Microparticle formation after co-culture of human whole blood and umbilical artery in a novel in vitro model of flow

Cytometry Part A

Volumn 81 A, Issue 5, 2012, Pages 390-399

  Holtom, Emma ^a   Usherwood, James R ^a   Macey, Marion G ^b   Lawson, Charlotte ^a  

^a ROYAL VETERINARY COLLEGE   (United Kingdom)

^b ROYAL LONDON HOSPITAL   (United Kingdom)

Author keywords

Endothelium; Flow; Leukocytes; Microparticles; Red blood cells

Indexed keywords

REACTIVE OXYGEN METABOLITE;

ADULT; ARTICLE; COCULTURE; CYTOLOGY; ENDOTHELIUM; ENDOTHELIUM CELL; ERYTHROCYTE; FEMALE; FLOW CYTOMETRY; HUMAN; INFLAMMATION; LEUKOCYTE; MEMBRANE MICROPARTICLE; METABOLISM; PATHOLOGY; UMBILICAL ARTERY;

ADULT; CELL-DERIVED MICROPARTICLES; COCULTURE TECHNIQUES; ENDOTHELIAL CELLS; ENDOTHELIUM; ERYTHROCYTES; FEMALE; FLOW CYTOMETRY; HUMANS; INFLAMMATION; LEUKOCYTES; REACTIVE OXYGEN SPECIES; UMBILICAL ARTERIES;

EID: 84859988732     PISSN: 15524922     EISSN: 15524930     Source Type: Journal    
DOI: 10.1002/cyto.a.22010     Document Type: Article

References (57)

1. British Heart Foundation Deaths by cause, sex and age, 2008, United Kingdom; 2010 p [Accessed 17 Aug 2011].
2. Ross R. Atherosclerosis-An inflammatory disease. N Engl J Med 1999; 340: 115-126.
3. Libby P, Ridker PM, Hansson GK. Inflammation in atherosclerosis: From pathophysiology to practice. J Am Coll Cardiol 2009; 54: 2129-2138.
4. Jennings LK. Role of platelets in atherothrombosis. Am J Cardiol 2009; 103: 4A-10A.
5. Baumgartner HR, Haudenschild C. Adhesion of platelets to subendothelium. Ann NY Acad Sci 1972; 201: 22-36.
6. Gimbrone MAJr, Topper JN, Nagel T, Anderson KR, Garcia-Cardena G. Endothelial dysfunction, hemodynamic forces, and atherogenesis. Ann NY Acad Sci 2000; 902: 230-239; discussion 239-240.
7. Resnick N, Yahav H, Shay-Salit A, Shushy M, Schubert S, Zilberman LC, Wofovitz E. Fluid shear stress and the vascular endothelium: For better and for worse. Prog Biophys Mol Biol 2003; 81: 177-199.
8. Traub O, Berk BC. Laminar shear stress: mechanisms by which endothelial cells transduce an atheroprotective force. Arterioscler Thromb Vasc Biol 1998; 18: 677-685.
9. Frangos JA, Eskin SG, McIntire LV, Ives CL. Flow effects on prostacyclin production by cultured human endothelial cells. Science 1985; 227: 1477-1479.
10. Rainger GE, Rowley AF, Nash GB. Adhesion-dependent release of elastase from human neutrophils in a novel, flow-based model: specificity of different chemotactic agents. Blood 1998; 92: 4819-4827.
11. Blackman BR, Garcia-Cardena G, Gimbrone MAJr. A new in vitro model to evaluate differential responses of endothelial cells to simulated arterial shear stress waveforms. J Biomech Eng 2002; 124: 397-407.
12. Peng X, Recchia FA, Byrne BJ, Wittstein IS, Ziegelstein RC, Kass DA. In vitro system to study realistic pulsatile flow and stretch signaling in cultured vascular cells. Am J Physiol Cell Physiol 2000; 279: C797-C805.
13. Zhao S, Suciu A, Ziegler T, Moore JEJr, Burki E, Meister JJ, Brunner HR. Synergistic effects of fluid shear stress and cyclic circumferential stretch on vascular endothelial cell morphology and cytoskeleton. Arterioscler Thromb Vasc Biol 1995; 15: 1781-1786.
14. Farcas MA, Rouleau L, Fraser R, Leask RL. The development of 3-D, in vitro, endothelial culture models for the study of coronary artery disease. Biomed Eng Online 2009; 8:30.
15. Conklin BS, Surowiec SM, Lin PH, Chen C. A simple physiologic pulsatile perfusion system for the study of intact vascular tissue. Med Eng Phys 2000; 22: 441-449.
16. Surowiec SM, Conklin BS, Li JS, Lin PH, Weiss VJ, Lumsden AB, Chen C. A new perfusion culture system used to study human vein. J Surg Res 2000; 88: 34-41.
17. Amirak E, Zakkar M, Evans PC, Kemp PR. Perfusion of veins at arterial pressure increases the expression of KLF5 and cell cycle genes in smooth muscle cells. Biochem Biophys Res Commun 2011; 391: 818-823.
18. Macey MG, Wolf SI, Lawson C. Microparticle formation after exposure of blood to activated endothelium under flow. Cytometry Part A 2010; 77A: 761-768.
19. Macey MG, Wolf SI, Wheeler-Jones CP, Lawson C. Expression of blood coagulation factors on monocytes after exposure to TNF-treated endothelium in a novel whole blood model of arterial flow. J Immunol Methods 2009; 350: 133-141.
20. Cocucci E, Racchetti G, Meldolesi J. Shedding microvesicles: Artefacts no more. Trends Cell Biol 2009; 19: 43-51.
21. Heijnen HF, Schiel AE, Fijnheer R, Geuze HJ, Sixma JJ. Activated platelets release two types of membrane vesicles: Microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and alpha-granules. Blood 1999; 94: 3791-3799.
22. Murakami T, Horigome H, Tanaka K, Nakata Y, Ohkawara K, Katayama Y, Matsui A. Impact of weight reduction on production of platelet-derived microparticles and fibrinolytic parameters in obesity. Thromb Res 2007; 119: 45-53.
23. Agouni A, Lagrue-Lak-Hal AH, Ducluzeau PH, Mostefai HA, Draunet-Busson C, Leftheriotis G, Heymes C, Martinez MC, Andriantsitohaina R. Endothelial dysfunction caused by circulating microparticles from patients with metabolic syndrome. Am J Pathol 2008; 173: 1210-1219.
24. Chironi GN, Boulanger CM, Simon A, Dignat-George F, Freyssinet JM, Tedgui A. Endothelial microparticles in diseases. Cell Tissue Res 2009; 335: 143-151.
25. Halicka HD, Bedner E, Darzynkiewicz Z. Segregation of RNA and separate packaging of DNA and RNA in apoptotic bodies during apoptosis. Exp Cell Res 2000; 260: 248-256.
26. Boulanger CM, Dignat-George F. Microparticles: an introduction. Arterioscler Thromb Vasc Biol 2011; 31: 2-3.
27. Tushuizen ME, Diamant M, Sturk A, Nieuwland R. Cell-derived microparticles in the pathogenesis of cardiovascular disease: Friend or foe? Arterioscler Thromb Vasc Biol 2011; 31: 4-9.
28. Tilley RE, Holscher T, Belani R, Nieva J, Mackman N. Tissue factor activity is increased in a combined platelet and microparticle sample from cancer patients. Thromb Res 2008; 122: 604-609.
29. Trappenburg MC, van Schilfgaarde M, Marchetti M, Spronk HM, ten Cate H, Leyte A, Terpstra WE, Falanga A. Elevated procoagulant microparticles expressing endothelial and platelet markers in essential thrombocythemia. Haematologica 2009; 94: 911-918.
30. Leroyer AS, Tedgui A, Boulanger CM. Role of microparticles in atherothrombosis. J Intern Med 2008; 263: 528-537.
31. Morel O, Toti F, Morel N, Freyssinet JM. Microparticles in endothelial cell and vascular homeostasis: Are they really noxious? Haematologica 2009; 94: 313-317.
32. Macey M, Azam U, McCarthy D, Webb L, Chapman ES, Okrongly D, Zelmanovic D, Newland A. Evaluation of the anticoagulants EDTA and citrate, theophylline, adenosine, and dipyridamole (CTAD) for assessing platelet activation on the ADVIA 120 hematology system. Clin Chem 2002; 48: 891-899.
33. Macey M, McCarthy D, Azam U, Milne T, Golledge P, Newland A. Ethylenediaminetetraacetic acid plus citrate-theophylline-adenosine-dipyridamole (EDTA-CTAD): A novel anticoagulant for the flow cytometric assessment of platelet and neutrophil activation ex vivo in whole blood. Cytometry Part B 2003; 51B: 30-40.
34. Macey MG, Enniks N, Bevan S. Flow cytometric analysis of microparticle phenotype and their role in thrombin generation. Cytometry Part B 2011; 80B: 57-63.
35. McCarthy DA, Macey MG, Allen PD. A simple, novel, procedure for monitoring membrane scrambling and permeability in microparticles, platelets, and leukocytes in whole blood samples. Exp Hematol 2008; 36: 909-921.
36. Lawson C, Ainsworth M, Yacoub M, Rose M. Ligation of ICAM-1 on endothelial cells leads to expression of VCAM-1 via a nuclear factor-kappaB-independent mechanism. J Immunol 1999; 162: 2990-2996.
37. Macey MG, McCarthy DA, Vordermeier S, Newland AC, Brown KA. Effects of cell purification methods on CD11b and L-selectin expression as well as the adherence and activation of leucocytes. J Immunol Methods 1995; 181: 211-219.
38. Shiraga M, Tomiyama Y, Honda S, Suzuki H, Kosugi S, Tadokoro S, Kanakura Y, Tanoue K, Kurata Y, Matsuzawa Y. Involvement of Na+/Ca2+ exchanger in inside-out signaling through the platelet integrin IIbbeta3. Blood 1998; 92: 3710-3720.
39. Linden MD, Jackson DE. Platelets: Pleiotropic roles in atherogenesis and atherothrombosis. Int J Biochem Cell Biol 2010; 42: 1762-1766.
40. Belting M, Dorrell MI, Sandgren S, Aguilar E, Ahamed J, Dorfleutner A, Carmeliet P, Mueller BM, Friedlander M, Ruf W. Regulation of angiogenesis by tissue factor cytoplasmic domain signaling. Nat Med 2004; 10: 502-509.
41. Rao LV, Pendurthi UR. Tissue factor-factor VIIa signaling. Arterioscler Thromb Vasc Biol 2005; 25: 47-56.
42. Xu H, Ploplis VA, Castellino FJ. A coagulation factor VII deficiency protects against acute inflammatory responses in mice. J Pathol 2006; 210: 488-496.
43. McVey JH. Tissue factor pathway. Baillieres Clin Haematol 1994; 7: 469-484.
44. Blum A. The possible role of red blood cell microvesicles in atherosclerosis. Eur J Intern Med 2009; 20: 101-105.
45. Nagy E, Eaton JW, Jeney V, Soares MP, Varga Z, Galajda Z, Szentmiklosi J, Mehes G, Csonka T, Smith A, et al. Red cells, hemoglobin, heme, iron, and atherogenesis. Arterioscler Thromb Vasc Biol 2010; 30: 1347-1353.
46. Tziakas DN, Chalikias GK, Stakos D, Boudoulas H. The role of red blood cells in the progression and instability of atherosclerotic plaque. Int J Cardiol 2009; 142: 2-7.
47. Amabile N, Rautou PE, Tedgui A, Boulanger CM. Microparticles: Key protagonists in cardiovascular disorders. Semin Thromb Hemost 2010; 36: 907-916.
48. Boulanger CM. Microparticles, vascular function and hypertension. Curr Opin Nephrol Hypertens 2010; 19: 177-180.
49. Galkina E, Ley K. Immune and inflammatory mechanisms of atherosclerosis (*). Annu Rev Immunol 2009; 27: 165-197.
50. Bedard K, Krause KH. The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology. Physiol Rev 2007; 87: 245-313.
51. Janiszewski M, Do Carmo AO, Pedro MA, Silva E, Knobel E, Laurindo FR. Platelet-derived exosomes of septic individuals possess proapoptotic NAD(P)H oxidase activity: A novel vascular redox pathway. Crit Care Med 2004; 32: 818-825.
52. Lo SC, Hung CY, Lin DT, Peng HC, Huang TF. Involvement of platelet glycoprotein Ib in platelet microparticle mediated neutrophil activation. J Biomed Sci 2006; 13: 787-796.
53. Jank H, Salzer U. Vesicles generated during storage of red blood cells enhance the generation of radical oxygen species in activated neutrophils. ScientificWorldJournal 2011; 11: 173-185.
54. Perez-Casal M, Downey C, Cutillas-Moreno B, Zuzel M, Fukudome K, Toh CH. Microparticle-associated endothelial protein C receptor and the induction of cytoprotective and anti-inflammatory effects. Haematologica 2009; 94: 387-394.
55. Perez-Casal M, Downey C, Fukudome K, Marx G, Toh CH. Activated protein C induces the release of microparticle-associated endothelial protein C receptor. Blood 2005; 105: 1515-1522.
56. Lacroix R, Sabatier F, Mialhe A, Basire A, Pannell R, Borghi H, Robert S, Lamy E, Plawinski L, Camoin-Jau L, et al. Activation of plasminogen into plasmin at the surface of endothelial microparticles: A mechanism that modulates angiogenic properties of endothelial progenitor cells in vitro. Blood 2007; 110: 2432-2439.
57. Agouni A, Mostefai HA, Porro C, Carusio N, Favre J, Richard V, Henrion D, Martinez MC, Andriantsitohaina R. Sonic hedgehog carried by microparticles corrects endothelial injury through nitric oxide release. FASEB J 2007; 21: 2735-2741.