Insights into the mechanism of the antibiotic-synthesizing enzyme MoeO5 from crystal structures of different complexes

Angewandte Chemie - International Edition

Volumn 51, Issue 17, 2012, Pages 4157-4160

  Ren, Feifei ^a   Ko, Tzu Ping ^b   Feng, Xinxin ^c   Huang, Chun Hsiang ^a   Chan, Hsiu Chien ^a   Hu, Yumei ^a   Wang, Ke ^c   Ma, Yanhe ^a   Liang, Po Huang ^b   Wang, Andrew H J ^b   Oldfield, Eric ^c   Guo, Rey Ting ^a  

^a Chinese Academy of Sciences   (China)

^b INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

biosynthesis; enzyme catalysis; prenyltransferases; protein folding; protein structures

Indexed keywords

3-PHOSPHOGLYCERATE; ENZYME CATALYSIS; FARNESYL PYROPHOSPHATES; PRENYLTRANSFERASES; PROTEIN STRUCTURES; X-RAY CRYSTALLOGRAPHIC STRUCTURES;

BIOCHEMISTRY; BIOSYNTHESIS; CATALYSIS; ENZYMES; PROTEIN FOLDING; X RAY CRYSTALLOGRAPHY;

SYNTHESIS (CHEMICAL);

ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; ENZYME;

ARTICLE; BINDING SITE; CHEMISTRY; CRYSTALLIZATION; ENZYME SPECIFICITY; METABOLISM; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BINDING SITES; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; ENZYMES; SUBSTRATE SPECIFICITY;

EID: 84859940094     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201108002     Document Type: Article

References (10)

1. B. Ostash, S. Walker, Nat. Prod. Rep. 2010, 27, 1594-1617.
2. B. Ostash, A. Saghatelian, S. Walker, Chem. Biol. 2007, 14, 257-267
3. B. Ostash, E. H. Doud, C. Lin, I. Ostash, D. L. Perlstein, S. Fuse, M. Wolpert, D. Kahne, Biochemistry 2009, 48, 8830-8841.
4. J. Payandeh, M. Fujihashi, W. Gillon, E. F. Pai, J. Biol. Chem. 2006, 281, 6070-6078.
5. E. H. Doud, D. L. Perlstein, M. Wolpert, D. E. Cane, S. Walker, J. Am. Chem. Soc. 2011, 133, 1270-1273.
6. H. Guldan, F. M. Matysik, M. Bocola, R. Sterner, P. Babinger, Angew. Chem. 2011, 123, 8338-8341
7. Angew. Chem. Int. Ed. 2011, 50, 8188-8191
8. J. Badger, J. M. Sauder, J. M. Adams, S. Antonysamy, K. Bain, M. G. Bergseid, S. G. Buchanan, M. D. Buchanan, Y. Batiyenko, J. A. Christopher, S. Emtage, A. Eroshkina, I. Feil, E. B. Furlong, K. S. Gajiwala, X. Gao, D. He, J. Hendle, A. Huber, K. Hoda, P. Kearins, C. Kissinger, B. Laubert, H. A. Lewis, J. Lin, K. Loomis, D. Lorimer, G. Louie, M. Maletic, C. D. Marsh, I. Miller, J. Molinari, H. J. Muller-Dieckmann, J. M. Newman, B. W. Noland, B. Pagarigan, F. Park, T. S. Peat, K. W. Post, S. Radojicic, A. Ramos, R. Romero, M. E. Rutter, W. E. Sanderson, K. D. Schwinn, J. Tresser, J. Winhoven, T. A. Wright, L. Wu, J. Xu, T. J. Harris, Proteins 2005, 60, 787-796.
9. R. T. Guo, T. P. Ko, A. P. Chen, C. J. Kuo, A. H. Wang, P. H. Liang, J. Biol. Chem. 2005, 280, 20762-20774
10. P. H. Liang, Biochemistry 2009, 48, 6562-6570.