Pleiotropy of glycogen synthase kinase-3 inhibition by CHIR99021 promotes self-renewal of embryonic stem cells from refractory mouse strains

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Ye, Shoudong ^a   Tan, Li ^b   Yang, Rongqing ^a   Fang, Bo ^a   Qu, Su ^a   Schulze, Eric N ^c   Song, Houyan ^a   Ying, Qilong ^c   Li, Ping ^a  

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^b FUDAN UNIVERSITY   (China)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; BETA CATENIN; CHIR 99021; EPIDERMAL GROWTH FACTOR RECEPTOR; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; KRUPPEL LIKE FACTOR 4; LYMPHOID ENHANCER FACTOR 1; MYC PROTEIN; N (2,3 DIHYDROXYPROPOXY) 3,4 DIFLUORO 2 (2 FLUORO 4 IODOANILINO)BENZAMIDE; OCTAMER TRANSCRIPTION FACTOR 4; REX PROTEIN; T CELL FACTOR PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR TBX3; UNCLASSIFIED DRUG; UVOMORULIN; PYRIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ADHESION; CELL DIFFERENTIATION; CELL MEMBRANE; CELL RENEWAL; CELL STRUCTURE; CONTROLLED STUDY; CULTURE MEDIUM; ECTODERM; EMBRYONIC STEM CELL; ENZYME ACTIVITY; ENZYME INHIBITION; MOUSE; MOUSE STRAIN; NONHUMAN; PLEIOTROPY; PLURIPOTENT STEM CELL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CHEMISTRY; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; METABOLISM;

ANIMALS; BETA CATENIN; EMBRYONIC STEM CELLS; GLYCOGEN SYNTHASE KINASE 3; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; PROTO-ONCOGENE PROTEINS C-MYC; PYRIDINES; PYRIMIDINES; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TCF TRANSCRIPTION FACTORS;

EID: 84859940340     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0035892     Document Type: Article

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