Development and application of 15N-tracer substances for measuring the whole-body protein turnover rates in the human, especially in neonates: A review

Isotopes in Environmental and Health Studies

Volumn 48, Issue 2, 2012, Pages 239-258

  Wutzke, Klaus D ^a  

^a UNIVERSITY OF ROSTOCK   (Germany)

Author keywords

amino acids; glycine; human; isotope application in medicine; nitrogen 15; premature infants; stable isotope tracer technique; whole body protein turnover rates; yeast protein thermitase hydrolysate

Indexed keywords

ABSORPTION; AMINO ACID; MEDICINE; METABOLISM; NEONATE; NITROGEN ISOTOPE; PEPTIDE; PROTEIN; REACTION KINETICS; STABLE ISOTOPE; TRACER; YEAST;

AMINO ACID; DIAGNOSTIC AGENT; FUNGAL PROTEIN; NITROGEN; PROTEIN;

CHEMISTRY; FECES; HUMAN; KINETICS; METABOLISM; NEWBORN; PHYSIOLOGY; PREMATURITY; PROTEIN SYNTHESIS; REVIEW; URINE;

AMINO ACIDS; FECES; FUNGAL PROTEINS; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; KINETICS; NITROGEN; NITROGEN ISOTOPES; PROTEIN BIOSYNTHESIS; PROTEINS;

EID: 84859903859     PISSN: 10256016     EISSN: 14772639     Source Type: Journal    
DOI: 10.1080/10256016.2012.662971     Document Type: Review

References (88)

1. Schönheimer, R. 1942. "The Dynamic State of Body Constituents". 78Cambridge, MA: Harvard University Press.
2. Ratner, S., Rittenberg, D., Keston, A. S. and Schoenheimer, R. 1940. Studies in Protein Metabolism. XIV. The Chemical Interaction of Dietary Glycine and Body Proteins in Rats. J. Biol. Chem., 134: 665
3. 15N-markierter Tracersubstanzen in der pädiatrischen Ernährungsforschung". 47Germany: University of Rostock. Ph.D. thesis
4. 15N-Tracer Substance". In Recent Advances in Infant Feeding, Edited by: Koletzko, B., Okken, A., Rey, J., Salle, B. and Van Biervliet, J. P. 123-132. Stuttgart, New York, Germany: Georg Thieme.
5. Sharp, G. S., Lassen, S., Shankman, S., Hazlet, J. W. and Kendis, M. S. 1957. Studies of Protein Retention and Turnover Using Nitrogen-15 as a Tag. J. Nutr., 63: 155
6. Crane, C. W. and Neuberger, A. 1960. The Digestion and Absorption of Protein by Normal Man. Biochem. J., 74: 313
7. Waterlow, J. C., Garlick, P. J. and Millward, D. J. 1960. "Protein Turnover in Mammalian Tissues and in the Whole Body". 443-479. New York: North-Holland.
8. 14C]Leucine. Clin. Sci. Mol. Med., 53: 277
9. 15N. Clin. Sci., 68: 271
10. 15N]Arginine. Clin. Sci., 66: 337
11. 15N]-Wheat. Hum. Nutr. Clin. Nutr., 37C: 91
12. 15N-markiertes Hefeproteinhydrolysat als Tracer für Stoffwechseluntersuchungen. Isotopenpraxis, 23: 214
13. Simon, O., Bergner, H., Münchmeyer, R. and Zebrowska, T. 1972. Studies on the Range of Tissue Protein Synthesis in Pigs: the Effect of Thyroid Hormones. Br. J. Nutr., 48: 571
14. 15N-Studies in Severe Renal Failure. Scand. J. Clin. Lab. Invest., 30: 307
15. Bennet, W. M., Connacher, A. A., Jung, R. T., Stehle, P. and Rennie, M. J. 1991. Effects of Insulin and Amino Acids on Leg Protein Turnover in IDDM Patients. Diabetes, 40: 499
16. 15N-tracerkinetischen Bestimmung der Halbwertszeit des Gesamtkörperproteins bei frühgeborenen und reifgeborenen Säuglingen. Monatsschr. Kinderheilkd., 133: 291
17. 15N]-Hefeprotein beim Kurzdarmsyndrom. Monatsschr. Kinderheilkd., 137: 210
18. Hoffer, L. J., Yang, R. D., Matthews, D. E., Bistrian, B. R., Bier, D. M. and Young, V. R. 1985. Effects of Meal Consumption on Whole Body Leucine and Alanine Kinetics in Young Adult Men. Br. J. Nutr., 53: 31
19. 15N-Tracer Technique for the Differential Diagnosis of Dwarfism and Prediction of Growth Hormone Action in Children. J. Clin. Endocrinol. Metabol., 65: 74
20. De Benoist, B., Jackson, A. A., Hall, J. S.E. and Persaud, C. 1987. Whole-Body Protein Turnover in Jamaican Women During Normal Pregnancy. Hum. Nutr. Clin. Nutr., 39C: 167
21. Essen, P., Mc Nurlan, M. A., Wernerman, J., Vinnars, J. E. and Garlick, P. J. 1992. Uncomplicated Sugery, but not General Anesthesia, Decreases Muscle Protein Synthesis. Am. J. Physiol., 262: E253
22. Sprinson, D. B. and Rittenberg, D. 1949. The Rate of Interaction of Amino Acids of the Diet with the Tissue Proteins. J. Biol. Chem., 180: 715
23. San Pietro, A. and Rittenberg, D. 1953. A Study of the Rate of Protein Synthesis in Humans. II. Measurement of the Metabolic Pool and the Rate of Protein Synthesis. J. Biol. Chem., 201: 457
24. Picou, D. and Taylor-Roberts, T. 1969. The Measurement of Total Protein Synthesis and Catabolism and Nitrogen Turnover in Infants in Different Nutritional States and Receiving Different Amounts of Dietary Protein. Clin. Sci., 36: 283
25. Waterlow, J. C. 1981. "Methods of Measuring Protein Turnover". In Nitrogen Metabolism in Man, Edited by: Waterlow, J. C. and Stephen, J. M.L. 279-289. London: Applied Science Publishers.
26. 15N-Tracer Substances for Calculation of Whole Body Protein Parameters in Infants. J. Pediatr. Gastroenterol. Nutr., 2: 599
27. 15N]-Glycine. Hum. Nutr. Clin. Nutr., 37: 317
28. 15N Tracer Substances and Different Methods. Pediatr. Res., 31: 95
29. Bier, D. M. and Young, V. R. 1986. "Assessment of Whole-Body Protein-Nitrogen Kinetics in the Human Infant". In Energy and Protein Needs During Infancy, Edited by: Fomon, S. J. and Heird, W. C. 107-125. Orlando, FL: Academic Press.
30. 15N beim Menschen. I. Allgemeine Grundlagen. Isotopenpraxis, 14: 349
31. 15N-Tracertechnik in der Medizin. Isotopenpraxis, 20: 87
32. Fern, E. B., Garlick, P. J. and Waterlow, J. C. 1995. The Concept of the Single Body Pool of Metabolic Nitrogen in Determining the Rate of Whole-Body Nitrogen Turnover. Hum. Nutr. Clin. Nutr., 39C: 85
33. 15N-Aminosäuren, Patent WP DD 207 004, C 12 P 13/04".
34. 15N-markiertem Hefeprotein. Isotopenpraxis, 20: 90
35. 15N]Peptidgemischen, Patent WP DD 243 045 A1, C 12 P 13/0".
36. 13C. J. Pediatr. Gastroenterol. Nutr., 4: 9
37. 15N]Leucine and the Forearm Model. Eur. J. Clin. Invest., 15: 349
38. 15N]Lysine: Response in Healthy Young Men Given Excess Energy Intake. Metabolism, 30: 783
39. 18O Enrichment in Biological Fluids by Continuous Flow-Isotope Ratio Mass Spectrometry. Biomed. Environ. Mass Spectrom., 18: 543
40. De Lany, J. P., Schoeller, D. A. and Hoyt, R. W. 1989. Field Use of DO to Measure Energy Expenditure of Soldiers at Different Energy Intakes. J. Appl. Physiol., 67: 1922
41. 13C]Leucine Infused Simultaneously by Gut and Vein. Am. J. Physiol., 260: E111
42. 13C]Tyrosine in the Postabsorptive State. Metabolism, 31: 999
43. Nissim, I., Yudkoff, M., Pereira, G. and Segal, S. 1983. Effects of Conceptual Age and Dietary Intake on Protein Metabolism in Premature Infants. J. Pediatr. Gastroenterol. Nutr., 2: 507
44. 15N-Tracer Kinetic Studies on the Nitrogen Metabolism of Very Small Preterm Infants on a Diet of Mother's Milk. Hum. Nutr. Clin. Nutr., 39C: 399
45. 15N Yeast Protein Hydrolysate and of Human Milk-and Formula-Fed Babies. Pediatr. Res., 25: 167
46. 15N-Excretion Data to Estimate Whole-Body Protein Turnover". In Nitrogen Metabolism in Man, Edited by: Waterlow, J. C. and Stephen, J. M.L. 323-344. London: Applied Science Publishers.
47. 15N]Glycine. Clin. Sci., 61: 217
48. Matthews, D. E., Conway, J. M., Young Vr, V. R. and Bier, D. M. 1981. Glycine Nitrogen Metabolism in Man. Metabolism, 30: 886
49. Neuberger, A. 1981. "Pathways of Glycine Metabolism". In Nitrogen Metabolism in Man, Edited by: Waterlow, J. C. and Stephen, J. M.L. 253-261. London: Applied Science Publishers.
50. 15N]Glycine. Am. J. Physiol., 239: E294
51. 15N]Glycine. Hum. Nutr. Clin. Nutr., 38C: 63
52. Amir, J., Reisner, H. and Lapidot, A. 1980. Glycine Turnover Rates and Pool Sizes in Neonates as Determined by Gas Chromatography-Mass Spectrometry and Nitrogen-15. Pediatr. Res., 14: 1238
53. 15N]Glycine Metabolism in Normal Man: the Metabolic α -Amino-Nitrogen Pool. Clin. Sci., 58: 517
54. 15N-Glycine". In Nitrogen Metabolism in Man, Edited by: Waterlow, J. C. and Stephen, J. M.L. 357-359. London: Applied Science Publishers.
55. 15N-markiertem Hefeprotein. Isotopenpraxis, 21: 99
56. 15N Tracer Substances for Determining Whole-Body Protein Parameters in Very Small Preterm Infants. J. Pediatr. Gastroenterol. Nutr., 6: 400
57. 15N and Incorporation into Plasma Proteins after High-Dosage Puls Labelling with Various Tracer Substances in Infants. Hum. Nutr. Clin. Nutr., 41C: 431
58. Heine, W., Wutzke, K. D., Walther, F., Müller, M. and Friedrich, M. 1987. Eiweißstoffwechsel-und Fettbilanzen unter diätetischer Behandlung der akuten Säuglingsenteritis mit einer definierten, standardisierten Oligopeptid-Nahrung. Monatsschr. Kinderheilkd., 135: 99
59. 15N-Inkorporation in Organproteine neugeborener Ratten nach Pulsmarkierung mit verschiedenen Tracern. Arch. Tierernähr., 37: 551
60. 15N]Hefeprotein-Thermitase Hydrolysat. Isotopenpraxis, 28: 36
61. 15N-Glycine and Enrichment in Urinary Ammonia. Hum. Nutr. Clin. Nutr., 41C: 263
62. Wykes, L. J., Ball, R. O., Menendez, C. E., Ginther, D. M. and Pencharz, P. B. 1992. Glycine, Leucine, and Phenylalanine Flux in Low-Birth-Weight Infants During Parenteral and Enteral Feeding. Am. J. Clin. Nutr, 55: 971
63. Pencharz, P. B., Steffee, W. P., Cochran, W., Scrimshaw, N. S., Rand, W. M. and Young, V. R. 1977. Protein Metabolism in Human Neonates: Nitrogen-Balance Studies, Estimated Obligatory Losses of Nitrogen and Whole-Body Turnover of Nitrogen. Clin. Sci. Mol. Med., 52: 485
64. Pencharz, P. B., Parsons, H. G., Motil, K. J. and Duffy, B. J. 1981. Total Body Protein Turnover and Growth in Children: is it a Futile Cycle?. Med. Hypoth., 7: 155
65. Pencharz, P. B., Masson, M., Desgranges, F. and Papageorgiou, A. 1981. Total-Body Protein Turnover in Human Premature Neonates: Effects of Birth Weight, Intrauterine Nutritional Status and Diet. Clin. Sci., 61: 207
66. Jackson, A. A., Shaw, J. C., Barber, A. and Golden, M. H.N. 1981. Nitrogen Metabolism in Preterm Infants Fed Human Donor Breast Milk: the Possible Essentiality of Glycine. Pediatr. Res., 15: 1454
67. Faust, H., Bornhak, H., Hirschberg, K., Jung, K., Junghans, P., Krumbiegel, P. and Reinhard, R. 1981. "Klinisch-chemische und isotopenanalytische Methoden zur Untersuchung des Stickstoffstoffwechsels mit N-15 beim Menschen". In Methodenkatalog 1-210. edited by Akademie der Wissenschaften der DDR (ZfI-Mitteilungen, Vol. 36, Leipzig, Germany
68. Gerstenberger, H. and Meier, G. 1981. Die Stellung der Emissionsspektrometrie unter den nichtmassenspektrometrischen Methoden der Isotopenanalyse. Isotopenpraxis, 17: 150
69. Meier, G. and Mauersberger, K. 1982. NOI-6-ein neuer emissionsspektrometrischer Analysator. Isotopenpraxis, 18: 164
70. Barrie, A., Davies, J. E., Park, A. J. and Workmann, C. T. 1989. Continuous-Flow Stable Isotope Analysis for Biologists. Spectroscopy, 4: 42
71. Wutzke, K. D., Heine, W. E., Köster, D., Muscheites, J., Mix, M., Mohr, C., Popp, K. and Wigger, M. 2001. Metabolic Effects of HAY's Diet. Isot. Environ. Health Stud., 37: 227
72. Wutzke, K. D. and Lorenz, H. 2004. The Effect of L-Carnitine on Fat Oxidation, Protein Turnover and Body Composition in Slightly Overweight Subjects. Metabolism, 53: 1002
73. Wigger, M. and Wutzke, K. D. 2004. Whole-Body Protein Turnover in Nephrotic Subjects: a Comparison Between Different Degrees of Proteinuria. Isot. Environ. Health Stud., 40: 155
74. Wutzke, K. D., Krentz, H. and Bruns, G. 2011. Effect of Alcohol Consumption on Whole-Body Protein Turnover in Healthy Adults. Isot. Environ. Health Stud., 47: 26
75. 15N: Comparison of End Products and Dose Regimes. Am. J. Physiol., 235: E165
76. 15N End-Product Methods for the Study of Whole Body Protein Turnover. Proc. Nutr. Soc., 40: 317
77. Waterlow, J. C. and Jackson, A. A. 1981. Nutrition and Protein Turnover in Man. Br. Med. Bull., 37: 5
78. 15N After Administration of Isotopically Labelled Yeast Protein and Yeast Protein Hydrolysate to Adult Patients With Coeliac Disease. 2. Elimination of Isotope in the Urine and Faeces. Br. Med. J., 2: 888
79. Jackson, A. A. 1991. The Glycine Story. Eur. J. Clin. Nutr., 45: 59
80. Catzeflis, C., Schutz, Y., Micheli, J. L., Welsch, C., Arnaud, M. J. and Jequier, E. 1985. Whole Body Protein Synthesis and Energy Expenditure in Very Low Birth Weight Infants. Pediatr. Res., 19: 679
81. 13C]Leucine and Sampling of the Urinary Leucine Pool. Clin. Sci., 66: 155
82. 13C-Leucine and Energy Expenditure in Preterm Infants. Pediatr. Res., 28: 147
83. Steffee, W. O., Goldsmith, R. S., Pencharz, P. B., Scrimshaw, N. S. and Young, V. R. 1976. Dietary Protein Intake and Dynamic Aspects of Whole Body Nitrogen Metabolism in Adult Humans. Metabolism, 25: 281
84. 13C]Leucine. Am. J. Physiol., 238: E473
85. 15N Nucleic Acids in Children". In Nitrogen Metabolism in Man, Edited by: Waterlow, J. C. and Stephen, J. M.L. 269-273. London: Applied Science Publishers.
86. 13C]Leucine. Am. J. Clin. Nutr., 50: 1395
87. 15N-Tracer Studies in Formula-Fed Preterm Infants: the Role of Glycine Supply on Protein Turnover. J. Pediatr. Gastroenterol. Nutr., 23: 287
88. Young, V. R., El-Khoury, A. E., Sanchez, M. and Castillo, L. 1994. "The Biochemistry and Physiology of Protein and Amino Acid Metabolism With Reference to Protein Nutrition". In Protein Metabolism During Infancy, Nestlé Nutrition Workshop Series Edited by: Räihä, N. C.R. Vol. 33, 1-28. New York, Vevey, U.S: Nestec, Raven Press.