Absence of canonical smad signaling in ureteral and bladder mesenchyme causes ureteropelvic junction obstruction

Journal of the American Society of Nephrology

Volumn 23, Issue 4, 2012, Pages 618-628

  Tripathi, Piyush ^a   Wang, Yinqiu ^a   Casey, Adam M ^a   Chen, Feng ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; INHIBITOR OF DIFFERENTIATION 2; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER; EMBRYO DEVELOPMENT; GENE MUTATION; HYDRONEPHROSIS; MESENCHYME; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMOOTH MUSCLE; URETER; URETEROPELVIC JUNCTION OBSTRUCTION;

EID: 84859819047     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2011060566     Document Type: Article

References (39)

1. Johnson CE, Elder JS, Judge NE, Adeeb FN, Grisoni ER, Fattlar DC: The accuracy of antenatal ultrasonography in identifying renal abnormalities. Am J Dis Child 146: 1181-1184, 1992
2. Roth JA, Diamond DA: Prenatal hydronephrosis. Curr Opin Pediatr 13: 138-141, 2001 (Pubitemid 32382418)
3. Woodward M, Frank D: Postnatal management of antenatal hydronephrosis. BJU Int 89: 149-156, 2002
4. Dressler GR: The cellular basis of kidney development. Annu Rev Cell Dev Biol 22: 509-529, 2006
5. Brenner-Anantharam A, Cebrian C, Guillaume R, Hurtado R, Sun TT, Herzlinger D: Tailbud-derived mesenchyme promotes urinary tract segmentation via BMP4 signaling. Development 134: 1967-1975, 2007 (Pubitemid 46939241)
6. Yu J, Carroll TJ, McMahon AP: Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney. Development 129: 5301-5312, 2002 (Pubitemid 35460691)
7. Bush KT, Sakurai H, Steer DL, Leonard MO, Sampogna RV, Meyer TN, Schwesinger C, Qiao J, Nigam SK: TGF-beta superfamily members modulate growth, branching, shaping, and patterning of the ureteric bud. Dev Biol 266: 285-298, 2004 (Pubitemid 38102239)
8. Hu MC, Piscione TD, Rosenblum ND: Elevated SMAD1/beta-catenin molecular complexes and renal medullary cystic dysplasia in ALK3 transgenic mice. Development 130: 2753-2766, 2003 (Pubitemid 37069590)
9. Gupta IR, Macias-Silva M, Kim S, Zhou X, Piscione TD, Whiteside C, Wrana JL, Rosenblum ND: BMP-2/ALK3 and HGF signal in parallel to regulate renal collecting duct morphogenesis. J Cell Sci 113: 269-278, 2000 (Pubitemid 30088972)
10. Hartwig S, Bridgewater D, Di Giovanni V, Cain J, Mishina Y, Rosenblum ND: BMP receptor ALK3 controls collecting systemdevelopment.JAm Soc Nephrol 19: 117-124, 2008
11. Massagué J, Seoane J, Wotton D: Smad transcription factors. Genes Dev 19: 2783-2810, 2005 (Pubitemid 41739965)
12. Schmierer B, Hill CS: TGFbeta-SMAD signal transduction: Molecular specificity andfunctional flexibility. Nat Rev Mol Cell Biol 8:970-982, 2007 (Pubitemid 350174642)
13. Xu L: Regulation of Smad activities. Biochim Biophys Acta 1759: 503-513, 2006
14. Wang Y, Tripathi P, Guo Q, Coussens M, Ma L, Chen F: Cre/lox recombination in the lower urinary tract. Genesis 47: 409-413, 2009
15. Kern WF: Atlas of Renal Pathology, Philadelphia, Saunders, 1999
16. Wang GJ, Brenner-Anantharam A, Vaughan ED, Herzlinger D: Antagonism of BMP4 signaling disrupts smooth muscle investment of the ureter and ureteropelvic junction. J Urol 181: 401-407, 2009
17. Airik R, Bussen M, Singh MK, Petry M, Kispert A: Tbx18 regulates the development of the ureteral mesenchyme. J Clin Invest 116: 663-674, 2006 (Pubitemid 43326875)
18. Shin K, Lee J, Guo N, Kim J, Lim A, Qu L, Mysorekar IU, Beachy PA: Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder. Nature 472: 110-114, 2011
19. Oxburgh L, Chu GC, Michael SK, Robertson EJ: TGFbeta superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population. Development 131: 4593-4605, 2004 (Pubitemid 39409699)
20. Aoki Y, Mori S, Kitajima K, Yokoyama O, Kanamaru H, Okada K, Yokota Y: Id2 haploinsufficiency in mice leads to congenital hydronephrosis resembling that in humans. Genes Cells 9: 1287-1296, 2004 (Pubitemid 39618541)
21. Higashi-Fujime S, Hozumi T: Restoration of defective mechanochemical properties of cleaved actins by native tropomyosin: Involvement of the 40-50 loop in subdomain 2 of actin in interaction with myosin and tropomyosin. Biochem Biophys Res Commun 237: 121-125, 1997 (Pubitemid 27390336)
22. Sims-Lucas S, Caruana G, Dowling J, Kett MM, Bertram JF: Augmented and accelerated nephrogenesis in TGF-beta2 heterozygous mutant mice. Pediatr Res 63: 607-612, 2008
23. Fujita H, Hida M, Kanemoto K, Fukuda K, Nagata M, Awazu M: Cyclic stretch induces proliferation and TGF-beta1-mediated apoptosis via p38 and ERK in ureteric bud cells. Am J Physiol Renal Physiol 299: F648-F655, 2010
24. Miyazaki Y, Oshima K, Fogo A, Hogan BL, Ichikawa I: Bone morphogenetic protein 4 regulates the budding site and elongation of the mouse ureter. J Clin Invest 105: 863-873, 2000 (Pubitemid 30203059)
25. King JA, Marker PC, Seung KJ, Kingsley DM: BMP5 and the molecular, skeletal, and soft-tissue alterations in short ear mice. Dev Biol 166: 112-122, 1994 (Pubitemid 24374751)
26. Hattori K, Mabuchi R, Fujiwara H, Sanzen N, Sekiguchi K, Kawai K, Akaza H: Laminin expression patterns in human ureteral tissue. J Urol 170: 2040-2043, 2003 (Pubitemid 37255004)
27. Costello I, Biondi CA, Taylor JM, Bikoff EK, Robertson EJ: Smad4- dependent pathways control basement membrane deposition and endodermal cell migration at early stages of mouse development. BMC Dev Biol 9: 54, 2009
28. Ochala J: Thin filament proteins mutations associated with skeletal myopathies: Defective regulation of muscle contraction. J Mol Med (Berl) 86: 1197-1204, 2008
29. Paolini C, Quarta M, Nori A, Boncompagni S, Canato M, Volpe P, Allen PD, Reggiani C, Protasi F: Reorganized stores and impaired calcium handling in skeletal muscle of mice lacking calsequestrin-1. J Physiol 583: 767-784, 2007 (Pubitemid 47343505)
30. Odermatt A, Taschner PE, Khanna VK, Busch HF, Karpati G, Jablecki CK, Breuning MH, MacLennan DH: Mutations in the gene-encoding SERCA1, the fast-twitch skeletal muscle sarcoplasmic reticulum Ca2+ ATPase, are associated with Brody disease. Nat Genet 14: 191-194, 1996 (Pubitemid 26340106)
31. Drögemüller C, Drögemüller M, Leeb T, Mascarello F, Testoni S, Rossi M, Gentile A, Damiani E, Sacchetto R: Identification of a missense mutation in the bovine ATP2A1 gene in congenital pseudomyotonia of Chianina cattle: An animal model of human Brody disease. Genomics 92: 474-477, 2008
32. Moustakas A, Heldin CH: Non-Smad TGF-beta signals. J Cell Sci 118: 3573-3584, 2005
33. Yang X, Li C, Herrera PL, Deng CX: Generation of Smad4/Dpc4 conditional knockout mice. Genesis 32: 80-81, 2002 (Pubitemid 34211702)
34. McDill BW, Li SZ, Kovach PA, Ding L, Chen F: Congenital progressive hydronephrosis (cph) is caused by an S256L mutation in aquaporin-2 that affects its phosphorylation and apical membrane accumulation. Proc Natl Acad Sci USA 103: 6952-6957, 2006
35. Jia Q, McDill BW, Sankarapandian B, Wu S, Liapis H, Holzman LB, Capecchi MR, Miner JH, Chen F: Ablation of developing podocytes disrupts cellular interactions and nephrogenesis both inside and outside the glomerulus. Am J Physiol Renal Physiol 295: F1790-F1798, 2008
36. Xu X, Han J, Ito Y, Bringas P Jr, Deng C, Chai Y: Ectodermal Smad4 and p38 MAPK are functionally redundant in mediating TGF-beta/BMP signaling during tooth and palate development. DevCell 15: 322-329, 2008
37. Chang CP, McDill BW, Neilson JR, Joist HE, Epstein JA, Crabtree GR, Chen F: Calcineurin is required in urinary tract mesenchyme for the development of the pyeloureteral peristaltic machinery. J Clin Invest 113: 1051-1058, 2004 (Pubitemid 38544127)
38. Wang Y, Jarad G, Tripathi P, Pan M, Cunningham J, Martin DR, Liapis H, Miner JH, Chen F: Activation of NFAT signaling in podocytes causes glomerulosclerosis. J Am Soc Nephrol 21: 1657-1666, 2010
39. Livak KJ, Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25: 402-408, 2001 (Pubitemid 34164012)