, D.S.P.1    Rothermundt, C.2    Thomas, K.3
  • 15
    • 79955390596 scopus 로고    scopus 로고
    • Chemosensitivity and outcome of BRCA1- and BRCA2-associated ovarian cancer patients after first-line chemotherapy compared with sporadic ovarian cancer patients
    • Vencken P.M., Kriege M., Hoogwerf D., et al. Chemosensitivity and outcome of BRCA1- and BRCA2-associated ovarian cancer patients after first-line chemotherapy compared with sporadic ovarian cancer patients. Ann Oncol 2011, 22:1346-1352.
    • (2011) Ann Oncol , vol.22 , pp. 1346-1352
    • Vencken, P.M.1    Kriege, M.2    Hoogwerf, D.3
  • 16
    • 12144290945 scopus 로고    scopus 로고
    • Estrogen receptor status in BRCA1- and BRCA2-related breast cancer: the influence of age, grade, and histological type
    • Foulkes W.D., Metcalfe K., Sun P., et al. Estrogen receptor status in BRCA1- and BRCA2-related breast cancer: the influence of age, grade, and histological type. Clin Cancer Res 2004, 10:2029-2034.
    • (2004) Clin Cancer Res , vol.10 , pp. 2029-2034
    • Foulkes, W.D.1    Metcalfe, K.2    Sun, P.3
  • 17
    • 0034944856 scopus 로고    scopus 로고
    • Ovarian cancer survival in Ashkenazi Jewish patients with BRCA1 and BRCA2 mutations
    • Ramus S.J., Fishman A., Pharoah P.D., et al. Ovarian cancer survival in Ashkenazi Jewish patients with BRCA1 and BRCA2 mutations. Eur J Surg Oncol 2001, 27:278-281.
    • (2001) Eur J Surg Oncol , vol.27 , pp. 278-281
    • Ramus, S.J.1    Fishman, A.2    Pharoah, P.D.3
  • 18
    • 33847167062 scopus 로고    scopus 로고
    • Improved survival in BRCA2 carriers with ovarian cancer
    • Pal T., Permuth-Wey J., Kapoor R., et al. Improved survival in BRCA2 carriers with ovarian cancer. Fam Cancer 2007, 6:113-119.
    • (2007) Fam Cancer , vol.6 , pp. 113-119
    • Pal, T.1    Permuth-Wey, J.2    Kapoor, R.3
  • 19
    • 67650471685 scopus 로고    scopus 로고
    • Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from BRCA Mutation Carriers
    • Fong P.C., Boss D.S., Yap T.A., et al. Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from BRCA Mutation Carriers. N Engl J Med 2009, 361:123-134.
    • (2009) N Engl J Med , vol.361 , pp. 123-134
    • Fong, P.C.1    Boss, D.S.2    Yap, T.A.3
  • 20
    • 77954032829 scopus 로고    scopus 로고
    • Poly(ADP)-ribose polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval
    • Fong P.C., Yap T.A., Boss D.S., et al. Poly(ADP)-ribose polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval. J Clin Oncol 2010, 28:2512-2519.
    • (2010) J Clin Oncol , vol.28 , pp. 2512-2519
    • Fong, P.C.1    Yap, T.A.2    Boss, D.S.3
  • 21
    • 77955019276 scopus 로고    scopus 로고
    • Oral poly (ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial
    • Tutt A., Robson M., Garber J.E., et al. Oral poly (ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial. Lancet 2010, 376:235-244.
    • (2010) Lancet , vol.376 , pp. 235-244
    • Tutt, A.1    Robson, M.2    Garber, J.E.3
  • 22
    • 77955039099 scopus 로고    scopus 로고
    • Oral poly (ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial
    • Audeh M.W., Carmichael J., Penson R.T., et al. Oral poly (ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial. Lancet 2010, 376:245-251.
    • (2010) Lancet , vol.376 , pp. 245-251
    • Audeh, M.W.1    Carmichael, J.2    Penson, R.T.3
  • 23
    • 4544374528 scopus 로고    scopus 로고
    • BRCA1 and BRCA2: 1994 and beyond
    • Narod S.A., Foulkes W.D. BRCA1 and BRCA2: 1994 and beyond. Nat Rev Cancer 2004, 4:665-676.
    • (2004) Nat Rev Cancer , vol.4 , pp. 665-676
    • Narod, S.A.1    Foulkes, W.D.2
  • 24
    • 77953952646 scopus 로고    scopus 로고
    • BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair
    • O'Donovan P.J., Livingston D.M. BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair. Carcinogenesis 2010, 31:961-967.
    • (2010) Carcinogenesis , vol.31 , pp. 961-967
    • O'Donovan, P.J.1    Livingston, D.M.2
  • 25
    • 62549147782 scopus 로고    scopus 로고
    • BRCA1 and implications for response to chemotherapy in ovarian cancer
    • Quinn J.E., Carser J.E., James C.R., et al. BRCA1 and implications for response to chemotherapy in ovarian cancer. Gynecol Oncol 2009, 113:134-142.
    • (2009) Gynecol Oncol , vol.113 , pp. 134-142
    • Quinn, J.E.1    Carser, J.E.2    James, C.R.3
  • 26
    • 77958458006 scopus 로고    scopus 로고
    • First-in-human trial of a poly(ADP-ribose) polymerase (PARP) inhibitor MK-4827 in advanced cancer patients (pts) with antitumor activity in BRCA-deficient and sporadic ovarian cancers
    • Sandhu S.K., Wenham R.M., Wilding G., et al. First-in-human trial of a poly(ADP-ribose) polymerase (PARP) inhibitor MK-4827 in advanced cancer patients (pts) with antitumor activity in BRCA-deficient and sporadic ovarian cancers. ASCO Meeting Abstracts 2010, Vol. 28:3001.
    • (2010) ASCO Meeting Abstracts , vol.28 , pp. 3001
    • Sandhu, S.K.1    Wenham, R.M.2    Wilding, G.3
  • 27
    • 77955019962 scopus 로고    scopus 로고
    • Can we define tumors that will respond to PARP inhibitors? A phase II correlative study of olaparib in advanced serous ovarian cancer and triple-negative breast cancer
    • Gelmon K.A., Hirte H.W., Robidoux A., et al. Can we define tumors that will respond to PARP inhibitors? A phase II correlative study of olaparib in advanced serous ovarian cancer and triple-negative breast cancer. ASCO Meeting Abstracts 2010, Vol. 28:3002.
    • (2010) ASCO Meeting Abstracts , vol.28 , pp. 3002
    • Gelmon, K.A.1    Hirte, H.W.2    Robidoux, A.3
  • 28
    • 39849097680 scopus 로고    scopus 로고
    • Resistance to therapy caused by intragenic deletion in BRCA2
    • Edwards S.L., Brough R., Lord C.J., et al. Resistance to therapy caused by intragenic deletion in BRCA2. Nature 2008, 451:1111-1115.
    • (2008) Nature , vol.451 , pp. 1111-1115
    • Edwards, S.L.1    Brough, R.2    Lord, C.J.3
  • 29
    • 39849106300 scopus 로고    scopus 로고
    • Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers
    • Sakai W., Swisher E.M., Karlan B.Y., et al. Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers. Nature 2008, 451:1116-1120.
    • (2008) Nature , vol.451 , pp. 1116-1120
    • Sakai, W.1    Swisher, E.M.2    Karlan, B.Y.3
  • 30
    • 42349096328 scopus 로고    scopus 로고
    • Secondary BRCA1 Mutations in BRCA1-Mutated Ovarian Carcinomas with Platinum Resistance
    • Swisher E.M., Sakai W., Karlan B.Y., et al. Secondary BRCA1 Mutations in BRCA1-Mutated Ovarian Carcinomas with Platinum Resistance. Cancer Res 2008, 68:2581-2586.
    • (2008) Cancer Res , vol.68 , pp. 2581-2586
    • Swisher, E.M.1    Sakai, W.2    Karlan, B.Y.3
  • 31
    • 69249100461 scopus 로고    scopus 로고
    • Functional Restoration of BRCA2 Protein by Secondary BRCA2 Mutations in BRCA2-Mutated Ovarian Carcinoma
    • Sakai W., Swisher E.M., Jacquemont C., et al. Functional Restoration of BRCA2 Protein by Secondary BRCA2 Mutations in BRCA2-Mutated Ovarian Carcinoma. Cancer Res 2009, 69:6381-6386.
    • (2009) Cancer Res , vol.69 , pp. 6381-6386
    • Sakai, W.1    Swisher, E.M.2    Jacquemont, C.3
  • 32
    • 77950958141 scopus 로고    scopus 로고
    • 53BP1 Inhibits Homologous Recombination in BRCA1-Deficient Cells by Blocking Resection of DNA Breaks
    • Bunting S.F., Callén E., Wong N., et al. 53BP1 Inhibits Homologous Recombination in BRCA1-Deficient Cells by Blocking Resection of DNA Breaks. Cell 2010, 141:243-254.
    • (2010) Cell , vol.141 , pp. 243-254
    • Bunting, S.F.1    Callén, E.2    Wong, N.3
  • 33
    • 77953291328 scopus 로고    scopus 로고
    • 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers
    • Bouwman P., Aly A., Escandell J.M., et al. 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers. Nat Struct Mol Biol 2010, 17:688-695.
    • (2010) Nat Struct Mol Biol , vol.17 , pp. 688-695
    • Bouwman, P.1    Aly, A.2    Escandell, J.M.3
  • 34
    • 4944229642 scopus 로고    scopus 로고
    • Hallmarks of 'BRCAness' in sporadic cancers
    • Turner N., Tutt A., Ashworth A. Hallmarks of 'BRCAness' in sporadic cancers. Nat Rev Cancer 2004, 4:814-819.
    • (2004) Nat Rev Cancer , vol.4 , pp. 814-819
    • Turner, N.1    Tutt, A.2    Ashworth, A.3
  • 35
    • 77955911553 scopus 로고    scopus 로고
    • Personalizing Therapy for Ovarian Cancer: BRCAness and Beyond
    • Bast R.C., Mills G.B. Personalizing Therapy for Ovarian Cancer: BRCAness and Beyond. J Clin Oncol 2010, 28:3545-3548.
    • (2010) J Clin Oncol , vol.28 , pp. 3545-3548
    • Bast, R.C.1    Mills, G.B.2
  • 36
    • 78751629661 scopus 로고    scopus 로고
    • BRCA1 CpG island hypermethylation predicts sensitivity to poly(adenosine diphosphate)-ribose polymerase inhibitors
    • author reply e565-e566
    • Veeck J., Ropero S., Setien F., et al. BRCA1 CpG island hypermethylation predicts sensitivity to poly(adenosine diphosphate)-ribose polymerase inhibitors. J Clin Oncol 2010, 28:e563-e564. author reply e565-e566.
    • (2010) J Clin Oncol , vol.28
    • Veeck, J.1    Ropero, S.2    Setien, F.3
  • 37
    • 30444457408 scopus 로고    scopus 로고
    • Amplification of EMSY, a novel oncogene on 11q13, in high grade ovarian surface epithelial carcinomas
    • Brown L.A., Irving J., Parker R., et al. Amplification of EMSY, a novel oncogene on 11q13, in high grade ovarian surface epithelial carcinomas. Gynecol Oncol 2006, 100:264-270.
    • (2006) Gynecol Oncol , vol.100 , pp. 264-270
    • Brown, L.A.1    Irving, J.2    Parker, R.3
  • 38
    • 77955894453 scopus 로고    scopus 로고
    • Gene Expression Profile of BRCAness That Correlates With Responsiveness to Chemotherapy and With Outcome in Patients With Epithelial Ovarian Cancer
    • Konstantinopoulos P.A., Spentzos D., Karlan B.Y., et al. Gene Expression Profile of BRCAness That Correlates With Responsiveness to Chemotherapy and With Outcome in Patients With Epithelial Ovarian Cancer. J Clin Oncol 2010, 28:3555-3561.
    • (2010) J Clin Oncol , vol.28 , pp. 3555-3561
    • Konstantinopoulos, P.A.1    Spentzos, D.2    Karlan, B.Y.3
  • 39
    • 84870634521 scopus 로고    scopus 로고
    • BRCA2 Mutations Associated with Improved Survival for Ovarian Cancer
    • Presented at: American Association for Cancer Research 102nd Annual Meeting; April 2-6, 2011; Orlando, FL. [Abstract 2752].
    • Bolton K. BRCA2 Mutations Associated with Improved Survival for Ovarian Cancer. Presented at: American Association for Cancer Research 102nd Annual Meeting; April 2-6, 2011; Orlando, FL. [Abstract 2752].
    • Bolton, K.1
  • 40
    • 79959838081 scopus 로고    scopus 로고
    • Integrated genomic analyses of ovarian carcinoma
    • Cancer Genome Atlas Research Network
    • Integrated genomic analyses of ovarian carcinoma. Nature 2011, 474:609-615. Cancer Genome Atlas Research Network.
    • (2011) Nature , vol.474 , pp. 609-615
  • 41
    • 80053950209 scopus 로고    scopus 로고
    • Association of BRCA1 and BRCA2 mutations with survival, chemotherapy sensitivity, and gene mutator phenotype in patients with ovarian cancer
    • Yang D., Khan S., Sun Y., et al. Association of BRCA1 and BRCA2 mutations with survival, chemotherapy sensitivity, and gene mutator phenotype in patients with ovarian cancer. JAMA 2011, 306:1557-1565.
    • (2011) JAMA , vol.306 , pp. 1557-1565
    • Yang, D.1    Khan, S.2    Sun, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.