A single point mutation reverses the donor specificity of human blood group B-synthesizing galactosyltransferase

Journal of Biological Chemistry

Volumn 278, Issue 14, 2003, Pages 12403-12405

  Marcus, Sandra L ^a   Polakowski, Robert ^a   Seto, Nina O L ^b   Leinala, Eeva ^c   Borisova, Svetlana ^c   Blancher, Antoine ^d   Roubinet, Francis ^d,e   Evans, Stephen V ^c   Palcic, Monica M ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^c UNIVERSITY OF OTTAWA   (Canada)

^d UNIVERSITÉ DE TOULOUSE   (France)

^e ETABLISSEMENT FRANÇAIS DU SANG   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; BIOSYNTHESIS; BLOOD; CRYSTAL STRUCTURE; GENES; MUTAGENESIS; X RAY DIFFRACTION ANALYSIS;

BLOOD GROUPS;

ENZYME KINETICS;

ALPHA 1,3 N ACETYLGALACTOSAMINYLTRANSFERASE; ALPHA1 3 GALACTOSYLTRANSFERASE; CARBOHYDRATE; GALACTOSYLTRANSFERASE; N ACETYLGALACTOSAMINE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE GALACTOSE; BLOOD GROUP SUBSTANCE ALPHA D GALACTOSYLTRANSFERASE; BLOOD-GROUP-SUBSTANCE ALPHA-D-GALACTOSYLTRANSFERASE; GALACTOSE; RECOMBINANT PROTEIN;

ALLELE; ARTICLE; BINDING AFFINITY; BLOOD GROUP A; BLOOD GROUP B; CELL SURFACE; CODON; CRYSTAL STRUCTURE; ENZYME SPECIFICITY; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; X RAY CRYSTALLOGRAPHY; X RAY DIFFRACTION; BLOOD DONOR; BLOOD GROUP ABO SYSTEM; CHEMISTRY; GENETICS; HUMAN; KINETICS; METABOLISM; PHENOTYPE; PROTEIN TERTIARY STRUCTURE;

ABO BLOOD-GROUP SYSTEM; ACETYLGALACTOSAMINE; BLOOD DONORS; GALACTOSE; GALACTOSYLTRANSFERASES; HUMANS; KINETICS; PHENOTYPE; POINT MUTATION; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; X-RAY DIFFRACTION;

EID: 0038146943     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M212002200     Document Type: Article

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