메뉴 건너뛰기




Volumn 30, Issue 2, 2012, Pages 44-53

The ideal diabetes therapy: What will it look like? How close are we?

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIABETIC AGENT; BOVINE INSULIN; DAPAGLIFLOZIN; DEGLUDEC; DEGLUDECPLUS; DIPEPTIDYL PEPTIDASE IV INHIBITOR; EXENDIN 4; GLIBENCLAMIDE; GLIMEPIRIDE; GLIPIZIDE; GLITAZONE DERIVATIVE; HEMOGLOBIN A1C; INSULIN ASPART; INSULIN ASPART PLUS INSULIN DEGLUDEC; INSULIN DEGLUDEC; INSULIN DETEMIR; INSULIN GLARGINE; INSULIN LISPRO; ISOPHANE INSULIN; LINAGLIPTIN; LIRAGLUTIDE; METFORMIN; PIG INSULIN; PIOGLITAZONE; PLACEBO; RECOMBINANT HUMAN INSULIN; ROSIGLITAZONE; SAXAGLIPTIN; SITAGLIPTIN; SULFONYLUREA DERIVATIVE; TAK 875; TECHNOSPHERE INSULIN; TOLBUTAMIDE; UNCLASSIFIED DRUG;

EID: 84859826962     PISSN: 08918929     EISSN: None     Source Type: Journal    
DOI: 10.2337/diaclin.30.2.44     Document Type: Article
Times cited : (35)

References (60)
  • 1
    • 84856003217 scopus 로고    scopus 로고
    • National Diabetes Information Clearinghouse, article online]. Available from, Accessed 19 December 2011
    • National Diabetes Information Clearinghouse: National diabetes statistics, 2011 [article online]. Available from: http://diabetes.niddk.nih.gov/dm/pubs/ statistics/#Complications. Accessed 19 December 2011.
    • (2011) National Diabetes Statistics
  • 2
    • 35948955442 scopus 로고    scopus 로고
    • American Association of Clinical Endocrinologists, Jacksonville, Fla., American Association of Clinical Endocrinologists
    • American Association of Clinical Endocrinologists: State of Diabetes Complications in America. Jacksonville, Fla., American Association of Clinical Endocrinologists, 2007.
    • (2007) State of Diabetes Complications In America
  • 5
    • 36048991061 scopus 로고    scopus 로고
    • Insulin history, biochemistry, physiology and pharmacology
    • Joshi SR, Parikh RM, Das AK: Insulin history, biochemistry, physiology and pharmacology. J Assoc Physicians India 55:19-25, 2007.
    • (2007) J Assoc Physicians India , vol.55 , pp. 19-25
    • Joshi, S.R.1    Parikh, R.M.2    Das, A.K.3
  • 6
    • 42749106543 scopus 로고    scopus 로고
    • Short-acting insulin analogues versus regular human insulin in patients with diabetes mellitus
    • CD003287
    • Siebenhofer A, Plank J, Berghold A: Short-acting insulin analogues versus regular human insulin in patients with diabetes mellitus. Cochrane Database Syst Rev 2:CD003287, 2006.
    • (2006) Cochrane Database Syst Rev , vol.2
    • Siebenhofer, A.1    Plank, J.2    Berghold, A.3
  • 7
  • 8
    • 11844250564 scopus 로고    scopus 로고
    • Insulin analogues
    • Hirsch IB: Insulin analogues. N Engl J Med 352:174-183, 2005.
    • (2005) N Engl J Med , vol.352 , pp. 174-183
    • Hirsch, I.B.1
  • 10
    • 34247199553 scopus 로고    scopus 로고
    • New therapeutic options for treating type 2 diabetes: A review of insulin analogs and premixed insulin analogs
    • Choe C, Edelman S: New therapeutic options for treating type 2 diabetes: a review of insulin analogs and premixed insulin analogs. J Natl Med Assoc 99:357-360, 363-367, 2007.
    • (2007) J Natl Med Assoc 99 , vol.357-360 , pp. 363-367
    • Choe, C.1    Edelman, S.2
  • 11
    • 65449133147 scopus 로고    scopus 로고
    • Metformin: The gold standard in type 2 diabetes: What does the evidence tell us?
    • Bosi E: Metformin: the gold standard in type 2 diabetes: what does the evidence tell us? Diabetes Obes Metab 11:3-8, 2009.
    • (2009) Diabetes Obes Metab , vol.11 , pp. 3-8
    • Bosi, E.1
  • 12
    • 60449089649 scopus 로고    scopus 로고
    • Medical management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy: A consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes
    • Nathan DM, Buse JB, Davidson MB, Ferrannini E, Holman RR, Sherwin R, Zinman B: Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 32:193-203, 2009.
    • (2009) Diabetes Care , vol.32 , pp. 193-203
    • Nathan, D.M.1    Buse, J.B.2    Davidson, M.B.3    Ferrannini, E.4    Holman, R.R.5    Sherwin, R.6    Zinman, B.7
  • 13
    • 84859834244 scopus 로고    scopus 로고
    • Managing therapy and adverse effects with anti-hyperglycemic agents: A focus on metformin and acarbose
    • Wilson AL, Ed. Gaithersburg, Md., Jones & Bartlett Learning
    • Phillips BB: Managing therapy and adverse effects with anti-hyperglycemic agents: a focus on metformin and acarbose. In Managing the Patient with Type II Diabetes. Wilson AL, Ed. Gaithersburg, Md., Jones & Bartlett Learning, 1997, p. 69-78.
    • (1997) Managing the Patient With Type II Diabetes , pp. 69-78
    • Phillips, B.B.1
  • 14
    • 0344420380 scopus 로고    scopus 로고
    • Pasternak GA, Salpeter EE: Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus: Systematic review and meta-analysis
    • Salpeter SR, Greyber E, Pasternak GA, Salpeter EE: Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus: systematic review and meta-analysis. Arch Intern Med 163:2594-2602, 2003.
    • (2003) Arch Intern Med , vol.163 , pp. 2594-2602
    • Salpeter, S.R.1    Greyber, E.2
  • 17
    • 49449106673 scopus 로고    scopus 로고
    • Mechanisms of β-cell failure in the pathogenesis of type 2 diabetes
    • Accili D: Mechanisms of β-cell failure in the pathogenesis of type 2 diabetes. Drug Dev Res 69:111-115, 2008.
    • (2008) Drug Dev Res , vol.69 , pp. 111-115
    • Accili, D.1
  • 18
    • 60549097258 scopus 로고    scopus 로고
    • Targeting incretins in type 2 diabetes: Role of GLP-1 receptor agonists and DPP-4 inhibitors
    • Pratley RE, Gilbert M: Targeting incretins in type 2 diabetes: role of GLP-1 receptor agonists and DPP-4 inhibitors. Rev Diabet Stud 5:73-94, 2008.
    • (2008) Rev Diabet Stud , vol.5 , pp. 73-94
    • Pratley, R.E.1    Gilbert, M.2
  • 19
    • 33846006173 scopus 로고    scopus 로고
    • The incretin system: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
    • Drucker DJ, Nauck MA: The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet 368:1696-1705, 2006.
    • (2006) Lancet , vol.368 , pp. 1696-1705
    • Drucker, D.J.1    Nauck, M.A.2
  • 21
    • 0022617246 scopus 로고
    • Reduced incretin effect in type 2 (non-insulin-dependent) diabetes
    • Nauck M, Stöckmann F, Ebert R, Creutzfeldt W: Reduced incretin effect in type 2 (non-insulin-dependent) diabetes. Diabetologia 29:46-52, 1986.
    • (1986) Diabetologia , vol.29 , pp. 46-52
    • Nauck, M.1    Stöckmann, F.2    Ebert, R.3    Creutzfeldt, W.4
  • 23
    • 79955389153 scopus 로고    scopus 로고
    • Pharmacology of GLP-1-based therapies
    • Holst JJ: Pharmacology of GLP-1-based therapies. Brit J Diabetes Vasc Dis 8:S10-S18, 2008.
    • (2008) Brit J Diabetes Vasc Dis , vol.8
    • Holst, J.J.1
  • 24
    • 51949116060 scopus 로고    scopus 로고
    • An overview of incretin clinical trials
    • Garber A: An overview of incretin clinical trials. J Fam Pract 57:S10-S18, 2008.
    • (2008) J Fam Pract , vol.57
    • Garber, A.1
  • 26
    • 73349102524 scopus 로고    scopus 로고
    • The safety and efficacy of liraglutide with or without oral antidiabetic drug therapy in type 2 diabetes: An overview of the LEAD 1-5 studies
    • Blonde L, Russell-Jones D: The safety and efficacy of liraglutide with or without oral antidiabetic drug therapy in type 2 diabetes: an overview of the LEAD 1-5 studies. Diabetes Obes Metab 3:26-34, 2009.
    • (2009) Diabetes Obes Metab , vol.3 , pp. 26-34
    • Blonde, L.1    Russell-Jones, D.2
  • 27
    • 33947170920 scopus 로고    scopus 로고
    • Expanded use of exenatide in the management of type 2 diabetes
    • John LE, Kane MP, Busch RS, Robert A: Expanded use of exenatide in the management of type 2 diabetes. Diabetes Spectrum 20:59-63, 2007.
    • (2007) Diabetes Spectrum , vol.20 , pp. 59-63
    • John, L.E.1    Kane, M.P.2    Busch, R.S.3    Robert, A.4
  • 28
    • 78650106131 scopus 로고    scopus 로고
    • Incorporating incretinbased therapies into clinical practice: Differences between glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors
    • Davidson J: Incorporating incretinbased therapies into clinical practice: differences between glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors. Mayo Clin Proc 85:S27-S37, 2010.
    • (2010) Mayo Clin Proc , vol.85
    • Davidson, J.1
  • 29
    • 34247362355 scopus 로고    scopus 로고
    • Inhibition of DPP-4: A new therapeutic approach for the treatment of type 2 diabetes
    • Pratley RE, Salsali A: Inhibition of DPP-4: a new therapeutic approach for the treatment of type 2 diabetes. Curr Med Res Opin 23:919-931, 2007.
    • (2007) Curr Med Res Opin , vol.23 , pp. 919-931
    • Pratley, R.E.1    Salsali, A.2
  • 30
    • 79951701438 scopus 로고    scopus 로고
    • Use of dipeptidyl peptidase-4 inhibitors and the reporting of infections: A disproportionality analysis in the World Health Organization VigiBase
    • Willemen MJ, Mantel-Teeuwisse AK, Straus SM, Meyboom RH, Egberts TC, Leufkens HG: Use of dipeptidyl peptidase-4 inhibitors and the reporting of infections: a disproportionality analysis in the World Health Organization VigiBase. Diabetes Care 34:369-374, 2011.
    • (2011) Diabetes Care , vol.34 , pp. 369-374
    • Willemen, M.J.1    Mantel-Teeuwisse, A.K.2    Straus, S.M.3    Meyboom, R.H.4    Egberts, T.C.5    Leufkens, H.G.6
  • 31
    • 34447267513 scopus 로고    scopus 로고
    • Efficacy and safety of incretin therapy in type 2 diabetes: Systematic review and metaanalysis
    • Amori RE, Lau J, Pittas AG: Efficacy and safety of incretin therapy in type 2 diabetes: systematic review and metaanalysis. JAMA 298:194-206, 2007.
    • (2007) JAMA , vol.298 , pp. 194-206
    • Amori, R.E.1    Lau, J.2    Pittas, A.G.3
  • 32
    • 0033188402 scopus 로고    scopus 로고
    • Current views on the mechanism of action of thiazolidinedione insulin sensitizers
    • Goldstein BJ: Current views on the mechanism of action of thiazolidinedione insulin sensitizers. Diabetes Technol Ther 1:267-275, 1999.
    • (1999) Diabetes Technol Ther , vol.1 , pp. 267-275
    • Goldstein, B.J.1
  • 33
    • 35148856230 scopus 로고    scopus 로고
    • Treatment update: Thiazolidenediones in combination with metformin for the treatment of type 2 diabetes
    • Stafford JM, Elasy T: Treatment update: thiazolidenediones in combination with metformin for the treatment of type 2 diabetes. Vasc Health Risk Manag 3:503-510, 2007.
    • (2007) Vasc Health Risk Manag , vol.3 , pp. 503-510
    • Stafford, J.M.1    Elasy, T.2
  • 35
    • 84859838583 scopus 로고    scopus 로고
    • U.S. Food and Drug Administration: Avandia (rosiglitazone), Available from, Accessed 20 December 2011
    • U.S. Food and Drug Administration: Avandia (rosiglitazone): REMS: risk of cardiovascular events [article online]. Available from: http://www.fda.gov/ Safety/MedWatch/SafetyInformation/ SafetyAlertsforHumanMedicalProducts/ ucm226994.htm. Accessed 20 December 2011.
    • REMS: Risk of Cardiovascular Events [article Online]
  • 37
    • 80052700320 scopus 로고    scopus 로고
    • Clinical implications of exenatide as a twice-daily or once-weekly therapy for type 2 diabetes
    • Aroda VR, DeYoung MB: Clinical implications of exenatide as a twice-daily or once-weekly therapy for type 2 diabetes. Postgrad Med 123:228-238, 2011.
    • (2011) Postgrad Med , vol.123 , pp. 228-238
    • Aroda, V.R.1    Deyoung, M.B.2
  • 38
    • 53249142132 scopus 로고    scopus 로고
    • Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: A randomised, open-label, non-inferiority study
    • Drucker DJ, Buse JB, Taylor K, Kendall DM, Trautmann M, Zhuang D, Porter L: Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study. Lancet 372:1240-1250, 2008.
    • (2008) Lancet , vol.372 , pp. 1240-1250
    • Drucker, D.J.1    Buse, J.B.2    Taylor, K.3    Kendall, D.M.4    Trautmann, M.5    Zhuang, D.6    Porter, L.7
  • 39
    • 84859836666 scopus 로고    scopus 로고
    • Efficacy and safety of exenatide once weekly versus liraglutide in subjects with type 2 diabetes (DURATION-6): A randomized, open-label study
    • 12-16 September 2011, in Lisbon, Portugal
    • Buse JB: Efficacy and safety of exenatide once weekly versus liraglutide in subjects with type 2 diabetes (DURATION-6): a randomized, open-label study. Oral presentation (OP-13) presented at the 47th Annual Meeting of the European Association for the Study of Diabetes, 12-16 September 2011, in Lisbon, Portugal.
    • Oral Presentation (OP-13) Presented At the 47th Annual Meeting of the European Association For the Study of Diabetes
    • Buse, J.B.1
  • 40
    • 79958268386 scopus 로고    scopus 로고
    • Exenatide once weekly treatment maintained improvements in glycemic control and weight loss over 2 years
    • Taylor K, Gurney K, Han J, Pencek R, Walsh B, Trautmann M: Exenatide once weekly treatment maintained improvements in glycemic control and weight loss over 2 years. BMC Endocr Disord 11:9, 2011.
    • (2011) BMC Endocr Disord , vol.11 , pp. 9
    • Taylor, K.1    Gurney, K.2    Han, J.3    Pencek, R.4    Walsh, B.5    Trautmann, M.6
  • 42
    • 77955573674 scopus 로고    scopus 로고
    • Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): A randomised trial
    • Bergenstal RM, Wysham C, MacConell L, Malloy J, Walsh B, Yan P, Wilhelm K, Malone J, Porter LE: Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): a randomised trial. Lancet 376:431-439, 2010.
    • (2010) Lancet , vol.376 , pp. 431-439
    • Bergenstal, R.M.1    Wysham, C.2    Macconell, L.3    Malloy, J.4    Walsh, B.5    Yan, P.6    Wilhelm, K.7    Malone, J.8    Porter, L.E.9
  • 43
    • 79955960213 scopus 로고    scopus 로고
    • DURATION-2: Efficacy and safety of switching from maximum daily sitagliptin or pioglitazone to once-weekly exenatide
    • Wysham C, Bergenstal R, Malloy J, Yan P, Walsh B, Malone J, Taylor K: DURATION-2: efficacy and safety of switching from maximum daily sitagliptin or pioglitazone to once-weekly exenatide. Diabet Med 28:705-714, 2011.
    • (2011) Diabet Med , vol.28 , pp. 705-714
    • Wysham, C.1    Bergenstal, R.2    Malloy, J.3    Yan, P.4    Walsh, B.5    Malone, J.6    Taylor, K.7
  • 44
    • 84859836665 scopus 로고    scopus 로고
    • Efficacy and safety of exenatide once weekly versus metformin, pioglitazone, and sitagliptin used as monotherapy in drug-naïve patients with type 2 diabetes
    • 24-28 June, 2011 in San Diego, Calif
    • Russell-Jones D: Efficacy and safety of exenatide once weekly versus metformin, pioglitazone, and sitagliptin used as monotherapy in drug-naïve patients with type 2 diabetes. Oral presentation (280-OR) presented at the 71st Scientific Sessions of the American Diabetes Association, 24-28 June, 2011 in San Diego, Calif.
    • Oral Presentation (280-OR) Presented At the 71st Scientific Sessions of the American Diabetes Association
    • Russell-Jones, D.1
  • 46
    • 79952728903 scopus 로고    scopus 로고
    • Dapagliflozin: A sodium glucose cotransporter 2 inhibitor in development for type 2 diabetes
    • Tahrani AA, Barnett AH: Dapagliflozin: a sodium glucose cotransporter 2 inhibitor in development for type 2 diabetes. Diabetes Ther 1:45-56, 2010.
    • (2010) Diabetes Ther , vol.1 , pp. 45-56
    • Tahrani, A.A.1    Barnett, A.H.2
  • 47
    • 77956921439 scopus 로고    scopus 로고
    • Dapagliflozin monotherapy in type 2 diabetic patients with inadequate glycemic control by diet and exercise
    • Ferrannini E, Ramos S, Salsali A, Tang W: Dapagliflozin monotherapy in type 2 diabetic patients with inadequate glycemic control by diet and exercise. Diabetes 33:2217-2224, 2010.
    • (2010) Diabetes , vol.33 , pp. 2217-2224
    • Ferrannini, E.1    Ramos, S.2    Salsali, A.3    Tang, W.4
  • 48
    • 77953181310 scopus 로고    scopus 로고
    • Dapagliflozin treatment in patients with different stages of type 2 diabetes mellitus: Effects on glycaemic control and body weight
    • Zhang L, Feng Y, List J, Kasichayanula S, Pfister M: Dapagliflozin treatment in patients with different stages of type 2 diabetes mellitus: effects on glycaemic control and body weight. Diabetes Obes Metab 12:510-516, 2010.
    • (2010) Diabetes Obes Metab , vol.12 , pp. 510-516
    • Zhang, L.1    Feng, Y.2    List, J.3    Kasichayanula, S.4    Pfister, M.5
  • 54
    • 84859852401 scopus 로고    scopus 로고
    • Insulin degludec improves long-term glycemic control with less nocturnal hypoglycemia compared with insulin glargine: 1-year results from a randomized basal-bolus trial in type 1 diabetes
    • 24-28 June 2011, in San Diego, Calif
    • Heller S: Insulin degludec improves long-term glycemic control with less nocturnal hypoglycemia compared with insulin glargine: 1-year results from a randomized basal-bolus trial in type 1 diabetes. Oral presentation (70-OR) presented at the 71st Scientific Sessions of the American Diabetes Association, 24-28 June 2011, in San Diego, Calif.
    • Oral Presentation (70-OR) Presented At the 71st Scientific Sessions of the American Diabetes Association
    • Heller, S.1
  • 55
    • 84859852400 scopus 로고    scopus 로고
    • Insulin degludec improves long-term glycemic control with less nocturnal hypoglycemia compared with insulin glargine: 1-year results from a randomized basal-bolus trial in people with type 2 diabetes
    • 24-28 June 2011, in San Diego, Calif
    • Garber A: Insulin degludec improves long-term glycemic control with less nocturnal hypoglycemia compared with insulin glargine: 1-year results from a randomized basal-bolus trial in people with type 2 diabetes. Oral presentation (74-OR) presented at the 71st Scientific Sessions of the American Diabetes Association, 24-28 June 2011, in San Diego, Calif.
    • Oral Presentation (74-OR) Presented At the 71st Scientific Sessions of the American Diabetes Association
    • Garber, A.1
  • 58
    • 84859625938 scopus 로고    scopus 로고
    • TAK-875 versus placebo or glimepiride in type 2 diabete mellitus: A phase 2, randomised, double-blind, placebo-controlled trial
    • Published electronically ahead of print on 27 February 2012. (doi:10.1016/ S0140-6736(11)61879-5)
    • Burant CF, Viswanathan P, Marcinak J, Cao C, Vakilynejad M, Xie B, Leifke E: TAK-875 versus placebo or glimepiride in type 2 diabete mellitus: a phase 2, randomised, double-blind, placebo-controlled trial. Lancet. Published electronically ahead of print on 27 February 2012. (doi:10.1016/ S0140-6736(11)61879-5)
    • Lancet
    • Burant, C.F.1    Viswanathan, P.2    Marcinak, J.3    Cao, C.4    Vakilynejad, M.5    Xie, B.6    Leifke, E.7
  • 59
    • 84859852399 scopus 로고    scopus 로고
    • TAK-875, a novel GPR40 agonist, improves both postprandial and fasting hyperglycemia in Japanese patients with type 2 diabetes
    • 24-28 June 2011, in San Diego, Calif
    • Araki T: TAK-875, a novel GPR40 agonist, improves both postprandial and fasting hyperglycemia in Japanese patients with type 2 diabetes. Oral presentation (312-OR) at the 71st Scientific Sessions of the American Diabetes Association, 24-28 June 2011, in San Diego, Calif.
    • Oral Presentation (312-OR) At the 71st Scientific Sessions of the American Diabetes Association
    • Araki, T.1
  • 60
    • 79953004576 scopus 로고    scopus 로고
    • UnitedHealth Group Center for Health Reform and Modernization, Minnetonka, Minn., UnitedHealth Group Center for Health Reform and Modernization
    • UnitedHealth Group Center for Health Reform and Modernization: The United States of Diabetes: Challenges and Opportunities in the Decade Ahead. Minnetonka, Minn., UnitedHealth Group Center for Health Reform and Modernization, 2010
    • (2010) The United States of Diabetes: Challenges and Opportunities In the Decade Ahead


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.