Imaging amyloid precursor protein in vivo: An axonal transport assay

Methods in Molecular Biology

Volumn 846, Issue , 2012, Pages 295-303

  Falzone, Tomás L ^a   Stokin, Gorazd B ^b  

^a Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

^b UNIVERSITY PSYCHIATRIC HOSPITAL   (Slovenia)

Author keywords

Amyloid precursor protein; Axonal transport; Fluorescent probes; In vivo fluorescent imaging; Primary hippocampal cell culture

Indexed keywords

AMYLOID PRECURSOR PROTEIN;

ANIMAL; ARTICLE; CELL SEPARATION; CHEMISTRY; CYTOLOGY; ELECTROKYMOGRAPHY; FLUORESCENCE MICROSCOPY; HIPPOCAMPUS; METHODOLOGY; MOUSE; NERVE CELL; NERVE FIBER; NERVE FIBER TRANSPORT; NEWBORN; PHYSIOLOGY; ULTRASTRUCTURE;

AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ANIMALS, NEWBORN; AXONAL TRANSPORT; AXONS; CELL SEPARATION; HIPPOCAMPUS; KYMOGRAPHY; MICE; MICROSCOPY, FLUORESCENCE; NEURONS;

EID: 84859873131     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-61779-536-7_25     Document Type: Article

References (17)

1. Hirokawa N, and Noda Y (2008) Intracellular transport and kinesin superfamily proteins, KIFs: structure, function, and dynamics. Physiol Rev 88, 1089-1118
2. Kang J, Lemaire HG, Unterbeck A, Salbaum JM, Masters CL, Grzeschik KH, et al (1987) The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325, 733-736 (Pubitemid 17054046)
3. Bertram L, Lill CM, and Tanzi RE (2010) The genetics of Alzheimer disease: back to the future. Neuron 68, 270-281
4. Goedert M, and Spillantini MG (2006) A century of Alzheimer's disease. Science 314, 777-781 (Pubitemid 44706636)
5. Cras P, Kawai M, Lowery D, Gonzalez-DeWhitt P, Greenberg B, and Perry G (1991) Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein. Proc Natl Acad Sci USA 88, 7552-7556 (Pubitemid 21915191)
6. Stokin GB, and Goldstein LS (2006) Axonal transport and Alzheimer's disease. Annu Rev Biochem 75, 607-627 (Pubitemid 44118045)
7. Stokin GB, and Goldstein LS (2006) Linking molecular motors to Alzheimer's disease. J Physiol Paris 99, 193-200
8. Joachim CL, Duffy LK, Morris JH, and Selkoe DJ (1988) Protein chemical and immunocytochemical studies of meningovascular betaamyloid protein in Alzheimer's disease and normal aging. Brain Res 474, 100-111 (Pubitemid 19001187)
9. Koo EH, Sisodia SS, Archer DR, Martin LJ, Weidemann A, Beyreuther K, et al (1990) Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport. Proc Natl Acad Sci USA 87, 1561-1565
10. Kaether C, Skehel P, and Dotti CG (2000) Axonal membrane proteins are transported in distinct carriers: a two-color video microscopy study in cultured hippocampal neurons. Mol Biol Cell 11, 1213-1224 (Pubitemid 30211025)
11. Goldsbury C, Thies E, Konzack S, and Mandelkow EM (2007) Quantification of amyloid precursor protein and tau for the study of axonal traffic pathways. J Neurosci 27, 3357-3363 (Pubitemid 46515116)
12. Stokin GB, Lillo C, Falzone TL, Brusch RG, Rockenstein E, Mount SL, et al (2005) Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease. Science 307, 1282-1288 (Pubitemid 40299973)
13. Stokin GB, Almenar-Queralt A, Gunawardena S, Rodrigues EM, Falzone T, Kim J, et al (2008) Amyloid precursor protein-induced axonopathies are independent of amyloid-beta peptides. Hum Mol Genet 17, 3474-3486
14. Falzone TL, Stokin GB, Lillo C, Rodrigues EM, Westerman EL, Williams DS, et al (2009) Axonal stress kinase activation and tau misbehavior induced by kinesin-1 transport defects. J Neurosci 29, 5758-5767
15. Araki Y, Kawano T, Taru H, Saito Y, Wada S, Miyamoto K, et al (2007) The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport. EMBO J 26, 1475-1486 (Pubitemid 46480935)
16. Eva R, Dassie E, Caswell PT, Dick G, ffrench-Constant C, Norman JC, et al (2010) Rab11 and its effector Rab coupling protein contribute to the trafficking of beta 1 integrins during axon growth in adult dorsal root ganglion neurons and PC12 cells. J Neurosci 30, 11654-11669
17. Bilsland LG, Sahai E, Kelly G, Golding M, Greensmith L, and Schiavo G (2010) Deficits in axonal transport precede ALS symptoms in vivo. Proc Natl Acad Sci USA 107, 20523-20528