A novel multi-targeted tyrosine kinase inhibitor, linifanib (ABT-869), produces functional and structural changes in tumor vasculature in an orthotopic rat glioma model

Cancer Chemotherapy and Pharmacology

Volumn 69, Issue 4, 2012, Pages 911-921

  Luo, Yanping ^a   Jiang, Fang ^a   Cole, Todd B ^a   Hradil, Vincent P ^a   Reuter, David ^a   Chakravartty, Arunava ^a   Albert, Daniel H ^a   Davidsen, Steven K ^a   Cox, Bryan F ^a   McKeegan, Evelyn M ^a   Fox, Gerard B ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Angiogenesis; Blood vessel; DCE MRI; Glioma; Linifanib; Perfusion; Permeability

Indexed keywords

LINIFANIB; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; VASCULOTROPIN RECEPTOR 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLOOD VESSEL PERMEABILITY; CANCER INHIBITION; CANCER PROGNOSIS; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; FEMALE; GLIOMA; IMMUNOHISTOCHEMISTRY; MICROVASCULATURE; MORNING DOSAGE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PREDICTIVE VALUE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TUMOR VASCULARIZATION; TUMOR VOLUME;

ANIMALS; BRAIN NEOPLASMS; CELL GROWTH PROCESSES; DISEASE MODELS, ANIMAL; FEMALE; GLIOMA; IMMUNOHISTOCHEMISTRY; INDAZOLES; MAGNETIC RESONANCE ANGIOGRAPHY; NEOVASCULARIZATION, PATHOLOGIC; PHENYLUREA COMPOUNDS; PROTEIN KINASE INHIBITORS; RATS; RATS, INBRED F344; RECEPTOR PROTEIN-TYROSINE KINASES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84859787055     PISSN: 03445704     EISSN: 14320843     Source Type: Journal    
DOI: 10.1007/s00280-011-1740-7     Document Type: Article

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