Curcumin-loaded γ-cyclodextrin liposomal nanoparticles as delivery vehicles for osteosarcoma

Nanomedicine: Nanotechnology, Biology, and Medicine

Volumn 8, Issue 4, 2012, Pages 440-451

  Dhule, Santosh S ^a,b   Penfornis, Patrice ^b   Frazier, Trivia ^b   Walker, Ryan ^b   Feldman, Joshua ^b   Tan, Grace ^a   He, Jibao ^c   Alb, Alina ^a   John, Vijay ^a   Pochampally, Radhika ^b  

^a Tulane University   (United States)

^b TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c TULANE UNIVERSITY   (United States)

Author keywords

Apoptosis; Autophagy; Curcumin; Cyclodextrin; Liposome; Osteosarcoma

Indexed keywords

ANTICANCER DRUG; ANTICANCER POTENTIALS; APOPTOTIC CELL DEATH; AUTOPHAGIC CELLS; AUTOPHAGY; BREAST CANCER; CANCER MODELS; CASPASES; CELL LINES; CURCUMIN; DELIVERY ROUTES; DELIVERY VEHICLE; IN-VITRO; IN-VIVO; MCF-7 BREAST CANCER CELLS; OSTEOSARCOMA;

CELL CULTURE; CYCLODEXTRINS; DISEASES; LIPOSOMES; NANOPARTICLES; PHOSPHOLIPIDS; TISSUE;

CELL DEATH;

ANTINEOPLASTIC AGENT; CURCUMIN; GAMMA CYCLODEXTRIN; LIPOSOME;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG FORMULATION; ENCAPSULATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; OSTEOSARCOMA;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CASPASES; CELL LINE, TUMOR; CURCUMIN; FEMALE; GAMMA-CYCLODEXTRINS; HUMANS; LIPOSOMES; MICE; MICE, NUDE; NEOPLASM PROTEINS; NEOPLASM TRANSPLANTATION; OSTEOSARCOMA; TRANSPLANTATION, HETEROLOGOUS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84860229695     PISSN: 15499634     EISSN: 15499642     Source Type: Journal    
DOI: 10.1016/j.nano.2011.07.011     Document Type: Article

References (50)

1. Shishodia S., Chaturvedi M.M., Aggarwal B.B. Role of curcumin in cancer therapy. Curr Probl Cancer 2007, 31:243-305.
2. Ravindran J., Prasad S., Aggarwal B. Curcumin and cancer cells: how many ways can curry kill tumor cells selectively?. The AAPS J 2009, 11:495-510.
3. Ghoneim A. Effects of curcumin on ethanol-induced hepatocyte necrosis and apoptosis: implication of lipid peroxidation and cytochrome c. Naunyn-Schmiedeberg's Arch Pharmacol 2009, 379:47-60.
4. Kunwar A., Barik A., Mishra B., Rathinasamy K., Pandey R., Priyadarsini K.I. Quantitative cellular uptake, localization and cytotoxicity of curcumin in normal and tumor cells. Biochim Biophys Acta (G) 2008, 1780:673-679.
5. Kaminaga Y., Nagatsu A., Akiyama T., Sugimoto N., Yamazaki T., Maitani T., et al. Production of unnatural glucosides of curcumin with drastically enhanced water solubility by cell suspension cultures of catharanthus roseus. FEBS Lett 2003, 555:311-316.
6. Priyadarsini K.I. Photophysics, photochemistry and photobiology of curcumin: Studies from organic solutions, bio-mimetics and living cells. J Photochem Photobiol C: Photochemistry Reviews 2009, 10:81-95.
7. Lan L., Fadi S.B., Razelle K. Liposome-encapsulated curcumin. Cancer 2005, 104:1322-1331.
8. Wang D., Veena M.S., Stevenson K., Tang C., Ho B., Suh J.D., et al. Liposome-encapsulated curcumin suppresses growth of head and neck squamous cell carcinoma in vitro and in xenografts through the inhibition of nuclear factor κb by an akt-independent pathway. Clin Cancer Res 2008, 14:6228-6236.
9. Li L., Ahmed B., Mehta K., Kurzrock R. Liposomal curcumin with and without oxaliplatin: Effects on cell growth, apoptosis, and angiogenesis in colorectal cancer. Mol Cancer Ther 2007, 6:1276-1282.
10. Kunwar A., Barik A., Pandey R., Priyadarsini K.I. Transport of liposomal and albumin loaded curcumin to living cells: an absorption and fluorescence spectroscopic study. Biochim Biophys Acta (G) 2006, 1760:1513-1520.
11. Hamre M.R., Severson R.K., Chuba P., Lucas D.R., Thomas R.L., Mott M.P. Osteosarcoma as a second malignant neoplasm. Radiother Oncol 2002, 65:153-157.
12. Lisa M., Rebecca J.T., Sharon A.S. International osteosarcoma incidence patterns in children and adolescents, middle ages and elderly persons. Int J Cancer 2009, 125:229-234.
13. Walters D., Muff R., Langsam B., Born W., Fuchs B. Cytotoxic effects of curcumin on osteosarcoma cell lines. Inves New Drugs 2008, 26:289-297.
14. Mccormack B., Gregoriadis G. Drugs-in-cyclodextrins-in liposomes: A novel concept in drug delivery. Int J Pharm 1994, 112:249-258.
15. Loukas Y.L., Vraka V., Gregoriadis G. Drugs, in cyclodextrins, in liposomes: A novel approach to the chemical stability of drugs sensitive to hydrolysis. Int J Pharm 1998, 162:137-142.
16. Perrault S.D., Walkey C., Jennings T., Fischer H.C., Chan W.C. Mediating tumor targeting efficiency of nanoparticles through design. Nano Lett 2009, 9:1909-1915.
17. DeComas A.M., Penfornis P., Harris M.R., Meyer M.S., Pochampally R.R. Derivation and characterization of an extra-axial chordoma cell line (each-1) from a scapular tumor. J Bone Joint Surg Am 2010, 92:1231-1240.
18. Thangapazham R.L., Puri A., Tele S., Blumenthal R., Maheshwari R.K. Evaluation of a nanotechnology based carrier for delivery of curcumin in prostate cancer cells. Int J Oncol 2008, 32:1119-1123.
19. Tønnesen H.H., Másson M., Loftsson T. Studies of curcumin and curcuminoids. Xxvii. Cyclodextrin complexation: solubility, chemical and photochemical stability. Int J Pharm 2002, 244:127-135.
20. Xu P., Tan G., Zhou J., He J., Lawson L.B., McPherson G.L., et al. Undulating tubular liposomes through incorporation of a synthetic skin ceramide into phospholipid bilayers. Langmuir 2009, 25:10422-10425.
21. Chithrani D.B., Dunne M., Stewart J., Allen C., Jaffray D.A. Cellular uptake and transport of gold nanoparticles incorporated in a liposomal carrier. Nanomedicine 2010, 6:161-169.
22. Maestrelli F., González-Rodríguez M.L., Rabasco A.M., Mura P. Preparation and characterisation of liposomes encapsulating ketoprofen-cyclodextrin complexes for transdermal drug delivery. Int J Pharm 2005, 298:55-67.
23. Shaikh J., Ankola D.D., Beniwal V., Singh D., Kumar M.N. Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer. Eur J Pharm Sci 2009, 37:223-230.
24. Lal A., Pan Y., Navarro F., Dykxhoorn D.M., Moreau L., Meire E., et al. Mir-24-mediated downregulation of h2ax suppresses DNA repair in terminally differentiated blood cells. Nat Struct Mol Biol 2009, 16:492-498.
25. Selassie C.D., Kapur S., Verma R.P., Rosario M. Cellular apoptosis and cytotoxicity of phenolic compounds: a quantitative structure-activity relationship study. J Med Chem 2005, 48:7234-7242.
26. Shin H.C., Alani A.W., Rao D.A., Rockich N.C., Kwon G.S. Multi-drug loaded polymeric micelles for simultaneous delivery of poorly soluble anticancer drugs. J Control Release 2009, 140:294-300.
27. Gregorc A., Ellis J.D. Cell death localization in situ in laboratory reared honey bee (Apis mellifera L.) larvae treated with pesticides. Pest Biochem Physiol 2011, 99:200-207.
28. Singh R., Tønnesen H., Vogensen S., Loftsson T., Másson M. Studies of curcumin and curcuminoids. The stoichiometry and complexation constants of cyclodextrin complexes as determined by the phase-solubility method and uv-vis titration. J Incl Phenom Macrocycl Chem 2010, 66:335-348.
29. Moreno-Sánchez R., Rodríguez-Enríquez S., Marín-Hernández A., Saavedra E. Energy metabolism in tumor cells. FEBS J 2007, 274:1393-1418.
30. Lane J.D., Allan V.J., Woodman P.G. Active relocation of chromatin and endoplasmic reticulum into blebs in late apoptotic cells. J Cell Sci 2005, 118:4059-4071.
31. Darzynkiewicz Z., Galkowski D., Zhao H. Analysis of apoptosis by cytometry using tunel assay. Methods 2008, 44:250-254.
32. Li Z., Chen B., Wu Y., Jin F., Xia Y., Liu X. Genetic and epigenetic silencing of the beclin 1 gene in sporadic breast tumors. BMC Cancer 2010, 10:98.
33. Matas D., Juknat A., Pietr M., Klin Y., Vogel Z. Anandamide protects from low serum-induced apoptosis via its degradation to ethanolamine. J Biol Chem 2007, 282:7885-7892.
34. Bressenot A., Marchal S., Bezdetnaya L., Garrier J., Guillemin F., Plenat F. Assessment of apoptosis by immunohistochemistry to active caspase-3, active caspase-7, or cleaved parp in monolayer cells and spheroid and subcutaneous xenografts of human carcinoma. J Histochem Cytochem 2009, 57:289-300.
35. Carter R., Sykes V., Lanning D. Scarless fetal mouse wound healing may initiate apoptosis through caspase 7 and cleavage of PARP. J Surg Res 2009, 156:74-79.
36. Lubbad A., Oriowo M., Khan I. Curcumin attenuates inflammation through inhibition of TLR-4 receptor in experimental colitis. Mol Cell Biochem 2009, 322:127-135.
37. Wongcharoen W., Phrommintikul A. The protective role of curcumin in cardiovascular diseases. Int J Cardiol 2009, 133(2):145-151.
38. Kumar A., Ahuja A., Ali J., Baboota S. Conundrum and therapeutic potential of curcumin in drug delivery. Crit Rev Ther Drug Carrier Syst 2010, 27:279-312.
39. Piel G., Piette M., Barillaro V., Castagne D., Evrard B., Delattre L. Betamethasone-in-cyclodextrin-in-liposome: the effect of cyclodextrins on encapsulation efficiency and release kinetics. Int J Pharm 2006, 312:75-82.
40. Loukas Y.L., Jayasekera P., Gregoriadis G. Characterization and photoprotection studies of a model gamma-cyclodextrin included photolabile drug entrapped in liposomes incorporating light absorbers. J Phys Chem 1995, 99:11035-11040.
41. Holzer M., Barnert S., Momm J., Schubert R. Preparative size exclusion chromatography combined with detergent removal as a versatile tool to prepare unilamellar and spherical liposomes of highly uniform size distribution. J Chromatogra A 2009, 1216:5838-5848.
42. Crawford R., Dogdas B., Keough E., Haas R.M., Wepukhulu W., Krotzer S., et al. Analysis of lipid nanoparticles by Cryo-EM for characterizing siRNA delivery vehicles. Int J Pharm 2011, 403(1-2):237-244.
43. Daleke D.L., Hong K., Papahadjopoulos D. Endocytosis of liposomes by macrophages: Binding, acidification and leakage of liposomes monitored by a new fluorescence assay. Biochim Biophys Acta Biomembr 1990, 1024:352-366.
44. Hegge A.B., Schuller R.B., Kristensen S., Tonnesen H.H. In vitro release of curcumin from vehicles containing alginate and cyclodextrin. Studies of curcumin and curcuminoides. Pharmazie 2008, 63:585-592.
45. Rasheed A., Ashok Kumar C.K., Sravanthi V.V.N.S.S. Cyclodextrins as drug carrier molecule: a review. Sci Pharm 2008, 76:567-598.
46. Shao Y., Gao Z., Marks P.A., Jiang X. Apoptotic and autophagic cell death induced by histone deacetylase inhibitors. PNAS U S A 2004, 101:18030-18035.
47. Hippert M.M., O'Toole P.S., Thorburn A. Autophagy in cancer: good, bad, or both?. Cancer Res 2006, 66:9349-9351.
48. Gozuacik D., Kimchi A. Autophagy as a cell death and tumor suppressor mechanism. Oncogene 2004, 23:2891-2906.
49. Aoki H., Takada Y., Kondo S., Sawaya R., Aggarwal B.B., Kondo Y. Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathways. Mol Pharmacol 2007, 72:29-39.
50. ClinicalTrials.gov. US National Institutes of Health. Available from: Accessed August 31, 2011. http://www.clinicaltrials.gov/ct2/results?term=curcumin.