Extra copies of the Aspergillus fumigatus squalene epoxidase gene confer resistance to terbinafine: Genetic approach to studying gene dose-dependent resistance to antifungals in A. fumigatus

Antimicrobial Agents and Chemotherapy

Volumn 48, Issue 7, 2004, Pages 2490-2496

  Liu, Wei ^a   May, Gregory S ^a   Lionakis, Michail S ^a   Lewis, Russell E ^a,b   Kontoyiannis, Dimitrios P ^a,b  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF HOUSTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; ANTIFUNGAL AGENT; CASPOFUNGIN; FUNGAL DNA; GENOMIC DNA; ITRACONAZOLE; SQUALENE MONOOXYGENASE; TERBINAFINE; VORICONAZOLE;

ARTICLE; ASPERGILLOSIS; ASPERGILLUS FUMIGATUS; CULTURE MEDIUM; DNA LIBRARY; DNA SEQUENCE; DRUG RESISTANCE; DRUG TARGETING; ERG1 GENE; FUNGAL GENE; FUNGUS GROWTH; GENE AMPLIFICATION; GENE DOSAGE; GENE FUNCTION; GENE IDENTIFICATION; GENE VECTOR; GENETIC CODE; GENETIC TRANSFORMATION; HIGH RISK PATIENT; MOLECULAR CLONING; MOLECULAR GENETICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN TARGETING; PROTOPLAST; PYR 4 GENE; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; ANTIFUNGAL AGENTS; ASPERGILLUS FUMIGATUS; CLONING, MOLECULAR; CULTURE MEDIA; DNA FRAGMENTATION; DRUG RESISTANCE, FUNGAL; GENE DOSAGE; GENE LIBRARY; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; NAPHTHALENES; OXYGENASES; PLASMIDS; PROTOPLASTS; SQUALENE MONOOXYGENASE; TRANSFORMATION, GENETIC;

EID: 3042678033     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.48.7.2490-2496.2004     Document Type: Article

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