Scoring HLA Class I Mismatches by HistoCheck Does Not Predict Clinical Outcome in Unrelated Hematopoietic Stem Cell Transplantation

Biology of Blood and Marrow Transplantation

Volumn 18, Issue 5, 2012, Pages 739-746

  Spellman, Stephen ^a   Klein, John ^b   Haagenson, Michael ^a   Askar, Medhat ^c   Baxter Lowe, Lee Ann ^d   He, Jun ^e   Hsu, Susan ^f   Blasczyk, Rainer ^g   Hurley, Carolyn ^h  

^a CENTER FOR INTERNATIONAL BLOOD AND MARROW TRANSPLANT RESEARCH   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^f AMERICAN RED CROSS   (United States)

^g HANNOVER MEDICAL SCHOOL   (Germany)

^h GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

HLA mismatch; Transplant; Unrelated donor

Indexed keywords

HLA A ANTIGEN; HLA ANTIGEN CLASS 1; HLA B ANTIGEN; HLA C ANTIGEN;

ACUTE GRAFT VERSUS HOST DISEASE; ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; ALLELE; ARTICLE; CANCER SURVIVAL; CHILD; CHRONIC GRAFT VERSUS HOST DISEASE; CHRONIC MYELOID LEUKEMIA; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE COURSE; DISEASE FREE SURVIVAL; FEMALE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; MISMATCHED RANKING SYSTEM; MORTALITY; MYELODYSPLASTIC SYNDROME; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PRESCHOOL CHILD; RECIPIENT; SCHOOL CHILD; SCORING SYSTEM;

ADOLESCENT; ADULT; AGED; ALLELES; FEMALE; GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HISTOCOMPATIBILITY TESTING; HLA ANTIGENS; HUMANS; LEUKEMIA, MYELOID; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; RECURRENCE; REGISTRIES; RESEARCH DESIGN; RETROSPECTIVE STUDIES; RISK FACTORS; SURVIVAL ANALYSIS; TRANSPLANTATION, HOMOLOGOUS; TREATMENT OUTCOME;

EID: 84859826556     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2011.09.008     Document Type: Article

References (20)

1. Lee S.J., Klein J., Haagenson M., et al. High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation. Blood 2007, 110:4576-4583.
2. Woolfrey A., Klein J.P., Haagenson M., et al. HLA-C antigen mismatches are associated with worse outcomes in unrelated donor peripheral blood stem cell transplantation. Biol Blood Marrow Transplant 2011, 17(6):885-892.
3. Hurley C.K., Fernandez-Vina M., Hildebrand W.H., et al. A high degree of HLA disparity arises from limited allelic diversity: analysis of 1775 unrelated bone marrow transplant donor-recipient pairs. Hum Immunol 2007, 68:30-40.
4. Wade J.A., Hurley C.K., Takemoto S.K., et al. HLA mismatching within or outside of cross-reactive groups (CREGs) is associated with similar outcomes after unrelated hematopoietic stem cell transplantation. Blood 2007, 109:4064-4070.
5. Duquesnoy R., Spellman S., Haagenson M., et al. HLAMatchmaker-defined triplet matching is not associated with better survival rates of patients with class I HLA allele-mismatched hematopoietic cell transplants from unrelated donors. Biol Blood Marrow Transplant 2008, 14:1064-1071.
6. Heemskerk M.B., Roelen D.L., Dankers M.K., et al. Allogeneic MHC class I molecules with numerous sequence differences do not elicit a CTL response. Hum Immunol 2005, 66:969-976.
7. Heemskerk M.B., Cornelissen J.J., Roelen D.L., et al. Highly diverged MHC class I mismatches are acceptable for haematopoietic stem cell transplantation. Bone Marrow Transplant 2007, 40:193-200.
8. Morishima Y., Kawase T., Malkki M., et al. Effect of HLA-A2 allele disparity on clinical outcome in hematopoietic cell transplantation from unrelated donors. Tissue Antigens 2007, 69(Suppl 1):31-35.
9. Kawase T., Morishima Y., Matsuo K., et al. High-risk HLA allele-mismatch combinations responsible for severe acute graft-versus-host disease and implication for its molecular mechanism. Blood 2007, 110:2235-2241.
10. Kawase T., Matsuo K., Kashiwase K., et al. HLA mismatch combinations associated with decreased risk of relapse: implications for the molecular mechanism. Blood 2009, 113:2851-2858.
11. Elsner H., Blasczyk R. Sequence similarity matching: proposal of a structure-based rating system for bone marrow transplantation. Eur J Immunogenet 2002, 29:229-236.
12. Risler J.L., Delorme M.O., Delacroix H., et al. Amino acid substitutions in structurally related proteins: a pattern recognition approach. Determination of a new and efficient scoring matrix. J Mol Biol 1988, 204:1019-1029.
13. Elsner H.A., DeLuca D., Strub J., et al. HistoCheck: rating of HLA class I and II mismatches by an Internet-based software tool. Bone Marrow Transplant 2004, 33:165-169.
14. Shaw B.E., Barber L.D., Madrigal J.A., et al. Scoring for HLA matching? A clinical test of HistoCheck. Bone Marrow Transplant 2004, 34:367-368.
15. Askar M., Sobecks R., Morishima Y., H, et al. Predictions in the face of clinical reality: HistoCheck versus high-risk HLA allele mismatch combinations responsible for severe acute graft-versus-host disease. Biol Blood Marrow Transplant 2011, 17(9):1409-1415.
16. Glucksberg H., Storb R., Fefer A., et al. Clinical manifestations of graft-versus-host disease in human recipients of marrow from HLA-matched sibling donors. Transplantation 1974, 18:295-304.
17. Shulman H.M., Sullivan K.M., Weiden P.L., et al. Chronic graft-versus-host syndrome in man: a long-term clinicopathologic study of 20 Seattle patients. Am J Med 1980, 69:204-217.
18. Petersdorf E.W., Kollman C., Hurley C.K., et al. Effect of HLA class II gene disparity on clinical outcome in unrelated donor hematopoietic cell transplantation for chronic myeloid leukemia: the US National Marrow Donor Program Experience. Blood 2001, 98:2922-2929.
19. Spellman S., Bray R., Rosen-Bronson S., et al. The detection of donor-directed, HLA-specific alloantibodies in recipients of unrelated hematopoietic cell transplantation is predictive of graft failure. Blood 2010, 115:2704-2708.
20. Baxter-Lowe L.A., Maiers M., Spellman S.R., et al. HLA-A disparities illustrate challenges for ranking the impact of HLA mismatches on bone marrow transplant outcomes in the United States. Biol Blood Marrow Transplant 2009, 15:971-981.