The T788G mutation in the cyp51C gene confers voriconazole resistance in Aspergillus flavus causing aspergillosis

Antimicrobial Agents and Chemotherapy

Volumn 56, Issue 5, 2012, Pages 2598-2603

  Liu, Wei ^a   Sun, Yi ^a   Chen, Wei ^a   Liu, Weixia ^a   Wan, Zhe ^a   Bu, Dingfang ^a   Li, Ruoyu ^a  

^a PEKING UNIVERSITY FIRST HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; ISOENZYME; ITRACONAZOLE; PROTEIN CYP51C; STEROL 14ALPHA DEMETHYLASE; UNCLASSIFIED DRUG; VORICONAZOLE;

ACUTE GRANULOCYTIC LEUKEMIA; ADOLESCENT; AMINO ACID SUBSTITUTION; ANTIFUNGAL RESISTANCE; ANTIFUNGAL SUSCEPTIBILITY; ARTICLE; ASPERGILLOSIS; ASPERGILLUS FLAVUS; CASE REPORT; CONTROLLED STUDY; FEMALE; FUNGAL GENE; GENE MUTATION; GENE SEQUENCE; GENE TARGETING; HUMAN; MISSENSE MUTATION; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RHIZOBIUM RADIOBACTER; SITE DIRECTED MUTAGENESIS; STAPHYLOCOCCUS INFECTION;

ADOLESCENT; AGROBACTERIUM TUMEFACIENS; AMINO ACID SUBSTITUTION; ANTIFUNGAL AGENTS; ASPERGILLOSIS; ASPERGILLUS FLAVUS; CYTOCHROME P-450 ENZYME SYSTEM; DRUG RESISTANCE, FUNGAL; FEMALE; FUNGAL PROTEINS; GENE TRANSFER TECHNIQUES; HUMANS; LUNG; MICROBIAL SENSITIVITY TESTS; MUTAGENESIS, SITE-DIRECTED; MUTATION; PLASMIDS; PYRIMIDINES; SEQUENCE ANALYSIS, DNA; TRIAZOLES;

EID: 84860197333     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.05477-11     Document Type: Article

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