Prophylactic cranial irradiation for small-cell lung cancer: How, when and for whom?

Expert Review of Anticancer Therapy

Volumn 12, Issue 4, 2012, Pages 505-517

  Socha, Joanna ^a   Kepka, Lucyna ^b  

^a Regional Oncology Center   (Poland)

^b INSTITUTE OF ONCOLOGY   (Poland)

Author keywords

brain metastases; neurotoxicity; prophylactic cranial irradiation; quality of life; small cell lung cancer

Indexed keywords

AMNESIA; ANOREXIA; BRAIN METASTASIS; BRAIN RADIATION; CANCER CONTROL; CANCER SURVIVAL; CLINICAL EFFECTIVENESS; COGNITIVE DEFECT; CONSTIPATION; DEMENTIA; FATIGUE; FRAIL ELDERLY; HAIR LOSS; HEADACHE; HUMAN; INTELLECTUAL IMPAIRMENT; LIMB WEAKNESS; LUNG NON SMALL CELL CANCER; MOTOR DYSFUNCTION; NEUROLOGICAL COMPLICATION; NEUROTOXICITY; PATIENT IDENTIFICATION; PATIENT SELECTION; QUALITY OF LIFE; RADIATION DOSE FRACTIONATION; RADIATION INDUCED EMESIS; RADIATION RESPONSE; RADIATION SICKNESS; REVIEW; SOMNOLENCE; TREATMENT OUTCOME;

BRAIN NEOPLASMS; CARCINOMA, SMALL CELL; COMBINED MODALITY THERAPY; HUMANS; LUNG NEOPLASMS; QUALITY OF LIFE;

EID: 84859798652     PISSN: 14737140     EISSN: 17448328     Source Type: Journal    
DOI: 10.1586/era.12.19     Document Type: Review

References (74)

1. Govindan R, Page N, Morgensztern D et al. Changing epidemiology of small-cell lung cancer in the United States over the last 30 years: Analysis of the surveillance, epidemiologic, and end results database. J. Clin. Oncol. 24(28), 4539-4544 (2006). (Pubitemid 46630948)
2. Elias AD. Small-cell lung cancer: State-of-The-Art therapy in 1996. Chest 112(4), 251S-258S (1997). (Pubitemid 27441091)
3. Turrisi AT 3rd, Kim K, Blum R et al. Twice-daily compared with once-daily thoracic radiotherapy in limited small-cell lung cancer treated concurrently with cisplatin and etoposide. N. Engl. J. Med. 340(4), 265-271 (1999). (Pubitemid 29063268)
4. Micke P, Faldum A, Metz T et al. Staging small-cell lung cancer: Veterans Administration Lung Study Group versus International Association for the Study of Lung Cancer - What limits limited disease. Lung Cancer 37(3), 271-276 (2002). (Pubitemid 35286725)
5. Vallières E, Shepherd FA, Crowley J et al. The IASLC Lung Cancer Staging Project: Proposals regarding the relevance of TNM in the pathologic staging of small-cell lung cancer in the forthcoming (seventh) edition of the TNM classification for lung cancer. J. Thorac. Oncol. 4(9), 1049-1059 (2009).
6. Shepherd FA, Crowley J, Van Houtte P et al. The International Association for the Study of Lung Cancer lung cancer staging project: Proposals regarding the clinical staging of small-cell lung cancer in the forthcoming (seventh) edition of the tumor, node, metastasis classification for lung cancer. J. Thorac. Oncol. 2(12), 1067-1077 (2007). (Pubitemid 350307898)
7. Simon GR, Turrisi A. Management of small-cell lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition). Chest 132(3 Suppl.), S324-S339 (2007).
8. Kepka L, Sprawka A, Casas F, Abdel-Wahab S, Agarwal JP, Jeremic B. Radiochemotherapy in small-cell lung cancer. Expert Rev. Anticancer Ther. 9(10), 1379-1387 (2009).
9. Pignon JP, Arriagada R, Ihde DC et al. A meta-Analysis of thoracic radiotherapy for small-cell lung cancer. N. Engl. J. Med. 327(23), 1618-1624 (1992).
10. Warde P, Payne D. Does thoracic irradiation improve survival and local control in limited-stage small-cell carcinoma of the lung? A meta-Analysis. J. Clin. Oncol. 10(6), 890-895 (1992).
11. Auperin A, Arriagada R, Pignon JP et al. Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission: A meta-Analysis of individual data from 987 patients. N. Engl. J. Med. 341(7), 476-484 (1999). (Pubitemid 29372887)
12. Slotman B, Faivre-Finn C, Kramer G et al. Prophylactic cranial irradiation in extensive small-cell lung cancer. N. Engl. J. Med. 357(7), 664-672 (2007). (Pubitemid 47267236)
13. Lee JJ, Bekele BN, Zhou X, Cantor SB, Komaki R, Lee JS. Decision analysis for prophylactic cranial irradiation for patients with small-cell lung cancer. J. Clin. Oncol. 24(22), 3597-3603 (2006). (Pubitemid 46630532)
14. Seute T, Leffers P, ten Velde GPM, Twijnstra A. Detection of brain metastases from small-cell lung cancer: Consequences of changing imaging techniques (CT versus MRI). Cancer 112(8), 1827-1834 (2008). (Pubitemid 351536844)
15. Hirsch FR, Paulson OB, Hansen HH, Vraa-Jensen J. Intracranial metastases in small-cell carcinoma of the lung: Correlation of clinical and autopsy findings. Cancer 50(11), 2433-2437 (1982). (Pubitemid 13244181)
16. Nugent JL, Bunn PA Jr., Matthews MJ et al. CNS metastases in small-cell bronchogenic carcinoma: Increasing frequency and changing pattern with lengthening survival. Cancer 44(5), 1885-1893 (1979). (Pubitemid 10141970)
17. Postmus PE, Haaxma-Reiche H, Gregor A et al. Brain-only metastases of small-cell lung cancer: Efficacy of whole brain radiotherapy - An EORTC Phase II study. Radiother. Oncol. 46(1), 29-32 (1998). (Pubitemid 28072855)
18. Twelves CJ, Souhami RL, Harper PG et al. The response of cerebral metastases in small-cell lung cancer to systemic chemotherapy. Br. J. Cancer. 61(1), 147-150 (1990). (Pubitemid 20043562)
19. Postmus PE, Haaxma-Reiche H, Smit EF et al. Treatment of brain metastases of small-cell lung cancer: Comparing teniposide and teniposide with whole-brain radiotherapy - A Phase III study of the European Organization for the Research and Treatment of Cancer Lung Cancer Cooperative Group. J. Clin. Oncol. 18(19), 3400-3408 (2000).
20. Hansen HH. Should initial treatment of small-cell carcinoma include systemic chemotherapy and brain irradiation? Cancer Chemother. Rep. 3. 4(2), 239-241 (1973).
21. Kristjansen PE, Kristensen CA. The role of prophylactic cranial irradiation in the management of small-cell lung cancer. Cancer Treat. Rev. 19(1), 3-16 (1993). (Pubitemid 23087949)
22. Rosen ST, Makuch RW, Lichter AS et al. Role of prophylactic cranial irradiation in prevention of central nervous system metastases in small-cell lung cancer: Potential benefit restricted to patients with complete response. Am. J. Med. 74(4), 615-624 (1983). (Pubitemid 13125979)
23. Rosenstein M, Armstrong J, Kris M et al. A reappraisal of the role of prophylactic cranial irradiation in limited small-cell lung cancer. Int. J. Radiat. Oncol. Biol. Phys. 24(1), 43-48 (1992).
24. Rubenstein JH, Dosoretz DE, Katin MJ et al. Low doses of prophylactic cranial irradiation effective in limited stage small-cell carcinoma of the lung. Int. J. Radiat. Oncol. Biol. Phys. 33(2), 329-337 (1995).
25. Shaw EG, Su JQ, Eagan RT, Jett JR, Maksymiuk AW, Deigert FA. Prophylactic cranial irradiation in complete responders with small-cell lung cancer: Analysis of the Mayo Clinic and North Central Cancer Treatment Group data bases. J. Clin. Oncol. 12(11), 2327-2332 (1994). (Pubitemid 24346703)
26. Laplanche A, Monnet I, Santos-Miranda JA et al. Controlled clinical trial of prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission. Lung Cancer 21(3), 193-201 (1998). (Pubitemid 28491367)
27. Arriagada R, Le Chevalier T, Borie F et al. Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission. J. Natl Cancer Inst. 87(3), 183-190 (1995).
28. Gregor A, Cull A, Stephens RJ et al. Prophylactic cranial irradiation is indicated following complete response to induction therapy in small-cell lung cancer: Results of a multicentre randomised trial. Eur. J. Cancer 33(11), 1752-1758 (1997).
29. Meert AP, Paesmans M, Berghmans T et al. Prophylactic cranial irradiation in small-cell lung cancer: A systematic review of the literature with meta-Analysis. BMC Cancer 1, 5 (2001).
30. Paumier A, Le Péchoux C. Radiotherapy in small-cell lung cancer: Where should it go? Lung Cancer 69(2), 133-140 (2010).
31. Withers HR, Suwinski R. Radiation dose response for subclinical metastases. Semin. Radiat. Oncol. 8(3), 224-228 (1998). (Pubitemid 28323481)
32. Withers HR, Peters LJ, Taylor JM. Dose-response relationship for radiation therapy of subclinical disease. Int. J. Radiat. Oncol. Biol. Phys. 31(2), 353-359 (1995).
33. Suwinski R, Lee SP, Withers HR. Dose-response relationship for prophylactic cranial irradiation in small-cell lung cancer. Int. J. Radiat. Oncol. Biol. Phys. 40(4), 797-806 (1998). (Pubitemid 28150796)
34. Steel GG. Growth Kinetics of Tumours. Clarendon Press, Oxford, UK, 37-48 (1977).
35. Manapov F, Klautke G, Fietkau R. Prevalence of brain metastases immediately before prophylactic cranial irradiation in limited disease small-cell lung cancer patients with complete remission to chemoradiotherapy: A single institution experience. J. Thorac. Oncol. 3(6), 652-655 (2008). (Pubitemid 351787312)
36. Ball DL, Matthews JP. Prophylactic cranial irradiation: More questions than answers. Semin. Radiat. Oncol. 5(1), 61-68 (1995).
37. Herskovic AM, Orton CG. Elective brain irradiation for small-cell anaplastic lung cancer. Int. J. Radiat. Oncol. Biol. Phys. 12(3), 427-429 (1986). (Pubitemid 16108875)
38. Wolfson AH, Bae K, Komaki R et al. Primary analysis of a phase II randomized trial Radiation Therapy Oncology Group (RTOG) 0212: Impact of different total doses and schedules of prophylactic cranial irradiation on chronic neurotoxicity and quality of life for patients with limited-disease small-cell lung cancer. Int. J. Radiat. Oncol. Biol. Phys. 81(1), 77-84 (2011).
39. Le Péchoux C, Dunant A, Senan S et al. Standard-dose versus higher-dose prophylactic cranial irradiation (PCI) in patients with limited-stage small-cell lung cancer in complete remission after chemotherapy and thoracic radiotherapy (PCI 99-01, EORTC 22003-08004, RTOG 0212, and IFCT 99-01): A randomised clinical trial. Lancet Oncol. 10(5), 467-474 (2009).
40. Le Péchoux C, Laplanche A, Faivre-Finn C et al. Clinical neurological outcome and quality of life among patients with limited small-cell cancer treated with two different doses of prophylactic cranial irradiation in the intergroup Phase III trial (PCI99-01, EORTC 22003-08004, RTOG 0212 and IFCT 99-01). Ann. Oncol. 22(5), 1154-1163 (2011).
41. Nakamura H, Kato Y, Kato H. Outcome of surgery for small-cell lung cancer - Response to induction chemotherapy predicts survival. Thorac. Cardiovasc. Surg. 52(4), 206-210 (2004). (Pubitemid 39099884)
42. Tsuchiya R, Suzuki K, Ichinose Y et al. Phase II trial of postoperative adjuvant cisplatin and etoposide in patients with completely resected stage I-IIIa small-cell lung cancer: The Japan Clinical Oncology Lung Cancer Study Group Trial (JCOG9101). J. Thorac. Cardiovasc. Surg. 129(5), 977-983 (2005). (Pubitemid 40631415)
43. Bischof M, Debus J, Herfarth K et al. Surgery and chemotherapy for small-cell lung cancer in stages I-II with or without radiotherapy. Strahlenther. Onkol. 183(12), 679-684 (2007). (Pubitemid 350175411)
44. Patel S, Macdonald OK, Suntharalingam M. Evaluation of the use of prophylactic cranial irradiation in small-cell lung cancer. Cancer 115(4), 842-850 (2009).
45. Slotman BJ, Postmus P, Senan S. N. Engl. J. Med. 357(19), 1977-1978; author reply 1978 (2007).
46. Slotman BJ, Senan S. Radiotherapy in small-cell lung cancer: Lessons learned and future directions. Int. J. Radiat. Oncol. Biol. Phys. 79(4), 998-1003 (2011).
47. Ryken TC, McDermott M, Robinson PD et al. The role of steroids in the management of brain metastases: A systematic review and evidence-based clinical practice guideline. J. Neurooncol. 96(1), 103-114 (2010).
48. Crossen JR, Garwood D, Glatstein E, Neuwelt EA. Neurobehavioral sequelae of cranial irradiation in adults: A review of radiation-induced encephalopathy. J. Clin. Oncol. 12(3), 627-642 (1994). (Pubitemid 24079908)
49. Fleck JF, Einhorn LH, Lauer RC, Schultz SM, Miller ME. Is prophylactic cranial irradiation indicated in small-cell lung cancer? J. Clin. Oncol. 8(2), 209-214 (1990). (Pubitemid 20056550)
50. Johnson BE, Patronas N, Hayes W et al. Neurologic, computed cranial tomographic, and magnetic resonance imaging abnormalities in patients with small-cell lung cancer: Further follow-up to 6- to 13-year survivors. J. Clin. Oncol. 8(1), 48-56 (1990). (Pubitemid 20032446)
51. Lee JS, Umsawasdi T, Lee YY et al. Neurotoxicity in long-Term survivors of small-cell lung cancer. Int. J. Radiat. Oncol. Biol. Phys. 12(3), 313-321 (1986). (Pubitemid 16108856)
52. Craig J, Jackson D, Moody D et al. Prospective evaluation of changes in computerized cranial tomography (CCT) in patients with small-cell carcinoma (SCLC) treated with chemotherapy and cranial irradiation. J. Clin. Oncol. 2(10), 1151-1156 (1984). (Pubitemid 14022704)
53. Fonseca R, O'Neill BP, Foote RL, Grill JP, Sloan JA, Frytak S. Cerebral toxicity in patients treated for small-cell carcinoma of the lung. Mayo Clin. Proc. 74(5), 461-465 (1999). (Pubitemid 29207143)
54. Sculier JP, Feld R, Evans WK et al. Neurological disorders in patients with small-cell lung cancer. Cancer 60(9), 2275-2283 (1987). (Pubitemid 17153497)
55. Komaki R, Meyers CA, Shin DM et al. Evaluation of cognitive function in patients with limited small-cell lung cancer prior to and shortly following prophylactic cranial irradiation. Int. J. Radiat. Oncol. Biol. Phys. 33(1), 179-182 (1995).
56. Ahles TA, Silberfarb PM, Herndon J 2nd et al. Psychologic and neuropsychologic functioning of patients with limited small-cell lung cancer treated with chemotherapy and radiation therapy with or without warfarin: A study by the Cancer and Leukemia Group B. J. Clin. Oncol. 16(5), 1954-1960 (1998).
57. Powell C, Guerrero D, Sardell S et al. Somnolence syndrome in patients receiving radical radiotherapy for primary brain tumours; a prospective study. Radiother. Oncol. 100(1), 131-136 (2011).
58. Slotman BJ, Mauer ME, Bottomley A et al. Prophylactic cranial irradiation in extensive disease small-cell lung cancer: Short-Term health-related quality of life and patient reported symptoms: Results of an international Phase III randomised controlled trial. J. Clin. Oncol. 27(1), 78-84 (2009).
59. Gondi V, Tolakanahalli R, Mehta MP et al. Hippocampal-sparing whole-brain radiotherapy: A 'how-To' technique using helical tomotherapy and linear accelerator-based intensity-modulated radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 78(4), 1244-1252 (2010).
60. Gondi V, Tome WA, Marsh J et al. Estimated risk fo perihippocampal disease progression after hippocampal avoidance during whole-brain radiotherapy: Safety profile for RTOG 0933. Radiother. Oncol. 95(3), 327-331 (2010).
61. Gaspar LE, Gay EG, Crawford J, Putnam JB, Herbst RS, Bonner JA. Limited-stage small-cell lung cancer (stages I-III): Observations from the National Cancer Data Base. Clin. Lung Cancer 6(6), 355-360 (2005). (Pubitemid 41418417)
62. Lally BE, Geiger AM, Urbanic JJ et al. Trends in the outcomes for patients with limited stage small-cell lung cancer: An analysis of the Surveillance, Epidemiology, and End Results database. Lung Cancer 64(2), 226-231 (2009).
63. Hutchins LF, Unger JM, Crowley JJ, Coltman CA Jr, Albain KS. Underrepresentation of patients 65 years of age or older in cancer- treatment trials. N. Engl. J. Med. 341(27), 2061-2067 (1999). (Pubitemid 30035956)
64. Hurria A, Kris MG. Management of lung cancer in older adults. CA Cancer J. Clin. 53(6), 325-341 (2003). (Pubitemid 38081591)
65. Ludbrook JJ, Truong PT, MacNeil MV et al. Do age and comorbidity impact treatment allocation and outcomes in limited stage small-cell lung cancer? A community-based population analysis. Int. J. Radiat. Oncol. Biol. Phys. 55(5), 1321-1330 (2003). (Pubitemid 36338300)
66. Giuliani M, Sun A, Bezjak A et al. Utilization of prophylactic cranial irradiation in patients with limited stage small-cell lung carcinoma. Cancer 116(24), 5694-5699 (2010).
67. Uno T, Sumi M, Sawa Y et al. Process of care and preliminary outcome in limited-stage small-cell lung cancer: Results of the 1995-1997 patterns of care study in Japan. Int. J. Radiat. Oncol. Biol. Phys. 55(3), 626-632 (2003). (Pubitemid 36170003)
68. Rossi A, Maione P, Colantuoni G et al. Treatment of small-cell lung cancer in the elderly. Oncologist 10(6), 399-411 (2005). (Pubitemid 40993568)
69. Marsh JC, Gielda BT, Herskovic AM, Abrams RA. Cognitive sparing during the administration of whole brain radiotherapy and prophylactic cranial irradiation: Current concepts and approaches. J. Oncol. 198208 (2010) (2010).
70. Tarnawski R, Michalecki L, Blamek S et al. Feasibility of reducing the irradiation dose in regions of active neurogenesis for prophylactic cranial irradiation in patients with small-cell lung cancer. Neoplasma 58(6), 507-515 (2011).
71. Ammirati M, Cobbs CS, Linskey ME et al. The role of retreatment in the management of recurrent/progressive brain metastases: A systematic review and evidence-based clinical practice guideline. J. Neurooncol. 96(1), 85-96 (2010).
72. Aroney RS, Aisner J, Wesley MN et al. Value of prophylactic cranial irradiation given at complete remission in small-cell lung carcinoma. Cancer Treat. Rep. 67(7-8), 675-682 (1983). (Pubitemid 13001714)
73. Ohonoshi T, Ueoka H, Kawahara S et al. Comparative study of prophylactic cranial irradiation in patients with small-cell lung cancer achieving a complete response: A long-Term follow-up result. Lung Cancer 10(1-2), 47-54 (1993). (Pubitemid 23341209)
74. Wagner H, Kim K, Turrisi A et al. A randomized Phase III study of prophylactic cranial irradiation versus observation in patients with small-cell lung cancer achieving a complete response: Final report of an incomplete trial by the Eastern Cooperative Oncology Group and Radiation Therapy Oncology Group (E3589/R92-01). Presented at: 32rd ASCO Annual Meeting. PA, USA, 18-21 May 1996.