Accurate CD4 T-cell enumeration and antiretroviral drug toxicity monitoring in primary healthcare clinics using point-of-care testing

AIDS

Volumn 25, Issue 6, 2011, Pages 807-812

  Jani, Ilesh V ^a   Sitoe, Nádia E ^a   Chongo, Patrina L ^a   Alfai, Eunice R ^a   Quevedo, Jorge I ^b   Tobaiwa, Ocean ^b   Lehe, Jonathan D ^b   Peter, Trevor F ^b  

^a INSTITUTO NACIONAL DE SAÚDE   (Mozambique)

^b CLINTON HEALTH ACCESS INITIATIVE   (United States)

Author keywords

antiretroviral therapy; CD4+ T cells; decentralized; laboratory monitoring; low resource; point of care; primary healthcare

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTIRETROVIRUS AGENT; ASPARTATE AMINOTRANSFERASE; HEMOGLOBIN;

ADOLESCENT; ADULT; AGED; ARTICLE; BLOOD SAMPLING; CAPILLARY BLOOD; CD4 LYMPHOCYTE COUNT; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DRUG MONITORING; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INTERMETHOD COMPARISON; LABORATORY TEST; MAJOR CLINICAL STUDY; MEDICAL INSTRUMENTATION; MOZAMBIQUE; NURSE; POINT OF CARE TESTING; PRIORITY JOURNAL; REPRODUCIBILITY; VENOUS BLOOD;

ADOLESCENT; ADULT; AGED; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4 LYMPHOCYTE COUNT; DRUG MONITORING; FEMALE; HIV INFECTIONS; HUMANS; MALE; MIDDLE AGED; MOZAMBIQUE; POINT-OF-CARE SYSTEMS; PRIMARY HEALTH CARE; YOUNG ADULT;

EID: 79953744214     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0b013e328344f424     Document Type: Article

References (19)

1. Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986; 1:307-310. (Pubitemid 16134762)
2. DART Trial Team. Routine versus clinically driven laboratory monitoring of HIV antiretroviral therapy in Africa (DART): a randomized noninferiority trial. Lancet 2010; 375:123-131.
3. Loubiere S, Boyer S, Protopopescu C, Bonono CR, Abega SC, Spire B, Moatti JP. Decentralization of HIV care in Cameroon: increased access to antiretroviral treatment and associated persistent barriers. Health Policy 2009; 92:165-173.
4. Fredlund VG, Nash J. How far should they walk? Increasing antiretroviral therapy access in a rural community in northern KwaZulu-Natal, South Africa. J Infect Dis 2007; 196 (Suppl. 3):S469-S473. (Pubitemid 351417240)
5. Wools-Kaloustian KK, Sidle JE, Selke HM, Vedanthan R, Kemboi EK, Boit LJ, et al. A model for extending antiretroviral care beyond the rural health centre. J Int AIDS Soc 2009; 12:22.
6. ChanAK,Mateyu G, Jahn A, Schouten E, Arora P, MlothaW,et al. Outcome assessment of decentralization of antiretroviral therapy provision in a rural district of Malawi using an integrated primary care model. Trop Med Int Health 2010; 15:90-97.
7. Fatti G, Grimwood A, Bock P. Better Antiretroviral Therapy Outcomes at Primary Healthcare Facilities: An Evaluation of Three Tiers of ART Services in Four South African Provinces. PLoS One 2010; 5:e12888.
8. Bedelu M, Ford N, Hilderbrand K, Reuter H. Implementing antiretroviral therapy in rural communities: the Lusikisiki model of decentralized HIV/AIDS care. J Infect Dis 2007; 196 (Suppl. 3):S464-S468. (Pubitemid 351417239)
9. Geng EH, Nash D, Kambugu A, Zhang Y, Braitstein P, Christopoulos KA, Muyindike W. Retention in care among HIV-infected patients in resource-limited settings: emerging insights and new directions. Curr HIV/AIDS Rep 2010; 7:234-244.
10. Boyer S, Eboko F, Camara M, Abé C, Nguini ME, Koulla-Shiro S, Moatti JP. Scaling up access to antiretroviral treatment for HIV infection: the impact of decentralization of healthcare delivery in Cameroon. AIDS 2010; 24:S5-S15.
11. UNAIDS. UNAIDS outlook report 2010. http://www.unaids.org/outlook/ Response.aspx. http://data.unaids.org/pub/Outlook/2010/20100713-outlook- specialsection-en.pdf. [Accessed 2 October 2010].
12. Miller CM, Ketlhapile M, Rybasack-Smith H, Rosen S. Why are antiretroviral treatment patients lost to follow-up? A qualitative study from South Africa. Trop Med Int Health 2010; 15(Suppl. 1):48-54.
13. Hardon AP, Akurut D, Comoro C, Ekezie C, Irunde HF, Gerrits T, et al. Hunger, waiting time and transport costs: time to confront challenges to ART adherence in Africa. AIDS Care 2007; 19:658-665. (Pubitemid 46763738)
14. World Health Organization. Antiretroviral therapy for HIV infection in adults and adolescents: recommendations for a public health approach: 2010 revision. Geneva: WHO Press; 2010. http://whqlibdoc.who.int/publications/2010/ 9789241599764-eng.pdf. [Accessed 22 December 2010]
15. Walensky RP, Wood R, Ciaranello AL, Paltiel AD, Lorenzana SB, Anglaret X, et al. Scaling up the 2010 World Health Organization HIV treatment guidelines in resource-limited settings: a model-based analysis. PLoS Med 2010; 7:e1000382.
16. Mandy F, Nicholson J, McDougal J, CDC. Guidelines for performing single-platform absolute CD4+ T-cell determinations with CD45 gating for persons infected with human immunodeficiency virus. Centers for Disease Control and Prevention. MMWR Recomm Rep 2003; 52 (RR-2):1-13.
17. Pattanapanyasat K, Shain H, Noulsri E, Lerdwana S, Thepthai C, Prasertsilpa V, et al. A multicenter evaluation of the panleucogating method and the use of generic monoclonal antibody reagents for CD4 enumeration in HIV-infected patients in Thailand. Cytometry B Clin Cytom 2005; 65:29-36. (Pubitemid 40617009)
18. Granade TC. Use of rapid HIV antibody testing for controlling the HIV pandemic. Expert Rev Anti Infect Ther 2005; 3:957-969. (Pubitemid 41782596)
19. Walsh A, Ndubani P, Simbaya J, Dicker P, Brugha R. Task sharing in Zambia: HIV service scale-up compounds the human resource crisis. BMC Health Serv Res 2010; 10:272.