Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 9, 2012, Pages 3362-3365

  Youngsaye, Willmen ^a   Dockendorff, Chris ^a   Vincent, Benjamin ^b,c   Hartland, Cathy L ^a   Bittker, Joshua A ^a   Dandapani, Sivaraman ^a   Palmer, Michelle ^a   Whitesell, Luke ^b   Lindquist, Susan ^b,c   Schreiber, Stuart L ^a   Munoz, Benito ^a  

^a BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^b WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Antifungal; Candida albicans; Chemosensitizer; Fluconazole; Molecular libraries probe production center network (MLPCN)

Indexed keywords

AMPHOTERICIN B; CALCINEURIN; FLUCONAZOLE; HEAT SHOCK PROTEIN 90; INDOLE DERIVATIVE; ML 229; UNCLASSIFIED DRUG;

ANTIFUNGAL RESISTANCE; ARTICLE; CANDIDA ALBICANS; CELL VIABILITY; CHEMOSENSITIZATION; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENTIATION; DRUG SCREENING; FUNGAL CELL; FUNGAL STRAIN; FUNGICIDAL ACTIVITY; IC 50; SACCHAROMYCES CEREVISIAE; SENSITIZATION; STRUCTURE ACTIVITY RELATION;

CANDIDA ALBICANS; DRUG RESISTANCE, FUNGAL; FLUCONAZOLE; INDOLES; SIGNAL TRANSDUCTION;

CANDIDA ALBICANS; SACCHAROMYCES CEREVISIAE;

EID: 84859856064     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.02.035     Document Type: Article

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