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Angewandte Chemie - International Edition

Volumn 51, Issue 17, 2012, Pages 4171-4175

A glycosyltransferase inhibitor from a molecular fragment library simultaneously interferes with metal ion and substrate binding

(5) Jørgensen, Rene a Grimm, Lena Lisbeth b Sindhuwinata, Nora b Peters, Thomas b Palcic, Monica M a

a CARLSBERG LABORATORY (Denmark)

b UNIVERSITY OF LÜBECK (Germany)

Author keywords

glycosyltransferases; NMR spectroscopy; surface plasmon resonance; X ray crystallography

Indexed keywords

BINDING POCKETS; DONOR BINDING; GLYCOSYL TRANSFERASE; GLYCOSYLTRANSFERASES; HUMAN BLOODS; MOLECULAR FRAGMENTS; SUBSTRATE BINDING;

MANGANESE; MANGANESE COMPOUNDS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SURFACE PLASMON RESONANCE; X RAY CRYSTALLOGRAPHY;

METAL IONS;

BLOOD GROUP ANTIGEN; DIVALENT CATION; ENZYME INHIBITOR; GLYCOSYLTRANSFERASE; MANGANESE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; HUMAN; HYDROGEN BOND; MOLECULAR LIBRARY; PROTEIN BINDING; PROTEIN DOMAIN;

BLOOD GROUP ANTIGENS; CATALYTIC DOMAIN; CATIONS, DIVALENT; ENZYME INHIBITORS; GLYCOSYLTRANSFERASES; HUMANS; HYDROGEN BONDING; MANGANESE; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; SMALL MOLECULE LIBRARIES; SUBSTRATE SPECIFICITY;

EID: 84859982558 PISSN: 14337851 EISSN: 15213773 Source Type: Journal
DOI: 10.1002/anie.201108345 Document Type: Article

Times cited : (20)

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