Development and validation of an UPLC method for the rapid separation of positional isomers and potential impurities of rivastigmine hydrogen tartrate in drug substance and drug product

Journal of Liquid Chromatography and Related Technologies

Volumn 35, Issue 7, 2012, Pages 896-911

  Satyanarayana Raju, T ^a,b   Kalyanaraman, L ^a   Venkat Reddy, V ^a   Yadagiri Swamy, P ^b  

^a DR REDDY'S LABORATORIES LTD   (India)

^b OSMANIA UNIVERSITY   (India)

Author keywords

Forced degradation; Rivastigmine hydrogen tartrate; Stability indicating UPLC; Validation

Indexed keywords

ACQUITY; ACTIVE PHARMACEUTICAL INGREDIENTS; CHROMATOGRAPHIC SEPARATIONS; DEGRADATION PRODUCTS; DRUG SUBSTANCES; FORCED DEGRADATION; IMPURITIES IN; LIMIT OF DETECTION; LIMIT OF QUANTIFICATIONS; MIXTURE OF SOLVENTS; MOBILE PHASE; NUMBER OF METHODS; OVEN TEMPERATURE; PHARMACEUTICAL DOSAGE FORMS; PHOTODIODE ARRAY DETECTORS; POSITIONAL ISOMERS; PROCESS-RELATED IMPURITIES; QUANTITATIVE DETERMINATIONS; RAPID SEPARATION; REVERSE PHASE; RIVASTIGMINE; RUNTIMES; STABILITY-INDICATING UPLC; VALIDATION;

DEGRADATION; HYDROGEN; ISOMERS; LIQUID CHROMATOGRAPHY; SEPARATION;

DRUG PRODUCTS;

RIVASTIGMINE;

ACCURACY; ARTICLE; DRUG DEGRADATION; DRUG DOSAGE FORM; DRUG IMPURITY; ISOMER; QUANTITATIVE ANALYSIS; SEPARATION TECHNIQUE; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; VALIDATION PROCESS;

EID: 84859788790     PISSN: 10826076     EISSN: 1520572X     Source Type: Journal    
DOI: 10.1080/10826076.2011.613143     Document Type: Article

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