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Volumn 20, Issue 6, 2007, Pages 574-578

Attenuation of echinocandin activity at elevated concentrations: A review of the paradoxical effect

Author keywords

Anidulafungin; Aspergillus; Candida; Caspofungin; Echinocandins; Micafungin; Paradoxical effect

Indexed keywords

ANIDULAFUNGIN; CALCINEURIN; CANDIDAS; CASPOFUNGIN; CHITIN; CILOFUNGIN; ECHINOCANDIN; MICAFUNGIN; PROTEIN KINASE C; UNCLASSIFIED DRUG;

EID: 35848946331     PISSN: 09517375     EISSN: None     Source Type: Journal    
DOI: 10.1097/QCO.0b013e3282f1be7f     Document Type: Review
Times cited : (63)

References (49)
  • 1
    • 0028283764 scopus 로고
    • Morphological effects of lipopeptides against Aspergillus fumigatus correlate with activities against (1,3)-beta-D-glucan synthase
    • Kurtz MB, Heath IB, Marrinan J, et al. Morphological effects of lipopeptides against Aspergillus fumigatus correlate with activities against (1,3)-beta-D-glucan synthase. Antimicrob Agents Chemother 1994; 38:1480-1489.
    • (1994) Antimicrob Agents Chemother , vol.38 , pp. 1480-1489
    • Kurtz, M.B.1    Heath, I.B.2    Marrinan, J.3
  • 2
    • 0042134553 scopus 로고    scopus 로고
    • The echinocandin antifungals: An overview of the pharmacology, spectrum and clinical efficacy
    • Wiederhold NP, Lewis RE. The echinocandin antifungals: an overview of the pharmacology, spectrum and clinical efficacy. Expert Opin Investig Drugs 2003; 12:1313-1333.
    • (2003) Expert Opin Investig Drugs , vol.12 , pp. 1313-1333
    • Wiederhold, N.P.1    Lewis, R.E.2
  • 3
    • 0037137576 scopus 로고    scopus 로고
    • Comparison of caspofungin and amphotericin B for invasive candidiasis
    • Mora-Duarte J, Betts R, Rotstein C, et al. Comparison of caspofungin and amphotericin B for invasive candidiasis. N Engl J Med 2002; 347:2020-2029.
    • (2002) N Engl J Med , vol.347 , pp. 2020-2029
    • Mora-Duarte, J.1    Betts, R.2    Rotstein, C.3
  • 4
    • 34247564562 scopus 로고    scopus 로고
    • Micafungin versus liposomal amphotericin B for candidaemia and invasive candidosis: A phase III randomised double-blind trial
    • Kuse ER, Chetchotisakd P, da Cunha CA, et al. Micafungin versus liposomal amphotericin B for candidaemia and invasive candidosis: a phase III randomised double-blind trial. Lancet 2007; 369:1519-1527.
    • (2007) Lancet , vol.369 , pp. 1519-1527
    • Kuse, E.R.1    Chetchotisakd, P.2    da Cunha, C.A.3
  • 5
    • 34250341787 scopus 로고    scopus 로고
    • Anidulafungin versus fluconazole for invasive candidiasis
    • Reboli AC, Rotstein C, Pappas PG, et al. Anidulafungin versus fluconazole for invasive candidiasis. N Engl J Med 2007; 356:2472-2482.
    • (2007) N Engl J Med , vol.356 , pp. 2472-2482
    • Reboli, A.C.1    Rotstein, C.2    Pappas, P.G.3
  • 6
    • 0037377996 scopus 로고    scopus 로고
    • In vivo pharmacodynamics of HMR 3270 a glucan synthase inhibitor, in a murine candidiasis model
    • Andes D, Marchillo K, Lowther J, et al. In vivo pharmacodynamics of HMR 3270 a glucan synthase inhibitor, in a murine candidiasis model. Antimicrob Agents Chemother 2003; 47:1187-1192.
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 1187-1192
    • Andes, D.1    Marchillo, K.2    Lowther, J.3
  • 7
    • 33847652168 scopus 로고    scopus 로고
    • Once-weekly micafungin therapy is as effective as daily therapy for disseminated candidiasis in mice with persistent neutropenia
    • Gumbo T, Drusano GL, Liu W, et al. Once-weekly micafungin therapy is as effective as daily therapy for disseminated candidiasis in mice with persistent neutropenia. Antimicrob Agents Chemother 2007; 51:968-974.
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 968-974
    • Gumbo, T.1    Drusano, G.L.2    Liu, W.3
  • 8
    • 4944230721 scopus 로고    scopus 로고
    • Pharmacodynamics of caspofungin in a murine model of invasive pulmonary aspergillosis: Evidence of concentration-dependent activity
    • Wiederhold NP, Kontoyiannis DP, Chi J, et al. Pharmacodynamics of caspofungin in a murine model of invasive pulmonary aspergillosis: evidence of concentration-dependent activity. J Infect Dis 2004; 190:1464-1471.
    • (2004) J Infect Dis , vol.190 , pp. 1464-1471
    • Wiederhold, N.P.1    Kontoyiannis, D.P.2    Chi, J.3
  • 9
    • 0002753264 scopus 로고
    • The rate of bactericidal action of penicillin in vitro as a function of its concentration, and its paradoxically reduced activity at high concentrations against certain organisms
    • Eagle H, Musselman AD. The rate of bactericidal action of penicillin in vitro as a function of its concentration, and its paradoxically reduced activity at high concentrations against certain organisms. J Exp Med 1948; 88:99-131.
    • (1948) J Exp Med , vol.88 , pp. 99-131
    • Eagle, H.1    Musselman, A.D.2
  • 10
    • 0023772408 scopus 로고
    • Cilofungin (LY121019), an antifungal agent with specific activity against Candida albicans and Candida tropicalis
    • Hall GS, Myles C, Pratt KJ, Washington JA. Cilofungin (LY121019), an antifungal agent with specific activity against Candida albicans and Candida tropicalis. Antimicrob Agents Chemother 1988; 32:1331-1335.
    • (1988) Antimicrob Agents Chemother , vol.32 , pp. 1331-1335
    • Hall, G.S.1    Myles, C.2    Pratt, K.J.3    Washington, J.A.4
  • 11
    • 34247856050 scopus 로고    scopus 로고
    • Micafungin activity against Candida bloodstream isolates: Effect of growth medium and susceptibility testing method
    • Pai MP, Jones AL, Mullen CK. Micafungin activity against Candida bloodstream isolates: effect of growth medium and susceptibility testing method. Diagn Microbiol Infect Dis 2007; 58:129-132.
    • (2007) Diagn Microbiol Infect Dis , vol.58 , pp. 129-132
    • Pai, M.P.1    Jones, A.L.2    Mullen, C.K.3
  • 12
    • 0025887095 scopus 로고
    • Efficacy of cilofungin alone and in combination with amphotericin B in a murine model of disseminated aspergillosis
    • Denning DW, Stevens DA. Efficacy of cilofungin alone and in combination with amphotericin B in a murine model of disseminated aspergillosis. Antimicrob Agents Chemother 1991; 35:1329-1333.
    • (1991) Antimicrob Agents Chemother , vol.35 , pp. 1329-1333
    • Denning, D.W.1    Stevens, D.A.2
  • 13
    • 0035215090 scopus 로고    scopus 로고
    • Clinical efficacy of echinocandin antifungals
    • Arathoon EG. Clinical efficacy of echinocandin antifungals. Curr Opin Infect Dis 2001; 14:685-691.
    • (2001) Curr Opin Infect Dis , vol.14 , pp. 685-691
    • Arathoon, E.G.1
  • 14
    • 0036841154 scopus 로고    scopus 로고
    • In vitro pharmacodynamic properties of three antifungal agents against preformed Candida albicans biofilms determined by time-kill studies
    • Ramage G, VandeWalle K, Bachmann SP, et al. In vitro pharmacodynamic properties of three antifungal agents against preformed Candida albicans biofilms determined by time-kill studies. Antimicrob Agents Chemother 2002; 46:3634-3636.
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 3634-3636
    • Ramage, G.1    VandeWalle, K.2    Bachmann, S.P.3
  • 15
    • 35848948735 scopus 로고    scopus 로고
    • Paradoxical growth effect of caspofungin observed on biofilms and planktonic cells of five different Candida species
    • 25 June, E-pub ahead of print. doi: 10.1128/AAC.00676-07
    • Melo AS, Colombo AL, Arthington-Skaggs BA. Paradoxical growth effect of caspofungin observed on biofilms and planktonic cells of five different Candida species. Antimicrob Agents Chemother 25 June 2007; E-pub ahead of print. doi: 10.1128/AAC.00676-07.
    • (2007) Antimicrob Agents Chemother
    • Melo, A.S.1    Colombo, A.L.2    Arthington-Skaggs, B.A.3
  • 16
    • 4344587092 scopus 로고    scopus 로고
    • Paradoxical effect of caspofungin: Reduced activity against Candida albicans at high drug concentrations
    • Stevens DA, Espiritu M, Parmar R. Paradoxical effect of caspofungin: reduced activity against Candida albicans at high drug concentrations. Antimicrob Agents Chemother 2004; 48:3407-3411.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 3407-3411
    • Stevens, D.A.1    Espiritu, M.2    Parmar, R.3
  • 17
    • 28844490053 scopus 로고    scopus 로고
    • Attenuation of the activity of caspofungin at high concentrations against Candida albicans: Possible role of cell wall integrity and calcineurin pathways
    • Wiederhold NP, Kontoyiannis DP, Prince RA, Lewis RE. Attenuation of the activity of caspofungin at high concentrations against Candida albicans: possible role of cell wall integrity and calcineurin pathways. Antimicrob Agents Chemother 2005; 49:5146-5148.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 5146-5148
    • Wiederhold, N.P.1    Kontoyiannis, D.P.2    Prince, R.A.3    Lewis, R.E.4
  • 18
    • 34250217778 scopus 로고    scopus 로고
    • Chamilos G, Lewis RE, Albert N, Kontoyiannis DP. Paradoxical effect of echinocandins across Candida species in vitro: evidence for echinocandinspecific and Candida species-related differences. Antimicrob Agents Chemother 2007; 51:2257-2259. This study demonstrated species-related and echinocandin-specific differences for the paradoxical effect in Candida.
    • Chamilos G, Lewis RE, Albert N, Kontoyiannis DP. Paradoxical effect of echinocandins across Candida species in vitro: evidence for echinocandinspecific and Candida species-related differences. Antimicrob Agents Chemother 2007; 51:2257-2259. This study demonstrated species-related and echinocandin-specific differences for the paradoxical effect in Candida.
  • 19
    • 35848949669 scopus 로고    scopus 로고
    • Stevens DA, McCullough MJ, Clemons KV, Martinez MC. Candida dubliniensis, a species with an extremely high frequency of paradoxical effect with caspofungin. In: 46th Interscience Conference on Antimicrobial Agents and Chemotherapy. San Francisco, CA; 27-30 September 2006. Abstract M-1756.
    • Stevens DA, McCullough MJ, Clemons KV, Martinez MC. Candida dubliniensis, a species with an extremely high frequency of paradoxical effect with caspofungin. In: 46th Interscience Conference on Antimicrobial Agents and Chemotherapy. San Francisco, CA; 27-30 September 2006. Abstract M-1756.
  • 20
    • 22844431862 scopus 로고    scopus 로고
    • Characterization of Aspergillus fumigatus mutants with reduced susceptibility to caspofungin
    • Gardiner RE, Souteropoulos P, Park S, Perlin DS. Characterization of Aspergillus fumigatus mutants with reduced susceptibility to caspofungin. Med Mycol 2005; 43 (Suppl 1):S299-S305.
    • (2005) Med Mycol , vol.43 , Issue.SUPPL. 1
    • Gardiner, R.E.1    Souteropoulos, P.2    Park, S.3    Perlin, D.S.4
  • 21
    • 35848948967 scopus 로고    scopus 로고
    • Eagle-like effect of caspofungin against Candida and Aspergillus spp.: Association with homeostatic mechanisms of cell wall integrity
    • Washington, DC; 30 October-2 November, Abstract
    • Wiederhold NP, Kontoyiannis DP, Prince RA, Lewis RE. Eagle-like effect of caspofungin against Candida and Aspergillus spp.: association with homeostatic mechanisms of cell wall integrity. In: 44th Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington, DC; 30 October-2 November 2004. Abstract M-1682.
    • (2004) 44th Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Wiederhold, N.P.1    Kontoyiannis, D.P.2    Prince, R.A.3    Lewis, R.E.4
  • 22
    • 0035213371 scopus 로고    scopus 로고
    • Comparison of spectrophotometric and visual readings of NCCLS method and evaluation of a colorimetric method based on reduction of a soluble tetrazolium salt 2, 3-bis [2-methoxy-4-nitro-5-[(sulfenylamino) carbonyl]-2H-tetrazolium-hydroxide], for antifungal susceptibility testing of Aspergillus species
    • Meletiadis J, Mouton JW, Meis JF, et al. Comparison of spectrophotometric and visual readings of NCCLS method and evaluation of a colorimetric method based on reduction of a soluble tetrazolium salt 2, 3-bis [2-methoxy-4-nitro-5-[(sulfenylamino) carbonyl]-2H-tetrazolium-hydroxide], for antifungal susceptibility testing of Aspergillus species. J Clin Microbiol 2001; 39:4256-4263.
    • (2001) J Clin Microbiol , vol.39 , pp. 4256-4263
    • Meletiadis, J.1    Mouton, J.W.2    Meis, J.F.3
  • 23
    • 33845244538 scopus 로고    scopus 로고
    • Antifungal effects on metabolite profiles of medically important yeast species measured by nuclear magnetic resonance spectroscopy
    • Coen M, Bodkin J, Power D, et al. Antifungal effects on metabolite profiles of medically important yeast species measured by nuclear magnetic resonance spectroscopy. Antimicrob Agents Chemother 2006; 50:4018-4026.
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 4018-4026
    • Coen, M.1    Bodkin, J.2    Power, D.3
  • 24
    • 0036135430 scopus 로고    scopus 로고
    • Antifungal efficacy of caspofungin (MK-0991) in experimental pulmonary aspergillosis in persistently neutropenic rabbits: Pharmacokinetics, drug disposition, and relationship to galactomannan antigenemia
    • Petraitiene R, Petraitis V, Groll AH, et al. Antifungal efficacy of caspofungin (MK-0991) in experimental pulmonary aspergillosis in persistently neutropenic rabbits: pharmacokinetics, drug disposition, and relationship to galactomannan antigenemia. Antimicrob Agents Chemother 2002; 46:12-23.
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 12-23
    • Petraitiene, R.1    Petraitis, V.2    Groll, A.H.3
  • 25
    • 0036093584 scopus 로고    scopus 로고
    • Comparative antifungal activities and plasma pharmacokinetics of micafungin (FK463) against disseminated candidiasis and invasive pulmonary aspergillosis in persistently neutropenic rabbits
    • Petraitis V, Petraitiene R, Groll AH, et al. Comparative antifungal activities and plasma pharmacokinetics of micafungin (FK463) against disseminated candidiasis and invasive pulmonary aspergillosis in persistently neutropenic rabbits. Antimicrob Agents Chemother 2002; 46:1857-1869.
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 1857-1869
    • Petraitis, V.1    Petraitiene, R.2    Groll, A.H.3
  • 26
    • 0031783659 scopus 로고    scopus 로고
    • Antifungal efficacy, safety, and single-dose pharmacokinetics of LY303366, a novel echinocandin B, in experimental pulmonary aspergillosis in persistently neutropenic rabbits
    • Petraitis V, Petraitiene R, Groll AH, et al. Antifungal efficacy, safety, and single-dose pharmacokinetics of LY303366, a novel echinocandin B, in experimental pulmonary aspergillosis in persistently neutropenic rabbits. Antimicrob Agents Chemother 1998; 42:2898-2905.
    • (1998) Antimicrob Agents Chemother , vol.42 , pp. 2898-2905
    • Petraitis, V.1    Petraitiene, R.2    Groll, A.H.3
  • 27
    • 0034425534 scopus 로고    scopus 로고
    • Efficacies of two new antifungal agents, the triazole ravuconazole and the echinocandin LY-303366, in an experimental model of invasive aspergillosis
    • Roberts J, Schock K, Marino S, Andriole VT. Efficacies of two new antifungal agents, the triazole ravuconazole and the echinocandin LY-303366, in an experimental model of invasive aspergillosis. Antimicrob Agents Chemother 2000; 44:3381-3388.
    • (2000) Antimicrob Agents Chemother , vol.44 , pp. 3381-3388
    • Roberts, J.1    Schock, K.2    Marino, S.3    Andriole, V.T.4
  • 28
    • 33645113982 scopus 로고    scopus 로고
    • Caspofungin: Antifungal activity in vitro, pharmacokinetics, and effects on fungal load and animal survival in neutropenic rats with invasive pulmonary aspergillosis
    • Van Vianen W, De Marie S, Ten Kate MT, et al. Caspofungin: antifungal activity in vitro, pharmacokinetics, and effects on fungal load and animal survival in neutropenic rats with invasive pulmonary aspergillosis. J Antimicrob Chemother 2006; 57:732-740.
    • (2006) J Antimicrob Chemother , vol.57 , pp. 732-740
    • Van Vianen, W.1    De Marie, S.2    Ten Kate, M.T.3
  • 30
    • 28844486224 scopus 로고    scopus 로고
    • Pharmacodynamics of caspofungin in a murine model of systemic candidiasis: Importance of persistence of caspofungin in tissues to understanding drug activity
    • Louie A, Deziel M, Liu W, et al. Pharmacodynamics of caspofungin in a murine model of systemic candidiasis: importance of persistence of caspofungin in tissues to understanding drug activity. Antimicrob Agents Chemother 2005; 49:5058-5068.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 5058-5068
    • Louie, A.1    Deziel, M.2    Liu, W.3
  • 32
    • 33748695822 scopus 로고    scopus 로고
    • Escape of Candida from caspofungin inhibition at concentrations above the MIC (paradoxical effect) accomplished by increased cell wall chitin; evidence for beta-1,6-glucan synthesis inhibition by caspofungin
    • This study reported significant increases in cell wall chitin after exposure to high caspofungin concentrations
    • Stevens DA, Ichinomiya M, Koshi Y, Horiuchi H. Escape of Candida from caspofungin inhibition at concentrations above the MIC (paradoxical effect) accomplished by increased cell wall chitin; evidence for beta-1,6-glucan synthesis inhibition by caspofungin. Antimicrob Agents Chemother 2006; 50:3160-3161. This study reported significant increases in cell wall chitin after exposure to high caspofungin concentrations.
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 3160-3161
    • Stevens, D.A.1    Ichinomiya, M.2    Koshi, Y.3    Horiuchi, H.4
  • 33
    • 0024845675 scopus 로고
    • Effects of cilofungin (LY121019) on carbohydrate and sterol composition of Candida albicans
    • Pfaller M, Riley J, Koerner T. Effects of cilofungin (LY121019) on carbohydrate and sterol composition of Candida albicans. Eur J Clin Microbiol Infect Dis 1989; 8:1067-1070.
    • (1989) Eur J Clin Microbiol Infect Dis , vol.8 , pp. 1067-1070
    • Pfaller, M.1    Riley, J.2    Koerner, T.3
  • 34
    • 0038460048 scopus 로고    scopus 로고
    • The Cryptococcus neoformans MAP kinase Mpk1 regulates cell integrity in response to antifungal drugs and loss of calcineurin function
    • Kraus PR, Fox DS, Cox GM, Heitman J. The Cryptococcus neoformans MAP kinase Mpk1 regulates cell integrity in response to antifungal drugs and loss of calcineurin function. Mol Microbiol 2003; 48:1377-1387.
    • (2003) Mol Microbiol , vol.48 , pp. 1377-1387
    • Kraus, P.R.1    Fox, D.S.2    Cox, G.M.3    Heitman, J.4
  • 35
    • 0032731716 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase Mkp1 of Pneumocystis carinii complements the slt2Delta defect in the cell integrity pathway of Saccharomyces cerevisiae
    • Fox D, Smulian AG. Mitogen-activated protein kinase Mkp1 of Pneumocystis carinii complements the slt2Delta defect in the cell integrity pathway of Saccharomyces cerevisiae. Mol Microbiol 1999; 34:451-462.
    • (1999) Mol Microbiol , vol.34 , pp. 451-462
    • Fox, D.1    Smulian, A.G.2
  • 36
    • 0033042979 scopus 로고    scopus 로고
    • A mitogen-activated protein kinase (MPKA) is involved in polarized growth in the filamentous fungus, Aspergillus nidulans
    • Bussink HJ, Osmani SA. A mitogen-activated protein kinase (MPKA) is involved in polarized growth in the filamentous fungus, Aspergillus nidulans. FEMS Microbiol Lett 1999; 173:117-125.
    • (1999) FEMS Microbiol Lett , vol.173 , pp. 117-125
    • Bussink, H.J.1    Osmani, S.A.2
  • 37
    • 16544392041 scopus 로고    scopus 로고
    • A mitogen-activated protein kinase that senses nitrogen regulates conidial germination and growth in Aspergillus fumigatus
    • Xue T, Nguyen CK, Romans A, May GS. A mitogen-activated protein kinase that senses nitrogen regulates conidial germination and growth in Aspergillus fumigatus. Eukaryot Cell 2004; 3:557-560.
    • (2004) Eukaryot Cell , vol.3 , pp. 557-560
    • Xue, T.1    Nguyen, C.K.2    Romans, A.3    May, G.S.4
  • 38
    • 4143152800 scopus 로고    scopus 로고
    • Disordered cell integrity signaling caused by disruption of the kexB gene in Aspergillus oryzae
    • Mizutani O, Nojima A, Yamamoto M, et al. Disordered cell integrity signaling caused by disruption of the kexB gene in Aspergillus oryzae. Eukaryot Cell 2004; 3:1036-1048.
    • (2004) Eukaryot Cell , vol.3 , pp. 1036-1048
    • Mizutani, O.1    Nojima, A.2    Yamamoto, M.3
  • 39
    • 0042818290 scopus 로고    scopus 로고
    • Genome-wide expression profiling of the response to polyene, pyrimidine, azole, and echinocandin antifungal agents in Saccharomyces cerevisiae
    • Agarwal AK, Rogers PD, Baerson SR, et al. Genome-wide expression profiling of the response to polyene, pyrimidine, azole, and echinocandin antifungal agents in Saccharomyces cerevisiae. J Biol Chem 2003; 278:34998-35015.
    • (2003) J Biol Chem , vol.278 , pp. 34998-35015
    • Agarwal, A.K.1    Rogers, P.D.2    Baerson, S.R.3
  • 40
    • 0346433839 scopus 로고    scopus 로고
    • The yeast protein kinase C cell integrity pathway mediates tolerance to the antifungal drug caspofungin through activation of Slt2p mitogen-activated protein kinase signaling
    • Reinoso-Martin C, Schuller C, Schuetzer-Muehlbauer M, Kuchler K. The yeast protein kinase C cell integrity pathway mediates tolerance to the antifungal drug caspofungin through activation of Slt2p mitogen-activated protein kinase signaling. Eukaryot Cell 2003; 2:1200-1210.
    • (2003) Eukaryot Cell , vol.2 , pp. 1200-1210
    • Reinoso-Martin, C.1    Schuller, C.2    Schuetzer-Muehlbauer, M.3    Kuchler, K.4
  • 41
    • 33846976163 scopus 로고    scopus 로고
    • Munro CA, Selvaggini S, de Bruijn I, et al. The PKC,HOGand Ca2+ signalling pathways co-ordinately regulate chitin synthesis in Candida albicans. Mol Microbiol 2007; 63:1399-1413. This study demonstrated the coordination of chitin synthesis by the PKC cell wall integrity, high-osmolarity glycerol mitogen-activated protein kinase, and calcineurin pathways in C. albicans.
    • Munro CA, Selvaggini S, de Bruijn I, et al. The PKC,HOGand Ca2+ signalling pathways co-ordinately regulate chitin synthesis in Candida albicans. Mol Microbiol 2007; 63:1399-1413. This study demonstrated the coordination of chitin synthesis by the PKC cell wall integrity, high-osmolarity glycerol mitogen-activated protein kinase, and calcineurin pathways in C. albicans.
  • 42
    • 35848952863 scopus 로고    scopus 로고
    • Increased gene expression of mitogen-activated protein kinase A is associated with attenuated caspofungin activity in Aspergillus fumigatus
    • San Francisco, CA; 27-30 September, Abstract M-364
    • Wiederhold NP, Wickes BL, Patterson TP. Increased gene expression of mitogen-activated protein kinase A is associated with attenuated caspofungin activity in Aspergillus fumigatus. In: 46th Interscience Conference on Antimicrobial Agents and Chemotherapy. San Francisco, CA; 27-30 September 2006. Abstract M-364.
    • (2006) 46th Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Wiederhold, N.P.1    Wickes, B.L.2    Patterson, T.P.3
  • 43
    • 33747412583 scopus 로고    scopus 로고
    • Paradoxical increase in circulating Aspergillus antigen during treatment with caspofungin in a patient with pulmonary aspergillosis
    • Klont RR, Mennink-Kersten MA, Ruegebrink D, et al. Paradoxical increase in circulating Aspergillus antigen during treatment with caspofungin in a patient with pulmonary aspergillosis. Clin Infect Dis 2006; 43:e23-e25.
    • (2006) Clin Infect Dis , vol.43
    • Klont, R.R.1    Mennink-Kersten, M.A.2    Ruegebrink, D.3
  • 44
    • 24044533026 scopus 로고    scopus 로고
    • Evaluation of serum sandwich enzyme-linked immunosorbent assay for circulating galactomannan during caspofungin therapy: Results from the caspofungin invasive aspergillosis study
    • Maertens J, Glasmacher A, Selleslag D, et al. Evaluation of serum sandwich enzyme-linked immunosorbent assay for circulating galactomannan during caspofungin therapy: results from the caspofungin invasive aspergillosis study. Clin Infect Dis 2005; 41:e9-e14.
    • (2005) Clin Infect Dis , vol.41
    • Maertens, J.1    Glasmacher, A.2    Selleslag, D.3
  • 45
    • 0037629905 scopus 로고    scopus 로고
    • Petraitis V, Petraitiene R, Sarafandi AA, et al. Combination therapy in treatment of experimental pulmonary aspergillosis: synergistic interaction between an antifungal triazole and an echinocandin. J Infect Dis 2003; 187:1834-1843.
    • Petraitis V, Petraitiene R, Sarafandi AA, et al. Combination therapy in treatment of experimental pulmonary aspergillosis: synergistic interaction between an antifungal triazole and an echinocandin. J Infect Dis 2003; 187:1834-1843.
  • 47
    • 33645111403 scopus 로고    scopus 로고
    • Progressive loss of echinocandin activity following prolonged use for treatment of Cadida albicans oesophagitis
    • Lavediere M, Laonde RG, Bail JG, et al. Progressive loss of echinocandin activity following prolonged use for treatment of Cadida albicans oesophagitis. J Antimicrob Chemother 2006; 57:705-708.
    • (2006) J Antimicrob Chemother , vol.57 , pp. 705-708
    • Lavediere, M.1    Laonde, R.G.2    Bail, J.G.3
  • 48
    • 33744494301 scopus 로고    scopus 로고
    • Progressive esophagitis caused by Candida albicans with reduced susceptibility to caspofungin
    • Miller CD, Lomaestro BW, Park S, Perlin DS. Progressive esophagitis caused by Candida albicans with reduced susceptibility to caspofungin. Pharmacotherapy 2006; 26:877-880.
    • (2006) Pharmacotherapy , vol.26 , pp. 877-880
    • Miller, C.D.1    Lomaestro, B.W.2    Park, S.3    Perlin, D.S.4
  • 49
    • 23044471740 scopus 로고    scopus 로고
    • Specific substitutions in the echinocandin target Fks1p account for reduced susceptibility of rare laboratory and clinical Candida sp. isolates
    • Park S, Kelly R, Kahn JN, et al. Specific substitutions in the echinocandin target Fks1p account for reduced susceptibility of rare laboratory and clinical Candida sp. isolates. Antimicrob Agents Chemother 2005; 49:3264-3273.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 3264-3273
    • Park, S.1    Kelly, R.2    Kahn, J.N.3


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