Comparison of extraction procedures for benzodiazepines determination in hair by LC-MS/MS

Forensic Science International

Volumn 218, Issue 1-3, 2012, Pages 53-56

  Morini, Luca ^a   Vignali, Claudia ^a   Polla, Marina ^a   Sponta, Andrea ^a   Groppi, Angelo ^a  

^a UNIVERSITY OF PAVIA   (Italy)

Author keywords

Benzodiazepines; Direct injection; Hair; Hypnotics; LC MS MS

Indexed keywords

BENZODIAZEPINE; DICHLORODIFLUOROMETHANE; DRUG METABOLITE; ETHER; METHANOL; ORGANIC SOLVENT; PHOSPHATE BUFFERED SALINE;

ACCURACY; ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG HAIR LEVEL; DRUG USE; HAIR ANALYSIS; HUMAN; HUMAN TISSUE; INTERMETHOD COMPARISON; LIMIT OF DETECTION; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MASS SPECTROMETRY; PRIORITY JOURNAL; PROCESS DEVELOPMENT; SENSITIVITY AND SPECIFICITY; ULTRASOUND; VALIDATION PROCESS;

EID: 84860227920     PISSN: 03790738     EISSN: 18726283     Source Type: Journal    
DOI: 10.1016/j.forsciint.2011.10.013     Document Type: Article

References (10)

1. Xiang P., Sun Q., Shen B., Chen P., Liu W., Shen M. Segmental hair analysis using liquid chromatography-tandem mass spectrometry after a single dose of benzodiazepines. Forensic Sci. Int. 2011, 204:19-26.
2. Villain M., Concheiro M., Cirimele V., Kintz P. Screening method for benzodiazepines and hypnotics in hair at pg/mg level by liquid chromatography-mass spectrometry/mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2005, 825:72-78.
3. Laloup M., Fernandez Mdel M., De Boeck G., Wood M., Maes V., Samyn N. Validation of a liquid chromatography-tandem mass spectrometry method for the simultaneous determination of 26 benzodiazepines and metabolites, zolpidem and zopiclone, in blood, urine, and hair. J. Anal. Toxicol. 2005, 29:616-626.
4. Vogliardi S., Favretto D., Tucci M., Stocchero G., Ferrara S.D. Simultaneous LC-HRMS determination of 28 benzodiazepines and metabolites in hair. Anal. Bioanal. Chem. 2011, 400:51-67.
5. Kim J., Lee S., In S., Choi H., Chung H. Validation of a simultaneous analytical method for the detection of 27 benzodiazepines and metabolites and zolpidem in hair using LC-MS/MS and its application to human and rat hair. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2011, [Epub ahead of print].
6. Villain M., Chèze M., Dumestre V., Ludes B., Kintz P. Hair to document drug-facilitated crimes: four cases involving bromazepam. J. Anal. Toxicol. 2004, 28:516-519.
7. Kintz P., Villain M., Cirimele V. Chemical abuse in the elderly: evidence from hair analysis. Ther. Drug Monit. 2008, 30:207-211.
8. Kintz P., Villain M., Dumestre-Toulet V., Ludes B. Drug-facilitated sexual assault and analytical toxicology: the role of LC-MS/MS A case involving zolpidem. Clin. Forensic Med. 2005, 12:36-41.
9. Kintz P., Villain M., Chèze M., Pépin G. Identification of alprazolam in hair in two cases of drug-facilitated incidents. Forensic Sci. Int. 2005, 29:222-226.
10. Concheiro M., Villain M., Bouchet S., Ludes B., López-Rivadulla M., Kintz P. Windows of detection of tetrazepam in urine, oral fluid, beard, and hair, with a special focus on drug-facilitated crimes. Ther. Drug Monit. 2005, 27:565-570.