Effect of osthol on apoptosis and bone resorption of osteoclasts cultured in vitro

Yaoxue Xuebao

Volumn 47, Issue 2, 2012, Pages 174-179

  Ming, Lei Guo ^a   Wang, Ming Gang ^a   Chen, Ke Ming ^b   Zhou, Jian ^a   Han, Gui Qiu ^a   Zhu, Rui Qing ^a  

^a LANZHOU UNIVERSITY OF TECHNOLOGY   (China)

^b LANZHOU GENERAL HOSPITAL   (China)

Author keywords

Apoptosis; Bone resorption; OPG; Osteoclast; Osthol; RANKL; TRAP

Indexed keywords

OSTEOCLAST DIFFERENTIATION FACTOR; OSTHOLE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL ACTIVITY; CELL CULTURE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; FLUORESCENCE MICROSCOPE; GENE EXPRESSION; IN VITRO STUDY; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; PHASE CONTRAST MICROSCOPE; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ACID PHOSPHATASE; ANIMALS; APOPTOSIS; BONE RESORPTION; CELLS, CULTURED; CNIDIUM; COUMARINS; GENE EXPRESSION; ISOENZYMES; MITOGEN-ACTIVATED PROTEIN KINASE 8; MITOGEN-ACTIVATED PROTEIN KINASE 9; OSTEOCLASTS; OSTEOPROTEGERIN; PHOSPHORYLATION; PLANTS, MEDICINAL; RABBITS; RANK LIGAND; SEEDS; SIGNAL TRANSDUCTION;

EID: 84859863343     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Bao JJ, Xie ML, Zhu LJ. Treatment of osthol on osteoporosis in ovariectomized rats [J]. Chin Pharmacol Bull, 2011, 27: 591-592.
2. Zheng LQ, Zhang DS, Zhang L, et al. Pharmacokinetics of osthol in the rabbits [J]. Chin Tradit Pat Med, 2010, 32: 1698-1702.
3. Sakae T, Ichiro N, Jun I, et al. Signal transduction pathways regulating osteoclast differentiation and function [J]. J Bone Miner Metab, 2003, 21: 123-133.
4. Yip KH, Zheng MH, Steer JH, et al. Thapsigargin modulates osteoclastogenesis through the regulation of RANKL-induced signaling pathways and reactive oxygen species production [J]. J Bone Miner Res, 2005, 20: 1462-1471. (Pubitemid 41033530)
5. Mirosavljevic D, Quinn JM, Elliott J, et al. T-cells mediate an inhibitory effect of interleukin-4 on osteoclastogenesis [J]. J Bone Miner Res, 2003, 18: 984-993. (Pubitemid 37294934)
6. Yamaoto A, Miyazaki T, Kadono Y, et al. Possible involvement of IKB kinase 2 and MKK7 in osteoclastogenesis induced by receptor of nuclear factor KB ligand [J]. J Bone Miner Res, 2002, 17: 612-620.
7. Xing L, Venegas AM, Chen A, et al. Genetic evidence for a role for Src family in TNF family receptor signaling and cell survival [J]. Genes Dev, 2001, 15: 241-253. (Pubitemid 32107668)
8. Pfaff M, Jurdic P. Podosomes in osteoclast-like cells: structural analysis and cooperative roles of paxillin, proline-rich tyrosine kinase 2 (Pyk 2) and integrin αVβ2 [J]. J Cell Sci, 2001, 114: 2775-2786. (Pubitemid 32785456)
9. Lakkakorpil PT, Nakamura I, Young M, et al. Abnormal localization and hyperclustering of αVβ3 integrins and associated proteins in Src-deficient or tyrphostin A9-treated osteoclasts [J]. J Cell Sci, 2001, 114: 149-160. (Pubitemid 32118065)
10. Ma HP, Ming LG, Ge BF, et al. Icarrin is more potent than genistein in promoting osteoblast differentiation and mineralization in vitro [J]. J Cell Biochem, 2011, 112: 916-923.
11. Ming LG, Ge BF, Chen KM, et al. Effects of osthol on bone marrow stromal stem cell differentiation and proliferation in vitro [J]. Chin Pharmacol Bull, 2010, 26: 1098-1103.
12. Ming LG, Ge BF, Chen KM, et al. Effect of osthol on the proliferation and differentiate of osteoblasts in vitro [J]. China J Orthop Traumatol, 2010, 23: 42-45.