Linking women who test HIV-positive in pregnancy-related services to long-term HIV care and treatment services: A systematic review

Tropical Medicine and International Health

Volumn 17, Issue 5, 2012, Pages 564-580

  Ferguson, Laura ^a,b   Grant, Alison D ^a   Watson Jones, Deborah ^a,c   Kahawita, Tanya ^a   Ong'ech, John O ^b,d   Ross, David A ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b UNIVERSITY OF NAIROBI   (Kenya)

^c National Institute for Medical Research   (Tanzania)

^d ELIZABETH GLASER PEDIATRIC AIDS FOUNDATION   (United States)

Author keywords

Antiretroviral therapy; Developing countries; Female; HIV infections; Patient dropouts

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CD4 ANTIGEN;

BIBLIOGRAPHY; DEVELOPING WORLD; DISEASE TRANSMISSION; DISEASE TREATMENT; HEALTH CARE; HUMAN IMMUNODEFICIENCY VIRUS; INFECTIVITY; LITERATURE REVIEW; PREGNANCY; WOMENS HEALTH;

ARTICLE; HEALTH CARE ACCESS; HEALTH CARE PERSONNEL; HEALTH CARE SYSTEM; HEALTH SERVICE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HIV TEST; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INCOME; LONG TERM CARE; PREGNANCY; SOUTH AFRICA; SYSTEMATIC REVIEW; VERTICAL TRANSMISSION;

AFRICA SOUTH OF THE SAHARA; ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; FEMALE; HEALTH SERVICES ACCESSIBILITY; HIV INFECTIONS; HIV SEROPOSITIVITY; HUMANS; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; LONG-TERM CARE; PATIENT ACCEPTANCE OF HEALTH CARE; PATIENT DROPOUTS; PRECONCEPTION CARE; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS;

SUB-SAHARAN AFRICA;

EID: 84859986796     PISSN: 13602276     EISSN: 13653156     Source Type: Journal    
DOI: 10.1111/j.1365-3156.2012.02958.x     Document Type: Article

References (45)

1. Abrams EJ, Myer L, Rosenfield A & El-Sadr WM (2007) Prevention of mother-to-child transmission services as a gateway to family-based human immunodeficiency virus care and treatment in resource-limited settings: rationale and international experiences. American Journal of Obstetrics & Gynecology 197, S101-S106.
2. Balira R (2010) Implementation of Prevention of Mother-to-Child Transmission of HIV and Maternal Syphilis Screening and Treatment Programmes in Mwanza Region, Tanzania: Uptake and Challenges. Department of Clinical Research, London School of Hygiene & Tropical Medicine, London.
3. Berman P, Kendall C & Bhattacharyya K (1994) The household production of health: integrating social science perspectives on micro-level health determinants. Social Science & Medicine 38, 5-215.
4. Betancourt TS, Abrams EJ, Mcbain R & Fawzi MCS (2010) Family-centred approaches to the prevention of mother to child transmission of HIV. Journal of the International AIDS Society 13(Suppl 2), S2.
5. Black V, Brooke S & Chersich MF (2009) Effect of human immunodeficiency virus treatment on maternal mortality at a tertiary center in South Africa: a 5-year audit. Obstetrics and Gynecology 114, 292-299.
6. Chen JY, Ogwu AC, Svab P et al. (2010) Antiretroviral treatment initiation among HIV-infected pregnant women with low CD4(+) cell counts in Gaborone, Botswana. Journal of Acquired Immune Deficiency Syndromes: JAIDS 54, 102-106.
7. Chi BH, Chintu N, Lee A, Stringer EM, Sinkala M & Stringer AJS (2007) Expanded services for the prevention of mother-to-child HIV transmission: field acceptability of a pilot program in Lusaka, Zambia. Journal of Acquired Immune Deficiency Syndromes 45, 125-127.
8. Chinkonde JR, Sundby J & Martinson F (2009) The prevention of mother-to-child HIV transmission programme in Lilongwe, Malawi: why do so many women drop out. Reproductive Health Matters 17, 143-151.
9. Delva W, Draper B & Temmerman M (2006) Implementation of single-dose nevirapine for prevention of MTCT of HIV - lessons from Cape Town. South African Medical Journal 96, 706-710.
10. Duff P, Kipp W, Wild TC et al. (2010) Barriers to accessing highly active antiretroviral therapy by HIV-positive women attending an antenatal clinic in a regional hospital in western Uganda. Journal of the International AIDS Society 13, 37.
11. Geddes R, Knight S, Esterhuizen T, Reid S, Giddy J & Roberts C (2008) Prevention of mother-to-child transmission of HIV programme: low vertical transmission in KwaZulu-Natal, South Africa. SAMJ - South African Medical Journal 98, 458-462.
12. Ginsburg AS, Hoblitzelle CW, Sripipatana TL & Wilfert CM (2007) Provision of care following prevention of mother-to-child HIV transmission services in resource-limited settings. AIDS 21, 2529-2532.
13. Gruskin S, Ahmed S & Ferguson L (2008) Provider-initiated HIV testing and counseling in health facilities - What does this mean for the health and human rights of pregnant women? Developing World Bioethics 8, 23-32.
14. Horwood C, Haskins L, Vermaak K, Phakathi S, Subbaye R & Doherty T (2010) Prevention of mother to child transmission of HIV (PMTCT) programme in KwaZulu-Natal, South Africa: an evaluation of PMTCT implementation and integration into routine maternal, child and women's health services. Tropical Medicine and International Health 15, 992-999.
15. Jani IV, Sitoe NE, Chongo PL et al. (2011) Accurate CD4 T-cell enumeration and antiretroviral drug toxicity monitoring in primary healthcare clinics using point-of-care testing. AIDS 25, 807-812.
16. Kilewo C, Karlsson K, Ngarina M et al. (2009) Prevention of mother-to-child transmission of HIV-1 through breastfeeding by treating mothers with triple antiretroviral therapy in Dar es Salaam, Tanzania: the Mitra Plus study. Journal of Acquired Immune Deficiency Syndromes: JAIDS 52, 406-416.
17. Killam WP, Tambatamba BC, Chintu N et al. (2010) Antiretroviral therapy in antenatal care to increase treatment initiation in HIV-infected pregnant women: a stepped-wedge evaluation. AIDS 24, 85-91.
18. Kouanda S, Tougri H, Cisse M et al. (2010) Impact of maternal HAART on the prevention of mother-to-child transmission of HIV: results of an 18-month follow-up study in Ouagadougou, Burkina Faso. AIDS care 22, 843-850.
19. Kranzer K, Zeinecker J, Ginsberg P et al. (2010) Linkage to HIV care and antiretroviral therapy in Cape Town, South Africa. PLoS One 5, e13801. DOI:
20. Levy JM (2009) Women's expectations of treatment and care after an antenatal HIV diagnosis in Lilongwe, Malawi. Reproductive Health Matters 17, 152-161.
21. Mandala J, Torpey K, Kasonde P et al. (2009) Prevention of mother-to-child transmission of HIV in Zambia: implementing efficacious ARV regimens in primary health centers. BMC Public Health 9, 314.
22. Medley A, Garcia-Moreno C, Mcgill S & Maman S (2004) Rates, barriers and outcomes of HIV serostatus disclosure among women in developing countries: implications for prevention of mother-to-child transmission programmes.[see comment]. Bulletin of the World Health Organization 82, 299-307.
23. Mermin J, Were W, Ekwaru JP et al. (2008) Mortality in HIV-infected Ugandan adults receiving antiretroviral treatment and survival of their HIV-uninfected children: a prospective cohort study. The Lancet 371, 752-759.
24. van der Merwe K, Chersich MF, Technau K, Umurungi Y, Conradie F & Coovadia A (2006) Integration of antiretroviral treatment within antenatal care in Gauteng Province, South Africa. Journal of Acquired Immune Deficiency Syndromes: JAIDS 43, 577-581.
25. Mtapuri-Zinyowera S, Chideme M, Mangwanya D et al. (2010) Evaluation of the PIMA point-of-care CD4 analyzer in VCT clinics in Zimbabwe. Journal of Acquired Immune Deficiency Syndromes: JAIDS 55, 1-7.
26. Muchedzi A, Chandisarewa W, Keatinge J, et al. (2010) Factors associated with access to HIV care and treatment in a prevention of mother to child transmission programme in urban Zimbabwe. Journal of the International AIDS Society 13, 38.
27. Myer L, Rabkin M, Abrams EJ, Rosenfield A & El-Sadr WM (2005) Focus on women: linking HIV care and treatment with reproductive health services in the MTCT-Plus Initiative. Reproductive Health Matters 13, 136-146.
28. Nakanjako D, Colebunders R, Coutinho AG & Kamya MR (2009) Strategies to optimize HIV treatment outcomes in resource-limited settings. AIDS Reviews 11, 179-189.
29. Nanda P (2002) Gender dimensions of user fees: implications for women's utilization of health care. Reproductive Health Matters 10, 8.
30. Newell M-L, Coovadia H, Cortina-Borja M, Rollins N, Gaillard P & Dabis F (2004) Mortality of infected and uninfected infants born to HIV-infected mothers in Africa: a pooled analysis. The Lancet 364, 1236-1243.
31. Otieno PA, Kohler PK, Bosire RK, Brown ER, Macharia SW & John-Stewart GC (2010) Determinants of failure to access care in mothers referred to HIV treatment programs in Nairobi, Kenya. AIDS Care 22, 729-736.
32. Pfeiffer J, Montoya P, Baptista AJ et al. (2010) Integration of HIV/AIDS services into African primary health care: lessons learned for health system strengthening in Mozambique - a case study. Journal of the International AIDS Society 13, 1-9.
33. Rabkin M, El-Sadr WM & Abrams EJ (2004) The Columbia Clinical Manual. International Center for AIDS Programs, Mailman School of Public Health, Columbia University, New York.
34. Rosen S & Fox MP (2011) Retention in HIV care between testing and treatment in Sub-Saharan Africa: a systematic review. PLoS Medicine/Public Library of Science 8, e1001056.
35. Shapiro R, Hughes M, Ogwu A et al. (2009) A Randomized Trial Comparing Highly Active Antiretroviral Therapy Regimens for Virologic Efficacy and the Prevention of Mother-to-Child Hiv Transmission Among Breastfeeding Women in Botswana (The Mma Bana Study). 5th IAS Conference on HIV Pathogenesis, Treatment and Prevention. Cape Town, South Africa.
36. Stinson K, Boulle A, Coetzee D, Abrams EJ & Myer L (2010) Initiation of highly active antiretroviral therapy among pregnant women in Cape Town, South Africa. Tropical Medicine & International Health 15, 825-832.
37. Taha T, Kumwenda J, Cole S et al. (2009) Effect of Maternal HAART on Postnatal HIV-1 Transmission after Cessation of Extended Infant Antiretroviral Prophylaxis. Sixteenth Conference on Retroviruses and Opportunistic Infections. Montreal, Canada.
38. The Kesho Bora Study Group (2011) Triple antiretroviral compared with zidovudine and single-dose nevirapine prophylaxis during pregnancy and breastfeeding for prevention of mother-to-child transmission of HIV-1 (Kesho Bora study): a randomised controlled trial. The Lancet Infectious Diseases 11, 171-80.
39. Thomas T, Masaba R, Ndivo R et al. (2008) Prevention of Mother-to-Child Transmission of HIV-1 among Breastfeeding Mothers Using HAART: the Kisumu Breastfeeding Study, Kisumu, Kenya 2003-2007. Conference on Retroviruses and Opportunistic Infections. Boston, USA.
40. Tonwe-Gold B, Ekouevi DK, Viho I et al. (2007) Antiretroviral treatment and prevention of peripartum and postnatal HIV transmission in West Africa: evaluation of a two-tiered approach. PLoS Medicine 4, e257.
41. Tonwe-Gold B, Ekouevi DK, Bosse CA et al. (2009) Implementing family-focused HIV care and treatment: the first 2years' experience of the mother-to-child transmission-plus program in Abidjan, Cote d'Ivoire. Tropical Medicine and International Health 14, 4-212.
42. Tudor Car L, Van-Velthoven MH, Brusamento S et al. (2011) Integrating prevention of mother-to-child HIV transmission (PMTCT) programmes with other health services for preventing HIV infection and improving HIV outcomes in developing countries. Cochrane Database of Systematic Reviews (6), CD008741. DOI:
43. UNAIDS (2010) Report on the Global AIDS Epidemic. UNAIDS, Geneva, Switzerland.
44. de Vincenzi I & Study Kesho Bora Group (2009) Triple Antiretroviral (ARV) Prophylaxis during Pregnancy and Breastfeeding Compared to Short-ARV Prophylaxis to Prevent Mother-to-Child Transmission of HIV-1 (MTCT): The Kesho Bora Randomized Controlled Clinical Trial in Five Sites in Burkina Faso, Kenya. Fifth IAS Conference on HIV Pathogenesis, Treatment and Prevention. Cape Town, South Africa.
45. Vlassoff C & Moreno CG (2002) Placing gender at the centre of health programming: challenges and limitations. Social Science & Medicine 54, 1713-1723.