Cellular prion protein mediates toxic signaling of amyloid beta

Neurodegenerative Diseases

Volumn 10, Issue 1-4, 2012, Pages 298-300

  Resenberger, Ulrike K ^a   Winklhofer, Konstanze F ^a,b   Tatzelt, Jörg ^a,b  

^a UNIVERSITY OF MUNICH   (Germany)

^b GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

Author keywords

Sheet; Alzheimer's disease; Intrinsically disordered N terminal domain of PrP C; N methyl D aspartate; Neurodegeneration; Prion

Indexed keywords

AMYLOID BETA PROTEIN; PRION PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BETA SHEET; CELL CULTURE; HETEROLOGOUS EXPRESSION; MOUSE; NERVE CELL; NEUROTOXICITY; NONHUMAN; PATHOPHYSIOLOGY; PRION DISEASE; PRIORITY JOURNAL; PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

AMYLOID BETA-PEPTIDES; ANIMALS; HUMANS; MICE; MICE, TRANSGENIC; PRIONS; PROTEIN CONFORMATION; SIGNAL TRANSDUCTION;

EID: 84860225557     PISSN: 16602854     EISSN: 16602862     Source Type: Journal    
DOI: 10.1159/000332596     Document Type: Article

References (22)

1. Büeler H, Aguzzi A, Sailer A, Greiner R-A, Autenried P, Aguet M, Weissmann C: Mice devoid of PrP are resistant to scrapie. Cell 1993; 73: 1339-1347.
2. Brandner S, Isenmann S, Raeber A, Fischer M, Sailer A, Kobayashi Y, Marino S, Weissmann C, Aguzzi A: Normal host prion protein necessary for scrapie-induced neurotoxicity. Nature 1996; 379: 339-343.
3. Mallucci G, Dickinson A, Linehan J, Klohn PC, Brandner S, Collinge J: Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis. Science 2003; 302: 871-874.
4. Chesebro B, Trifilo M, Race R, Meade-White K, Teng C, LaCasse R, Raymond L, Favara C, Baron G, Priola S, Caughey B, Masliah E, Oldstone M: Anchorless prion protein results in infectious amyloid disease without clinical scrapie. Science 2005; 308: 1435-1439.
5. Rambold AS, Müller V, Ron U, Ben-Tal N, Winklhofer KF, Tatzelt J: Stress-protective activity of prion protein is corrupted by scrapie- prions. EMBO J 2008; 27: 1974-1984.
6. Scott MR, Safar J, Telling G, Nguyen O, Groth D, Torchia M, Koehler R, Tremblay P, Walther D, Cohen FE, DeArmond SJ, Prusiner SB: Identification of a prion protein epitope modulating transmission of bovine spongiform encephalopathy prions to transgenic mice. Proc Natl Acad Sci USA 1997; 94: 14279-14284.
7. Scott M, Foster D, Mirenda C, Serban D, Coufal F, Walchli M, Torchia M, Groth D, Carlson G, DeArmond SJ, Westaway D, Prusiner SB: Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques. Cell 1989; 59: 847-857.
8. Resenberger UK, Harmeier A, Woerner AC, Goodman JL, Muller V, Krishnan R, Vabulas RM, Kretzschmar HA, Lindquist S, Hartl FU, Multhaup G, Winklhofer KF, Tatzelt J: The cellular prion protein mediates neurotoxic signalling of beta-sheet-rich conformers independent of prion replication. EMBO J 2011; 30: 2057-2070.
9. Resenberger UK, Winklhofer KF, Tatzelt J: Neuroprotective and neurotoxic signaling by the prion protein. Top Curr Chem 2011; 305: 101-119.
10. Lauren J, Gimbel DA, Nygaard HB, Gilbert JW, Strittmatter SM: Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers. Nature 2009; 457: 1128-1132.
11. Gimbel DA, Nygaard HB, Coffey EE, Gunther EC, Lauren J, Gimbel ZA, Strittmatter SM: Memory impairment in transgenic Alzheimer mice requires cellular prion protein. J Neurosci 2010; 30: 6367-6374.
12. Balducci C, Beeg M, Stravalaci M, Bastone A, Sclip A, Biasini E, Tapella L, Colombo L, Manzoni C, Borsello T, Chiesa R, Gobbi M, Salmona M, Forloni G: Synthetic amyloidbeta oligomers impair long-term memory independently of cellular prion protein. Proc Natl Acad Sci USA 2010; 107: 2295-2300.
13. Calella AM, Farinelli M, Nuvolone M, Mirante O, Moos R, Falsig J, Mansuy IM, Aguzzi A: Prion protein and Abeta-related synaptic toxicity impairment. EMBO Mol Med 2010; 2: 306-314.
14. Kessels HW, Nguyen LN, Nabavi S, Malinow R: The prion protein as a receptor for amyloid- beta. Nature 2010; 466:E3-E4; discussion E4-E5.
15. Chung E, Ji Y, Sun Y, Kascsak RJ, Kascsak RB, Mehta PD, Strittmatter SM, Wisniewski T: Anti-PrPC monoclonal antibody infusion as a novel treatment for cognitive deficits in an Alzheimer's disease model mouse. BMC Neurosci 2010; 11: 130.
16. Caetano FA, Beraldo FH, Hajj GN, Guimaraes AL, Jurgensen S, Wasilewska-Sampaio AP, Hirata PH, Souza I, Machado CF, Wong DY, De Felice FG, Ferreira ST, Prado VF, Rylett RJ, Martins VR, Prado MA: Amyloidbeta oligomers increase the localization of prion protein at the cell surface. J Neurochem 2011; 117: 538-553.
17. Barry AE, Klyubin I, McDonald JM, Mably AJ, Farrell MA, Scott M, Walsh DM, Rowan MJ: Alzheimer's disease brain-derived amyloid-3β -mediated inhibition of LTP in vivo is prevented by immunotargeting cellular prion protein. J Neurosci 2011; 31: 7259-7263.
18. Freir DB, Nicoll AJ, Klyubin I, Panico S, Mc Donald JM, Risse E, Asante EA, Farrow MA, Sessions RB, Saibil HR, Clarke AR, Rowan MJ, Walsh DM, Collinge J: Interaction between prion protein and toxic amyloid beta assemblies can be therapeutically targeted at multiple sites. Nat Commun 2011; 2: 336.
19. Li L, Lindquist S: Creating a protein-based element of inheritance. Science 2000; 287: 661-664.
20. Olzscha H, Schermann SM, Woerner AC, Pinkert S, Hecht MH, Tartaglia GG, Vendruscolo M, Hayer-Hartl M, Hartl FU, Vabulas RM: Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions. Cell 2011; 144: 67-78.
21. Chen S, Yadav SP, Surewicz WK: Interaction between human prion protein and amyloidbeta (Abeta) oligomers: role of N-terminal residues. J Biol Chem 2010; 285: 26377-26383.
22. Mouillet-Richard S, Ermonval M, Chebassier C, Laplanche JL, Lehmann S, Launay JM, Kellermann O: Signal transduction through prion protein. Science 2000; 289: 1925-1928.