Insulin-regulated aminopeptidase deficiency provides protection against ischemic stroke in mice

Journal of Neurotrauma

Volumn 29, Issue 6, 2012, Pages 1243-1248

  Pham, Vi ^a,b   Albiston, Anthony L ^a   Downes, Catherine E ^c   Wong, Connie H Y ^c,d   Diwakarla, Shanti ^a   Ng, Leelee ^a   Lee, Seyoung ^a,b   Crack, Peter J ^c   Chai, Siew Yeen ^a,b  

^a FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d UNIVERSITY OF CALGARY   (Canada)

Author keywords

Ang IV; cerebral ischemia; IRAP; middle cerebral artery occlusion

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN BLOOD FLOW; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CONTROLLED STUDY; GENE; GENE DELETION; INSULIN REGULATED AMINOPEPTIDASE GENE; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; REPERFUSION INJURY;

ANIMALS; BRAIN ISCHEMIA; CEREBROVASCULAR CIRCULATION; CYSTINYL AMINOPEPTIDASE; DISEASE MODELS, ANIMAL; FLUORESCENT ANTIBODY TECHNIQUE; LASER-DOPPLER FLOWMETRY; MALE; MICE; MICE, KNOCKOUT; STROKE;

EID: 84859904002     PISSN: 08977151     EISSN: 15579042     Source Type: Journal    
DOI: 10.1089/neu.2011.1824     Document Type: Article

References (20)

1. Albiston, A.L., Fernando, R.N., Yeatman, H.R., Burns, P., Ng, L., Daswani, D., Diwakarla, S., Pham, V., and Chai, S.Y. (2010). Gene knockout of insulin-regulated aminopeptidase: loss of the specific binding site for angiotensin IV and age-related deficit in spatial memory. Neurobiol. Learn. Mem. 93, 19-30.
2. Albiston, A.L., Morton, C.J., Ng, H.L., Pham, V., Yeatman, H.R., Ye, S., Fernando, R.N., De Bundel, D., Ascher, D.B., Mendelsohn, F.A., Parker M.W., and Chai, S.Y. (2008). Identification and characterization of a new cognitive enhancer based on inhibition of insulin-regulated aminopeptidase. FASEB J. 22, 4209-4217.
3. Albiston, A.L., Ye, S., and Chai, S.Y. (2004). Membrane bound members of the M1 family: more than aminopeptidases. Protein Pept. Lett. 11, 491-500. (Pubitemid 39197500)
4. Connolly, E.S., Jr., Winfree, C.J., Stern, D.M., Solomon, R.A., and Pinsky, D.J. (1996). Procedural and strain-related variables significantly affect outcome in a murine model of focal cerebral ischemia. Neurosurgery 38, 523-531; discussion 532.
5. Faure, S., Chapot, R., Tallet, D., Javellaud, J., Achard, J.M., and Oudart, N. (2006). Cerebroprotective effect of angiotensin IV in experimental ischemic stroke in the rat mediated by AT(4) receptors. J. Physiol. Pharmacol. 57, 329-342. (Pubitemid 44543870)
6. Fernando, R.N., Albiston, A.L., and Chai, S.Y. (2008). The insulin- regulated aminopeptidase IRAP is colocalised with GLUT4 in the mouse hippocampus-potential role in modulation of glucose uptake in neurones? Eur. J. Neurosci. 28, 588-598. (Pubitemid 352040410)
7. Fernando, R.N., Larm, J., Albiston, A.L., and Chai, S.Y. (2005). Distribution and cellular localization of insulin-regulated aminopeptidase in the rat central nervous system. J Comp Neurol 487, 372-390. (Pubitemid 40756877)
8. Jordens, I., Molle, D., Xiong, W., Keller, S.R., and McGraw, T.E. (2010). Insulin-regulated aminopeptidase is a key regulator of GLUT4 trafficking by controlling the sorting of GLUT4 from endosomes to specialized insulin-regulated vesicles. Mol. Biol. Cell 21, 2034-2044.
9. Keller, S.R., Scott, H.M., Mastick, C.C., Aebersold, R., and Lienhard, G.E. (1995). Cloning and characterization of a novel insulin-regulated membrane aminopeptidase from Glut4 vesicles. J. Biol. Chem. 270, 23,612-23,618.
10. Kramar, E.A., Krishnan, R., Harding, J.W., and Wright, J.W. (1998). Role of nitric oxide in angiotensin IV-induced increases in cerebral blood flow. Regul. Pept. 74, 185-192. (Pubitemid 28288981)
11. Magy, L., Vincent, F., Faure, S., Messerli, F.H., Wang, J.G., Achard, J.M., and Fournier, A. (2005). The renin-angiotensin systems: evolving pharmacological perspectives for cerebroprotection. Curr Pharm Des 11, 3275-3291. (Pubitemid 41300777)
12. Majid, A., He, Y.Y., Gidday, J.M., Kaplan, S.S., Gonzales, E.R., Park, T.S., Fenstermacher, J.D., Wei, L., Choi, D.W., and Hsu, C.Y. (2000). Differences in vulnerability to permanent focal cerebral ischemia among 3 common mouse strains. Stroke 31, 2707-2714.
13. Moeller, I., Clune, E.F., Fennessy, P.A., Bingley, J.A., Albiston, A.L., Mendelsohn, F.A., and Chai, S.Y. (1999). Up regulation of AT4 receptor levels in carotid arteries following balloon injury. Regul. Pept. 83, 25-30. (Pubitemid 29378362)
14. Naveri, L., Stromberg, C., and Saavedra, J.M. (1994). Angiotensin IV reverses the acute cerebral blood flow reduction after experimental subarachnoid hemorrhage in the rat. J. Cereb. Blood Flow Metab. 14, 1096-1099. (Pubitemid 24332956)
15. Numaguchi, Y., Ishii, M., Kubota, R., Morita, Y., Yamamoto, K., Matsushita, T., Okumura, K., and Murohara, T. (2009). Ablation of angiotensin IV receptor attenuates hypofibrinolysis via PAI-1 downregulation and reduces occlusive arterial thrombosis. Arterioscler. Thromb. Vasc. Biol. 29, 2102-2108.
16. Patel, J.M., Martens, J.R., Li, Y.D., Gelband, C.H., Raizada, M.K., and Block, E.R. (1998). Angiotensin IV receptor-mediated activation of lung endothelial NOS is associated with vasorelaxation. Am. J. Physiol. 275, L1061-1068.
17. Segura, E., Albiston, A.L., Wicks, I.P., Chai, S.Y., and Villadangos, J.A. (2009). Different cross-presentation pathways in steady-state and inflammatory dendritic cells. Proc. Natl. Acad. Sci. U. S. A. 106, 20,377-20,381.
18. Swanson, G.N., Hanesworth, J.M., Sardinia, M.F., Coleman, J.K., Wright, J.W., Hall, K.L., Miller-Wing, A.V., Stobb, J.W., Cook, V.I., Harding, E.C., and Harding, J.W. (1992). Discovery of a distinct binding site for angiotensin II (3-8), a putative angiotensin IV receptor. Regul. Pept. 40, 409-419.
19. Yamamoto, B.J., Elias, P.D., Masino, J.A., Hudson, B.D., McCoy, A.T., Anderson, Z.J., Varnum, M.D., Sardinia, M.F., Wright, J.W., and Harding, J.W. (2010). The angiotensin IV analog Nle- Tyr-Leu-psi-(CH2-NH2)3-4-His-Pro-Phe (norleual) can act as a hepatocyte growth factor/c-Met inhibitor. J. Pharmacol. Exp. Ther. 333, 161-173.
20. Yang, R., Walther, T., Gembardt, F., Smolders, I., Vanderheyden, P., Albiston, A.L., Chai, S.Y., and Dupont, A.G. (2010). Renal vasoconstrictor and pressor responses to angiotensin IV in mice are AT1a-receptor mediated. J. Hypertens. 28, 487-494.