Aging of the extracellular matrix

Medecine et Longevite

Volumn 4, Issue 1, 2012, Pages 3-32

  Labat Robert, J ^a,b   Robert, A M ^a   Robert, L ^a,b  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b NONE   (France)

Author keywords

Cell senescence; Collagens; Connective Tissue; Elastin; Extracellular matrix; Fibronectin; Glycosaminoglycans; Integrins

Indexed keywords

ANDROGEN RECEPTOR; BETA ADRENERGIC RECEPTOR; CHOLINERGIC RECEPTOR; CHONDROITIN 4 SULFATE; CHONDROITIN 6 SULFATE; COLLAGEN; CORTICOSTEROID RECEPTOR; DOPAMINE RECEPTOR; ELASTIN; ESTROGEN RECEPTOR; FIBRONECTIN; GLYCOSAMINOGLYCAN; GONADOTROPIN RECEPTOR; INSULIN RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR; PROTEINASE;

AGING; ANEURYSM; APOPTOSIS; BACKACHE; BIOSYNTHESIS; BLOOD VESSEL WALL; BONE; CARDIOVASCULAR DISEASE; CARTILAGE; CELL AGING; CELL DIFFERENTIATION; COLLAGEN SYNTHESIS; CROSS LINKING; CUTANEOUS PARAMETERS; DEGENERATIVE DISEASE; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; GLYCATION; HUMAN; LIFE EXPECTANCY; LYMPHOCYTE; METHODOLOGY; NONHUMAN; OSTEOARTHRITIS; PROTEIN SYNTHESIS; RETINA CAPILLARY; REVIEW; SIGNAL TRANSDUCTION; SKIN; SKIN FIBROBLAST; UPREGULATION; VITAL CAPACITY;

EID: 84859880208     PISSN: 18757170     EISSN: 18757162     Source Type: Journal    
DOI: 10.1016/j.mlong.2012.02.003     Document Type: Review

References (138)

1. Macieira-Coelho A. Neoplastic disease through the human life span. Biogerontology 2001, 2:179-192.
2. Basement Membranes: Cell and Molecular Biology. Current Topics in Membranes 2005, vol. 56. Academic Press.
3. Miller E.J. Collagen Types: Structure, Distribution and Functions. Collagen. vol. I. Biochemistry 1988, CRC Press, Boca Raton, Florida, USA, p. 139-56. M.E. Nimni (Ed.).
4. Balazs E.A. The Biology of Hyaluronan. Ciba Foundation Symposium 143 1989, John Wiley and Sons.
5. Hargittai I., Hargittai M. Molecular structure of hyaluronan: an introduction. Struct Chem 2008, 19:697-717.
6. Functions of the proteoglycans. Ciba Foundation Symposium 124. John Wiley and Sons; 1986.
7. Robert A.M., Robert B., Robert L. Chemical and Physical Properties of Structural Glycoproteins. Chemistry and Molecular Biology of the Intercellular Matrix 1970, Academic Press, p. 237-42. E.A. Balazs (Ed.).
8. Robert L., Structural, Glycoproteins Historical Remarks. Frontiers in Matrix Biology. Structural Glycoproteins in Cell-Matrix Interactions 1986, vol. 11. Karger, Basel, p. 1-16.
9. Robert L., Labat-Robert J., Robert A.M. Genetic, epigenetic and posttranslational mechanisms of aging. Biogerontology 2010, 11:387-399. [doi:10.1007/S10522-010-9262-y].
10. Hayflick L. The Cellular Basis for Biological Aging. Handbook of the Biological Aging 1977, Van Nostrand Reinhold Co, p. 159-86. C.E. Finch, L. Hayflick (Eds.).
11. Paye M., Nusgens B.V., Lapière C.M. Modulation of cellular biosynthetic activity in the retracting collagen lattice. Eur J Cell Biol 1987, 45:44-50.
12. Robert L., Robert B. The macromolecular structure of normal cornea. Arch Ophthalmol 1975, 35:11-22.
13. Kern P., Menasche M., Robert L. Relative rates of biosynthesis of collagen type I, type V and type VI in calf cornea. Biochem J 1991, 274:615-617.
14. Macieira-Coelho A. Biology of Normal Proliferating Cells In Vitro. Relevance for In Vivo Aging 1988, Karger, Basel.
15. Gershon D., Rott R. Studies on the Nature of Faulty Protein Molecules and their Diminished Degradation in Cells of Aging Organisms: Functional Implications. Crossroads in Aging, The 1988 Sandoz Lectures in Gerontology 1988, Academic Press, p. 25-33. M. Bergener, M. Ermini, H.B. Stahelin (Eds.).
16. Adelman R.C., Roth G.S. Altered Proteins and Aging. CRC Series. Aging 1983, CRC Press, Boca Raton. R.C. Adelman, G.S. Roth (Eds.).
17. Molecular Basis of Aging. In: Macieira-Coelho A, editor. Boca Raton: CRC Press; 1995.
18. Orgel L.E. Ageing of clones of mammalian cells. Nature 1973, 273:441-445.
19. Rothstein M. Evidence For and Against the Error Catastrophe Hypothesis. Aging, vol. 31. Modern Biological Theories of Aging 1987, Raven Press, p. 139-54.
20. Moczar M., Ouzilou J., Courtois Y., Robert L. Age dependence of the biosynthesis of intercellular matrix macromolecules of rabbit aorta in organ culture and cell culture. Gerontology 1976, 22:461-472.
21. Parks W.C. Developmental Regulation of Elastin Production. The Molecular Biology and Pathology of Elastic Tissues 1995, Ciba Foundation Symposium 192. John Wiley and Sons, p. 279-85.
22. Kelleher C.M., McLean S.E., Mecham R.P. Vascular extracellular matrix and aortic development. Curr Top Dev Biol 2004, 62:153-188.
23. Robert A.M., Boniface R., Robert L. Biochemistry and Pathology of Basement Membranes. Role in Diabetes. Frontiers of Matrix Biology, vol. 7. Biochemistry and Pathology of Basement Membranes 1979, Karger, Basel. A.M. Robert, R. Boniface, L. Robert (Eds.).
24. Regnault F., Romquin N., Kern P. Glycosaminoglycan Modifications in the Conjunctiva of Hereditary Diabetic Mice. Frontiers of matrix Biology, vol. 7, Biochemistry and Pathology of Basement Membranes 1979, Karger, Basel, p. 271-80. A.M. Robert, R. Boniface, L. Robert (Eds.).
25. Robert A.M., Miskulin M., Tixier J.-M., Rivault A., Robert L. Biopsy Technique for the Exploration of the Relative Rates of Biosynthesis of Matrix Macromolecules in Normal and Diabetic Connective Tissue. Frontiers of Matrix Biology. vol. 7. Biochemistry and Pathology of Basement Membranes. Role in Diabetes 1979, Karger Basel, p. 314-23. A.M. Robert, R. Boniface, L. Robert (Eds.).
26. Labat-Robert J., Robert L. Modulation of collagens and fibronectin expression during ageing and age-related diseases. The theoretical basis of aging research, vol. 2 1990, Vienna Aging Series, Facultas, Wien, p. 163-8. L. Robert, G. Hofecker (Eds.).
27. Labat-Robert J., Kern P., Robert L. Biomarkers of connective tissue aging: biosynthesis of fibronectin, collagen type III and elastase. Ann New York Acad Sci 1992, 673:16-22.
28. Bizbiz L., Labat-Robert J., Alperovitch A., Robert L. Cardiovascular determinants of plasma fibronectin in an elderly population. The EVA study. Arch Gerontol Geriatrics 1997, 25:201-209. EVA Group.
29. Labat-Robert J., Potazman J.P., Derouette J.C., Robert L. Age-dependent increase of human plasma fibronectin. Cell Biol Internat 1981, 5:969-973.
30. Sandberg L., Van Reken D., Waikuku K., Martin-Yeboah P., Weiss C., Updegrass V., et al. Plasma fibronectin levels in acute and recovering malnourished children. Clin Physiol Biochem 1985, 3:257-264.
31. McKone T.K., Davis A.T., Dean R.E. Fibronectin. A new nutritional parameter. Am Surg 1985, 51:336-339.
32. Labat-Robert J. Plasma fibronectin, a nutritional marker. Rev Geriatr 2007, 33:1-6.
33. Hynes R.O. Fibronectins 1990, Springer Verlag, New York, Berlin, Heidelberg.
34. Phan-Thanh L., Robert L., Derouette J.C., Labat-Robert J. Increased biosynthesis and processing of fibronectin in fibroblasts from diabetic mice. Proc Natl Acad Sci 1987, 84:1911-1915.
35. Rasoamanantena P., Thweatt R., Labat-Robert J., Goldstein S. Altered regulation of fibronectin gene expression in Werner syndrome fibroblasts. Exper Cell Res 1994, 213:121-127.
36. Rasoamanantena P., Labat-Robert J., Goldstein S. Variations de la biosynthèse et quantification de l'ARNm de la fibronectine humaine au cours du vieillissement en culture. C R Soc Biol 1993, 187:238-246.
37. Labat-Robert J., Robert L. Modifications of fibronectin in age-related diseases: diabetes and cancer. Arch Gerontol Geriatr 1984, 3:1-10.
38. Antia M., Baneyx G., Kubow K.E., Vogel V. Fibronectin in aging extracellular matrix fibrils is progressively unfolded by cells and elicits an enhanced rigidity response. Faraday Discuss 2008, 139:229-420.
39. Ohashi T., Kiehart D.P., Erikson H.P. Dynamics and elasticity of the fibronectin matrix in living cell culture visualised by fibronectin-green fluorescent protein. Proc Natl Acad Sci USA 1999, 96:2453-2458.
40. Hynes R.O. The dynamic dialogue between cells and matrices: implication of fibronectin's elasticity. Proc Natl Acad Sci 1999, 96:2588-2590.
41. Labat-Robert J., Marques M.A., N'Doye S., Alperovitch A., Moulias R., Allard M., et al. Plasma fibronectin in French Centenarians. Arch Gerontol Geriatr 2000, 31:95-105.
42. Labat-Robert J. Cell-matrix interactions in aging: role of receptors and matricryptins. Ageing Res Rev 2004, 3:233-247.
43. Hynes R.O. Integrins: versatility, modulation and signalling in cell adhesion. Cell 1992, 69:11-25.
44. Calderwood D.A., Zeat R., Grant R., Rees D.J.G., Hynes R.O., Ginsberg M.H. The talin head domain binds to integrin β subunit cytoplasmic tails and regulates integrin activation. J Biol Chem 1999, 274:28071-28074.
45. Burke R.D. Invertebrate integrins: structure, function and evolution. Int Rev Cytol 1999, 191:257-284.
46. Johnson M.S., Lu N., Denessiouk K., Heino J., Gullberg D. Integrins during evolution: evolutionary trees and model organisms. Biochim Biophys Acta 2009, 1788:779-789.
47. Barczyk M., Carracedo S., Gullberg D. Integrins. Cell Tissue Res 2010, 339:269-280.
48. Flickinger K.S., Carter W.G., Culp L.A. Deficiency in integrin-mediated transmembrane-signalling and microfilament stress fibre formation by aging fibroblasts from normal and Down's syndrome patients. Exp Cell Res 1992, 203:466-475.
49. Hu Q., Merman E.J., Goldstein S. Altered expression and regulation of the α5β1 integrin-fibronectin receptor lead to reduced amounts of functional α5β1 heterodimer on the plasma membrane of senescent human diploid fibroblasts. Exp Cell Res 1996, 224:251-263.
50. Reed M.J., Ferara M.S., Vernon R.B. Impaired migration, integrin function and actin cytoskeletal organisation in dermal fibroblasts from a subset of aged human donors. Mech Ageing Dev 2001, 122:1203-1220.
51. Bosset S., Bonnet-Duquesnoy M., Barré P., Chalon A., Lazou K., Kurfurst R., et al. Decreased expression of keratinocytes β1 integrins in chronically sun-exposed skin in vivo. Br J Dermatol 2003, 148:770-778.
52. Branchet M.C., Boisnic S., Frances C., Robert A.M. Skin thickness changes in normal aging skin. Gerontology 1990, 36:28-35.
53. Greider C.W. Telomeres, telomerase and senescence. Bioessays 1990, 12:363-366.
54. Macieira-Coelho A. Ups and downs of aging studies in vitro: the crooked path of science. Gerontology 2000, 46:55-63.
55. Campisi J. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbours. Cell 2005, 120:513-522.
56. Labat-Robert J, Robert L. The Effect of Cell Matrix Interactions and Aging on the Malignant Process. In: Vande Woude F, Klein G, editors. Adv Cancer Res 98; 2007. p. 221-59.
57. Adams P.D. Healing and hurting: molecular mechanisms, functions and pathologies of cellular senescence. Molecular Cell 2009, 36:2-14.
58. Dimri G.P., Lee X., Basile G., Acosta M., Scott G., et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci 1995, 92:9363-9367.
59. Ravelojaona V., Robert A.M., Robert L. Expression of senescence-associated β-galactosidase (SA-β-gal) by human skin fibroblasts, effect of advanced glycation end-products and fucose or rhamnose-rich polysaccharides. Arch Gerontol Geriatr 2009, 48:151-154.
60. Ravelojaona V., Robert L., Robert A.M. Effect of cellular aging on collagen biosynthesis. II. Collagen synthesis and deposition by a human skin fibroblast strain over 25 passages. Arch Gerontol Geriatr 2008, 47:368-376.
61. Martin M., El Nabout R., Lafuma C., Crechet F., Remy J. Fibronectin and collagen gene expression during in vitro aging of pig skin fibroblasts. Exp Cell Res 1990, 191:8-13.
62. Branchet M.C., Boisnic S., Frances C., Lesty C., Robert L. Morphometric analysis of dermal collagen fibers in normal human skin as a function of age. Arch Gerontol Geriatr 1991, 13:1-14.
63. Borel J.P., Bellon G., Garnotel R., Monboisse J.C. Adhesion and activation of human neutrophils on basement membrane molecules. Kidney Internatl 1992, 43:26-29.
64. Hayashi K., Cao T., Passmore H., Jourdan-Le Saux C., Fogelgren B., et al. progressive hair loss and myocardial degeneration in rough coat mice: reduced lysyl oxidase-like (LOXL) in the skin and heart. J Invest Dermatol 2004, 123:864-871.
65. Biology of Proteoglycans 1987, Academic Press, Harcourt Brace Jovanovich Publishers. T.N. Wight, R.P. Mecham (Eds.).
66. The Chemistry, Biology and Medical Applications of Hyaluronan and its Derivatives. Wenner-Gren International Series, vol. 72 1998, Portland Press, London and Miami. T.C. Laurent (Ed.).
67. Functions of the Proteoglycans. Ciba Foundation Symposium 124 1986, John Wiley and Sons. D. Evered, J. Whelan (Eds.).
68. Robert L., Robert A.M., Renard G. Biological effects of hyaluronan in connective tissues, eye, skin, venous wall. Role in aging. Path Biol 2010, 58:187-198. [doi:10.1016/jpatbio.2009.09.010].
69. Hyaluronan. From Basic Science to Clinical Applications 2009, PubMatrix, Edgewater, New Yersey. E.A. Balazs (Ed.).
70. Underhill C. Hyaluronan is inversely correlated with the expression of CD44 in the dermal condensation of the embryonic hair follicle. J Invest Dermatol 1993, 101:820-826.
71. Meyer L.J., Stern M., Stern R. Age-dependent changes of hyaluronan in human skin. J Invest Dermatol 1994, 102:383-389.
72. Sobel H. Metabolism of hyaluronic acid in the skin of aging mice. J Gerontol 1971, 26:5455-5557.
73. Balazs E.A., Bloom G.D., Swann D.A. Fine structure and glycosaminoglycan content of the surface layer of articular cartilage. Fed Proc 1966, 25:1813-1816.
74. Thonar EJ-MA, Sweet M.B.E., Immelman A.R., Lyons G. Hyaluronate in articular cartilage: age-related changes. Calcif Tiss Res 1978, 26:19-21.
75. Hallen A. Hexosamine and ester sulphate content of the human nucleus pulposus at different ages. Acta Chemica Scand 1958, 12:1869-1872.
76. Schachtschabel D.O., Wever J. Age-related decline in the synthesis of glycosaminoglycans by cultured human fibroblasts (WI-38). Mech Age Develop 1978, 8:257-264.
77. Sweet M.B.E., Thonar E.J-M.A., Marsh J. Age-related changes in proteoglycan structure. Arch Biochem Biophys 1979, 198:439-448.
78. Honda A., Abe M., Murota S., Mori Y. The effect of aging on the synthesis of hexosamine-containing substances from rat costal cartilage. J Biochem 1979, 85:519-528.
79. 35s-sulphate into two proteoglycan populations from human cartilage. Hoppe-Seyler's Z Physiol Chem 1980, 361:1773-1779.
80. Roughley P.J., White R.J. Age-related changes in the structure of the proteoglycan subunits from human articular cartilage. J Biol Chem 1980, 255:217-224.
81. Pacifici M., Fellini S.A., Holtzer H., De Luca S. Changes in the sulphated proteoglycans synthesized by " aging" chondrocytes. J Biol Chem 1981, 256:1029-1037.
82. Grundboeck-Jusco J., Paul Binette J., Kimura A., Talarico L., Kaelin R., Schmid K. The glycosaminoglycan composition of the lung with acute and chronic pathology and in senescence. Clin Chim Acta 1992, 208:77-84.
83. Nevo Z., Lis D., Silbergeld A., Levin H., Zak Y., Zadik Z. The effect of serum growth factors and xyloside on molecular aging of proteoglycan in embryonal chick cartilage. Mech Aging Dev 1984, 26:133-147.
84. Passi A., Albertini R., Bardoni A., Rindi S., Salvini R., Pallavicini G., et al. Modifications of proteoglycans produced by human skin fibroblast cultures during replicative senescence. Cell Biochem Function 1993, 11:263-269.
85. Singh J., Di Ferrante N., Gyorkey F., Wilson N. Plasma glycosaminoglycans in normal individuals of various age. Atherosclerosis 1977, 28:319-324.
86. Bihari-Varga M., Gerö S. Role of intimal mucoid substances in the pathogenesis of atherosclerosis. Investigations on the interacting components in the mucopolysaccharide-beta-lipoprotein complex formation in vitro. Acta Physiol Acad Sci Hung 1966, 29:273-281.
87. Bihari-Varga M., Gergely J., Gerö S. Further investigations on complex formation in vitro between aortic mucopolysaccharides and beta-lipoproteins. J Atheroscler Res 1964, 4:106-109.
88. Berenson G.S., et al. Cardiovascular Risk Factors in Children. The Early Natural History of Atherosclerosis and Essential Hypertension 1980, Oxford University Press.
89. Robert L., Moczar M. Age-related Changes of Proteoglycans and Glycosaminoglycans. Glycosaminoglycans and Proteoglycans in Physiological and Pathological Processes of Body Systems 1982, Karger, Basel, p. 440-60. R.S. Varma, R. Varma, P. Warren (Eds.).
90. Robert L., Fodil I., Isnard N., Dupuy F., Robert A.M., Renard G. Aging and Regulation of Hyaluronan Biosynthesis. Comparative Studies on Human Skin Fibroblasts and Corneal Keratocytes. Hyaluronan. vol. I. Chemical, Biochemical and Biological Aspects 2002, Woodhead Publishing Limited, p. 537-43.
91. Murata K. Distribution of acidic glycosaminoglycans, lipids and water in normal human cerebral arteries at various ages. Stroke 1985, 16:687-694.
92. Balo J. Connective Tissue Changes in Atherosclerosis. International Review of Connective Tissue Research. vol. I 1963, Academic Press, p. 241-306.
93. Bellon G., Hornebeck W., Robert L. Méthodes simples pour quantifier l'élastase et ses inhibiteurs dans le sérum humain. Pathol Biol 1978, 26:515-521.
94. Robert B., Derouette J.C., Robert L. Mise en évidence d'une protéase à activité élastolytique dans les extraits d'aortes humaines et animales. C R Acad Sci 1974, 278:3251-3254.
95. Hornebeck W., Derouette J.C., Roland J., Chatelet F., Bouissou H., Robert L. Corrélation ante âge, l'artériosclérose et l'activité élastolytique de la paroi aortique humaine. C R Acad Sci 1976, 292:2003-2006.
96. Hornebeck W., Brechemier D., Soleilhac J.M., Bourdillon M.C., Robert L. Studies on rat aorta smooth muscle cells elastase activity. Extracellular matrix: structure and function 1985, 25. Alan Liss Inc, p. 269-82.
97. Robert L., Hornebeck W. Elastase-type proteases of the arterial wall: their properties and biological role. Biology and pathology of platelet-vessel wall interactions 1986, Academic Press, p. 124-44. G. Jolles, Y.J. Legrand, A. Nurden (Eds.).
98. Labat-Robert J., Fourtanier A., Boyer-Lafargue B., Robert L. Age dependent increase of elastase-type protease activity in mouse skin. Effect of UV-irradiation. J Photochem Photobiol B Biology 2000, 57:113-118.
99. Miosge N., Sasaki T., Timpl R. Angiogenesis inhibitor endostatin is a distinct component of elastic fibers in vessel walls. Faseb J 1999, 13:1743-1750.
100. Robert L., Labat-Robert J., Robert A.M. The Maillard reaction. From nutritional problems to preventive medicine. Pathol Biol 2010, 58:200-206. 10.1016/j .pathbio.2009.09.004.
101. The Maillard Reaction. Chemistry at the Interface of Nutrition, Aging and Disease 2005, Annals of the New York Academy of Sciences, vol. 1043. J.W. Baynes, V.M. Monnier, J.M. Ames, S.R. Thorpe (Eds.).
102. Robert L. Fritz Verzar was born 120 years ago: His contribution to experimental gerontology through the collagen research as assessed after half a century. Arch Gerontol Geriatr 2006, 43:13-43.
103. Bailey A.J., Robins S.P. Development and Maturation of the Crosslinks in the Collagen Fibres of Skin. Frontiers in Matrix Biology, vol. I., Aging of Connective Tissues-Skin 1973, Karger Basel, p. 130-56. L. Robert, B. Robert (Eds.).
104. Péterszegi G., Molinari J., Ravelojaona V., Robert L. Effect of advanced glycation end-products on cell proliferation and cell death. Pathol Biol 2006, 54:396-404.
105. Urios P., Grigorova-Borsos A.-M., Peyroux J., Sternberg M. Inhibition de la glycation avancée par les flavonoïdes. Implication nutritionnelle dans la prévention des complications du diabète. J Soc Biol 2007, 201:189-198.
106. Vlassara H. Advanced Glycation in Health and Disease. Role of the Modern Environment. The Maillard Reaction. Chemistry at the Interface of Nutrition, Aging and Disease 2005, 1043. Annals of the New York Academy of Sciences, p. 452-60.
107. Robert L., Robert A.M., Fülöp T. Rapid increase in human life expectancy: will it soon be limited by the aging of elastin?. Biogerontology 2008, 9:119-133.
108. Robert L., Robert A.M., Jacotot B. Elastin-elastase-atherosclerosis revisited. Atherosclerosis 1998, 140:281-295.
109. Urry D.W. Sequential Polypeptides of Elastin: Structural Properties and Molecular pathologies. Frontiers in Matrix Biology, vol. 8. Biology and Pathology of Elastic Tissues 1980, Karger Basel, p. 78-103.
110. Tamburro A.M., Bochicchio B., Pepe A. The dissection of human tropoelastin: from the molecular structure to the self-assembly to the elasticity mechanism. Pathol Biol 2005, 53:383-389.
111. Robert L., Robert A.M. Elastin, Elastase and Atherosclerosis. Frontiers in Matrix Biology, vol. 8, Biology and Pathology of Elastic Tissues 1980, Karger, Basel, p. 130-73. A.M. Robert, L. Robert (Eds.).
112. Claire M., Jacotot B., Robert L. Characterisation of lipids associated with the macromolecules of the intercellular matrix of human aorta. Connect Tissue Res 1976, 4:61-71.
113. Kramsch D.M., Hollander W. Interaction of serum and arterial lipoproteins with elastin of the arterial intima and its role in the lipid accumulation in atherosclerotic plaques. J Clin Invest 1973, 52:236-247.
114. Hornebeck W., Partridge S.M. Conformation changes in fibrous elastin due to calcium ions. Eur J Biochem 1975, 51:73-78.
115. ++ fluxes and gene expression. Biochem Biophys Acta 2008, 1780:1388-1394.
116. Roth G.S. Changes in tissue responsiveness to hormones and neurotransmitters during aging. Exp Gerontol 1995, 30:361-368.
117. Lakatta E.G. Deficient neuroendocrine regulation of the cardiovascular system with advancing age in healthy humans. Circulation 1993, 87:631-636.
118. Varga Z., Jacob M.P., Csongor J., Robert L., Leovey A., Fülöp T. Altered phosphatidylinositol breakdown after κ-elastin stimulation in PMBI-s of elderly. Mech Ageing Dev 1990, 52:61-70.
119. Robert L. mechanisms of aging of the extracellular matrix: role of the elastin-laminin receptor. Gerontology 1998, 44:307-317.
120. Fülöp T., Douziech N., Jacob M.P., Hauck M., Wallach J., Robert L. Age-related alterations in the signal transduction pathways of the elastin-laminin receptor. Pathol Biol 2001, 49:339-348.
121. Varga Z., Jacob M.P., Robert L., Fülöp T. Identification of signal transduction mechanism of elastin peptide receptor in human leucocytes. FEBS Letters 1989, 258:5-8.
122. Péterszegi G., Texier S., Robert L. Cell death by overload of the elastin receptor on human activated lymphocytes: protection by lactose and melibiose. Eur J Clin Inves 1999, 29:166-172.
123. Bizbiz L., Alperovitch A., Robert L. Aging of the vascular wall. Serum concentration of elastin peptides and elastase inhibitors in relation with cardiovascular risk factors. The EVA study. Atherosclerosis 1997, 131:73-78. The EVA group.
124. Ravelojaona V., Molinari J., Robert L. Protection by rhamnose-rich polysaccharides against the cytotoxicity of Maillard reaction products. Biomed Pharmacother 2006, 60:359-362.
125. Carnes B.A., Staats D.O., Sonntag W.E. Does senescence give rise to disease?. Mech Ageing Dev 2008, 129:693-699.
126. Rinder L., Roupe S., Steen B., Svanborg A. Seventy-year-old People in Gothenburg. A Population Study in an Industrialised Swedish City. Acta Med Scand 1975, 198:397-407.
127. Gerontological Studies on Hungarian Centenarians. Haranghy L, editor. Akadémiai Kiado: Budapest; 1965.
128. Robert L. Cellular and molecular mechanisms of aging and age-related diseases. Pathology Oncology Res 2000, 6:3-9.
129. Greiling H., Stuhlsatz H.W., Gresner A. Structure, métabolisme et pathobiochimie des protéoglycannes. Les maladies du tissu conjonctif. Dieckmann Arzneimittel, Bielefeld 1980, Allemagne and Laboratories Boehringer-Ingelheim, Reims, p. 83-100. F. Delbarre, H. Kaiser, L. Robert (Eds.).
130. Tamini R.M., Hankinson S.E., Chen W.Y., et al. Combined estrogen and testosteron use and risk of breast cancer in post-menopausal women. Arch Int Med 2006, 166:1483-1489.
131. Athérosclérose. Jacotot B, editor. Sandoz: Paris; 1993.
132. Atherosclerosis. Biology and Clinical Science. Olsson AG, editor. Churchill Livingstone; 1987.
133. Wissler R.W., Robert L. Aging and cardiovascular disease. Circulation 1996, 93:1608-1612.
134. Hornebeck W., Legrand Y.J. Human Platelet-Derived Elastase (EC 3.4.21). Elastin and Elastases, vol. II. Chapter 4 1989, CRC Press, p. 33-55.
135. Fülöp T., Larbi A., Fortun A., Robert L., Khalil A. Elastin peptides induced oxidation of LDL by phagocytic cells. Pathol Biol 2005, 53:416-423.
136. Fleg J.L., Morrell C.H., Bos A.G., Brant L.J., Talbot L.A., Wright J.G., et al. Accelerated longitudinal decline of aerobic capacity in healthy older adults. Circulation 2005, 112:674-682.
137. Labat-Robert J., Robert L. The metabolic syndrome and the Maillard reaction. An introduction. Pathol Biol 2006, 54:371-374.
138. Hynes R.O. The extracellular matrix: not just pretty fibrils. Science 2009, 326:1216-1219.