Population pharmacokinetics of single-dose intravenous paracetamol in children

British Journal of Anaesthesia

Volumn 108, Issue 5, 2012, Pages 823-829

  Mohammed, B S ^a   Engelhardt, T ^a   Cameron, G A ^a   Cameron, L ^a   Hawksworth, G M ^a   Hawwa, A F ^b   McElnay, J ^b   Helms, P J ^a   McLay, J S ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Children; Intravenous; Paracetamol; Pharmacokinetics

Indexed keywords

ISOFLURANE; PARACETAMOL; PROPOFOL; SEVOFLURANE;

ADOLESCENT; ARTICLE; BLOOD SAMPLING; CHILD; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; PHARMACOKINETICS; PLASMA CONCENTRATION-TIME CURVE; POSTOPERATIVE PAIN; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SINGLE DRUG DOSE;

EID: 84859841148     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aes025     Document Type: Article

References (31)

1. Allegaert K, Murat I, Anderson BJ. Not all intravenous paracetamol formulations are created equal. Pediatr Anesth 2007; 17: 809-18
2. Murat I, Baujard C, Foussat C, et al. Tolerance an analgesic efficacy of a new i.v paracetamol solution in children after inguinal hernia repair. Pediatr Anesth 2005; 15: 663-70 (Pubitemid 41623798)
3. Flouvat B, Leneveu A, Fitoussi S, Delhotal-Landes B, Gendron A. Bioequivalence study comparing a new paracetamol solution for injection and propacetamol after single intravenous infusion in healthy subjects. Int J Clin Pharmacol Ther 2004; 42: 50-7 (Pubitemid 38100861)
4. Morselli PL, Franco-Morselli R, Bossi L. Clinical pharmacokinetics in newborns and infants. Clin Pharmacokinet 1980; 5: 485-527
5. Wurthwein G, Koling S, Reich A, et al. Pharmacokinetics of intravenous paracetamol in children and adolescents under major surgery. Eur J Clin Pharmacol 2005; 60: 883-8 (Pubitemid 40386159)
6. Summary of Product Characteristics eMC: 30 November 2009
7. Oliveira EJ, Watson DG, Morton NS. A simple microanalytical technique for the determination of paracetamol and its main metabolites in blood spots. J Pharm Biochem Anal 2002; 29: 803-9 (Pubitemid 34686997)
8. Validation of analytical procedures: Text and Methodology Q2 (R1). International Conference on harmonisation of technical requirements for registration of pharmaceuticals for human use. ICH Harmonised Tripartite Guideline. Current step 4 version. 2005
9. Ahn JE, Karlsson MO, Dunne A, Ludden TM. Likelihood based approaches to handling data below the quantification limit using NONMEM VI. J Pharmacokinet Pharmacodyn 2008; 35: 401-21
10. Cole TJ, Bellizzi MC, Flegal KM, Dietz WH. Establishing a standard definition for child overweight and obesity worldwide: international survey. Br Med J 2000; 320: 1240-3 (Pubitemid 30240471)
11. Rawlins MD, Henderson DB, Hijab AR. Pharmacokinetics of paracetamol (acetaminophen) after intravenous and oral administration. Eur J Clin Pharmacol 1977; 11: 283-6 (Pubitemid 8082106)
12. Bannwarth B, Netter P, Lapicque F, et al. Plasma and cerebrospinal fluid concentrations of paracetamol after a single intravenous dose of propacetamol. Br J Clin Pharmacol 1992; 34: 79-81
13. Autret E, Dutertre JP, Breteau M, Jonville AP, Furet Y, Laugier J. Pharmacokinetic in the neonate and infant after administration of propacetamol chlorhydrate. Dev Pharmacol Ther 1993; 20: 129-34 (Pubitemid 24280261)
14. Hahn TW, Mogensen T, Lund C, et al. Analgesic effect of i.v paracetamol: possible ceiling effect of paracetamol in postoperative pain. Acta Anaesthesiol Scand 2003; 47: 138-45 (Pubitemid 36349772)
15. Anderson BJ, Pons G, Autret-Leca E, Allegaert K, Boccard E. Pediatric intravenous paracetamol (propacetamol) pharmacokinetics: a population analysis. Paediatr Anaesth 2005; 15: 282-92 (Pubitemid 40462802)
16. Anderson BJ, Holford NHG. Mechanistic basis of using body size and maturation to predict clearance in humans. Drug Metab Pharmacokinet 2009; 24: 25-36
17. Palmer GM, Atkins M, Anderson BJ, et al. I.V. acetaminophen pharmacokinetics in neonates after multiple doses. Br J Anaesth 2008; 101: 523-30
18. Miller RP, Roberts RJ, Fischer LJ. Acetaminophen elimination kinetics in neonates, children and adults. Clin Pharmacol Ther 1976; 3: 284-94
19. Abernethy DR, Greenblatt DJ, Ameer B, Shader RI. Probenecid impairment of acetaminophen and lorazepam clearance: direct inhibition of ether glucuronide formation. J Pharmacol Exp Ther 1985; 234: 345-9 (Pubitemid 15241851)
20. Scavone JM, Greenblatt DJ, Blyden GT, et al. Acetaminophen pharmacokinetics in women receiving conjugated estrogen. Eur J Clin Pharmacol 1990; 38: 97-8 (Pubitemid 20050822)
21. Sonne J, Boesgaard S, Poulsen HE, et al. Pharmacokinetics and pharmacodynamics of oxazepam and metabolism of paracetamol in severe hypothyroidism. Br J Clin Pharmacol 1990; 30: 737-42 (Pubitemid 20377604)
22. Depre M, van Hecken A, Verbesselt R, et al. Tolerance and pharmacokinetics of propacetamol, a paracetamol formulation for intravenous use. Fundam Clin Pharmacol 1992; 6: 259-262
23. Manyike PT, Kharasch ED, Kalhorn TF, Slattery JT. Contribution of CYP2E1 and CYP3A to acetaminophen reactive metabolites formation. Clin Pharmacol Ther 2000; 67: 275-82 (Pubitemid 30176386)
24. O'Shea D, Davis SN, Kim RB, Wilkinson GR. Effect of fasting and obesity in humans on the 6-hydroxylation of chlorzoxazone: a putative probe on CYP2E1 activity. Clin Pharmacol Ther 1994; 56: 359-67 (Pubitemid 24339082)
25. Lucas D, Farez C, Bardou LG, Vaisse J, Attali JR, Valensi P. Cytochrome P450 2E1 activity in diabetic and obese patients as assessed by chlorzoxazone hydroxylation. Fundam Clin Pharmacol 1998; 12: 553-8 (Pubitemid 29166500)
26. Strolin Benedetti M, Whomsley R, Baltes EL. Differences in absorption, distribution, metabolism and excretion of xenobiotics between the paediatric and adult populations. Expert Opin Drug Metab Toxicol 2005; 1: 447-71
27. Friis-Hansen B. Water distribution in the foetus and newborn infant. Acta Scand Suppl 1983; 305: 7-11
28. Silber GR, Echeverria P, Smith AL, Paisley JW, Smith DH. Pharmacokinetic of gentamicin in children and adults. J Infect Dis 1975; 132: 637-51
29. Mandema JW, Verotta D, Sheiner LB. Building population pharmacokinetic models. I. Models for covariate effects. J Pharmacokinet Biopharm 1992; 20: 511-28 (Pubitemid 23034413)
30. Green B, Duffull SB. What is the best size descriptor to use for pharmacokinetic studies in the obese? Br J Clin Pharmacol 2004; 58: 119-33 (Pubitemid 39043992)
31. Morgan DJ, Bray KM. Lean body mass as a predictor of drug dosage. Clin Pharmacokinet 1994; 26: 292-307