Clearance of amyloid-β protein deposits in transgenic mice following focal cerebral ischemia

Neurodegenerative Diseases

Volumn 10, Issue 1-4, 2012, Pages 108-111

  Van Nostrand, W E ^a,b   Davis, J ^a   Previti, M L ^a   Xu, F ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

Alzheimer's disease; Amyloid protein; Clearance; Ischemia; Transgenic mice

Indexed keywords

AMYLOID BETA PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CELL INFILTRATION; CLEARANCE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HEMISPHERE; IMAGE ANALYSIS; MACROPHAGE; MICROGLIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE;

AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BRAIN ISCHEMIA; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FUNCTIONAL LATERALITY; HUMANS; MACROPHAGES; MICE; MICE, TRANSGENIC; MICROGLIA; MUTATION; TIME FACTORS;

EID: 84860214043     PISSN: 16602854     EISSN: 16602862     Source Type: Journal    
DOI: 10.1159/000334763     Document Type: Article

References (8)

1. Hardy J, Selkoe DJ: The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002; 297: 353-356.
2. Jendroska K, Poewe W, Daniel SE, Pluess J, Iwessen-Schmidt H, Paulsen J, Barthel S, Schelosky L, Cervos-Navarro J, DeArmond SJ: Ischemic stress induces deposition of amyloidβ immunoreactivity in human brain. Acta Neuropathol 1995; 90: 461-466.
3. Pierce JE, Trojanowski JQ, Graham DI, Smith DH, McIntosh TK: Immunohistochemical characterization of alterations in the distribution of amyloid precursor proteins and beta-amyloid peptide after experimental brain injury in the rat. J Neurosci 1996; 16: 1083-1090.
4. van Groen T, Puurunen K, Maki H-M, Sivenius J, Jolkkonen J: Transformation of diffuse3β 42-amyloid precursor protein and3β 42-amyloid deposits to plaques in the thalamus following transient occlusion of the middle cerebral artery in rats. Stroke 2005; 36: 1551-1556.
5. Sadowski M, Pankiewicz J, Scholtzovva H, Li YS, Quartermain D, Duff K, Wisniewski T: Links between the pathology of Alzheimer's disease and vascular dementia. Neurochem Res 2004; 29: 1257-1266.
6. Davis J, Xu F, Deane R, Romanov G, Previti ML, Zeigler K, Zlokovic BV, Van Nostrand WE: Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor. J Biol Chem 2004; 279: 20296-20306.
7. Miao J, Xu F, Davis J, Otte-Holler I, Verbeek MM, Van Nostrand WE: Cerebral microvascular amyloid beta protein deposition induces vascular degeneration and neuroinflammation in transgenic mice expressing human vasculotropic mutant amyloid beta precursor protein. Am J Pathol 2005; 167: 505-515.
8. Lee J-K, Park M-S, Kim Y-S, Moon K-S, Joo S-P, Kim T-S, Kim S-H: Photochemically induced cerebral ischemia in a mouse model. Surg Neurol 2007; 67: 620-625.