The treatment of glioblastoma multiforme through activation of microglia and TRAIL induced by rAAV2-mediated IL-12 in a syngeneic rat model

Journal of Biomedical Science

Volumn 19, Issue 1, 2012, Pages

  Chiu, Tsung Lang ^a,b   Wang, Mei Jan ^b,c   Su, Chin Cheng ^d  

^a TZU CHI UNIVERSITY   (Taiwan)

^b BUDDHIST TZU CHI GENERAL HOSPITAL   (Taiwan)

^c TZU CHI COLLEGE OF TECHNOLOGY   (Taiwan)

^d CHANGHUA CHRISTIAN HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ED1 PROTEIN; GAMMA INTERFERON; INTERLEUKIN 12; KI 67 ANTIGEN; PROTEIN; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG; NERVE PROTEIN; TNFSF10 PROTEIN, RAT;

ADENO ASSOCIATED VIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER SURVIVAL; CELL ACTIVATION; CELL INFILTRATION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETIC TRANSFECTION; GLIOBLASTOMA; IMMUNOHISTOCHEMISTRY; MALE; MICROGLIA; MOUSE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; VIRAL GENE DELIVERY SYSTEM; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; CANCER TRANSPLANTATION; DISEASE MODEL; FISCHER 344 RAT; GENE EXPRESSION REGULATION; GENE THERAPY; GENETIC TRANSDUCTION; GENETICS; HUMAN; ISOGRAFT; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ADENO-ASSOCIATED VIRUS; RATTUS;

ANIMALS; CELL LINE, TUMOR; DEPENDOVIRUS; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE THERAPY; GLIOBLASTOMA; HUMANS; INTERLEUKIN-12; MALE; MICROGLIA; NEOPLASM TRANSPLANTATION; NERVE TISSUE PROTEINS; RATS; RATS, INBRED F344; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TRANSDUCTION, GENETIC; TRANSPLANTATION, ISOGENEIC;

EID: 84859886866     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1186/1423-0127-19-45     Document Type: Article

References (29)

1. IL-12: a promising adjuvant for cancer vaccination. Portielje J, Gratama J, van Ojik H, Stoter G, Kruit W, Cancer Immunol Immunother 2003 52 133 144 12649742 (Pubitemid 36384713)
2. Antitumor and antimetastatic effects of interleukin 12. Fujiwara H, Hamaoka T, Cancer Chemother Pharmacol 1996 38 Suppl 22 26 8765411
3. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Trinchieri G, Nat Rev Immunol 2003 3 133 146 10.1038/nri1001 12563297 (Pubitemid 37328691)
4. Adjuvants and the promotion of Th1-type cytokines in tumour immunotherapy. Dredge K, Marriott JB, Todryk SM, Dalgleish AG, Cancer Immunol Immunother 2002 51 521 531 10.1007/s00262-002-0309-z 12384803 (Pubitemid 35232001)
5. Effects of single-dose interleukin-12 exposure on interleukin-12- associated toxicity and interferon-gamma production. Leonard JP, Sherman ML, Fisher GL, Buchanan LJ, Larsen G, Atkins MB, Sosman JA, Dutcher JP, Vogelzang NJ, Ryan JL, Blood 1997 90 2541 2548 9326219 (Pubitemid 27413462)
6. A novel synergistic combination of cyclophosphamide and gene transfer of interleukin-12 eradicates colorectal carcinoma in mice. Malvicini M, Rizzo M, Alaniz L, Pinero F, Garcia M, Atorrasagasti C, Aquino JB, Rozados V, Scharovsky OG, Matar P, Mazzolini G, Clin Cancer Res 2009 15 7256 7265 10.1158/1078-0432. CCR-09-1861 19920110
7. Use of benznidazole to treat chronic Chagas' disease: a systematic review with a meta-analysis. Pérez-Molina JA, Pérez-Ayala A, Moreno S, Fernández-González MC, Zamora J, Lápez-Velez R, Journal of Antimicrobial Chemotherapy 2009 64 1139 1147 10.1093/jac/dkp357 19819909
8. Generation of a tumor-specific systemic response after intratumoral injection of IL-12 and IL-18-loaded polylactic acid microspheres. Sabel MS, Arora A, Su G, Griffith KA, Mathiowitz E, Reineke JJ, Chang AE, J Immunother 2007 30 808 816 10.1097/CJI.0b013e318156e6a7 18049332 (Pubitemid 350295359)
9. A phase I study of an adeno-associated virus-CFTR gene vector in adult CF patients with mild lung disease. Flotte T, Carter B, Conrad C, Guggino W, Reynolds T, Rosenstein B, Taylor G, Walden S, Wetzel R, Hum Gene Ther 1996 7 1145 1159 10.1089/hum.1996.7.9-1145 8773517 (Pubitemid 26202733)
10. Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial. Kaplitt MG, Feigin A, Tang C, Fitzsimons HL, Mattis P, Lawlor PA, Bland RJ, Young D, Strybing K, Eidelberg D, During MJ, Lancet 2007 369 2097 2105 10.1016/S0140-6736(07)60982-9 17586305 (Pubitemid 46935946)
11. Safety and efficacy of gene transfer for Leber's congenital amaurosis. Maguire AM, Simonelli F, Pierce EA, Pugh EN Jr, Mingozzi F, Bennicelli J, Banfi S, Marshall KA, Testa F, Surace EM, et al. N Engl J Med 2008 358 2240 2248 10.1056/NEJMoa0802315 18441370 (Pubitemid 351724453)
12. Local distribution of microglia in the normal adult human central nervous system differs by up to one order of magnitude. Mittelbronn M, Dietz K, Schluesener HJ, Meyermann R, Acta Neuropathol 2001 101 249 255 11307625 (Pubitemid 32219759)
13. Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Hanisch UK, Kettenmann H, Nat Neurosci 2007 10 1387 1394 10.1038/nn1997 17965659 (Pubitemid 350014685)
14. Flow cytometric characterization of tumor-associated macrophages in experimental gliomas. Badie B, Schartner JM, Neurosurgery 2000 46 957 961 discussion 961-952 10764271
15. Role of microglia in glioma biology. Badie B, Schartner J, Microsc Res Tech 2001 54 106 113 10.1002/jemt.1125 11455617 (Pubitemid 32645875)
16. The role of human glioma-infiltrating microglia/macrophages in mediating antitumor immune responses. Hussain SF, Yang D, Suki D, Aldape K, Grimm E, Heimberger AB, Neuro Oncol 2006 8 261 279 10.1215/15228517-2006-008 16775224 (Pubitemid 46542651)
17. The invasion promoting effect of microglia on glioblastoma cells is inhibited by cyclosporin A. Sliwa M, Markovic D, Gabrusiewicz K, Synowitz M, Glass R, Zawadzka M, Wesolowska A, Kettenmann H, Kaminska B, Brain 2007 130 476 489 10.1093/brain/awl263 17107968 (Pubitemid 46181101)
18. Microglia function in brain tumors. Watters JJ, Schartner JM, Badie B, Journal of Neuroscience Research 2005 81 447 455 10.1002/jnr.20485 15959903 (Pubitemid 41359299)
19. AAV2-mediated interleukin-12 in the treatment of malignant brain tumors through activation of NK cells. Chiu T-L, Lin S-Z, Hsieh W-H, Peng C-W, International Journal of Oncology 2009 35 1361 1367 19885559
20. Adeno-associated virus-mediated gene transfer to the brain: duration and modulation of expression. Lo WD, Qu G, Sferra TJ, Clark R, Chen R, Johnson PR, Hum Gene Ther 1999 10 201 213 10.1089/10430349950018995 10022545 (Pubitemid 29070634)
21. Time course of transgene expression after intrastriatal pseudotyped rAAV2/1, rAAV2/2, rAAV2/5, and rAAV2/8 transduction in the rat. Reimsnider S, Manfredsson FP, Muzyczka N, Mandel RJ, Mol Ther 2007 15 1504 1511 10.1038/sj.mt.6300227 17565350 (Pubitemid 47103062)
22. Interferon gamma and lipopolysaccharide upregulate TNF-related apoptosis-inducing ligand expression in murine microglia. Genc S, Kizildag S, Genc K, Ates H, Atabey N, Immunol Lett 2003 85 271 274 10.1016/S0165-2478(02) 00245-6 12663142 (Pubitemid 36349031)
23. Induction of nitric-oxide synthase and activation of NF-kappaB by interleukin-12 p40 in microglial cells. Pahan K, Sheikh FG, Liu X, Hilger S, McKinney M, Petro TM, J Biol Chem 2001 276 7899 7905 10.1074/jbc.M008262200 11110796
24. Human microglial cells express a functional IL-12 receptor and produce IL-12 following IL-12 stimulation. Taoufik Y, de Goer, de Herve MG, Giron-Michel J, Durali D, Cazes E, Tardieu M, Azzarone B, Delfraissy JF, Eur J Immunol 2001 31 3228 3239 10.1002/1521-4141(200111)31:11<3228::AID-IMMU3228>3.0.CO;2-7 11745339 (Pubitemid 33100514)
25. Production of interferon-gamma by microglia. Kawanokuchi J, Mizuno T, Takeuchi H, Kato H, Wang J, Mitsuma N, Suzumura A, Mult Scler 2006 12 558 564 10.1177/1352458506070763 17086900 (Pubitemid 46940628)
26. Innate immune functions of microglia isolated from human glioma patients. Hussain SF, Yang D, Suki D, Grimm E, Heimberger AB, J Transl Med 2006 4 15 10.1186/1479-5876-4-15 16573834 (Pubitemid 44069682)
27. Malignant gliomas in adults. Wen PY, Kesari S, N Engl J Med 2008 359 492 507 10.1056/NEJMra0708126 18669428
28. Interstitial chemotherapy with biodegradable BCNU (Gliadel) wafers in the treatment of malignant gliomas. Bota DA, Desjardins A, Quinn JA, Affronti ML, Friedman HS, Ther Clin Risk Manag 2007 3 707 715 18472995 (Pubitemid 350162070)
29. Incorporating BCNU wafers into malignant glioma treatment: European case studies. Balossier A, Dorner L, Emery E, Heese O, Mehdorn H, Menei P, Singh J, Clin Drug Investig 2010 30 195 204 10.2165/11532900-000000000-00000 20155992