Design of potent and selective hybrid inhibitors of the mitotic kinase nek2: Structure-activity relationship, structural biology, and cellular activity

Journal of Medicinal Chemistry

Volumn 55, Issue 7, 2012, Pages 3228-3241

  Innocenti, Paolo ^a   Cheung, Kwai Ming J ^a   Solanki, Savade ^a   Mas Droux, Corine ^a   Rowan, Fiona ^a   Yeoh, Sharon ^b   Boxall, Kathy ^a   Westlake, Maura ^a   Pickard, Lisa ^a   Hardy, Tara ^b   Baxter, Joanne E ^b   Aherne, G Wynne ^a   Bayliss, Richard ^a,b   Fry, Andrew M ^b   Hoelder, Swen ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

METHYL 4 (2 AMINO 5 BROMOPYR IDIN 3 YL) 2 [(4 METHOXYBENZYL)OXY]BENZOIC ACID; METHYL 4 BROMO 2 HYDROXYBENZOIC ACID; METHYL 4 BROMO 2 [(4 METHOXYBENZYL)OXY]BENZOIC ACID; NEK2 INHIBITOR; PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

EID: 84859792763     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201683b     Document Type: Article

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