Validation of a simultaneous analytical method for the detection of 27 benzodiazepines and metabolites and zolpidem in hair using LC-MS/MS and its application to human and rat hair

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 879, Issue 13-14, 2011, Pages 878-886

  Kim, Jihyun ^a   Lee, Sooyeun ^a   In, Sanghwan ^a   Choi, Hwakyung ^a   Chung, Heesun ^a  

^a National Forensic Service   (South Korea)

Author keywords

Benzodiazepines; Drug abuse; Drug facilitated crime; Hair analysis; LC MS MS

Indexed keywords

BENZODIAZEPINES; DRUG ABUSE; DRUG FACILITATED CRIME; HAIR ANALYSIS; LC-MS/MS;

BIOMOLECULES; CRIME; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; METHANOL;

METABOLITES;

7 AMINO 1,3 DIHYDRO 5 PHENYL 2H 1,4 BENZODIAZEPIN 2 ONE; 7 AMINOCLONAZEPAM; 7 AMINOFLUNITRAZEPAM; ALPRAZOLAM; BENZODIAZEPINE DERIVATIVE; BROMAZEPAM; CHLORDIAZEPOXIDE; CLOBAZAM; CLONAZEPAM; CLOTIAZEPAM; DEALKYLFLURAZEPAM; DIAZEPAM; DRUG METABOLITE; ESTAZOLAM; FLUNITRAZEPAM; FLURAZEPAM; HYDROXYALPRAZOLAM; HYDROXYMIDAZOLAM; HYDROXYTRIAZOLAM; LORAZEPAM; LORMETAZEPAM; MEDAZEPAM; MIDAZOLAM; NITRAZEPAM; NORDAZEPAM; OXAZEPAM; PRAZEPAM; TEMAZEPAM; TRIAZOLAM; UNCLASSIFIED DRUG; ZOLPIDEM;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG HAIR LEVEL; HAIR ANALYSIS; HAIR COLOR; HUMAN; LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

ADULT; AGED; ANIMALS; BENZODIAZEPINES; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; FEMALE; HAIR; HUMANS; MALE; MIDDLE AGED; PIGMENTATION; PYRIDINES; RATS; RATS, ZUCKER; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; STREET DRUGS; TANDEM MASS SPECTROMETRY;

ANIMALIA; RATTUS;

EID: 79953317405     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.02.038     Document Type: Article

References (18)

1. Drummer O.H. The Forensic Pharmacology of Drugs of Abuse 2001, Arnold, London.
2. Pragst F., Balikova M.A. Clin. Chim. Acta 2006, 370:17.
3. Sun Q., Xiang P., Shen B., Yan H., Shen M. J. Anal. Toxicol. 2010, 34:89.
4. Laloup M., Fernandez Mdel M., Wood M., Maes V., De Boeck G., Vanbeckevoort Y., Samyn N. Anal. Bioanal. Chem. 2007, 388:1545.
5. Miller E.I., Wylie F.M., Oliver J.S. J. Anal. Toxicol. 2006, 30:441.
6. Laloup M., Ramirez Fernandez Mdel M., De Boeck G., Wood M., Maes V., Samyn N. J. Anal. Toxicol. 2005, 29:616.
7. Scott K.S., Nakahara Y. Forensic Sci. Int. 2003, 23:47.
8. Staikos V., Beyer J., Gerostamoulos D., Drummer O.H. Poster Presentation, 47th Annual Meeting of the International Association of Forensic Toxicologists 2009.
9. Peters F.T., Drummer O.H., Musshoff F. Forensic Sci. Int. 2007, 165:216.
10. Matuszewski B.K., Constanzer M.L., Chavez-Eng C.M. Anal. Chem. 2003, 75:3019.
11. S. Lee, E. Han, S. In, H. Choi, H. Chung, K.H. Chung, J. Anal. Toxicol., accepted on 26 Dec 2010.
12. Xiang P., Sun Q., Shen B., Chen P., Liu W., Shen M. Forensic Sci. Int. 2011, 204:19.
13. Stout P.R., Ruth J.A. Drug Metab. Dispos. 1999, 27:731.
14. Rollins D.E., Wilkins D.G., Krueger G.G., Augsburger M.P., Mizuno A., O'Neal C., Borges C.R., Slawson M.H. J. Anal. Toxicol. 2003, 27:545.
15. Borges C.R., Wilkins D.G., Rollins D.E. J. Anal. Toxicol. 2001, 25:221.
16. Scheidweiler K.B., Cone E.J., Moolchan E.T., Huestis M.A. J. Pharmacol. Exp. Ther. 2005, 313:909.
17. Hubbard D.L., Wilkins D.G., Rollins D.E. Drug Metab. Dispos. 2000, 28:1464.
18. Gygi S.P., Wilkins D.G., Rollins D.E. J. Pharm. Sci. 1997, 86:209.